List of works - Caroline Kisker

'Close-fitting sleeves': DNA damage recognition by the UvrABC nuclease system

scientific article

A Long Residence Time Enoyl-Reductase Inhibitor Explores an Extended Binding Region with Isoenzyme-Dependent Tautomer Adaptation and Differential Substrate-Binding Loop Closure

scientific article published on 12 March 2021

A Slow, Tight Binding Inhibitor of InhA, the Enoyl-Acyl Carrier Protein Reductase from Mycobacterium tuberculosis

scientific article

A closer look at the active site of gamma-class carbonic anhydrases: high-resolution crystallographic studies of the carbonic anhydrase from Methanosarcina thermophila

scientific article

A simple pressure cell and delivery system for the preparation of Xe derivatives for protein crystallography

A structural comparison of molybdenum cofactor-containing enzymes

scientific article

A structural comparison of molybdenum cofactor-containing enzymes

scholarly article by Caroline Kisker et al published December 1998 in FEMS Microbiology Reviews

An ordered water channel in Staphylococcus aureus FabI: unraveling the mechanism of substrate recognition and reduction.

scientific article

Bax1 is a novel endonuclease: implications for archaeal nucleotide excision repair

scientific article published on 15 September 2009

Biophysical and functional analyses suggest that adenovirus E4-ORF3 protein requires higher-order multimerization to function against promyelocytic leukemia protein nuclear bodies

scientific article

Catabolism of the Cholesterol Side Chain in Mycobacterium tuberculosis Is Controlled by a Redox-Sensitive Thiol Switch.

scientific article

Characterizing septum inhibition in Mycobacterium tuberculosis for novel drug discovery

scientific article published on 13 May 2008

Chlamydia trachomatis-containing vacuole serves as deubiquitination platform to stabilize Mcl-1 and to interfere with host defense.

scientific article published on 28 March 2017

Comparing crystallographic and solution structures of nitrogenase complexes

article

Conservation and Divergence in Nucleotide Excision Repair Lesion Recognition.

scientific article published on 12 July 2016

Conserved salt-bridge competition triggered by phosphorylation regulates the protein interactome.

scientific article published on 5 December 2017

Constitutive activation of PKA catalytic subunit in adrenal Cushing's syndrome

scientific article published on 26 February 2014

Correlating Drug-Target Kinetics and In vivo Pharmacodynamics: Long Residence Time Inhibitors of the FabI Enoyl-ACP Reductase

scientific article published on 25 May 2016

Crystal Structure of the FeS Cluster–Containing Nucleotide Excision Repair Helicase XPD

scientific article

Crystal Structures of Mycobacterium tuberculosis KasA Show Mode of Action within Cell Wall Biosynthesis and its Inhibition by Thiolactomycin

scientific article

Crystal structure of Mycobacterium tuberculosis MenB, a key enzyme in vitamin K2 biosynthesis

scientific article

Crystal structures of the active and alloxanthine-inhibited forms of xanthine dehydrogenase from Rhodobacter capsulatus

scientific article

Crystallizing the 6S and 8S spliceosomal assembly intermediates: a complex project

scientific article published on 26 September 2015

Crystallographic characterization of an exocyclic DNA adduct: 3,N4-etheno-2'-deoxycytidine in the dodecamer 5'-CGCGAATTepsilonCGCG-3'

scientific article (publication date: 13 June 2003)

DNA Helicases in NER, BER, and MMR.

scientific article published in January 2013

DNA binding cooperativity of p53 modulates the decision between cell-cycle arrest and apoptosis.

scientific article published in May 2010

DNA damage, mutagenesis, and DNA repair.

scientific article published on 27 December 2010

Damage recognition in nucleotide excision DNA repair.

scientific article published on 17 January 2012

Development of modern InhA inhibitors to combat drug resistant strains of Mycobacterium tuberculosis

scientific article published on January 2007

Die Fettsäuresynthese als Angriffspunkt

scientific article published on 01 January 2012

Different promoter affinities account for specificity in MYC-dependent gene regulation.

scientific article published on 27 July 2016

Differential Oligomerization of the Deubiquitinases USP25 and USP28 Regulates Their Activities

scientific article published on 26 March 2019

Elucidation of the protonation states of the catalytic residues in mtKasA: implications for inhibitor design.

scientific article published on 7 June 2011

Error-Prone DNA Polymerases

Evaluating the Contribution of Transition-State Destabilization to Changes in the Residence Time of Triazole-Based InhA Inhibitors

scientific article

FANCM interacts with PCNA to promote replication traverse of DNA interstrand crosslinks.

scientific article published on 28 January 2016

FadA5 a thiolase from Mycobacterium tuberculosis: a steroid-binding pocket reveals the potential for drug development against tuberculosis

scientific article

Front Cover: Structural Basis of Substrate Recognition and Covalent Inhibition of Cdu1 from Chlamydia trachomatis (ChemMedChem 19/2018)

scholarly article by Yesid A. Ramirez et al published 8 October 2018 in ChemMedChem

Functional and structural studies of the nucleotide excision repair helicase XPD suggest a polarity for DNA translocation

scientific article

Functional human mitochondrial DNA polymerase gamma forms a heterotrimer

scientific article

Global discovery of bacterial RNA-binding proteins by RNase-sensitive gradient profiles reports a new FinO domain protein

scientific article published on 09 July 2020

High Affinity InhA Inhibitors with Activity against Drug-Resistant Strains of Mycobacterium tuberculosis

scientific article published on 01 February 2006

High accuracy FIONA-AFM hybrid imaging.

scientific article

How to limit the speed of a motor: the intricate regulation of the XPB ATPase and translocase in TFIIH

scientific article published on 16 November 2020

Identification of residues within UvrB that are important for efficient DNA binding and damage processing.

scientific article

Impact of age-associated cyclopurine lesions on DNA repair helicases

scientific article

In TFIIH the Arch domain of XPD is mechanistically essential for transcription and DNA repair

scientific article published on 03 April 2020

In TFIIH, XPD helicase is exclusively devoted to DNA repair

scientific article

Interactions between UvrA and UvrB: the role of UvrB's domain 2 in nucleotide excision repair

scientific article published on 10 June 2004

Isolated sulfite oxidase deficiency: identification of 12 novel SUOX mutations in 10 patients

scientific article (publication date: July 2002)

Lesion (in)tolerance reveals insights into DNA replication fidelity

scientific article

Lysine 190 is the catalytic base in MenF, the menaquinone-specific isochorismate synthase from Escherichia coli: implications for an enzyme family

scientific article

Mechanism of Substrate and Inhibitor Binding of Rhodobacter capsulatus Xanthine Dehydrogenase

scientific article

Mechanism of the Intramolecular Claisen Condensation Reaction Catalyzed by MenB, a Crotonase Superfamily Member

scientific article

Mechanistic insights into the enzymatic activity and inhibition of the replicative polymerase exonuclease domain from Mycobacterium tuberculosis

scientific article published on 26 December 2018

Michael acceptor based antiplasmodial and antitrypanosomal cysteine protease inhibitors with unusual amino acids

scientific article published in March 2010

Molecular basis of sulfite oxidase deficiency from the structure of sulfite oxidase

scientific article

Molecular dynamics of Mycobacterium tuberculosis KasA: implications for inhibitor and substrate binding and consequences for drug design

article

Molybdopterin from molybdenum and tungsten enzymes.

scientific article

Mouse Rev1 protein interacts with multiple DNA polymerases involved in translesion DNA synthesis

scientific article

Novel somatic mutations in the catalytic subunit of the protein kinase A as a cause of adrenal Cushing's syndrome: a European multicentric study

scientific article published on 24 July 2014

Nucleotide Excision Repair from Bacteria to Humans: Structure–Function Studies

OmoMYC blunts promoter invasion by oncogenic MYC to inhibit gene expression characteristic of MYC-dependent tumors

scientific article

On-bead screening of a combinatorial fumaric acid derived peptide library yields antiplasmodial cysteine protease inhibitors with unusual peptide sequences

scientific article published in September 2009

PKA catalytic subunit mutations in adrenocortical Cushing's adenoma impair association with the regulatory subunit.

scientific article

Prokaryotic nucleotide excision repair.

scientific article published on March 2013

Prokaryotic nucleotide excision repair: the UvrABC system.

scientific article

Proximity mapping of the Tet repressor-tetracycline-Fe2+ complex by hydrogen peroxide mediated protein cleavage.

scientific article published in January 1995

Raf kinase inhibitor protein (RKIP) dimer formation controls its target switch from Raf1 to G protein-coupled receptor kinase (GRK) 2.

scientific article published on 17 May 2012

Rational Design of Broad Spectrum Antibacterial Activity Based on a Clinically Relevant Enoyl-Acyl Carrier Protein (ACP) Reductase Inhibitor

scientific article

Rational Optimization of Drug-Target Residence Time: Insights from Inhibitor Binding to the Staphylococcus aureus FabI Enzyme–Product Complex

scientific article

Rationalizing the Binding Kinetics for the Inhibition of the Burkholderia pseudomallei FabI1 Enoyl-ACP Reductase

scientific article published on 22 February 2017

Repurposing a Library of Human Cathepsin L Ligands: Identification of Macrocyclic Lactams as Potent Rhodesain and Trypanosoma brucei Inhibitors

scientific article published on 13 April 2018

Role of XPD in cellular functions: To TFIIH and beyond

scientific article published on 16 May 2016

Selectivity of Pyridone- and Diphenyl Ether-Based Inhibitors for the Yersinia pestis FabV Enoyl-ACP Reductase.

scientific article published on 02 May 2016

Single molecule analysis reveals monomeric XPA bends DNA and undergoes episodic linear diffusion during damage search

scientific article published on 13 March 2020

Slow onset inhibition of bacterial beta-ketoacyl-acyl carrier protein synthases by thiolactomycin

scientific article

Slow-Onset Inhibition of the FabI Enoyl Reductase from Francisella tularensis : Residence Time and in Vivo Activity

scientific article

Specialization among iron-sulfur cluster helicases to resolve G-quadruplex DNA structures that threaten genomic stability

scientific article published on 09 August 2013

Staphylococcus aureus FabI: Inhibition, Substrate Recognition, and Potential Implications for In Vivo Essentiality

scientific article

Stereoselectivity of enoyl-CoA hydratase results from preferential activation of one of two bound substrate conformers

scientific article

Strand-specific recognition of DNA damages by XPD provides insights into nucleotide excision repair substrate versatility

scientific article published on 14 December 2013

Structural Basis for the Recognition of Mycolic Acid Precursors by KasA, a Condensing Enzyme and Drug Target from Mycobacterium Tuberculosis

scientific article

Structural Basis for the Recruitment of Ctf18-RFC to the Replisome.

scientific article published on 6 December 2017

Structural Basis of Substrate Recognition and Covalent Inhibition of Cdu1 from Chlamydia trachomatis

scientific article published on 06 September 2018

Structural analysis of missense mutations causing isolated sulfite oxidase deficiency

scientific article

Structural basis and mechanism of enoyl reductase inhibition by triclosan

scientific article

Structural basis for CDK7 activation by MAT1 and Cyclin H

scientific article published on 14 October 2020

Structural basis for DNA recognition and processing by UvrB

scientific article published on 12 March 2006

Structural basis for the shielding function of the dynamic trypanosome variant surface glycoprotein coat

scientific article

Structural basis of assembly chaperone- mediated snRNP formation

scientific article

Structural insights into sulfite oxidase deficiency

scientific article

Structural insights into the first incision reaction during nucleotide excision repair

scientific article (publication date: 9 March 2005)

Structural insights into the recognition of cisplatin and AAF-dG lesion by Rad14 (XPA)

scientific article published on 22 June 2015

Structure and mechanism of MbtI, the salicylate synthase from Mycobacterium tuberculosis

scientific article

Structure of acyl carrier protein bound to FabI, the FASII enoyl reductase from Escherichia coli

scientific article published on 29 September 2006

Structure of the C-terminal half of UvrC reveals an RNase H endonuclease domain with an Argonaute-like catalytic triad

scientific article

Structure of the Yersinia pestis FabV Enoyl-ACP Reductase and Its Interaction with Two 2-Pyridone Inhibitors

scientific article

Structure of the mouse peptide N-glycanase-HR23 complex suggests co-evolution of the endoplasmic reticulum-associated degradation and DNA repair pathways.

scientific article

The 1.2 A structure of the human sulfite oxidase cytochrome b(5) domain

scientific article

The 1.2 Å structure of the human sulfite oxidase cytochromeb5domain

article published in 2003

The EM structure of human DNA polymerase gamma reveals a localized contact between the catalytic and accessory subunits

scientific article

The Q motif of Fanconi anemia group J protein (FANCJ) DNA helicase regulates its dimerization, DNA binding, and DNA repair function

scientific article

The Structure of the TFIIH p34 Subunit Reveals a Von Willebrand Factor A Like Fold

scientific article

The TFIIH subunits p44/p62 act as a damage sensor during nucleotide excision repair

scientific article published on 09 November 2020

The XPD helicase: XPanDing archaeal XPD structures to get a grip on human DNA repair.

scientific article published on July 2010

The complex between ribonuclease T1 and 3'GMP suggests geometry of enzymic reaction path. An X-ray study

scientific article

The crystal structure of plant sulfite oxidase provides insights into sulfite oxidation in plants and animals

scientific article

The intricate network between the p34 and p44 subunits is central to the activity of the transcription/DNA repair factor TFIIH.

scientific article published on 25 August 2017

The nucleotide excision repair protein UvrB, a helicase-like enzyme with a catch.

scientific article

The structural and functional characterization of human RecQ4 reveals insights into its helicase mechanism.

scientific article published on 27 June 2017

The structures of the C185S and C185A mutants of sulfite oxidase reveal rearrangement of the active site

scientific article

The β-Hairpin Motif of UvrB Is Essential for DNA Binding, Damage Processing, and UvrC-mediated Incisions

scientific article published in Journal of Biological Chemistry

Third EU-US workshop on “Nucleotide excision repair and crosslink repair—From molecules to mankind”, Smolenice Castle, Slovak Republic, May 7th–11th 2017

Transcriptional pausing to scout ahead for DNA damage.

scientific article published on 05 March 2014

When One Protein Does the Job of Many

scientific article published on 01 October 2007

XPB helicase regulates DNA incision by the Thermoplasma acidophilum endonuclease Bax1.

scientific article

List of works by Caroline Kisker

'Close-fitting sleeves': DNA damage recognition by the UvrABC nuclease system

A Long Residence Time Enoyl-Reductase Inhibitor Explores an Extended Binding Region with Isoenzyme-Dependent Tautomer Adaptation and Differential Substrate-Binding Loop Closure

A Slow, Tight Binding Inhibitor of InhA, the Enoyl-Acyl Carrier Protein Reductase from Mycobacterium tuberculosis

A closer look at the active site of gamma-class carbonic anhydrases: high-resolution crystallographic studies of the carbonic anhydrase from Methanosarcina thermophila

A simple pressure cell and delivery system for the preparation of Xe derivatives for protein crystallography

A structural comparison of molybdenum cofactor-containing enzymes

A structural comparison of molybdenum cofactor-containing enzymes

An ordered water channel in Staphylococcus aureus FabI: unraveling the mechanism of substrate recognition and reduction.

Bax1 is a novel endonuclease: implications for archaeal nucleotide excision repair

Biophysical and functional analyses suggest that adenovirus E4-ORF3 protein requires higher-order multimerization to function against promyelocytic leukemia protein nuclear bodies

Catabolism of the Cholesterol Side Chain in Mycobacterium tuberculosis Is Controlled by a Redox-Sensitive Thiol Switch.

Characterizing septum inhibition in Mycobacterium tuberculosis for novel drug discovery

Chlamydia trachomatis-containing vacuole serves as deubiquitination platform to stabilize Mcl-1 and to interfere with host defense.

Comparing crystallographic and solution structures of nitrogenase complexes

Conservation and Divergence in Nucleotide Excision Repair Lesion Recognition.

Conserved salt-bridge competition triggered by phosphorylation regulates the protein interactome.

Constitutive activation of PKA catalytic subunit in adrenal Cushing's syndrome

Correlating Drug-Target Kinetics and In vivo Pharmacodynamics: Long Residence Time Inhibitors of the FabI Enoyl-ACP Reductase

Crystal Structure of the FeS Cluster–Containing Nucleotide Excision Repair Helicase XPD

Crystal Structures of Mycobacterium tuberculosis KasA Show Mode of Action within Cell Wall Biosynthesis and its Inhibition by Thiolactomycin

Crystal structure of Mycobacterium tuberculosis MenB, a key enzyme in vitamin K2 biosynthesis

Crystal structures of the active and alloxanthine-inhibited forms of xanthine dehydrogenase from Rhodobacter capsulatus

Crystallizing the 6S and 8S spliceosomal assembly intermediates: a complex project

Crystallographic characterization of an exocyclic DNA adduct: 3,N4-etheno-2'-deoxycytidine in the dodecamer 5'-CGCGAATTepsilonCGCG-3'

DNA Helicases in NER, BER, and MMR.

DNA binding cooperativity of p53 modulates the decision between cell-cycle arrest and apoptosis.

DNA damage, mutagenesis, and DNA repair.

Damage recognition in nucleotide excision DNA repair.

Development of modern InhA inhibitors to combat drug resistant strains of Mycobacterium tuberculosis

Die Fettsäuresynthese als Angriffspunkt

Different promoter affinities account for specificity in MYC-dependent gene regulation.

Differential Oligomerization of the Deubiquitinases USP25 and USP28 Regulates Their Activities

Elucidation of the protonation states of the catalytic residues in mtKasA: implications for inhibitor design.

Error-Prone DNA Polymerases

Evaluating the Contribution of Transition-State Destabilization to Changes in the Residence Time of Triazole-Based InhA Inhibitors

FANCM interacts with PCNA to promote replication traverse of DNA interstrand crosslinks.

FadA5 a thiolase from Mycobacterium tuberculosis: a steroid-binding pocket reveals the potential for drug development against tuberculosis

Front Cover: Structural Basis of Substrate Recognition and Covalent Inhibition of Cdu1 from Chlamydia trachomatis (ChemMedChem 19/2018)

Functional and structural studies of the nucleotide excision repair helicase XPD suggest a polarity for DNA translocation

Functional human mitochondrial DNA polymerase gamma forms a heterotrimer

Global discovery of bacterial RNA-binding proteins by RNase-sensitive gradient profiles reports a new FinO domain protein

High Affinity InhA Inhibitors with Activity against Drug-Resistant Strains of Mycobacterium tuberculosis

High accuracy FIONA-AFM hybrid imaging.

How to limit the speed of a motor: the intricate regulation of the XPB ATPase and translocase in TFIIH

Identification of residues within UvrB that are important for efficient DNA binding and damage processing.

Impact of age-associated cyclopurine lesions on DNA repair helicases

In TFIIH the Arch domain of XPD is mechanistically essential for transcription and DNA repair

In TFIIH, XPD helicase is exclusively devoted to DNA repair

Interactions between UvrA and UvrB: the role of UvrB's domain 2 in nucleotide excision repair

Isolated sulfite oxidase deficiency: identification of 12 novel SUOX mutations in 10 patients

Lesion (in)tolerance reveals insights into DNA replication fidelity

Lysine 190 is the catalytic base in MenF, the menaquinone-specific isochorismate synthase from Escherichia coli: implications for an enzyme family

Mechanism of Substrate and Inhibitor Binding of Rhodobacter capsulatus Xanthine Dehydrogenase

Mechanism of the Intramolecular Claisen Condensation Reaction Catalyzed by MenB, a Crotonase Superfamily Member

Mechanistic insights into the enzymatic activity and inhibition of the replicative polymerase exonuclease domain from Mycobacterium tuberculosis

Michael acceptor based antiplasmodial and antitrypanosomal cysteine protease inhibitors with unusual amino acids

Molecular basis of sulfite oxidase deficiency from the structure of sulfite oxidase

Molecular dynamics of Mycobacterium tuberculosis KasA: implications for inhibitor and substrate binding and consequences for drug design

Molybdopterin from molybdenum and tungsten enzymes.

Mouse Rev1 protein interacts with multiple DNA polymerases involved in translesion DNA synthesis

Novel somatic mutations in the catalytic subunit of the protein kinase A as a cause of adrenal Cushing's syndrome: a European multicentric study

Nucleotide Excision Repair from Bacteria to Humans: Structure–Function Studies

OmoMYC blunts promoter invasion by oncogenic MYC to inhibit gene expression characteristic of MYC-dependent tumors

On-bead screening of a combinatorial fumaric acid derived peptide library yields antiplasmodial cysteine protease inhibitors with unusual peptide sequences

PKA catalytic subunit mutations in adrenocortical Cushing's adenoma impair association with the regulatory subunit.

Prokaryotic nucleotide excision repair.

Prokaryotic nucleotide excision repair: the UvrABC system.

Proximity mapping of the Tet repressor-tetracycline-Fe2+ complex by hydrogen peroxide mediated protein cleavage.

Raf kinase inhibitor protein (RKIP) dimer formation controls its target switch from Raf1 to G protein-coupled receptor kinase (GRK) 2.

Rational Design of Broad Spectrum Antibacterial Activity Based on a Clinically Relevant Enoyl-Acyl Carrier Protein (ACP) Reductase Inhibitor

Rational Optimization of Drug-Target Residence Time: Insights from Inhibitor Binding to the Staphylococcus aureus FabI Enzyme–Product Complex

Rationalizing the Binding Kinetics for the Inhibition of the Burkholderia pseudomallei FabI1 Enoyl-ACP Reductase

Repurposing a Library of Human Cathepsin L Ligands: Identification of Macrocyclic Lactams as Potent Rhodesain and Trypanosoma brucei Inhibitors

Role of XPD in cellular functions: To TFIIH and beyond

Selectivity of Pyridone- and Diphenyl Ether-Based Inhibitors for the Yersinia pestis FabV Enoyl-ACP Reductase.

Single molecule analysis reveals monomeric XPA bends DNA and undergoes episodic linear diffusion during damage search

Slow onset inhibition of bacterial beta-ketoacyl-acyl carrier protein synthases by thiolactomycin

Slow-Onset Inhibition of the FabI Enoyl Reductase from Francisella tularensis : Residence Time and in Vivo Activity

Specialization among iron-sulfur cluster helicases to resolve G-quadruplex DNA structures that threaten genomic stability