Search filters

List of works by Caroline Austin

A complex suite of loci and elements in eukaryotic type II topoisomerases determine selective sensitivity to distinct poisoning agents

scientific article published on 01 September 2019

A high-throughput fluorescence anisotropy-based assay for human topoisomerase II β-catalyzed ATP-dependent supercoiled DNA relaxation.

scientific article published on 3 December 2013

A novel DNA-dependent protein kinase inhibitor, NU7026, potentiates the cytotoxicity of topoisomerase II poisons used in the treatment of leukemia

scientific article

Alchemix: a novel alkylating anthraquinone with potent activity against anthracycline- and cisplatin-resistant ovarian cancer.

scientific article

Alpha, beta-unsaturated lactones 2-furanone and 2-pyrone induce cellular DNA damage, formation of topoisomerase I- and II-DNA complexes and cancer cell death

scientific article published on 15 July 2013

Amsacrine-promoted DNA cleavage site determinants for the two human DNA topoisomerase II isoforms alpha and beta

scientific article published on 01 December 1996

An investigation into the formation of N- [2-(dimethylamino)ethyl]acridine-4-carboxamide (DACA) and 6-[2-(dimethylamino)ethylamino]- 3-hydroxy-7H-indeno[2, 1-C]quinolin-7-one dihydrochloride (TAS-103) stabilised DNA topoisomerase I and II cleavable

scientific article published on 01 September 2000

An overview of the visualisation and quantitation of low and high MW DNA adducts using the trapped in agarose DNA immunostaining (TARDIS) assay.

scientific article

Analysis of foetal expression sites of human type II DNA topoisomerase alpha and beta mRNAs by in situ hybridisation.

scientific article published in June 1996

Brief reports: Controlling the survival of human pluripotent stem cells by small molecule-based targeting of topoisomerase II alpha.

scientific article

Camptothecin-stabilised topoisomerase I-DNA complexes in leukaemia cells visualised and quantified in situ by the TARDIS assay (trapped in agarose DNA immunostaining)

scientific article published on 01 March 2000

Carbamate analogues of amsacrine active against non-cycling cells: relative activity against topoisomerases IIalpha and beta

scientific article published on 01 January 1999

Cells lacking DNA topoisomerase II beta are resistant to genistein

scientific article

Characterisation of the DNA-dependent ATPase activity of human DNA topoisomerase IIbeta: mutation of Ser165 in the ATPase domain reduces the ATPase activity and abolishes the in vivo complementation ability

scientific article

Complementation of temperature-sensitive topoisomerase II mutations in Saccharomyces cerevisiae by a human TOP2 beta construct allows the study of topoisomerase II beta inhibitors in yeast

scientific article published on 01 January 1997

Curcumin induces high levels of topoisomerase I- and II-DNA complexes in K562 leukemia cells.

scientific article published on 13 December 2007

DNA binding and intercalation by novel porphyrins: role of charge and substituents probed by DNase I footprinting and topoisomerase I unwinding

scientific article published on 01 March 1990

DNA supercoiling and relaxation by ATP-dependent DNA topoisomerases

scientific article published on April 29, 1992

DNA-dependent protein kinase is a therapeutic target and an indicator of poor prognosis in B-cell chronic lymphocytic leukemia.

scientific article published in June 2008

Differences in the longevity of topo IIalpha and topo IIbeta drug-stabilized cleavable complexes and the relationship to drug sensitivity.

scientific article published on 23 September 2003

Different patterns of gene expression of topoisomerase II isoforms in differentiated tissues during murine development

scientific article published on August 17, 1992

Differential Targeting of Human Topoisomerase II Isoforms with Small Molecules.

scientific article published on 6 May 2015

Differential selection of acridine resistance mutations in human DNA topoisomerase IIbeta is dependent on the acridine structure

article

Digitoxin inhibits the growth of cancer cell lines at concentrations commonly found in cardiac patients

scientific article published on November 2005

Digitoxin, at concentrations commonly found in the plasma of cardiac patients, antagonizes etoposide and idarubicin activity in K562 leukemia cells.

scientific article published on 4 January 2006

Distinct expression patterns for type II topoisomerases IIA and IIB in the early foetal human telencephalon.

scientific article published on 27 November 2015

Do transcription factories and TOP2B provide a recipe for chromosome translocations in therapy-related leukemia?

scientific article published on 16 August 2012

Does oxidative damage contribute to the generation of leukemia?

scientific article published on 26 June 2009

Effect of TDP2 on the Level of TOP2-DNA Complexes and SUMOylated TOP2-DNA Complexes

scientific article published on 14 July 2018

Effect of phenazine compounds XR11576 and XR5944 on DNA topoisomerases

scientific article

Etoposide Targets Topoisomerase IIα and IIβ in Leukemic Cells: Isoform-Specific Cleavable Complexes Visualized and QuantifiedIn Situby a Novel Immunofluorescence Technique ⬇️

scientific article published on July 1, 1998

Eukaryotic DNA topoisomerase IIβ ⬇️

scientific article published on March 1, 1998

Expression, domain structure, and enzymatic properties of an active recombinant human DNA topoisomerase II beta

scientific article published on 01 June 1995

Formation and longevity of idarubicin-induced DNA topoisomerase II cleavable complexes in K562 human leukaemia cells.

scientific article published in May 2002

Genome-wide ChIP-seq analysis of human TOP2B occupancy in MCF7 breast cancer epithelial cells

scientific article published on 12 October 2015

Green tea constituents (-)-epigallocatechin-3-gallate (EGCG) and gallic acid induce topoisomerase I- and topoisomerase II-DNA complexes in cells mediated by pyrogallol-induced hydrogen peroxide

scientific article published on 7 March 2011

Guanidine-reactive agent phenylglyoxal induces DNA damage and cancer cell death.

scientific article published in January 2012

H2AX phosphorylation as a genotoxicity endpoint.

scientific article

Histone deacetylase inhibition redistributes topoisomerase IIβ from heterochromatin to euchromatin

scientific article

Human DNA topoisomerase IIbeta binds and cleaves four-way junction DNA in vitro.

scientific article published on February 1999

Human Tra2 proteins jointly control a CHEK1 splicing switch among alternative and constitutive target exons

scientific article published on 11 September 2014

Intercalating TOP2 Poisons Attenuate Topoisomerase Action at Higher Concentrations

scientific article published on 09 August 2019

Isolation and characterization of a human cDNA clone encoding a novel DNA topoisomerase II homologue from HeLa cells.

scientific article

Kinetic analysis of human topoisomerase IIalpha and beta DNA binding by surface plasmon resonance.

scientific article

MRE11 facilitates the removal of human topoisomerase II complexes from genomic DNA.

scientific article

Mechanism of generation of therapy related leukemia in response to anti-topoisomerase II agents.

scientific article published on 31 May 2012

Model for MLL translocations in therapy-related leukemia involving topoisomerase IIβ-mediated DNA strand breaks and gene proximity

scientific article

Molecular cloning and characterization of the human topoisomerase IIalpha and IIbeta genes: evidence for isoform evolution through gene duplication.

scientific article

Mutation E522K in human DNA topoisomerase IIbeta confers resistance to methyl N-(4'-(9-acridinylamino)-phenyl)carbamate hydrochloride and methyl N-(4'-(9-acridinylamino)-3-methoxy-phenyl) methane sulfonamide but hypersensitivity to etoposide

scientific article

Mutation P732L in human DNA topoisomerase IIbeta abolishes DNA cleavage in the presence of calcium and confers drug resistance.

scientific article published on 20 October 2005

Mutations in topoisomerase IIβ result in a B cell immunodeficiency

scientific article published on 13 August 2019

Myeloperoxidase Enhances Etoposide and Mitoxantrone-Mediated DNA Damage: A Target for Myeloprotection in Cancer Chemotherapy

scientific article (publication date: 2017)

NK314, a topoisomerase II inhibitor that specifically targets the alpha isoform.

scientific article

Nick-forming sequences may be involved in the organization of eukaryotic chromatin into approximately 50 kbp loops

scientific article published on 30 September 2005

Novel HeLa topoisomerase II is the II beta isoform: complete coding sequence and homology with other type II topoisomerases.

scientific article

Nuclear distribution of human DNA topoisomerase IIbeta: a nuclear targeting signal resides in the 116-residue C-terminal tail.

scientific article published in September 1998

Plant and Human MORC Proteins Have DNA-Modifying Activities Similar to Type II Topoisomerases, but Require One or More Additional Factors for Full Activity.

scientific article published on 19 December 2016

Poly(ADP-ribose) metabolism is essential for proper nucleoprotein exchange during mouse spermiogenesis

scientific article

Poly(ADP-ribose) polymerases PARP1 and PARP2 modulate topoisomerase II beta (TOP2B) function during chromatin condensation in mouse spermiogenesis.

scientific article

Position-specific effects of base mismatch on mammalian topoisomerase II DNA cleaving activity.

scientific article published in January 1996

Position-specific trapping of topoisomerase II by benzo[a]pyrene diol epoxide adducts: implications for interactions with intercalating anticancer agents

scientific article

Probing the interaction of the cytotoxic bisdioxopiperazine ICRF-193 with the closed enzyme clamp of human topoisomerase IIalpha

scientific article published on 01 September 2000

Proteasomal inhibition potentiates drugs targeting DNA topoisomerase II.

scientific article published on 12 January 2016

Quantitation of DNA topoisomerase IIalpha and beta in human leukaemia cells by immunoblotting.

scientific article published in November 2000

Role of Topoisomerase IIβ in DNA Damage Response following IR and Etoposide

scientific article published on 19 August 2010

Salicylate, a catalytic inhibitor of topoisomerase II, inhibits DNA cleavage and is selective for the α isoform.

scientific article published on 12 November 2013

Schedule-dependent response of neuroblastoma cell lines to combinations of etoposide and cisplatin.

scientific article published on February 2002

Selenite induces topoisomerase I and II-DNA complexes in K562 leukemia cells

scientific article published on 01 November 2008

Self-association of chromo domain peptides.

scientific article published in February 1997

Site-directed mutagenesis of human DNA topoisomerase II beta

scientific article published on 01 November 1997

Site-specific DNA cleavage by mammalian DNA topoisomerase II induced by novel flavone and catechin derivatives ⬇️

scientific article published on March 15, 1992

Small molecule inhibitors confirm ubiquitin-dependent removal of TOP2-DNA covalent complexes

scientific article published on 25 June 2020

Structure and partial amino acid sequence of calf thymus DNA topoisomerase II: comparison with other type II enzymes.

scientific article published on July 1990

TOP2B Is Required to Maintain the Adrenergic Neural Phenotype and for ATRA-Induced Differentiation of SH-SY5Y Neuroblastoma Cells

scientific article published in 2022

TOP2B: The First Thirty Years

scientific article published on 14 September 2018

The Deubiquitinating Enzyme Inhibitor PR-619 is a Potent DNA Topoisomerase II Poison

scientific article published on 12 September 2019

The Structure of DNA-Bound Human Topoisomerase II Alpha: Conformational Mechanisms for Coordinating Inter-Subunit Interactions with DNA Cleavage

scientific article

The coffee constituent chlorogenic acid induces cellular DNA damage and formation of topoisomerase I- and II-DNA complexes in cells

scientific article

The dietary flavonoids myricetin and fisetin act as dual inhibitors of DNA topoisomerases I and II in cells

scientific article

The impact of the C-terminal domain on the interaction of human DNA topoisomerase II α and β with DNA.

scientific article

The impact of the human DNA topoisomerase II C-terminal domain on activity.

scientific article

The novel poly(ADP-Ribose) polymerase inhibitor, AG14361, sensitizes cells to topoisomerase I poisons by increasing the persistence of DNA strand breaks.

scientific article published in December 2005

The role of topoisomerase II beta on breakage and proximity of RUNX1 to partner alleles RUNX1T1 and EVI1.

scientific article published on 5 November 2013

The role of topoisomerase II in the excision of DNA loop domains during apoptosis

scientific article published on 8 April 2002

Threonine 1342 in human topoisomerase IIalpha is phosphorylated throughout the cell cycle

scientific article published on 01 November 1996

Topoisomerase II Chromatin Immunoprecipitation

scientific article published in January 2018

Transcription of carbonyl reductase 1 is regulated by DNA topoisomerase II beta

scientific article published on 06 August 2020

Visualization and Quantification of Topoisomerase-DNA Covalent Complexes Using the Trapped in Agarose Immunostaining (TARDIS) Assay

scientific article published in January 2018

gammaH2AX foci form preferentially in euchromatin after ionising-radiation.

scientific article

mAMSA resistant human topoisomerase IIbeta mutation G465D has reduced ATP hydrolysis activity

scientific article

sox30: a novel zebrafish sox gene expressed in a restricted manner at the midbrain-hindbrain boundary during neurogenesis.

scientific article published in June 1999

Paulina is supported by:

About Paulina

Help