List of works - Angela Rösen-Wolff

"Allergic mood" - Depressive and anxiety symptoms in patients with seasonal allergic rhinitis (SAR) and their association to inflammatory, endocrine, and allergic markers

scientific article published on 08 May 2017

* Central Growth Factor Loaded Depots in Bone Tissue Engineering Scaffolds for Enhanced Cell Attraction

scientific article published on 19 March 2017

A Protective Role for Inflammasome Activation Following Injury—Shock 2012;37(1) ⬇️

scientific article published on 01 June 2012

A splice-supporting intronic mutation in the last bp position of a cryptic exon within intron 6 of the CYBB gene induces its incorporation into the mRNA causing chronic granulomatous disease (CGD).

scientific article published on 3 March 2006

A tissue-based approach to selection of reference genes for quantitative real-time PCR in a sheep osteoporosis model

scientific article published on 19 December 2017

Alu repeat-induced deletions in chronic granulomatous disease: a cause not only for p67-phox, but also for p47-phox deficiency ⬇️

scientific article published on December 29, 2012

Alu-repeat-induced deletions within the NCF2 gene causing p67-phox-deficient chronic granulomatous disease (CGD).

scientific article

An optimized whole blood assay measuring expression and activity of NLRP3, NLRC4 and AIM2 inflammasomes

scientific article published on 25 November 2017

Attenuated TLR4/MAPK signaling in monocytes from patients with CRMO results in impaired IL-10 expression.

scientific article

Benefit assessment of preventive medical check-ups in patients suffering from chronic granulomatous disease (CGD)

scientific article published on 01 December 2005

CARD15 genotype and phenotype analysis in 55 pediatric patients with Crohn disease from Saxony, Germany

scientific article published in October 2003

CASP1 variants influence subcellular caspase-1 localization, pyroptosome formation, pro-inflammatory cell death and macrophage deformability

scientific article published on 26 June 2019

Capofungin therapy for Aspergillus lung infection in a boy with chronic granulomatous disease

scientific article

Caspase-1: an integral regulator of innate immunity

scientific article

Characterization of expression of Puumala virus nucleocapsid protein in transgenic plants

scientific article published in January 2002

Chemotaxis of mesenchymal stem cells within 3D biomimetic scaffolds--a modeling approach

scientific article published on 18 November 2010

Chronic Nonbacterial Osteomyelitis: Pathophysiological Concepts and Current Treatment Strategies

scientific article published on September 2016

Chronic granulomatous disease (CGD) and complete myeloperoxidase deficiency both yield strongly reduced dihydrorhodamine 123 test signals but can be easily discerned in routine testing for CGD.

scientific article

Chronic granulomatous disease (CGD) mimicking neoplasms: a suspected mediastinal teratoma unmasking as thymic granulomas due to X-linked CGD, and 2 related cases

scientific article published in December 2008

Clinical and prognostic role of annexin A2 in multiple myeloma.

scientific article

Consensus protocols for the diagnosis and management of the hereditary autoinflammatory syndromes CAPS, TRAPS and MKD/HIDS: a German PRO-KIND initiative

scientific article published on 17 February 2020

Contribution of the inflammasomes to autoinflammatory diseases and recent mouse models as research tools ⬇️

scientific article published on 04 February 2013

Current knowledge on procaspase-1 variants with reduced or abrogated enzymatic activity in autoinflammatory disease

scientific article published on July 2015

Distinct interferon signatures and cytokine patterns define additional systemic autoinflammatory diseases

scientific article published on 01 April 2020

E

Enzymatically Inactive Procaspase 1 stabilizes the ASC Pyroptosome and Supports Pyroptosome Spreading during Cell Division

scientific article published on 8 July 2016

Fluorescent tags influence the enzymatic activity and subcellular localization of procaspase-1.

scientific article published on 27 May 2015

Genetic architecture distinguishes systemic juvenile idiopathic arthritis from other forms of juvenile idiopathic arthritis: clinical and therapeutic implications

article

Haploinsufficiency, rather than the effect of an excessive production of soluble CD95 (CD95{Delta}TM), is the basis for ALPS Ia in a family with duplicated 3' splice site AG in CD95 intron 5 on one allele

scientific article published on 3 May 2005

Heparin modification of a biomimetic bone matrix for controlled release of VEGF.

scientific article published on 15 November 2013

Human procaspase-1 variants with decreased enzymatic activity are associated with febrile episodes and may contribute to inflammation via RIP2 and NF-κB signaling

scientific article published on 4 April 2014

Hypoxia-conditioned media allows species-specific attraction of bone marrow stromal cells without need for recombinant proteins.

scientific article

IL-11 and soluble VCAM-1 are important components of Hypoxia Conditioned Media and crucial for Mesenchymal Stromal Cells attraction

scientific article published on 20 April 2020

IL1RN Variation Influences both Disease Susceptibility and Response to Human Recombinant IL-1RA Therapy in Systemic Juvenile Idiopathic Arthritis

scientific article published on 2 April 2018

Immunomodulatory Effects of Dendritic Poly(ethyleneimine) Glycoarchitectures on Human Multiple Myeloma Cell Lines, Mesenchymal Stromal Cells, and in Vitro Differentiated Macrophages for an Ideal Drug Delivery System in the Local Treatment of Multipl

scientific article published on 25 June 2019

In vitro ossification and remodeling of mineralized collagen I scaffolds

scientific article published in April 2006

Influence of CARD15 mutations on disease activity and response to therapy in 65 pediatric Crohn patients from Saxony, Germany

scientific article published in July 2005

Interference of canakinumab with commercial IL-1β ELISAs

scientific article published on 13 May 2019

Juvenile arthritis caused by a novel FAMIN (LACC1) mutation in two children with systemic and extended oligoarticular course.

scientific article

Meningoencephalitis caused by varicella-zoster virus reactivation in a child with dominant partial interferon-gamma receptor-1 deficiency ⬇️

scientific article published on March 1, 2011

Metabolically conditioned media derived from bone marrow stromal cells or human skin fibroblasts act as effective chemoattractants for mesenchymal stem cells

scientific article

More severe than CVID: Combined immunodeficiency due to a novel NFKB2 mutation

scientific article published on 28 December 2020

N

Naturally occurring genetic variants of human caspase-1 differ considerably in structure and the ability to activate interleukin-1β.

scientific article

No association of IL-12p40 pro1.1 polymorphism with juvenile idiopathic arthritis

scientific article published on 15 December 2015

Non-canonical Caspase-1 Signaling Drives RIP2-Dependent and TNF-α-Mediated Inflammation In Vivo

scientific article published on 01 February 2020

Novel STAT1 alleles in otherwise healthy patients with mycobacterial disease

scientific article published in August 2006

Osteocyte Regulation of Receptor Activator of NF-κB Ligand/Osteoprotegerin in a Sheep Model of Osteoporosis.

scientific article published on 12 June 2017

P-glycoprotein expression increases ATP release in respiratory cystic fibrosis cells

scientific article published on September 2005

P67-phox (NCF2) lacking exons 11 and 12 is functionally active and leads to an extremely late diagnosis of chronic granulomatous disease (CGD)

scientific article

Periodic fever, mild arthralgias, and reversible moderate and severe organ inflammation associated with the V198M mutation in the CIAS1 gene in three German patients--expanding phenotype of CIAS1 related autoinflammatory syndrome

scientific article published on August 2004

Polyclonal long-term MFGS-gp91phox marking in rhesus macaques after nonmyeloablative transplantation with transduced autologous peripheral blood progenitor cells

scientific article

Positive and negative behaviours in workplace relationships: a scoping review protocol.

scientific article

Predictors of new graduate nurses’ health over the first 4 years of practice

article

Proceedings of the 23rd Paediatric Rheumatology European Society Congress: part one

article

Pseudomonas aeruginosa and Burkholderia cepacia cannot be detected by PCR in the breath condensate of patients with cystic fibrosis

scientific article published in October 2003

Puumala virus nucleocapsid protein expressed in transgenic plants is not immunogenic after oral administration

scientific article published on August 2004

Redundant ability of phagocytes to kill Aspergillus species

scientific article published on 01 September 2011

STING Gain-of-Function Disrupts Lymph Node Organogenesis and Innate Lymphoid Cell Development in Mice

scientific article published on 01 June 2020

STING-associated lung disease in mice relies on T cells but not type I interferon

scientific article published on 14 February 2019

Starting Out: A time-lagged study of new graduate nurses' transition to practice

scientific article published on 29 January 2016

Stem Cell Engineering for Regeneration of Bone Tissue

Stromal cell-derived factor-1alpha-directed chemoattraction of transiently CXCR4-overexpressing bone marrow stromal cells into functionalized three-dimensional biomimetic scaffolds.

scientific article published in December 2009

Successful elimination of an invasive Aspergillus nidulans lung infection by voriconazole after failure of a combination of caspofungin and liposomal amphotericin B in a boy with chronic granulomatous disease

scientific article

The German National Registry of Primary Immunodeficiencies (2012-2017)

scientific article published on 19 July 2019

The Secretome of Hypoxia Conditioned hMSC Loaded in a Central Depot Induces Chemotaxis and Angiogenesis in a Biomimetic Mineralized Collagen Bone Replacement Material

scientific article published on 12 December 2019

The development of lymphomas in families with autoimmune lymphoproliferative syndrome with germline Fas mutations and defective lymphocyte apoptosis

scientific article

Two German CINCA (NOMID) patients with different clinical severity and response to anti-inflammatory treatment

scientific article published on September 2003

Type I interferon-independent T cell impairment in a Tmem173 N153S/WT mouse model of STING associated vasculopathy with onset in infancy (SAVI)

scientific article published on 26 May 2020

Variant PIK3R1 Hypermorphic Mutation and Clinical Phenotypes in a Family with Short Statures, Mild Immunodeficiency and Lymphoma

scientific article published on 30 May 2017

List of works by Angela Rösen-Wolff

"Allergic mood" - Depressive and anxiety symptoms in patients with seasonal allergic rhinitis (SAR) and their association to inflammatory, endocrine, and allergic markers

* Central Growth Factor Loaded Depots in Bone Tissue Engineering Scaffolds for Enhanced Cell Attraction

A Protective Role for Inflammasome Activation Following Injury—Shock 2012;37(1) ⬇️

A splice-supporting intronic mutation in the last bp position of a cryptic exon within intron 6 of the CYBB gene induces its incorporation into the mRNA causing chronic granulomatous disease (CGD).

A tissue-based approach to selection of reference genes for quantitative real-time PCR in a sheep osteoporosis model

Alu repeat-induced deletions in chronic granulomatous disease: a cause not only for p67-phox, but also for p47-phox deficiency ⬇️

Alu-repeat-induced deletions within the NCF2 gene causing p67-phox-deficient chronic granulomatous disease (CGD).

An optimized whole blood assay measuring expression and activity of NLRP3, NLRC4 and AIM2 inflammasomes

Attenuated TLR4/MAPK signaling in monocytes from patients with CRMO results in impaired IL-10 expression.

Benefit assessment of preventive medical check-ups in patients suffering from chronic granulomatous disease (CGD)

CARD15 genotype and phenotype analysis in 55 pediatric patients with Crohn disease from Saxony, Germany

CASP1 variants influence subcellular caspase-1 localization, pyroptosome formation, pro-inflammatory cell death and macrophage deformability

Capofungin therapy for Aspergillus lung infection in a boy with chronic granulomatous disease

Caspase-1: an integral regulator of innate immunity

Characterization of expression of Puumala virus nucleocapsid protein in transgenic plants

Chemotaxis of mesenchymal stem cells within 3D biomimetic scaffolds--a modeling approach

Chronic Nonbacterial Osteomyelitis: Pathophysiological Concepts and Current Treatment Strategies

Chronic granulomatous disease (CGD) and complete myeloperoxidase deficiency both yield strongly reduced dihydrorhodamine 123 test signals but can be easily discerned in routine testing for CGD.

Chronic granulomatous disease (CGD) mimicking neoplasms: a suspected mediastinal teratoma unmasking as thymic granulomas due to X-linked CGD, and 2 related cases

Clinical and prognostic role of annexin A2 in multiple myeloma.

Consensus protocols for the diagnosis and management of the hereditary autoinflammatory syndromes CAPS, TRAPS and MKD/HIDS: a German PRO-KIND initiative

Contribution of the inflammasomes to autoinflammatory diseases and recent mouse models as research tools ⬇️

Current knowledge on procaspase-1 variants with reduced or abrogated enzymatic activity in autoinflammatory disease

Distinct interferon signatures and cytokine patterns define additional systemic autoinflammatory diseases

E

Enzymatically Inactive Procaspase 1 stabilizes the ASC Pyroptosome and Supports Pyroptosome Spreading during Cell Division

Fluorescent tags influence the enzymatic activity and subcellular localization of procaspase-1.

Genetic architecture distinguishes systemic juvenile idiopathic arthritis from other forms of juvenile idiopathic arthritis: clinical and therapeutic implications

Haploinsufficiency, rather than the effect of an excessive production of soluble CD95 (CD95{Delta}TM), is the basis for ALPS Ia in a family with duplicated 3' splice site AG in CD95 intron 5 on one allele

Heparin modification of a biomimetic bone matrix for controlled release of VEGF.

Human procaspase-1 variants with decreased enzymatic activity are associated with febrile episodes and may contribute to inflammation via RIP2 and NF-κB signaling

Hypoxia-conditioned media allows species-specific attraction of bone marrow stromal cells without need for recombinant proteins.

IL-11 and soluble VCAM-1 are important components of Hypoxia Conditioned Media and crucial for Mesenchymal Stromal Cells attraction

IL1RN Variation Influences both Disease Susceptibility and Response to Human Recombinant IL-1RA Therapy in Systemic Juvenile Idiopathic Arthritis

Immunomodulatory Effects of Dendritic Poly(ethyleneimine) Glycoarchitectures on Human Multiple Myeloma Cell Lines, Mesenchymal Stromal Cells, and in Vitro Differentiated Macrophages for an Ideal Drug Delivery System in the Local Treatment of Multipl

In vitro ossification and remodeling of mineralized collagen I scaffolds

Influence of CARD15 mutations on disease activity and response to therapy in 65 pediatric Crohn patients from Saxony, Germany

Interference of canakinumab with commercial IL-1β ELISAs

Juvenile arthritis caused by a novel FAMIN (LACC1) mutation in two children with systemic and extended oligoarticular course.

Meningoencephalitis caused by varicella-zoster virus reactivation in a child with dominant partial interferon-gamma receptor-1 deficiency ⬇️

Metabolically conditioned media derived from bone marrow stromal cells or human skin fibroblasts act as effective chemoattractants for mesenchymal stem cells

More severe than CVID: Combined immunodeficiency due to a novel NFKB2 mutation

N

Naturally occurring genetic variants of human caspase-1 differ considerably in structure and the ability to activate interleukin-1β.

No association of IL-12p40 pro1.1 polymorphism with juvenile idiopathic arthritis

Non-canonical Caspase-1 Signaling Drives RIP2-Dependent and TNF-α-Mediated Inflammation In Vivo

Novel STAT1 alleles in otherwise healthy patients with mycobacterial disease

Osteocyte Regulation of Receptor Activator of NF-κB Ligand/Osteoprotegerin in a Sheep Model of Osteoporosis.

P-glycoprotein expression increases ATP release in respiratory cystic fibrosis cells

P67-phox (NCF2) lacking exons 11 and 12 is functionally active and leads to an extremely late diagnosis of chronic granulomatous disease (CGD)

Periodic fever, mild arthralgias, and reversible moderate and severe organ inflammation associated with the V198M mutation in the CIAS1 gene in three German patients--expanding phenotype of CIAS1 related autoinflammatory syndrome

Polyclonal long-term MFGS-gp91phox marking in rhesus macaques after nonmyeloablative transplantation with transduced autologous peripheral blood progenitor cells

Positive and negative behaviours in workplace relationships: a scoping review protocol.

Predictors of new graduate nurses’ health over the first 4 years of practice

Proceedings of the 23rd Paediatric Rheumatology European Society Congress: part one

Pseudomonas aeruginosa and Burkholderia cepacia cannot be detected by PCR in the breath condensate of patients with cystic fibrosis

Puumala virus nucleocapsid protein expressed in transgenic plants is not immunogenic after oral administration

Redundant ability of phagocytes to kill Aspergillus species

STING Gain-of-Function Disrupts Lymph Node Organogenesis and Innate Lymphoid Cell Development in Mice

STING-associated lung disease in mice relies on T cells but not type I interferon

Starting Out: A time-lagged study of new graduate nurses' transition to practice

Stem Cell Engineering for Regeneration of Bone Tissue

Stromal cell-derived factor-1alpha-directed chemoattraction of transiently CXCR4-overexpressing bone marrow stromal cells into functionalized three-dimensional biomimetic scaffolds.

Successful elimination of an invasive Aspergillus nidulans lung infection by voriconazole after failure of a combination of caspofungin and liposomal amphotericin B in a boy with chronic granulomatous disease

The German National Registry of Primary Immunodeficiencies (2012-2017)

The Secretome of Hypoxia Conditioned hMSC Loaded in a Central Depot Induces Chemotaxis and Angiogenesis in a Biomimetic Mineralized Collagen Bone Replacement Material

The development of lymphomas in families with autoimmune lymphoproliferative syndrome with germline Fas mutations and defective lymphocyte apoptosis

Two German CINCA (NOMID) patients with different clinical severity and response to anti-inflammatory treatment

Type I interferon-independent T cell impairment in a Tmem173 N153S/WT mouse model of STING associated vasculopathy with onset in infancy (SAVI)

Variant PIK3R1 Hypermorphic Mutation and Clinical Phenotypes in a Family with Short Statures, Mild Immunodeficiency and Lymphoma