List of works - Agnieszka Chacińska

A High-Resolution Luminescent Assay for Rapid and Continuous Monitoring of Protein Translocation across Biological Membranes

scientific article published on 13 March 2019

A discrete pathway for the transfer of intermembrane space proteins across the outer membrane of mitochondria

scientific article

Assembly of the three small Tim proteins precedes docking to the mitochondrial carrier translocase

scientific article

Biogenesis of the essential Tim9-Tim10 chaperone complex of mitochondria: site-specific recognition of cysteine residues by the intermembrane space receptor Mia40.

scientific article published on 6 June 2007

COA6 Facilitates Cytochrome c Oxidase Biogenesis as Thiol-reductase for Copper Metallochaperones in Mitochondria

scientific article published on 13 February 2020

Cell biology: Sort and destroy

scientific article published in March 2017

Chaperoning through the mitochondrial intermembrane space

scientific article

Chatty Mitochondria: Keeping Balance in Cellular Protein Homeostasis

scientific article published on 19 March 2016

Control of mitochondrial biogenesis and function by the ubiquitin-proteasome system

scientific article

Correction: Loss of the Mia40a oxidoreductase leads to hepato-pancreatic insufficiency in zebrafish

Coupling of mitochondrial import and export translocases by receptor-mediated supercomplex formation

scientific article

Coupling of mitochondrial translation with the formation of respiratory complexes in yeast mitochondria.

scientific article

Cox17 Protein Is an Auxiliary Factor Involved in the Control of the Mitochondrial Contact Site and Cristae Organizing System

scientific article published on 27 April 2015

Cytosolic aggregation of mitochondrial proteins disrupts cellular homeostasis by stimulating the aggregation of other proteins

scientific article published on 20 July 2021

Cytosolic translational responses differ under conditions of severe short-term and long-term mitochondrial stress

scientific article published on 22 May 2019

DNA Repair Protein APE1 Degrades Dysfunctional Abasic mRNA in Mitochondria Affecting Oxidative Phosphorylation

scientific article published in September 2021

Determinants of the cytosolic turnover of mitochondrial intermembrane space proteins

scientific article published on 22 June 2018

Distinct forms of mitochondrial TOM-TIM supercomplexes define signal-dependent states of preprotein sorting

scientific article

Distinct yet linked: chaperone networks in the eukaryotic cytosol

scientific article

Disulfide bond formation: sulfhydryl oxidase ALR controls mitochondrial biogenesis of human MIA40.

scientific article published on 16 December 2012

Diverse mechanisms and machineries for import of mitochondrial proteins

scientific article published on September 2007

Dual role of mitofilin in mitochondrial membrane organization and protein biogenesis

scientific article

Essential role of Mia40 in import and assembly of mitochondrial intermembrane space proteins

scientific article

Glucocerebrosidase 1 deficient Danio rerio mirror key pathological aspects of human Gaucher disease and provide evidence of early microglial activation preceding alpha-synuclein-independent neuronal cell death

scientific article

How mitochondria import hydrophilic and hydrophobic proteins.

scientific article

Identification of the signal directing Tim9 and Tim10 into the intermembrane space of mitochondria

scientific article published on 18 March 2009

Importing mitochondrial proteins: machineries and mechanisms

scientific article (publication date: 21 August 2009)

In vivo evidence for cooperation of Mia40 and Erv1 in the oxidation of mitochondrial proteins.

scientific article

Inactivation of the mitochondrial heat shock protein zim17 leads to aggregation of matrix hsp70s followed by pleiotropic effects on morphology and protein biogenesis.

scientific article

Inhibition of proteasome rescues a pathogenic variant of respiratory chain assembly factor COA7

scientific article published on 01 May 2019

Intermembrane space proteome of yeast mitochondria

scientific article

Isolation and functional characterization of mutant ferrochelatases in Saccharomyces cerevisiae.

scientific article

Loss of the Mia40a oxidoreductase leads to hepato-pancreatic insufficiency in zebrafish

scientific article published on 20 November 2018

Machinery for protein sorting and assembly in the mitochondrial outer membrane

scientific article

Mgr2 functions as lateral gatekeeper for preprotein sorting in the mitochondrial inner membrane

scientific article

Mia40 and MINOS act in parallel with Ccs1 in the biogenesis of mitochondrial Sod1.

scientific article published on 22 July 2013

Mistargeted mitochondrial proteins activate a proteostatic response in the cytosol

scientific article

Mitochondria use different mechanisms for transport of multispanning membrane proteins through the intermembrane space

scientific article published on November 2003

Mitochondrial biogenesis, switching the sorting pathway of the intermembrane space receptor Mia40.

scientific article published on 08 September 2008

Mitochondrial control of cellular protein homeostasis

scientific article published on 01 August 2020

Mitochondrial oxidative stress induces rapid intermembrane space/matrix translocation of Apurinic/apyrimidinic endonuclease 1 protein through TIM23 complex

scientific article published on 13 November 2020

Mitochondrial presequence translocase: switching between TOM tethering and motor recruitment involves Tim21 and Tim17.

scientific article

Mitochondrial protein biogenesis in the synapse is supported by local translation

scientific article published on 18 June 2020

Mitochondrial protein homeostasis

scientific article published on 22 January 2013

Mitochondrial protein import motor: differential role of Tim44 in the recruitment of Pam17 and J-complex to the presequence translocase

scientific article

Mitochondrial protein import: Mia40 facilitates Tim22 translocation into the inner membrane of mitochondria

scientific article published on 2 January 2013

Mitochondrial protein import: precursor oxidation in a ternary complex with disulfide carrier and sulfhydryl oxidase

scientific article published on 13 October 2008

Mitochondrial protein translocases for survival and wellbeing

scientific article published on 24 May 2014

Mitochondrial proteins - import, export, degradation

scientific article published in January 2016

Mitochondrial stress-dependent regulation of cellular protein synthesis

scientific article published on 26 April 2019

Mitochondrial translocation contact sites: separation of dynamic and stabilizing elements in formation of a TOM-TIM-preprotein supercomplex

scientific article

Mitochondrial translocation of APE1 relies on the MIA pathway

scientific article published on 8 May 2015

Motor recruitment to the TIM23 channel's lateral gate restricts polypeptide release into the inner membrane

scientific article published in Nature Communications

Native techniques for analysis of mitochondrial protein import

scientific article published in January 2010

Non-canonical translation initiation in yeast generates a cryptic pool of mitochondrial proteins

scientific article published on 01 June 2019

Novel mitochondrial intermembrane space proteins as substrates of the MIA import pathway

scientific article

Ovarian carcinoma immunoreactive antigen-like protein 2 (OCIAD2) is a novel complex III-specific assembly factor in mitochondria

scientific article published in April 2022

Pam17 is required for architecture and translocation activity of the mitochondrial protein import motor

scientific article

Precursor oxidation by Mia40 and Erv1 promotes vectorial transport of proteins into the mitochondrial intermembrane space

scientific article

Preprotein Transport Machineries of Yeast Mitochondrial Outer Membrane Are not Required for Bax-induced Release of Intermembrane Space Proteins

Presequence recognition by the tom40 channel contributes to precursor translocation into the mitochondrial matrix

scientific article

Prion-dependent switching between respiratory competence and deficiency in the yeast nam9-1 mutant.

scientific article

Profiling subcellular localization of nuclear-encoded mitochondrial gene products in zebrafish

scientific article published in January 2023

Proteasome activity contributes to pro-survival response upon mild mitochondrial stress in Caenorhabditis elegans

scientific article published on 12 July 2021

Protein Import by the Mitochondrial Presequence Translocase in the Absence of a Membrane Potential.

scientific article published on 29 January 2016

Protein homeostasis is maintained by proteasomes containing PSMB9 induced by EEF1A2 upon mitochondrial stress

scientific article published on 23 December 2021

Protein trafficking at the crossroads to mitochondria

scientific article

Quantitative proteomics identifies redox switches for global translation modulation by mitochondrially produced reactive oxygen species

scientific article published on 22 January 2018

Retro-translocation of mitochondrial intermembrane space proteins

scientific article published on 8 June 2015

Role of mitochondrial inner membrane organizing system in protein biogenesis of the mitochondrial outer membrane

scientific article

Structural and Functional Requirements for Activity of the Tim9-Tim10 Complex in Mitochondrial Protein Import

scientific article

TIM29 is a subunit of the human carrier translocase required for protein transport

scientific journal article

The MIA pathway: A tight bond between protein transport and oxidative folding in mitochondria ⬇️

scientific article published on 02 May 2012

The MIA system for protein import into the mitochondrial intermembrane space

scientific article published on 22 October 2007

The Mitochondrial Presequence Translocase

article published in 2002

The Oxidation Status of Mic19 Regulates MICOS Assembly

scientific article

The Tim21 binding domain connects the preprotein translocases of both mitochondrial membranes

scientific article

The essential mitochondrial protein Erv1 cooperates with Mia40 in biogenesis of intermembrane space proteins

scientific article

The mitochondrial import machinery: preprotein-conducting channels with binding sites for presequences

scientific article

The mitochondrial import protein Mim1 promotes biogenesis of multispanning outer membrane proteins

scientific article

The mitochondrial morphology protein Mdm10 functions in assembly of the preprotein translocase of the outer membrane

scientific article

The mitochondrial presequence translocase: an essential role of Tim50 in directing preproteins to the import channel

scientific article

The morphology proteins Mdm12/Mmm1 function in the major beta-barrel assembly pathway of mitochondria

scientific article

The presence of disulfide bonds reveals an evolutionarily conserved mechanism involved in mitochondrial protein translocase assembly

scientific article published on 06 June 2016

The proteome of Saccharomyces cerevisiae mitochondria

scientific article

The ubiquitin-proteasome system regulates mitochondrial intermembrane space proteins

scientific article published on 18 March 2013

Tim50 maintains the permeability barrier of the mitochondrial inner membrane

scientific article

Tim50's presequence receptor domain is essential for signal driven transport across the TIM23 complex

scientific article published on 7 November 2011

Ubiquitin - proteasome system and its crosstalk with mitochondria as therapeutic targets in medicine

scientific article published on 13 October 2020

Uniform nomenclature for the mitochondrial contact site and cristae organizing system

scientific article published on March 2014

Visualization of cytosolic ribosomes on the surface of mitochondria by electron cryo-tomography.

scientific article published on 21 August 2017

List of works by Agnieszka Chacińska

A High-Resolution Luminescent Assay for Rapid and Continuous Monitoring of Protein Translocation across Biological Membranes

A discrete pathway for the transfer of intermembrane space proteins across the outer membrane of mitochondria

Assembly of the three small Tim proteins precedes docking to the mitochondrial carrier translocase

Biogenesis of the essential Tim9-Tim10 chaperone complex of mitochondria: site-specific recognition of cysteine residues by the intermembrane space receptor Mia40.

COA6 Facilitates Cytochrome c Oxidase Biogenesis as Thiol-reductase for Copper Metallochaperones in Mitochondria

Cell biology: Sort and destroy

Chaperoning through the mitochondrial intermembrane space

Chatty Mitochondria: Keeping Balance in Cellular Protein Homeostasis

Control of mitochondrial biogenesis and function by the ubiquitin-proteasome system

Correction: Loss of the Mia40a oxidoreductase leads to hepato-pancreatic insufficiency in zebrafish

Coupling of mitochondrial import and export translocases by receptor-mediated supercomplex formation

Coupling of mitochondrial translation with the formation of respiratory complexes in yeast mitochondria.

Cox17 Protein Is an Auxiliary Factor Involved in the Control of the Mitochondrial Contact Site and Cristae Organizing System

Cytosolic aggregation of mitochondrial proteins disrupts cellular homeostasis by stimulating the aggregation of other proteins

Cytosolic translational responses differ under conditions of severe short-term and long-term mitochondrial stress

DNA Repair Protein APE1 Degrades Dysfunctional Abasic mRNA in Mitochondria Affecting Oxidative Phosphorylation

Determinants of the cytosolic turnover of mitochondrial intermembrane space proteins

Distinct forms of mitochondrial TOM-TIM supercomplexes define signal-dependent states of preprotein sorting

Distinct yet linked: chaperone networks in the eukaryotic cytosol

Disulfide bond formation: sulfhydryl oxidase ALR controls mitochondrial biogenesis of human MIA40.

Diverse mechanisms and machineries for import of mitochondrial proteins

Dual role of mitofilin in mitochondrial membrane organization and protein biogenesis

Essential role of Mia40 in import and assembly of mitochondrial intermembrane space proteins

Glucocerebrosidase 1 deficient Danio rerio mirror key pathological aspects of human Gaucher disease and provide evidence of early microglial activation preceding alpha-synuclein-independent neuronal cell death

How mitochondria import hydrophilic and hydrophobic proteins.

Identification of the signal directing Tim9 and Tim10 into the intermembrane space of mitochondria

Importing mitochondrial proteins: machineries and mechanisms

In vivo evidence for cooperation of Mia40 and Erv1 in the oxidation of mitochondrial proteins.

Inactivation of the mitochondrial heat shock protein zim17 leads to aggregation of matrix hsp70s followed by pleiotropic effects on morphology and protein biogenesis.

Inhibition of proteasome rescues a pathogenic variant of respiratory chain assembly factor COA7

Intermembrane space proteome of yeast mitochondria

Isolation and functional characterization of mutant ferrochelatases in Saccharomyces cerevisiae.

Loss of the Mia40a oxidoreductase leads to hepato-pancreatic insufficiency in zebrafish

Machinery for protein sorting and assembly in the mitochondrial outer membrane

Mgr2 functions as lateral gatekeeper for preprotein sorting in the mitochondrial inner membrane

Mia40 and MINOS act in parallel with Ccs1 in the biogenesis of mitochondrial Sod1.

Mistargeted mitochondrial proteins activate a proteostatic response in the cytosol

Mitochondria use different mechanisms for transport of multispanning membrane proteins through the intermembrane space

Mitochondrial biogenesis, switching the sorting pathway of the intermembrane space receptor Mia40.

Mitochondrial control of cellular protein homeostasis

Mitochondrial oxidative stress induces rapid intermembrane space/matrix translocation of Apurinic/apyrimidinic endonuclease 1 protein through TIM23 complex

Mitochondrial presequence translocase: switching between TOM tethering and motor recruitment involves Tim21 and Tim17.

Mitochondrial protein biogenesis in the synapse is supported by local translation

Mitochondrial protein homeostasis

Mitochondrial protein import motor: differential role of Tim44 in the recruitment of Pam17 and J-complex to the presequence translocase

Mitochondrial protein import: Mia40 facilitates Tim22 translocation into the inner membrane of mitochondria

Mitochondrial protein import: precursor oxidation in a ternary complex with disulfide carrier and sulfhydryl oxidase

Mitochondrial protein translocases for survival and wellbeing

Mitochondrial proteins - import, export, degradation

Mitochondrial stress-dependent regulation of cellular protein synthesis

Mitochondrial translocation contact sites: separation of dynamic and stabilizing elements in formation of a TOM-TIM-preprotein supercomplex

Mitochondrial translocation of APE1 relies on the MIA pathway

Motor recruitment to the TIM23 channel's lateral gate restricts polypeptide release into the inner membrane

Native techniques for analysis of mitochondrial protein import

Non-canonical translation initiation in yeast generates a cryptic pool of mitochondrial proteins

Novel mitochondrial intermembrane space proteins as substrates of the MIA import pathway

Ovarian carcinoma immunoreactive antigen-like protein 2 (OCIAD2) is a novel complex III-specific assembly factor in mitochondria

Pam17 is required for architecture and translocation activity of the mitochondrial protein import motor

Precursor oxidation by Mia40 and Erv1 promotes vectorial transport of proteins into the mitochondrial intermembrane space

Preprotein Transport Machineries of Yeast Mitochondrial Outer Membrane Are not Required for Bax-induced Release of Intermembrane Space Proteins

Presequence recognition by the tom40 channel contributes to precursor translocation into the mitochondrial matrix

Prion-dependent switching between respiratory competence and deficiency in the yeast nam9-1 mutant.

Profiling subcellular localization of nuclear-encoded mitochondrial gene products in zebrafish

Proteasome activity contributes to pro-survival response upon mild mitochondrial stress in Caenorhabditis elegans

Protein Import by the Mitochondrial Presequence Translocase in the Absence of a Membrane Potential.

Protein homeostasis is maintained by proteasomes containing PSMB9 induced by EEF1A2 upon mitochondrial stress

Protein trafficking at the crossroads to mitochondria

Quantitative proteomics identifies redox switches for global translation modulation by mitochondrially produced reactive oxygen species

Retro-translocation of mitochondrial intermembrane space proteins

Role of mitochondrial inner membrane organizing system in protein biogenesis of the mitochondrial outer membrane

Structural and Functional Requirements for Activity of the Tim9-Tim10 Complex in Mitochondrial Protein Import

TIM29 is a subunit of the human carrier translocase required for protein transport

The MIA pathway: A tight bond between protein transport and oxidative folding in mitochondria ⬇️

The MIA system for protein import into the mitochondrial intermembrane space

The Mitochondrial Presequence Translocase

The Oxidation Status of Mic19 Regulates MICOS Assembly

The Tim21 binding domain connects the preprotein translocases of both mitochondrial membranes

The essential mitochondrial protein Erv1 cooperates with Mia40 in biogenesis of intermembrane space proteins

The mitochondrial import machinery: preprotein-conducting channels with binding sites for presequences