List of works by Lorenz Studer

A Modular Platform for Differentiation of Human PSCs into All Major Ectodermal Lineages

scientific article published in September 2017

A Poised Chromatin Platform for TGF-β Access to Master Regulators

scientific article

A cell engineering strategy to enhance the safety of stem cell therapies.

scientific article

A hPSC-based platform to discover gene-environment interactions that impact human β-cell and dopamine neuron survival

scientific article published in Nature Communications

A mathematical model for the estimation of human embryonic and fetal age.

scientific article published in July 1996

Acquisition of in vitro and in vivo functionality of Nurr1-induced dopamine neurons.

scientific article published on 31 October 2006

Adapting human pluripotent stem cells to high-throughput and high-content screening

scientific article

Aging in iPS cells

scientific article published on April 2014

BAC transgenesis in human embryonic stem cells as a novel tool to define the human neural lineage.

scientific article published in March 2009

Back and forth in time: Directing age in iPSC-derived lineages.

scientific article

Bmi-1 cooperates with Foxg1 to maintain neural stem cell self-renewal in the forebrain

scientific article published on March 2009

Build-a-brain

scientific article

Cancer modeling by Transgene Electroporation in Adult Zebrafish (TEAZ)

scientific article published on 27 September 2018

Capturing the biology of disease severity in a PSC-based model of familial dysautonomia

scientific article published on 14 November 2016

Cell fate plug and play: direct reprogramming and induced pluripotency

scientific article published on June 2011

Combined small-molecule inhibition accelerates developmental timing and converts human pluripotent stem cells into nociceptors

scientific article

Combined small-molecule inhibition accelerates the derivation of functional cortical neurons from human pluripotent stem cells.

scientific article

Comparison of the effects of the neurotrophins on the morphological structure of dopaminergic neurons in cultures of rat substantia nigra

scientific article published on 01 February 1995

Comparison of the topology and growth rules of motoneuronal dendrites

article

Comparison of three congruent patient-specific cell types for the modelling of a human genetic Schwann-cell disorder

scientific article published on 08 April 2019

Constitutive gene expression predisposes morphogen-mediated cell fate responses of NT2/D1 and 27X-1 human embryonal carcinoma cells

scientific article published on 30 November 2006

Converting human pluripotent stem cells to neural tissue and neurons to model neurodegeneration

scientific article published on January 2011

Correction: Targeting Homologous Recombination in Notch-Driven C. elegans Stem Cell and Human Tumors

scientific article published on 22 January 2016

Creating Patient-Specific Neural Cells for the In Vitro Study of Brain Disorders

scientific article

DNA replication timing alterations identify common markers between distinct progeroid diseases.

scientific article published in December 2017

Deciphering Human Cell-Autonomous Anti-HSV-1 Immunity in the Central Nervous System

scientific article

Derivation of Diverse Hormone-Releasing Pituitary Cells from Human Pluripotent Stem Cells.

scientific article published on June 2016

Derivation of dopaminergic neurons from pluripotent stem cells

scientific article published on January 2012

Derivation of engraftable skeletal myoblasts from human embryonic stem cells

scientific article published on 8 April 2007

Derivation of enteric neuron lineages from human pluripotent stem cells

scientific article published on 25 March 2019

Derivation of midbrain dopamine neurons from human embryonic stem cells

scholarly article

Derivation of multipotent mesenchymal precursors from human embryonic stem cells

scientific article

Derivation of neural crest cells from human pluripotent stem cells.

scientific article published on 18 March 2010

Deriving human ENS lineages for cell therapy and drug discovery in Hirschsprung disease

scientific article published on 10 February 2016

Developmental chromatin programs determine oncogenic competence in melanoma

scientific article published in 2021

Differentiation of embryonic stem cell lines generated from adult somatic cells by nuclear transfer.

scientific article published on April 2001

Directed differentiation and functional maturation of cortical interneurons from human embryonic stem cells

scientific article published on May 2013

Directed differentiation and transplantation of human embryonic stem cell-derived motoneurons.

scientific article published on 3 May 2007

Disabling the Fanconi Anemia Pathway in Stem Cells Leads to Radioresistance and Genomic Instability

scientific article published on 03 May 2021

Dopamine neurons derived from human ES cells efficiently engraft in animal models of Parkinson's disease

scientific article (publication date: 6 November 2011)

Dopaminergic neuronal differentiation from rat embryonic neural precursors by Nurr1 overexpression.

scientific article

Dual-SMAD Inhibition/WNT Activation-Based Methods to Induce Neural Crest and Derivatives from Human Pluripotent Stem Cells

scientific article published on 4 December 2013

Early cortical precursors do not undergo LIF-mediated astrocytic differentiation

scientific article published on 01 February 2000

Effects of BDNF on dopaminergic, serotonergic, and GABAergic neurons in cultures of human fetal ventral mesencephalon.

scientific article published on May 1995

Efficient derivation of functional floor plate tissue from human embryonic stem cells

scientific article published on April 2010

Efficient generation of midbrain and hindbrain neurons from mouse embryonic stem cells.

scientific article

Embryonic stem cell-derived neurons form functional networks in vitro.

scientific article published on 16 November 2006

Enhanced in vitro midbrain dopamine neuron differentiation, dopaminergic function, neurite outgrowth, and 1-methyl-4-phenylpyridium resistance in mouse embryonic stem cells overexpressing Bcl-XL.

scientific article published in January 2004

Enhancement of polysialic acid expression improves function of embryonic stem-derived dopamine neuron grafts in Parkinsonian mice

scientific article published on 05 December 2013

Enriched motor neuron populations derived from bacterial artificial chromosome-transgenic human embryonic stem cells

scientific article published in January 2009

Epigenetic control of melanoma cell invasiveness by the stem cell factor SALL4

scientific article published on 20 August 2021

Evaluation of developmental toxicants and signaling pathways in a functional test based on the migration of human neural crest cells

scientific article

Excessive mobility interrupted ⬇️

scientific article published on November 18, 2010

Expansion and maintenance of human embryonic stem cell-derived endothelial cells by TGFbeta inhibition is Id1 dependent

scientific article

Expression profiling of lineage differentiation in pluripotential human embryonal carcinoma cells.

scientific article published on June 2002

Feeder-free Derivation of Melanocytes from Human Pluripotent Stem Cells

scientific article published on 3 March 2016

Feeder-free derivation of neural crest progenitor cells from human pluripotent stem cells

scientific article

Fetal ventral mesencephalon of human and rat origin maintained in vitro and transplanted to 6-hydroxydopamine-lesioned rats gives rise to grafts rich in dopaminergic neurons.

scientific article

Free Floating Microcultures of Human Fetal Ventral Mesencephalon.

scientific article published in October 1992

Fully defined human pluripotent stem cell-derived microglia and tri-culture system model C3 production in Alzheimer's disease

scientific article published on 08 February 2021

Functional Connectivity under Optogenetic Control Allows Modeling of Human Neuromuscular Disease.

scientific article

G-Force PD: a global initiative in coordinating stem cell-based dopamine treatments for Parkinson's disease

scientific article published on 24 September 2015

Generating Late-Onset Human iPSC-Based Disease Models by Inducing Neuronal Age-Related Phenotypes through Telomerase Manipulation

scientific article published on October 2016

Generation of neuropeptidergic hypothalamic neurons from human pluripotent stem cells

scientific article

Genome-wide identification of microRNA targets in human ES cells reveals a role for miR-302 in modulating BMP response

scientific article

Genomic safe harbors permit high β-globin transgene expression in thalassemia induced pluripotent stem cells

scientific article

HSP90-incorporating chaperome networks as biosensor for disease-related pathways in patient-specific midbrain dopamine neurons

scientific article published in Nature Communications

High-Content Screening in hPSC-Neural Progenitors Identifies Drug Candidates that Inhibit Zika Virus Infection in Fetal-like Organoids and Adult Brain.

scientific article published on 19 July 2017

High-throughput screening assay for the identification of compounds regulating self-renewal and differentiation in human embryonic stem cells

scientific article

Highly efficient neural conversion of human ES and iPS cells by dual inhibition of SMAD signaling

scientific article (publication date: March 2009)

Human ES cell-derived neural rosettes reveal a functionally distinct early neural stem cell stage

scientific article published on January 2008

Human SNORA31 variations impair cortical neuron-intrinsic immunity to HSV-1 and underlie herpes simplex encephalitis

scientific article published on 05 December 2019

Human Trials of Stem Cell-Derived Dopamine Neurons for Parkinson's Disease: Dawn of a New Era.

scientific article published in November 2017

Human iPSC-based modeling of late-onset disease via progerin-induced aging

scientific article published on December 2013

Human iPSC-derived oligodendrocyte progenitor cells can myelinate and rescue a mouse model of congenital hypomyelination

scientific article published on February 2013

Human iPSC-derived trigeminal neurons lack constitutive TLR3-dependent immunity that protects cortical neurons from HSV-1 infection

article published in the Proceedings of the National Academy of Sciences of the United States of America

IPSCs put to the test

scientific article published on 01 March 2011

Identification of embryonic stem cell-derived midbrain dopaminergic neurons for engraftment

scientific article

Impaired intrinsic immunity to HSV-1 in human iPSC-derived TLR3-deficient CNS cells

scientific article

Inborn Errors of RNA Lariat Metabolism in Humans with Brainstem Viral Infection

scientific article published in February 2018

Induced pluripotent stem cell technology for the study of human disease.

scientific article published in January 2010

Isolation and directed differentiation of neural crest stem cells derived from human embryonic stem cells.

scientific article published on 25 November 2007

Large-scale screening using familial dysautonomia induced pluripotent stem cells identifies compounds that rescue IKBKAP expression

scientific article published on 25 November 2012

Lessons Learned from Pioneering Neural Stem Cell Studies

scientific article published on February 2017

Lipid Deprivation Induces a Stable, Naive-to-Primed Intermediate State of Pluripotency in Human PSCs

scientific article published on 30 May 2019

Long-term survival of dopamine neurons derived from parthenogenetic primate embryonic stem cells (cyno-1) after transplantation.

scientific article published on 07 June 2005

Long-term survival of dopaminergic neurones in free-floating roller tube cultures of human fetal ventral mesencephalon

scientific article published on 01 September 1994

Loss of SATB1 Induces p21-Dependent Cellular Senescence in Post-mitotic Dopaminergic Neurons

scientific article published on 19 September 2019

MHC-I expression renders catecholaminergic neurons susceptible to T-cell-mediated degeneration

scientific article

Making and repairing the mammalian brain--in vitro production of dopaminergic neurons.

scientific article

Maturation of spinal motor neurons derived from human embryonic stem cells

scientific article

Mechanics-guided embryonic patterning of neuroectoderm tissue from human pluripotent stem cells

scientific article published on 21 May 2018

Mesenchymal cells

scientific article published on January 2006

Migration and differentiation of neural precursors derived from human embryonic stem cells in the rat brain

scientific article published on 24 April 2005

Modeling neural crest induction, melanocyte specification, and disease-related pigmentation defects in hESCs and patient-specific iPSCs

scientific article

Modelling familial dysautonomia in human induced pluripotent stem cells

scientific article

Modelling pathogenesis and treatment of familial dysautonomia using patient-specific iPSCs.

scientific article published on 19 August 2009

Moving stem cells to the clinic: potential and limitations for brain repair

scientific article

NFIA is a gliogenic switch enabling rapid derivation of functional human astrocytes from pluripotent stem cells

scientific article published on 25 February 2019

NGF increases neuritic complexity of cholinergic interneurons in organotypic cultures of neonatal rat striatum.

scientific article

Neural Crest Cells from Dual SMAD Inhibition

scientific article published in May 2015

Neural subtype specification of fertilization and nuclear transfer embryonic stem cells and application in parkinsonian mice.

scientific article published on 21 September 2003

Neural transplantation for the treatment of Parkinson's disease

scientific article

New ISSCR guidelines: clinical translation of stem cell research

scientific article published in The Lancet

Nonhuman primate parthenogenetic stem cells

scientific article

Optical bioluminescence imaging of human ES cell progeny in the rodent CNS.

scientific article

Optogenetics enables functional analysis of human embryonic stem cell-derived grafts in a Parkinson's disease model

scientific article

Parkin and PINK1 Patient iPSC-Derived Midbrain Dopamine Neurons Exhibit Mitochondrial Dysfunction and α-Synuclein Accumulation

scientific article published on 15 September 2016

Parthenogenetic dopamine neurons from primate embryonic stem cells restore function in experimental Parkinson's disease

scientific article published on 22 July 2008

Parthenogenetic stem cells in nonhuman primates.

scientific article published on February 2002

Pluripotent stem cell-based disease modeling: current hurdles and future promise

scientific article

Pluripotent stem cells in neuropsychiatric disorders

scientific article published on 21 March 2017

Pluripotent stem cells in regenerative medicine: challenges and recent progress

scientific article

Policy: Global standards for stem-cell research

scientific article

Production of green fluorescent protein transgenic embryonic stem cells using the GENSAT bacterial artificial chromosome library

scientific article

Programming and Reprogramming Cellular Age in the Era of Induced Pluripotency

scientific article

Prospective isolation of cortical interneuron precursors from mouse embryonic stem cells

scientific article published on March 2010

Protocols for generating ES cell-derived dopamine neurons

scientific article published on January 2009

Retinoic Acid-Mediated Regulation of GLI3 Enables Efficient Motoneuron Derivation from Human ESCs in the Absence of Extrinsic SHH Activation

scientific article

Setting Global Standards for Stem Cell Research and Clinical Translation: The 2016 ISSCR Guidelines

scientific article published on 11 May 2016

Single-molecule analysis reveals changes in the DNA replication program for the POU5F1 locus upon human embryonic stem cell differentiation.

scientific article

Specification of functional cranial placode derivatives from human pluripotent stem cells

scientific article published on 27 November 2013

Specification of positional identity in forebrain organoids

scientific article published on 01 April 2019

Stem cells with brainpower.

scientific article published in December 2001

Stoichiometric and temporal requirements of Oct4, Sox2, Klf4, and c-Myc expression for efficient human iPSC induction and differentiation

scientific article published on 23 June 2009

Strategies for bringing stem cell-derived dopamine neurons to the clinic-The NYSTEM trial

scientific article published on 21 March 2017

TCF3 alternative splicing controlled by hnRNP H/F regulates E-cadherin expression and hESC pluripotency

scientific article published on 16 August 2018

Targeting Homologous Recombination in Notch-Driven C. elegans Stem Cell and Human Tumors

scientific article published on 29 June 2015

The epichaperome is a mediator of toxic hippocampal stress and leads to protein connectivity-based dysfunction

scientific article published on 16 January 2020

The epichaperome is an integrated chaperome network that facilitates tumour survival

scientific article published on 05 October 2016

The expanding role of miR-302-367 in pluripotency and reprogramming.

scientific article published on 15 April 2012

The polycomb group protein L3MBTL1 represses a SMAD5-mediated hematopoietic transcriptional program in human pluripotent stem cells

scientific article

Therapeutic cloning in individual parkinsonian mice

scientific article published on 23 March 2008

Too much Sonic, too few neurons

scientific article published in February 2009

Transcriptional program of bone morphogenetic protein-2-induced epithelial and smooth muscle differentiation of pluripotent human embryonal carcinoma cells.

scientific article published on 3 February 2005

Transplanted dopamine neurons derived from primate ES cells preferentially innervate DARPP-32 striatal progenitors within the graft.

scientific article published on October 2006

Tumour-initiating stem-like cells in human prostate cancer exhibit increased NF-κB signalling ⬇️

scientific article

When rejuvenation is a problem: challenges of modeling late-onset neurodegenerative disease

scientific article published in September 2015

Wnt1 overexpression leads to enforced cardiomyogenesis and inhibition of hematopoiesis in murine embryonic stem cells

scientific article

ZFX controls the self-renewal of human embryonic stem cells

scientific article

miR-371-3 expression predicts neural differentiation propensity in human pluripotent stem cells.

scientific article published in June 2011

α-Synuclein-induced lysosomal dysfunction occurs through disruptions in protein trafficking in human midbrain synucleinopathy models

scientific article published on 2 February 2016

Paulina is supported by:

About Paulina

Help