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List of works by Chen Hualan

A 113-amino-acid truncation at the NS1 C-terminus is a determinant for viral replication of H5N6 avian influenza virus in vitro and in vivo

scientific article published on 13 September 2018

A Naturally Occurring Deletion in the Effector Domain of H5N1 Swine Influenza Virus Nonstructural Protein 1 Regulates Viral Fitness and Host Innate Immunity

scientific article published on 21 March 2018

A PB1 T296R substitution enhance polymerase activity and confer a virulent phenotype to a 2009 pandemic H1N1 influenza virus in mice.

scientific article

A Single-Amino-Acid Substitution at Position 225 in HA Alters the Transmissibility of Eurasian Avian-like H1N1 Swine Influenza Virus in Guinea Pigs

scientific article published on 16 August 2017

A Single-Amino-Acid Substitution in the NS1 Protein Changes the Pathogenicity of H5N1 Avian Influenza Viruses in Mice.

scientific article

A duck enteritis virus-vectored bivalent live vaccine provides fast and complete protection against H5N1 avian influenza virus infection in ducks ⬇️

scientific article published on August 24, 2011

A live attenuated vaccine prevents replication and transmission of H7N9 highly pathogenic influenza viruses in mammals

article

A live attenuated vaccine prevents replication and transmission of H7N9 virus in mammals

scientific article published on 10 June 2015

A naturally occurring deletion in its NS gene contributes to the attenuation of an H5N1 swine influenza virus in chickens

scientific article

A single-amino-acid substitution in the NS1 protein changes the pathogenicity of H5N1 avian influenza viruses in mice

scientific article

A subunit vaccine candidate derived from a classic H5N1 avian influenza virus in China protects fowls and BALB/c mice from lethal challenge.

scientific article

Absence of Middle East respiratory syndrome coronavirus in Bactrian camels in the West Inner Mongolia Autonomous Region of China: surveillance study results from July 2015.

scientific article published on 2 December 2015

Amino Acid Mutations A286V and T437M in the Nucleoprotein Attenuate H7N9 Viruses in Mice

scientific article published on 06 January 2020

Annexin A2 (ANXA2) interacts with nonstructural protein 1 and promotes the replication of highly pathogenic H5N1 avian influenza virus

scientific article published on 11 September 2017

Avian influenza vaccines against H5N1 'bird flu'.

scientific article published on February 2014

Broad-spectrum antiviral functions of duck interferon-induced protein with tetratricopeptide repeats (AvIFIT).

scientific article published on 8 February 2018

C-terminal region of apoptin affects chicken anemia virus replication and virulence

scientific article published on 21 February 2017

Characterization of an avian influenza virus of subtype H7N2 isolated from chickens in northern China

scientific article published on August 2006

Characterization of immune responses induced by immunization with the HA DNA vaccines of two antigenically distinctive H5N1 HPAIV isolates

scientific article

Characterization of the H5N1 highly pathogenic avian influenza virus derived from wild pikas in China

scientific article published on 24 June 2009

Co-circulation of H5N6, H3N2, H3N8, and Emergence of Novel Reassortant H3N6 in a Local Community in Hunan Province in China

scientific article published on 6 May 2016

Co-circulation of pandemic 2009 H1N1, classical swine H1N1 and avian-like swine H1N1 influenza viruses in pigs in China ⬇️

scientific article published on November 10, 2012

Complex Reassortment of Multiple Subtypes of Avian Influenza Viruses in Domestic Ducks at the Dongting Lake Region of China ⬇️

scientific article published on June 26, 2013

Continued evolution of H5N1 influenza viruses in wild birds, domestic poultry, and humans in China from 2004 to 2009.

scientific article

Correction: Genetics, Receptor Binding Property, and Transmissibility in Mammals of Naturally Isolated H9N2 Avian Influenza Viruses

scientific article published on 08 January 2020

Detection and differentiation of four poultry diseases using asymmetric reverse transcription polymerase chain reaction in combination with oligonucleotide microarrays

scientific article

Detection of antibodies against avian influenza virus by protein microarray using nucleoprotein expressed in insect cells

scientific article published on 19 December 2014

Development and application of avian influenza vaccines in China.

scientific article

Development of a reverse transcription loop-mediated isothermal amplification method for the rapid detection of avian influenza virus subtype H7 ⬇️

scientific article published on September 12, 2011

Development of a reverse transcription loop-mediated isothermal amplification method for the rapid detection of subtype H7N9 avian influenza virus

scientific article published on 06 February 2014

Development of an Influenza Rapid Diagnostic Kit Specific for the H7 Subtype.

scientific article published on 25 June 2018

Dogs are highly susceptible to H5N1 avian influenza virus

scientific article

Early control of H5N1 influenza virus replication by the type I interferon response in mice.

scientific article published on 18 March 2009

Efficacy of DNA immunization with F and G protein genes of Nipah virus

scientific article

Emergence of H3N8 equine influenza virus in donkeys in China in 2017.

scientific article published on 27 November 2017

Enhanced protective efficacy of H5 subtype avian influenza DNA vaccine with codon optimized HA gene in a pCAGGS plasmid vector

article

Enhancement of influenza virus transmission by gene reassortment.

scientific article

Establishment of MDCK Stable Cell Lines Expressing TMPRSS2 and MSPL and Their Applications in Propagating Influenza Vaccine Viruses in Absence of Exogenous Trypsin

scientific article

Evaluation and application of a one-step duplex real-time reverse transcription polymerase chain reaction assay for the rapid detection of influenza A (H7N9) virus from poultry samples

scientific article published on 16 July 2015

Evaluation of a genetically modified reassortant H5N1 influenza A virus vaccine candidate generated by plasmid-based reverse genetics.

scientific article published in January 2003

Evolution and extensive reassortment of H5 influenza viruses isolated from wild birds in China over the past decade

scientific article published on 20 July 2020

Evolution of H9N2 influenza viruses from domestic poultry in Mainland China

scientific article

Fatal H5N6 Avian Influenza Virus Infection in a Domestic Cat and Wild Birds in China

scientific article

Generating vesicular stomatitis virus pseudotype bearing the severe acute respiratory syndrome coronavirus spike envelope glycoprotein for rapid and safe neutralization test or cell-entry assay

scientific article published in October 2006

Generation and evaluation of a Newcastle disease virus-based H9 avian influenza live vaccine

scientific article

Generation and evaluation of a high-growth reassortant H9N2 influenza A virus as a pandemic vaccine candidate.

scientific article

Genetic and biological characterization of two novel reassortant H5N6 swine influenza viruses in mice and chickens

scientific article published on 18 August 2015

Genetics, Receptor Binding, Replication, and Mammalian Transmission of H4 Avian Influenza Viruses Isolated from Live Poultry Markets in China

scientific article

Genetics, Receptor Binding, and Virulence in Mice of H10N8 Influenza Viruses Isolated from Ducks and Chickens in Live Poultry Markets in China

scientific article published on 8 April 2015

Genetics, receptor binding property, and transmissibility in mammals of naturally isolated H9N2 Avian Influenza viruses

scientific article

Glycine at Position 622 in PB1 Contributes to the Virulence of H5N1 Avian Influenza Virus in Mice

scientific article published on 9 December 2015

Glycosylation and an amino acid insertion in the head of hemagglutinin independently affect the antigenic properties of H5N1 avian influenza viruses

scientific article published on 30 November 2018

Glycosylation of the Hemagglutinin Protein of H5N1 Influenza Virus Increases Its Virulence in Mice by Exacerbating the Host Immune Response

scientific article

Growth determinants for H5N1 influenza vaccine seed viruses in MDCK cells

scientific article

H3N2 avian influenza viruses detected in live poultry markets in China bind to human-type receptors and transmit in guinea pigs and ferrets

scientific article published on 01 January 2019

H5N1 Hybrid Viruses Bearing 2009/H1N1 Virus Genes Transmit in Guinea Pigs by Respiratory Droplet ⬇️

scientific article published on May 2, 2013

H5N1 influenza marker vaccine for serological differentiation between vaccinated and infected chickens

scientific article published on 22 May 2008

H5N1 influenza viruses: outbreaks and biological properties

scientific article

H6 influenza viruses pose a potential threat to human health

scientific article

H7N9 Influenza Viruses Are Transmissible in Ferrets by Respiratory Droplet ⬇️

scientific article published on July 18, 2013

H7N9 virulent mutants detected in chickens in China pose an increased threat to humans

scientific article

Herc5 attenuates influenza A virus by catalyzing ISGylation of viral NS1 protein

scientific article

High frequency of reassortment after co-infection of chickens with the H4N6 and H9N2 influenza A viruses and the biological characteristics of the reassortants

scientific article published on 18 June 2018

Honeysuckle-encoded atypical microRNA2911 directly targets influenza A viruses

scientific article

Host Cellular Protein TRAPPC6AΔ Interacts with Influenza A Virus M2 Protein and Regulates Viral Propagation by Modulating M2 Trafficking

scientific article published on 19 October 2016

Human Infection from Avian-like Influenza A (H1N1) Viruses in Pigs, China ⬇️

scientific article published on July 1, 2012

Identification of Key Amino Acids in the PB2 and M1 Proteins of H7N9 Influenza Virus That Affect Its Transmission in Guinea Pigs

scientific article published on 12 December 2019

Identification of PB2 mutations responsible for the efficient replication of H5N1 influenza viruses in human lung epithelial cells

scientific article

Identification of a Highly Conserved Epitope on Avian Influenza Virus Non-Structural Protein 1 Using a Peptide Microarray

scientific article

Identification of a key amino acid in hemagglutinin that increases human-type receptor binding and transmission of an H6N2 avian influenza virus

scientific article published on 23 September 2017

Identification of a linear epitope on the haemagglutinin protein of pandemic A/H1N1 2009 influenza virus using monoclonal antibodies.

scientific article

Identification of a novel linear epitope on the NS1 protein of avian influenza virus

scientific article published on 20 August 2015

Identification of amino acids in HA and PB2 critical for the transmission of H5N1 avian influenza viruses in a mammalian host

scientific article

Immune efficacy of an adenoviral vector-based swine influenza vaccine against antigenically distinct H1N1 strains in mice

scientific article published on 20 September 2017

Immunogenicity and efficacy of a recombinant adenovirus expressing hemagglutinin from the H5N1 subtype of swine influenza virus in mice

scientific article published on April 2014

Immunogenicity and protective efficacy of a live attenuated H5N1 vaccine in nonhuman primates

scientific article

Incorporation of conserved nucleoprotein into influenza virus-like particles could provoke a broad protective immune response in BALB/c mice and chickens.

scientific article

Insights from avian influenza surveillance of chickens and ducks before and after exposure to live poultry markets

scientific article published on 09 April 2019

Integrated Clinical, Pathologic, Virologic, and Transcriptomic Analysis of H5N1 Influenza Virus-Induced Viral Pneumonia in the Rhesus Macaque ⬇️

scientific article published on April 4, 2012

Key Molecular Factors in Hemagglutinin and PB2 Contribute to Efficient Transmission of the 2009 H1N1 Pandemic Influenza Virus ⬇️

scientific article published on June 27, 2012

LRCH1 deficiency enhances LAT signalosome formation and CD8+ T cell responses against tumors and pathogens

scientific article published on 29 July 2020

Lack of transmission of H5N1 avian-human reassortant influenza viruses in a ferret model

scientific article

Lethal infection by a novel reassortant H5N1 avian influenza A virus in a zoo-housed tiger

scientific article published on 22 October 2014

Limited compatibility between the RNA polymerase components of influenza virus type A and B.

scientific article published on 2 May 2008

Low Polymerase Activity Attributed to PA Drives the Acquisition of the PB2 E627K Mutation of H7N9 Avian Influenza Virus in Mammals.

scientific article published on 18 June 2019

Molecular Mechanisms for the Adaptive Switching Between the OAS/RNase L and OASL/RIG-I Pathways in Birds and Mammals.

scientific article published on 20 June 2018

Molecular basis of neurovirulence of flury rabies virus vaccine strains: importance of the polymerase and the glycoprotein R333Q mutation

scientific article

Molecular basis of replication of duck H5N1 influenza viruses in a mammalian mouse model

scientific article

New influenza A(H7N7) viruses detected in live poultry markets in China

scientific article

Newcastle disease virus-vectored Nipah encephalitis vaccines induce B and T cell responses in mice and long-lasting neutralizing antibodies in pigs ⬇️

scientific article published on June 21, 2012

Newcastle disease virus-vectored rabies vaccine is safe, highly immunogenic, and provides long-lasting protection in dogs and cats

scientific article

Novel influenza A(H7N2) virus in chickens, Jilin province, China, 2014.

scientific article

Novel triple reassortant H1N2 influenza viruses bearing six internal genes of the pandemic 2009/H1N1 influenza virus were detected in pigs in China.

scientific article

Outbreaks of Highly Pathogenic Avian Influenza (H5N6) Virus Subclade 2.3.4.4h in Swans, Xinjiang, Western China, 2020

scientific article published on 08 October 2020

PB2-E627K and PA-T97I substitutions enhance polymerase activity and confer a virulent phenotype to an H6N1 avian influenza virus in mice.

scientific article published on 6 September 2014

Pathogenicity of Chinese H5N1 highly pathogenic avian influenza viruses in pigeons

scientific article published on 9 September 2008

Pause on avian flu transmission research

scientific article published on January 2012

Phospholipid scramblase 1 interacts with influenza A virus NP, impairing its nuclear import and thereby suppressing virus replication.

scientific article published on 19 January 2018

Phylogenetic and pathogenic analysis of a novel H6N2 avian influenza virus isolated from a green peafowl in a wildlife park

scientific article published on December 2014

Polygenic virulence factors involved in pathogenesis of 1997 Hong Kong H5N1 influenza viruses in mice

scientific article published on 22 May 2007

Prevalence, genetics, and transmissibility in ferrets of Eurasian avian-like H1N1 swine influenza viruses.

scientific article

Properties and dissemination of H5N1 viruses isolated during an influenza outbreak in migratory waterfowl in western China

scientific article

Protective Efficacy of an H5N1 Inactivated Vaccine Against Challenge with Lethal H5N1, H5N2, H5N6, and H5N8 Influenza Viruses in Chickens

scientific article published on May 2016

Protective Efficacy of the Inactivated H5N1 Influenza Vaccine Re-6 Against Different Clades of H5N1 Viruses Isolated in China and the Democratic People's Republic of Korea

scientific article published on May 2016

Protective efficacy in chickens, geese and ducks of an H5N1-inactivated vaccine developed by reverse genetics

scientific article published on 01 October 2005

Protective efficacy in farmed ducks of a duck enteritis virus-vectored vaccine against H5N1, H5N6, and H5N8 avian influenza viruses

scientific article published on 27 August 2019

Protective efficacy of H7 subtype avian influenza DNA vaccine

scientific article published on 01 March 2010

Protective efficacy of an H1N1 cold-adapted live vaccine against the 2009 pandemic H1N1, seasonal H1N1, and H5N1 influenza viruses in mice ⬇️

scientific article published on January 18, 2012

Protective efficacy of an inactivated Eurasian avian-like H1N1 swine influenza vaccine against homologous H1N1 and heterologous H1N1 and H1N2 viruses in mice

scientific article

Proteomic analysis of the lungs of mice infected with different pathotypes of H5N1 avian influenza viruses ⬇️

scientific article published on June 1, 2012

Rapid Detection of Subtype H10N8 Influenza Virus by One-Step Reverse Transcription-Loop-Mediated Isothermal Amplification Methods

scientific article

Rapid Evolution of H7N9 Highly Pathogenic Viruses that Emerged in China in 2017

scholarly article published by Hualan Chen in 2018

Reassortant H1N1 influenza virus vaccines protect pigs against pandemic H1N1 influenza virus and H1N2 swine influenza virus challenge ⬇️

scientific article published on April 30, 2011

Recombinant duck enteritis virus works as a single-dose vaccine in broilers providing rapid protection against H5N1 influenza infection ⬇️

scientific article published on December 23, 2012

Recombinant duck enteritis viruses expressing the Newcastle disease virus (NDV) F gene protects chickens from lethal NDV challenge

article

Recombinant fowlpox virus vector-based vaccine completely protects chickens from H5N1 avian influenza virus

scientific article published on 25 December 2008

Single-amino-acid mutation in the HA alters the recognition of H9N2 influenza virus by a monoclonal antibody

scientific article

Strategies for improving the efficacy of a H6 subtype avian influenza DNA vaccine in chickens ⬇️

scientific article published on February 17, 2011

Susceptibility of ferrets, cats, dogs, and different domestic animals to SARS-coronavirus-2

scientific article published on 01 April 2020

Synergistic Effect of the PDZ and p85β-Binding Domains of the NS1 Protein on Virulence of an Avian H5N1 Influenza A Virus ⬇️

scientific article published on February 13, 2013

TRIM35 mediates protection against influenza infection by activating TRAF3 and degrading viral PB2

scientific article published on 19 June 2020

Targeting 7-Dehydrocholesterol Reductase Integrates Cholesterol Metabolism and IRF3 Activation to Eliminate Infection

scientific article published on 24 December 2019

The G Protein-Coupled Receptor FFAR2 Promotes Internalization during Influenza A Virus Entry

scientific article published on 06 January 2020

The Immune Adaptor ADAP Regulates Reciprocal TGF-β1-Integrin Crosstalk to Protect from Influenza Virus Infection.

scientific article published on 24 April 2015

The NS1 gene contributes to the virulence of H5N1 avian influenza viruses

scientific article

The PA protein directly contributes to the virulence of H5N1 avian influenza viruses in domestic ducks

scientific article

The PB2 E627K mutation contributes to the high polymerase activity and enhanced replication of H7N9 influenza virus.

scientific article

The duck genome and transcriptome provide insight into an avian influenza virus reservoir species

scientific article

The first confirmed human case of avian influenza A (H5N1) in Mainland China

scientific article published in January 2006

The innate immunity of guinea pigs against highly pathogenic avian influenza virus infection

scientific article

The nucleoprotein and matrix protein segments of H5N1 influenza viruses are responsible for dominance in embryonated eggs ⬇️

scientific article published on April 6, 2011

The sequential tissue distribution of duck Tembusu virus in adult ducks

scientific article

The vaccine efficacy of recombinant duck enteritis virus expressing secreted E with or without PrM proteins of duck tembusu virus

scientific article published on August 2014

Transmission studies resume for avian flu.

scientific article

Two amino acid residues in ion channel protein M2 and polymerase protein PA contribute to replication difference of H5N1 influenza viruses in mice

scientific article published on 24 October 2013

Two amino acid residues in the matrix protein M1 contribute to the virulence difference of H5N1 avian influenza viruses in mice

scientific article published on 30 December 2008

Two different genotypes of H1N2 swine influenza virus isolated in northern China and their pathogenicity in animals

scientific article published on 9 December 2014

Two genotypes of H1N2 swine influenza viruses appeared among pigs in China.

scientific article published on 25 July 2009

Typing and subtyping avian influenza virus using DNA microarrays

scientific article

Vaccination of poultry successfully eliminated human infection with H7N9 virus in China

article

[Development of one step RT-PCR technique for detection of H7 subtype avian influenza]

scientific article published on 01 November 2009

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