List of works - David Klenerman - Paulina

List of works by David Klenerman

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A human neuronal model of sporadic Alzheimer’s disease induced byFBXO2downregulation shows Aβ aggregation, tau hyperphosphorylation and functional network impairment

A non-catalytic role for MLL2 in controlling chromatin organisation and mobility during the priming of pluripotent cells for differentiation

Amyloid precipitation in biofluids using a structure-specific chemical antibody

Astrocytic RNA editing regulates the host immune response to alpha-synuclein

Author response: Activation of Toll-like receptors nucleates assembly of the MyDDosome signaling hub

Author response: The delayed kinetics of Myddosome formation explains why Aβ aggregates trigger TLR4 less efficiently than LPS

Co-aggregation with Apolipoprotein E modulates the function of Amyloid-β in Alzheimer's disease

Direct digital sensing of protein biomarkers in solution

Early synaptic pathology is associated with small tau aggregates in Alzheimer’s disease

Fingerprinting disease-derived protein aggregates reveals unique signature of Motor Neuron Disease

HP1β and densely packed chromatin form separate microdomains in mouse ES cells, which are reconfigured upon exit from naïve pluripotency

High-density volumetric super-resolution microscopy

Hyaluronidase unlocks sequestered CEACAM5 and improves CAR T-cell therapy in colorectal cancer

Hyperphosphorylated tau self-assembles into amorphous aggregates eliciting TLR4-dependent inflammatory responses

Live-cell 3D single-molecule tracking reveals how NuRD modulates enhancer dynamics

Lysosomal stress induces amyloid-β aggregate release and reactive transformation in human astrocytes

Multiparametric Correlative Topographical and Volumetric Fluorescence Microscopy

Nanoscopic tau aggregates in Parkinson’s disease

Neurodegeneration emerges at a cellular tipping point between aggregate accumulation and removal

POLCAM: Instant molecular orientation microscopy for the life sciences

Performing Correlative Light and Electron Microscopy to reveal the structural organization and location of alpha-synuclein aggregation hotspots inside the neuron.

Rare bioactive tau oligomers from Alzheimer brain support both templated misfolding and fibril formation

Selective suppression of oligodendrocyte-derived amyloid beta rescues neuronal dysfunction in Alzheimer’s Disease

Single-molecule characterisation of soluble beta-amyloid aggregate binding by Aducanumab, Lecanemab, Gantenerumab, and Donanemab

Single-molecule characterisation of soluble beta-amyloid aggregate binding by Aducanumab, Lecanemab, Gantenerumab, and Donanemab

Small tau aggregates exhibit disease-specific molecular profiles across tauopathies

Structural conversion of α-synuclein at the mitochondria induces neuronal toxicity

Super-resolution microscopy of nanoscopic alpha-synuclein aggregates in brain samples indicates a subset of cells have disrupted protein homeostasis prior to Lewy body formation in Parkinson’s disease

SynPull: a novel method for studying neurodegeneration-related aggregates in synaptosomes using super-resolution microscopy

T-cell signaling relies on partial CD45-exclusion at sub-micron sized cellular contacts

Tau accumulation patterns in PSP constrain mechanisms and quantify cell-to-cell and cell-autonomous aggregation rates

The delayed kinetics of Myddosome formation explains why Aβ aggregates trigger TLR4 less efficiently than LPS

The delayed kinetics of Myddosome formation explains why Aβ aggregates trigger TLR4 less efficiently than LPS

Wild-type sTREM2 blocks Aβ aggregation and neurotoxicity, while the Alzheimer’s R47H mutant does the opposite