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List of works by Ronald Hay

A Functional Interaction Between RHA and Ubc9, an E2-like Enzyme Specific for Sumo-1

scientific article published on 01 July 2004

A Generic Platform for Cellular Screening Against Ubiquitin Ligases

scientific article published on 8 January 2016

A SUMO-Dependent Protein Network Regulates Chromosome Congression during Oocyte Meiosis

scientific article

A cellular protein binds to a conserved sequence in the adenovirus type 2 enhancer

scientific article published on March 1987

A complex containing βTrCP recruits Ccd34 to catalyse ubiquitination of IκBα

scientific article published on 01 July 1999

A fluorescence-resonance-energy-transfer-based protease activity assay and its use to monitor paralog-specific small ubiquitin-like modifier processing

scientific article published on 04 January 2007

A mechanism for inhibiting the SUMO pathway

scientific article

A proteomic study of SUMO-2 target proteins

scientific article

A role for paralog-specific sumoylation in histone deacetylase 1 stability

scientific article published on 25 September 2013

Absolute SILAC-compatible expression strain allows Sumo-2 copy number determination in clinical samples

scientific article

Activation of NF-kappaB nuclear transcription factor by flow in human endothelial cells

scientific article

Activation of NF-κB by PM10 Occurs via an Iron-Mediated Mechanism in the Absence of IκB Degradation

scientific article published on 01 July 2000

Adenovirus DNA polymerase: domain organisation and interaction with preterminal protein

scientific article

An additional role for SUMO in ubiquitin-mediated proteolysis

scientific article published on 28 May 2009

An all-out assault on SARS-CoV-2 replication

scientific article published on 02 July 2021

An influenza virus-triggered SUMO switch orchestrates co-opted endogenous retroviruses to stimulate host antiviral immunity

scientific article published on 07 August 2019

Analysis of the SUMO2 Proteome during HSV-1 Infection

scientific article published on 22 July 2015

Androgen receptor acetylation governs trans activation and MEKK1-induced apoptosis without affecting in vitro sumoylation and trans-repression function

scientific article

Antipeptide antisera define neutralizing epitopes on the adenovirus hexon

scientific article published on June 1, 1992

Apoptin is modified by SUMO conjugation and targeted to promyelocytic leukemia protein nuclear bodies.

scientific article published on 21 August 2006

Arsenic-induced SUMO-dependent recruitment of RNF4 into PML nuclear bodies

scientific article

Autophagosomes cooperate in the degradation of intracellular C-terminal fragments of the amyloid precursor protein via the MVB/lysosomal pathway

scientific article published on 2 March 2017

BC-box protein domain-related mechanism for VHL protein degradation

scientific article published on 21 October 2013

Calpain 3 deficiency is associated with myonuclear apoptosis and profound perturbation of the IκBα/NF-κB pathway in limb-girdle muscular dystrophy type 2A

scientific article published on 01 May 1999

Characterisation of the adenovirus preterminal protein and its interaction with the POU homeodomain of NFIII (Oct-1)

scientific article published on July 1999

Characterization of IκBα Nuclear Import Pathway

scientific article published in Journal of Biological Chemistry

Characterization of SENP7, a SUMO-2/3-specific isopeptidase

scientific article published on 26 June 2009

Comparative proteomic analysis identifies a role for SUMO in protein quality control

scientific article

Conjugation of human topoisomerase 2 alpha with small ubiquitin-like modifiers 2/3 in response to topoisomerase inhibitors: cell cycle stage and chromosome domain specificity

scientific article published in April 2008

Cytokine-induced nuclear factor kappa B activation promotes the survival of developing neurons.

scientific article published on January 2000

DNA Sequence of the Adenovirus Type 41 Hexon Gene and Predicted Structure of the Protein

scientific article published on September 1, 1988

Decoding the SUMO signal

scientific article published on April 2013

Defective IκBα in Hodgkin cell lines with constitutively active NF-κB ⬇️

scientific article published on April 23, 1998

Detection and Quantitation of SUMO Chains by Mass Spectrometry ⬇️

scientific article published on January 1, 2012

Detection of Z DNA binding proteins in tissue culture cells ⬇️

scientific article published on September 12, 1988

Detection of modification by ubiquitin-like proteins

scientific article

Detection of protein SUMOylation in vivo

scientific article published on 03 September 2009

Distinct and overlapping sets of SUMO-1 and SUMO-2 target proteins revealed by quantitative proteomics

scientific article

Dss1 is a 26S proteasome ubiquitin receptor

scientific article published on 9 October 2014

Dual role of the adenovirus pVI C terminus as a nuclear localization signal and activator of the viral protease

scientific article published in November 2004

Dynamic Interplay of the SUMO and ERK Pathways in Regulating Elk-1 Transcriptional Activity

scientific article published on 01 July 2003

Dynamic SUMO modification regulates mitotic chromosome assembly and cell cycle progression in Caenorhabditis elegans

scientific article

E3 ubiquitin ligase HOIP attenuates apoptotic cell death induced by cisplatin

scientific article

Erratum: Dynamic SUMO modification regulates mitotic chromosome assembly and cell cycle progression in Caenorhabditis elegans.

scientific article published on 12 February 2015

Expanded Interactome of the Intrinsically Disordered Protein Dss1

article

FRET-based in vitro assays for the analysis of SUMO protease activities

scientific article published on January 2009

Family-wide analysis of poly(ADP-ribose) polymerase activity

scientific article

Fourier transform ion cyclotron resonance mass spectrometry for the analysis of small ubiquitin-like modifier (SUMO) modification: identification of lysines in RanBP2 and SUMO targeted for modification during the E3 autoSUMOylation reaction

scientific article

Functional 3D architecture in an intrinsically disordered E3 ligase domain facilitates ubiquitin transfer

scientific article published on 30 July 2020

Functional interactions between ubiquitin E2 enzymes and TRIM proteins.

scientific article

Global Reprogramming of Host SUMOylation during Influenza Virus Infection.

scientific article

HSP90 protein stabilizes unloaded argonaute complexes and microscopic P-bodies in human cells

scientific article published on 17 March 2010

High-stringency tandem affinity purification of proteins conjugated to ubiquitin-like moieties

scientific article

Hydrodynamic bead modelling of the 2:1 p50-IkappaBgamma complex

scientific article published on March 2004

Identification of RNF168 as a PML nuclear body regulator

scientific article published on 16 December 2015

Identification of a substrate recognition site on Ubc9.

scientific article published on 4 March 2002

Identification of conserved residues contributing to the activities of adenovirus DNA polymerase

scientific article published on December 2000

Identification of sites of ubiquitination in proteins: a fourier transform ion cyclotron resonance mass spectrometry approach

scientific article published in December 2004

In vivo identification of human small ubiquitin-like modifier polymerization sites by high accuracy mass spectrometry and an in vitro to in vivo strategy

scientific article

Inhibition of NF-kappa B by a cell permeable form of I kappa B alpha induces apoptosis in eosinophils

scientific article published in January 2005

Inhibition of NF-kappaB DNA binding by nitric oxide

scientific article published on June 1996

Inhibition of nuclear factor-kappaB activation un-masks the ability of TNF-alpha to induce human eosinophil apoptosis

scientific article published in February 2002

Initiation of SV40 DNA replication in vivo: Location and structure of 5′ ends of DNA synthesized in the ori region ⬇️

scientific article published on April 1, 1982

Interaction of the C-terminal region of p105 with the nuclear localisation signal of p50 is required for inhinition of NF-ϰB binding activity ⬇️

scientific article published on September 25, 1993

Iso-seco-tanapartholides: Isolation, Synthesis and Biological Evaluation.

scientific article published on 7 October 2009

Mdm2-mediated NEDD8 conjugation of p53 inhibits its transcriptional activity

scientific article

Mechanism and function of DNA replication‐independent DNA‐protein crosslink repair via the SUMO‐RNF4 pathway

scientific article published on 04 August 2021

Mechanism of ubiquitylation by dimeric RING ligase RNF4

scientific article

Medea SUMOylation restricts the signaling range of the Dpp morphogen in the Drosophila embryo

scientific article published on September 2008

Modification of nuclear PML protein by SUMO-1 regulates Fas-induced apoptosis in rheumatoid arthritis synovial fibroblasts

scholarly article

Modifiying NEMO

scientific article published on 01 February 2004

Modulation of Abeta generation by small ubiquitin-like modifiers does not require conjugation to target proteins

scientific article

Multiple C-terminal lysine residues target p53 for ubiquitin-proteasome-mediated degradation

scientific article published on November 2000

Mutations in the IkBa gene in Hodgkin's disease suggest a tumour suppressor role for IkappaBalpha.

scientific article

Mutations of NFKBIA, encoding IkappaB alpha, are a recurrent finding in classical Hodgkin lymphoma but are not a unifying feature of non-EBV-associated cases

scientific article

NEDP1, a highly conserved cysteine protease that deNEDDylates Cullins

scientific article (publication date: 11 July 2003)

NF-kappa B-dependent induction of the NF-kappa B p50 subunit gene promoter underlies self-perpetuation of human immunodeficiency virus transcription in monocytic cells ⬇️

scientific article published on August 15, 1992

NF-kappaB inhibits apoptosis in murine mammary epithelia

scientific article

NF-kappaB is a critical regulator of the survival of rodent and human hepatic myofibroblasts.

scientific article

Negative Modulation of Macroautophagy by Stabilized HERPUD1 is Counteracted by an Increased ER-Lysosomal Network With Impact in Drug-Induced Stress Cell Survival

scientific article published on 02 March 2022

Nuclear Retention of IκBα Protects It from Signal-induced Degradation and Inhibits Nuclear Factor κB Transcriptional Activation

scientific article published in Journal of Biological Chemistry

OMERO: flexible, model-driven data management for experimental biology

scientific article

Oligomerization conditions Mdm2-mediated efficient p53 polyubiquitylation but not its proteasomal degradation

scientific article

P14ARF promotes accumulation of SUMO-1 conjugated (H)Mdm2.

scientific article published on September 2002

PML isoforms IV and V contribute to adenovirus-mediated oncogenic transformation by functionally inhibiting the tumor-suppressor p53.

scientific article published on 16 March 2015

PML isoforms in response to arsenic: high-resolution analysis of PML body structure and degradation

scientific article published on 4 November 2013

Persistent activation of nuclear factor-kappaB in cultured rat hepatic stellate cells involves the induction of potentially novel Rel-like factors and prolonged changes in the expression of IkappaB family proteins.

scientific article

Polymeric chains of SUMO-2 and SUMO-3 are conjugated to protein substrates by SAE1/SAE2 and Ubc9.

scientific article

Post-translational modification by SUMO.

scientific article

Posttranslational hydroxylation of ankyrin repeats in IkappaB proteins by the hypoxia-inducible factor (HIF) asparaginyl hydroxylase, factor inhibiting HIF (FIH)

scientific article

Protein modification by SUMO

scientific article published on 01 May 2001

Proteome-wide identification of SUMO modification sites by mass spectrometry

scientific article published on 20 August 2015

Proteome-wide identification of SUMO2 modification sites

scientific article published on 29 April 2014

Proteotoxic stress reprograms the chromatin landscape of SUMO modification.

scientific article published on 7 July 2015

Purification and identification of endogenous polySUMO conjugates

scientific article

Pyridoxal 5'-phosphate inhibition of adenovirus DNA polymerase

scientific article published on September 1996

Quantitative analysis of multi-protein interactions using FRET: application to the SUMO pathway

scientific article published on April 2008

RNF4 is a poly-SUMO-specific E3 ubiquitin ligase required for arsenic-induced PML degradation

scientific article

Rapid generation of endogenously driven transcriptional reporters in cells through CRISPR/Cas9.

scientific article published on 29 April 2015

Reanalysis of phosphoproteomics data uncovers ADP-ribosylation sites

scientific article published on 30 July 2012

Recognition of the adenovirus type 2 origin of DNA replication by the virally encoded DNA polymerase and preterminal proteins ⬇️

scientific article published on February 1, 1992

Regulation of homeodomain-interacting protein kinase 2 (HIPK2) effector function through dynamic small ubiquitin-related modifier-1 (SUMO-1) modification

scientific article published on 15 June 2005

Regulation of the DNA binding activity of NF-kappa B.

scientific article

Replication of adenovirus type 4 DNA by a Purified fraction from infected Cells ⬇️

scientific article published on June 25, 1991

Repression of SOX6 transcriptional activity by SUMO modification

scientific article

Ribosomal proteins are targets for the NEDD8 pathway

scientific article

Role of IkappaBalpha ubiquitination in signal-induced activation of NFkappaB in vivo

scientific article published in March 1996

Role of an N-terminal site of Ubc9 in SUMO-1, -2, and -3 binding and conjugation

scientific article (publication date: 26 August 2003)

Role of the conserved lysine 80 in stabilisation of NF-kappaB p50 DNA binding

scientific article published on January 1999

Role of two residues proximal to the active site of Ubc9 in substrate recognition by the Ubc9.SUMO-1 thiolester complex

scientific article

SIRT1 deacetylation and repression of p300 involves lysine residues 1020/1024 within the cell cycle regulatory domain 1

scientific article

SUMO and transcriptional regulation

scientific journal article

SUMO chain-induced dimerization activates RNF4.

scientific article published on March 2014

SUMO modification of the DEAD box protein p68 modulates its transcriptional activity and promotes its interaction with HDAC1.

scientific article published on 19 March 2007

SUMO modification of the Ets-related transcription factor ERM inhibits its transcriptional activity

scientific article

SUMO modification regulates MafB-driven macrophage differentiation by enabling Myb-dependent transcriptional repression

scientific article

SUMO protease SENP1 induces isomerization of the scissile peptide bond

scientific article

SUMO-1 conjugation in vivo requires both a consensus modification motif and nuclear targeting

scientific article (publication date: 20 April 2001)

SUMO-1 modification activates the transcriptional response of p53

scientific article

SUMO-1 modification alters ADAR1 editing activity

scientific article published on 24 August 2005

SUMO-1 modification of human transcription factor (TF) IID complex subunits: inhibition of TFIID promoter-binding activity through SUMO-1 modification of hsTAF5

scientific article

SUMO-modified nuclear cyclin D1 bypasses Ras-induced senescence

scientific article published on 27 August 2010

SUMO-specific proteases: a twist in the tail

scientific article published on August 2007

SUMO-targeted ubiquitin E3 ligase RNF4 is required for the response of human cells to DNA damage

scientific journal article

SUMO: a history of modification

scientific article (publication date: April 2005)

SUMOylation of HNF4α regulates protein stability and hepatocyte function

scientific article published on 14 April 2012

SUMOylation of the GTPase Rac1 is required for optimal cell migration

scientific article

SUMOylation stabilizes sister kinetochore biorientation to allow timely anaphase

scientific article published on 30 April 2021

Screen for multi-SUMO-binding proteins reveals a multi-SIM-binding mechanism for recruitment of the transcriptional regulator ZMYM2 to chromatin.

scientific article

Selective SUMO modification of cAMP-specific phosphodiesterase-4D5 (PDE4D5) regulates the functional consequences of phosphorylation by PKA and ERK.

scientific article published on 28 April 2010

Sequence specificity for the initiation of RNA-primed simian virus 40 DNA synthesis in vivo ⬇️

scientific article published on May 15, 1984

SiRNA screening to identify ubiquitin and ubiquitin-like system regulators of biological pathways in cultured mammalian cells

scientific article

Single-stranded DNA-binding protein hSSB1 is critical for genomic stability

scientific article

Sp100 isoform-specific regulation of human adenovirus 5 gene expression

scientific article published on 12 March 2014

Stable-isotope labeling with amino acids in nematodes.

scientific article published on 28 August 2011

Structural Basis of BRCC36 Function in DNA Repair and Immune Regulation

scientific article published on 25 June 2019

Structural basis for the RING-catalyzed synthesis of K63-linked ubiquitin chains

scientific article published on 6 July 2015

Structural basis of NEDD8 ubiquitin discrimination by the deNEDDylating enzyme NEDP1.

scientific article

Structural insight into SUMO chain recognition and manipulation by the ubiquitin ligase RNF4

scientific article

Structure of a RING E3 ligase and ubiquitin-loaded E2 primed for catalysis

scientific article

Sumoylation controls host anti-bacterial response to the gut invasive pathogen Shigella flexneri

scientific article published on 5 August 2014

Sumoylation regulates central spindle protein dynamics during chromosome segregation in oocytes

article

Sumoylation regulates protein dynamics during meiotic chromosome segregation in C. elegans oocytes

scientific article published on 18 July 2019

System-wide changes to SUMO modifications in response to heat shock

scientific article

Targeting of SUMO substrates to a Cdc48-Ufd1-Npl4 segregase and STUbL pathway in fission yeast.

scientific article

Tetramerization-defects of p53 result in aberrant ubiquitylation and transcriptional activity

scientific article published on 13 April 2014

The DNA-binding Domain of Nuclear Factor I is Sufficient to Cooperate with the Adenovirus Type 2 DNA-binding Protein in Viral DNA Replication

scientific article published on December 1, 1991

The P-body component USP52/PAN2 is a novel regulator of HIF1A mRNA stability

scientific article published on April 2013

The Proteasomal Deubiquitinating Enzyme PSMD14 Regulates Macroautophagy by Controlling Golgi-to-ER Retrograde Transport

scientific article published on 23 March 2020

The S phase checkpoint promotes the Smc5/6 complex dependent SUMOylation of Pol2, the catalytic subunit of DNA polymerase ε

scientific article published on 25 November 2019

The SUMO protease SENP6 is a direct regulator of PML nuclear bodies

scientific article published on 9 December 2010

The adenovirus protease is activated by a virus-coded disulphide-linked peptide

scientific article

The carboxy-terminus of IκBα determines susceptibility to degradation by the catalytic core of the proteasome ⬇️

scientific article published on October 9, 1997

The seven wonders of ubiquitin: a multi-interview: Personal insights into the ubiquitin field. Interview by Nonia Pariente

scientific article

The structure of SENP1-SUMO-2 complex suggests a structural basis for discrimination between SUMO paralogues during processing

scientific article

Thioredoxin regulates the DNA binding activity of NF-kappa B by reduction of a disulphide bond involving cysteine 62 ⬇️

scientific article published on August 11, 1992

Tools to Study SUMO Conjugation in Caenorhabditis elegans

scientific article published in January 2016

Ubch9 conjugates SUMO but not ubiquitin ⬇️

scientific article published on November 17, 1997

Ube2W conjugates ubiquitin to α-amino groups of protein N-termini

scientific article

Ubiquitin C-terminal hydrolases cleave isopeptide- and peptide-linked ubiquitin from structured proteins but do not edit ubiquitin homopolymers

scientific article published in March 2015

Ubiquitin transfer by a RING E3 ligase occurs from a closed E2~ubiquitin conformation

scientific article published on 05 June 2020

Ufd1-Npl4 Recruit Cdc48 for Disassembly of Ubiquitylated CMG Helicase at the End of Chromosome Replication

scientific article published on March 2017

Unique binding interactions among Ubc9, SUMO and RanBP2 reveal a mechanism for SUMO paralog selection

scientific journal article

betaTrCP-mediated proteolysis of NF-kappaB1 p105 requires phosphorylation of p105 serines 927 and 932.

scientific article

p300 Transcriptional Repression Is Mediated by SUMO Modification

scientific article published on 01 April 2003

p75-mediated NF-kappaB activation enhances the survival response of developing sensory neurons to nerve growth factor

scientific article

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