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List of works by John Francis Xavier Diffley

A Mec1- and Rad53-dependent checkpoint controls late-firing origins of DNA replication

scientific article (publication date: 8 October 1998)

A central role for DNA replication forks in checkpoint activation and response

scientific article published in May 2003

A close relative of the nuclear, chromosomal high-mobility group protein HMG1 in yeast mitochondria

scientific article

ATPase-dependent quality control of DNA replication origin licensing

scientific article

Activation of S-phase-promoting CDKs in late G1 defines a "point of no return" after which Cdc6 synthesis cannot promote DNA replication in yeast

scientific article published on June 1996

Activation of dormant origins of DNA replication in budding yeast

scientific article

Activation of the replicative DNA helicase: breaking up is hard to do ⬇️

scientific article published on March 16, 2012

Affinity labeling the DNA polymerase alpha complex. I. Pyridoxal 5'-phosphate inhibition of DNA polymerase and DNA primase activities of the DNA polymerase alpha complex from Drosophila melanogaster embryos.

scientific article published in October 1988

Bidirectional eukaryotic DNA replication is established by quasi-symmetrical helicase loading

scientific article published in July 2017

Break dosage, cell cycle stage and DNA replication influence DNA double strand break response

scientific article published on 29 May 2008

CDK Inactivation Is the Only Essential Function of the APC/C and the Mitotic Exit Network Proteins for Origin Resetting during Mitosis

scientific article published on 01 January 2000

CDKs promote DNA replication origin licensing in human cells by protecting Cdc6 from APC/C-dependent proteolysis

scientific article

CMG-Pol epsilon dynamics suggests a mechanism for the establishment of leading-strand synthesis in the eukaryotic replisome

scientific article

Cdt1 stabilizes an open MCM ring for helicase loading

scientific article published on 23 June 2017

Checkpoint-dependent RNR induction promotes fork restart after replicative stress

scientific article published on 20 January 2015

Checkpoint-dependent inhibition of DNA replication initiation by Sld3 and Dbf4 phosphorylation ⬇️

scientific article published on September 12, 2010

Chromatin Controls DNA Replication Origin Selection, Lagging-Strand Synthesis, and Replication Fork Rates

scientific article

Concerted loading of Mcm2-7 double hexamers around DNA during DNA replication origin licensing

scientific article

Controlling DNA replication origins in response to DNA damage - inhibit globally, activate locally

scientific article

Coping with and recovering from hydroxyurea-induced replication fork arrest in budding yeast.

scientific article

Cryo-EM structure of a licensed DNA replication origin

scientific article published on 21 December 2017

DNA binding properties of an HMG1-related protein from yeast mitochondria.

scientific article published in February 1992

DNA replication and oncogene-induced replicative stress

scientific article published on May 2014

DNA replication as a target of the DNA damage checkpoint

scientific article published on 07 June 2009

DNA replication origins retain mobile licensing proteins

scientific article published on 26 March 2021

DNA replication: building the perfect switch

scientific article

Dbf4p, an essential S phase-promoting factor, is targeted for degradation by the anaphase-promoting complex

scientific article

Deregulated G1-cyclin expression induces genomic instability by preventing efficient pre-RC formation

scientific article published on October 2002

Dpb11 coordinates Mec1 kinase activation with cell cycle-regulated Rad9 recruitment

scientific article

Early events in eukaryotic DNA replication

scientific article published on 01 October 1992

Eukaryotic DNA replication

scientific article published on 01 June 1994

Eukaryotic DNA replication control: lock and load, then fire

scientific article published on 18 September 2009

Evidence for a Cdc6p-independent mitotic resetting event involving DNA polymerase alpha.

scientific article

Factors affecting the diversity of DNA replication licensing control in eukaryotes

scientific article published on 12 March 2009

Genomic footprinting of budding yeast replication origins during the cell cycle

scientific article published on 01 January 1997

Global effects of DNA replication and DNA replication origin activity on eukaryotic gene expression

scientific article

Global regulators of chromosome function in yeast

scientific article published on August 1, 1992

Homology explains the functional similarities of Treslin/Ticrr and Sld3.

scientific article published in June 2010

How the Eukaryotic Replisome Achieves Rapid and Efficient DNA Replication.

scientific article

Human origin recognition complex binds to the region of the latent origin of DNA replication of Epstein-Barr virus

scientific article

Identification of a heteromeric complex that promotes DNA replication origin firing in human cells

scientific article published in May 2013

Identifying SARS-CoV-2 antiviral compounds by screening for small molecule inhibitors of Nsp14 RNA cap methyltransferase

scientific article published on 02 July 2021

Initiation complex assembly at budding yeast replication origins begins with the recognition of a bipartite sequence by limiting amounts of the initiator, ORC

scientific article

Interaction of Dbf4, the Cdc7 protein kinase regulatory subunit, with yeast replication origins in vivo.

scientific article

Interaction of a nuclear factor with the polyomavirus enhancer region.

scientific article

Interdependent nuclear accumulation of budding yeast Cdt1 and Mcm2-7 during G1 phase.

scientific article

Is the MCM2-7 complex the eukaryotic DNA replication fork helicase?

scientific article

Lessons in how to hold a fork

scientific article published on 01 October 2003

MCM2-7 proteins are essential components of prereplicative complexes that accumulate cooperatively in the nucleus during G1-phase and are required to establish, but not maintain, the S-phase checkpoint

scientific article published on November 2001

MCM: one ring to rule them all.

scientific article published on 08 February 2016

Mechanisms involved in regulating DNA replication origins during the cell cycle and in response to DNA damage.

scientific article published on January 2004

Mutational analysis of conserved sequence motifs in the budding yeast Cdc6 protein

scientific article

Nucleotide-dependent prereplicative complex assembly by Cdc6p, a homolog of eukaryotic and prokaryotic clamp-loaders

scientific article published in July 1998

ORC- and Cdc6-dependent complexes at active and inactive chromosomal replication origins in Saccharomyces cerevisiae

scientific article

On the road to replication

scientific article published on 19 January 2016

Once and only once upon a time: specifying and regulating origins of DNA replication in eukaryotic cells

scientific article

Origin licensing requires ATP binding and hydrolysis by the MCM replicative helicase

scientific article published on 31 July 2014

Phosphopeptide binding by Sld3 links Dbf4-dependent kinase to MCM replicative helicase activation

scientific article

Phosphorylation of Sld2 and Sld3 by cyclin-dependent kinases promotes DNA replication in budding yeast.

scientific article

Phosphorylation-dependent binding of mitotic cyclins to Cdc6 contributes to DNA replication control

scientific article published in Nature

Positive supercoiling of mitotic DNA drives decatenation by topoisomerase II in eukaryotes.

scientific article published in March 2011

Pre-replicative complex assembly with purified proteins

scientific article published on 23 June 2012

Prereplicative complexes assembled in vitro support origin-dependent and independent DNA replication

scientific article published on 24 February 2014

Protein-DNA interactions at a yeast replication origin

scientific article

Protein-DNA interactions in the epsilon-globin gene silencer.

scientific article

Purification of a cellular, double-stranded DNA-binding protein required for initiation of adenovirus DNA replication by using a rapid filter-binding assay

scientific article published on May 1986

Quality control in the initiation of eukaryotic DNA replication

scientific article published on December 2011

Recent developments in the initiation of chromosomal DNA replication: a complex picture emerges

scientific article

Reconstitution of an efficient thymidine salvage pathway in Saccharomyces cerevisiae

scientific article

Recruitment of Mcm10 to Sites of Replication Initiation Requires Direct Binding to the Minichromosome Maintenance (MCM) Complex

scientific article

Regulated eukaryotic DNA replication origin firing with purified proteins

scientific article published on 4 March 2015

Regulating DNA replication in eukarya

scientific article published on September 2013

Regulation of DNA replication through Sld3-Dpb11 interaction is conserved from yeast to humans.

scientific article published on 23 June 2011

Regulation of early events in chromosome replication

scientific article

Replication control: Choreographing replication origins ⬇️

scientific article published on October 22, 1998

Replication origins in eukaroytes

scientific article published on April 1996

Replication timing: the early bird catches the worm

scientific article published in February 2012

Role of DNA replication proteins in double-strand break-induced recombination in Saccharomyces cerevisiae

scientific article published on August 2004

Rpd3L Contributes to the DNA Damage Sensitivity of Saccharomyces cerevisiae Checkpoint Mutants

scientific article published on 17 December 2018

S-phase-promoting cyclin-dependent kinases prevent re-replication by inhibiting the transition of replication origins to a pre-replicative state

scientific article published in November 1995

Separate SCF(CDC4) recognition elements target Cdc6 for proteolysis in S phase and mitosis.

scientific article

Separate roles for the DNA damage checkpoint protein kinases in stabilizing DNA replication forks.

scientific article

Similarity between the transcriptional silencer binding proteins ABF1 and RAP1.

scientific article

Stepwise assembly of initiation complexes at budding yeast replication origins during the cell cycle

scientific article published on January 1995

Stepwise assembly of initiation proteins at budding yeast replication origins in vitro

scientific article published in December 2000

Structural mechanism for the selective phosphorylation of DNA-loaded MCM double hexamers by the Dbf4-dependent kinase

scientific article published on 28 December 2021

The Cdc4/34/53 pathway targets Cdc6p for proteolysis in budding yeast

scientific article

The Cdc7 protein kinase is required for origin firing during S phase

scientific article

The Many Faces of Redundancy in DNA Replication Control ⬇️

scientific article published on January 1, 2010

The chromosome replication cycle

scientific article

The cyclin-dependent kinase Cdc28p regulates distinct modes of Cdc6p proteolysis during the budding yeast cell cycle.

scientific article published in March 2000

The initiation of DNA replication in the budding yeast cell division cycle

scientific article published on December 1995

The initiation of chromosomal DNA replication in eukaryotes

scientific article published on December 1990

Topoisomerase II inactivation prevents the completion of DNA replication in budding yeast

scientific article published in June 2008

Transcriptional silencing and lamins

scientific article published in November 1989

Two steps in the assembly of complexes at yeast replication origins in vivo

scientific article (publication date: 29 July 1994)

Visualization of altered replication dynamics after DNA damage in human cells

scientific article published on 23 February 2004

Yeast origin recognition complex is involved in DNA replication and transcriptional silencing

scientific article published in November 1993

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