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List of works by Christopher J. Schofield

"From one seed a whole handful": homologous proteins as seeds in crystallisation

scientific article published on 5 August 2014

1,3,5-Trisubstituted benzenes as fluorescent photoaffinity probes for human carbonic anhydrase II capture

scientific article

13C-Carbamylation as a mechanistic probe for the inhibition of class D β-lactamases by avibactam and halide ions

scientific article published on 5 July 2017

19 F-NMR Reveals the Role of Mobile Loops in Product and Inhibitor Binding by the São Paulo Metallo-β-Lactamase

19 F-NMR Reveals the Role of Mobile Loops in Product and Inhibitor Binding by the São Paulo Metallo-β-Lactamase.

scientific article published on 2 March 2017

19 F NMR Monitoring of Reversible Protein Post-Translational Modifications: Class D β-Lactamase Carbamylation and Inhibition

scientific article published on 20 August 2019

19F NMR studies on γ-butyrobetaine hydroxylase provide mechanistic insights and suggest a dual inhibition mode

scientific article published on 01 December 2019

2-Oxoglutarate analogue inhibitors of prolyl hydroxylase domain 2.

scientific article published on 6 September 2009

2-Oxoglutarate derivatives can selectively enhance or inhibit the activity of human oxygenases

scientific article published on 10 November 2021

2-Oxoglutarate oxygenases are inhibited by a range of transition metals

scientific article published on 20 May 2010

2-Oxoglutarate regulates binding of hydroxylated hypoxia-inducible factor to prolyl hydroxylase domain 2.

scientific article published on 9 March 2018

2-Oxoglutarate-Dependent Oxygenases

scientific article published in March 2018

2-oxoglutarate analogue inhibitors of HIF prolyl hydroxylase

scientific article published in August 2003

3-Meth-oxy-3-oxopropanaminium chloride

scientific article published on 4 February 2012

4-Nitrobenzyl 5-oxo-2-(2-oxopiperidin-1-yl)tetrahydrofuran-2-carboxylate

5,5-Fused thiophene gamma-lactams as templates for serine protease inhibition

scientific article

5-Carboxy-8-hydroxyquinoline is a Broad Spectrum 2-Oxoglutarate Oxygenase Inhibitor which Causes Iron Translocation.

scientific article published on August 2013

8-Substituted Pyrido[3,4-d]pyrimidin-4(3H)-one Derivatives As Potent, Cell Permeable, KDM4 (JMJD2) and KDM5 (JARID1) Histone Lysine Demethylase Inhibitors

scientific article

A Fluorescence-Based Assay for Screening β-Lactams Targeting the Mycobacterium tuberculosis Transpeptidase LdtMt2

scientific article published on 08 November 2019

A Fluorescent Benzo[g]isoquinoline-based HIF Prolyl Hydroxylase Inhibitor for Cellular Imaging

scientific article published on 21 December 2018

A New Mechanism for β-Lactamases: Class D Enzymes Degrade 1β-Methyl Carbapenems through Lactone Formation

A New Mechanism for β-Lactamases: Class D Enzymes Degrade 1β-Methyl Carbapenems through Lactone Formation.

scientific article

A Noninvasive Comparison Study between Human Gliomas with IDH1 and IDH2 Mutations by MR Spectroscopy

A Noninvasive Comparison Study between Human Gliomas with IDH1 and IDH2 Mutations by MR Spectroscopy

scientific article published on 20 February 2019

A boronic-acid-based probe for fluorescence polarization assays with penicillin binding proteins and β-lactamases

scientific article published on 26 August 2011

A cell-permeable ester derivative of the JmjC histone demethylase inhibitor IOX1

scientific article published on 6 February 2014

A code for RanGDP binding in ankyrin repeats defines a nuclear import pathway

scientific article

A comparison of 2-hydroxyglutarate detection at 3 and 7 T with long-TE semi-LASER.

scientific article published on 5 January 2018

A fluorescence-based assay for 2-oxoglutarate-dependent oxygenases

scientific article published in January 2005

A miniaturized screen for inhibitors of Jumonji histone demethylases

scientific article

A mouse model for the metabolic effects of the human fat mass and obesity associated FTO gene

scientific article

A photoreactive small-molecule probe for 2-oxoglutarate oxygenases

scientific article

A prodrug system for hydroxylamines based on esterase catalysis

article

A selective jumonji H3K27 demethylase inhibitor modulates the proinflammatory macrophage response

scientific article

A small-molecule probe for monitoring binding to prolyl hydroxylase domain 2 by fluorescence polarisation

scientific article published on 28 October 2020

Active site mutations of recombinant deacetoxycephalosporin C synthase

scientific article published in March 2002

Activity-based probes trap early active intermediates during metacaspase activation

scientific article published in 2022

Adipocyte pseudohypoxia suppresses lipolysis and facilitates benign adipose tissue expansion.

scientific article

Adventures in Defining Roles of Oxygenases in the Regulation of Protein Biosynthesis

scientific article published on 27 August 2018

Allosteric inhibition of the SARS-CoV-2 main protease - insights from mass spectrometry-based assays

scientific article published on 25 August 2020

An audit of growth hormone replacement for GH-deficient adults in Scotland

scientific article published on April 2013

An essential role for dNTP homeostasis following CDK-induced replication stress

scientific article published on 25 March 2019

Anaerobic Crystallisation of an Isopenicillin N Synthase . Fe(II) . Substrate Complex Demonstrated by X-Ray Studies

scientific article published on 01 December 1996

Anaerobic fixed-target serial crystallography

scientific article published on 21 August 2020

Analogues of dealanylalahopcin are inhibitors of human HIF prolyl hydroxylases

scientific article published in April 2003

Analysis of JmjC Demethylase-Catalyzed Demethylation Using Geometrically-Constrained Lysine Analogues

scientific article published on 25 November 2015

Analysis of Jmjd6 cellular localization and testing for its involvement in histone demethylation

scientific article

Analysis of β-lactone formation by clinically observed carbapenemases informs on a novel antibiotic resistance mechanism

scientific article published on 22 September 2020

Anatomy of a simple acyl intermediate in enzyme catalysis: combined biophysical and modeling studies on ornithine acetyl transferase

scientific article

Anion-exchange chromatography mass spectrometry provides extensive coverage of primary metabolic pathways revealing altered metabolism in IDH1 mutant cells

scientific article published on 20 May 2020

Antennal sensilla of Rhodnius

scientific article published on 01 February 1994

Antibiotics as food for bacteria

scientific article published on 01 July 2018

Application of a proteolysis/mass spectrometry method for investigating the effects of inhibitors on hydroxylase structure.

scientific article

Arginine demethylation is catalysed by a subset of JmjC histone lysine demethylases

scientific article

Asparagine and aspartate hydroxylation of the cytoskeletal ankyrin family is catalyzed by factor-inhibiting hypoxia-inducible factor

scientific article

Asparagine beta-hydroxylation stabilizes the ankyrin repeat domain fold

scientific article

Asparaginyl beta-hydroxylation of proteins containing ankyrin repeat domains influences their stability and function.

scientific article published on 30 July 2009

Asparaginyl hydroxylation of the Notch ankyrin repeat domain by factor inhibiting hypoxia-inducible factor

scientific article

Aspartate/asparagine-β-hydroxylase crystal structures reveal an unexpected epidermal growth factor-like domain substrate disulfide pattern

scientific article published on 28 October 2019

Aspartate/asparagine-β-hydroxylase: a high-throughput mass spectrometric assay for discovery of small molecule inhibitors

scientific article published on 26 May 2020

Assay for drug discovery: Synthesis and testing of nitrocefin analogues for use as β-lactamase substrates.

scientific article published on 30 June 2015

Assay platform for clinically relevant metallo-β-lactamases ⬇️

scientific article published on 16 August 2013

Assessing histone demethylase inhibitors in cells: lessons learned.

scientific article

Author Correction: Aspartate/asparagine-β-hydroxylase: a high-throughput mass spectrometric assay for discovery of small molecule inhibitors

scientific article published on 21 December 2020

Author Correction: Hypoxia-inducible factor (HIF) prolyl hydroxylase inhibitors induce autophagy and have a protective effect in an in-vitro ischaemia model

scientific article published on 08 April 2020

Autocatalysed oxidative modifications to 2-oxoglutarate dependent oxygenases

scientific article published on 20 February 2012

Betti reaction enables efficient synthesis of 8-hydroxyquinoline inhibitors of 2-oxoglutarate oxygenases

scientific article published in 2015

Bicyclic Boronate VNRX-5133 Inhibits Metallo- and Serine-β-Lactamases

scientific article published on 16 September 2019

Bicyclic Boronates as Potent Inhibitors of AmpC, the Class C β-Lactamase from Escherichia coli

scientific article published on 12 June 2020

Binding of (5S)-penicilloic acid to penicillin binding protein 3

scientific article

Binding of D- and L-captopril inhibitors to metallo-beta-lactamase studied by polarizable molecular mechanics and quantum mechanics

scientific article

Biocatalytic production of bicyclic β-lactams with three contiguous chiral centres using engineered crotonases

scientific article published on 24 January 2019

Biochemical and biophysical analyses of hypoxia sensing prolyl hydroxylases from Dictyostelium discoideum and Toxoplasma gondii

scientific article published on 15 September 2020

Biochemical and structural investigations clarify the substrate selectivity of the 2-oxoglutarate oxygenase JMJD6

scientific article published on 30 May 2019

Biochemical characterization of New Delhi metallo-β-lactamase variants reveals differences in protein stability.

scientific article

Biosynthesis of carbapenem antibiotics: new carbapenam substrates for carbapenem synthase (CarC).

scientific article

Biosynthesis of histone messenger RNA employs a specific 3' end endonuclease

scientific article published on 03 December 2018

Biosynthetic precursors of valclavam

scientific article published on 25 July 2002

Bisthiazolidines: A Substrate-Mimicking Scaffold as an Inhibitor of the NDM-1 Carbapenemase

scientific article published on 20 July 2015

Born to sense: biophysical analyses of the oxygen sensing prolyl hydroxylase from the simplest animal

article published in 2018

Broad Spectrum β-Lactamase Inhibition by a Thioether Substituted Bicyclic Boronate

scientific article published on 06 January 2020

C-H Cyanation of 6-Ring N-Containing Heteroaromatics.

scientific article

CHAPTER 2. Introduction to Structural Studies on 2-Oxoglutarate-Dependent Oxygenases and Related Enzymes

CHAPTER 6. The Role of 2-Oxoglutarate-Dependent Oxygenases in Hypoxia Sensing

Can Second Coordination Sphere and Long-Range Interactions Modulate Hydrogen Atom Transfer in a Non-Heme Fe(II)-Dependent Histone Demethylase?

scientific article published in 2022

Carboxymethylproline synthase (CarB), an unusual carbon-carbon bond-forming enzyme of the crotonase superfamily involved in carbapenem biosynthesis

scientific article published on 18 November 2003

Carboxymethylproline synthase catalysed syntheses of functionalised N-heterocycles.

scientific article published on 12 January 2010

Carotid body hyperplasia and enhanced ventilatory responses to hypoxia in mice with heterozygous deficiency of PHD2.

scientific article published on 20 May 2013

Catalysis by the Non-Heme Iron(II) Histone Demethylase PHF8 Involves Iron Center Rearrangement and Conformational Modulation of Substrate Orientation

scientific article published on 11 December 2019

Cation-π Interactions Contribute to Substrate Recognition in γ-Butyrobetaine Hydroxylase Catalysis

scientific article

Cellular oxygen sensing: Crystal structure of hypoxia-inducible factor prolyl hydroxylase (PHD2)

scientific article

Cephalosporin C biosynthesis; stereochemistry of the incorporation ofD,L,D-α-aminodipoyl-cysteinyl-(3S)-[2-2H,4-13C]valine into β-lactam compounds

article

Cephalosporin biosynthesis: A branched pathway sensitive to an isotope effect

article

Cephalosporins inhibit human metallo β-lactamase fold DNA repair nucleases SNM1A and SNM1B/apollo.

scientific article published on 28 April 2016

Characterisation of the SARS-CoV-2 ExoN (nsp14ExoN-nsp10) complex: implications for its role in viral genome stability and inhibitor identification

Characterization of the SARS-CoV-2 ExoN (nsp14ExoN–nsp10) complex: implications for its role in viral genome stability and inhibitor identification

scientific article

Characterization of the human SNM1A and SNM1B/Apollo DNA repair exonucleases

scientific article

ChemInform Abstract: Fluoromethylated Derivatives of Carnitine biosynthesis Intermediates - Synthesis and Applications

Chemical basis for the selectivity of the von Hippel Lindau tumor suppressor pVHL for prolyl-hydroxylated HIF-1alpha

scientific article published on August 2010

Chemistry and biosynthesis of clavulanic acid and other clavams

scientific article (publication date: August 1997)

Chromophore-linked substrate (CLS405): probing metallo-β-lactamase activity and inhibition.

scientific article

Chromosome homogeneity in populations of Triatoma brasiliensis Neiva 1911 (Hemiptera - reduviidae - triatominae).

scientific article published in January 2000

Clavulanic acid dehydrogenase: structural and biochemical analysis of the final step in the biosynthesis of the beta-lactamase inhibitor clavulanic acid

scientific article

Combined mass spectrometry and dynamic chemistry approach to identify metalloenzyme inhibitors

scientific article

Comments on the use of a dichromophoric circular dichroism assay for the identification of beta-turns in peptides

scientific article published on 01 February 1994

Comparison of Verona Integron-Borne Metallo-β-Lactamase (VIM) Variants Reveals Differences in Stability and Inhibition Profiles

scientific article

Comparison of the substrate selectivity and biochemical properties of human and bacterial γ-butyrobetaine hydroxylase

article

Competitive Inhibitors of the CphA Metallo- -Lactamase from Aeromonas hydrophila

scientific article

Complement C1q is hydroxylated by collagen prolyl 4 hydroxylase and is sensitive to off-target inhibition by prolyl hydroxylase domain inhibitors that stabilize hypoxia-inducible factor

scientific article published on 12 May 2017

Conformational Dynamics Underlies Different Functions of Human KDM7 Histone Demethylases

scientific article published on 26 March 2019

Conformational flexibility influences structure-function relationships in nucleic acid N-methyl demethylases

scientific article published on 01 February 2019

Contributions of cardiac "funny" (f) channels and sarcoplasmic reticulum Ca2+ in regulating beating rate of mouse and guinea pig sinoatrial node

scientific article published on December 2015

Controlling the substrate selectivity of deacetoxycephalosporin/deacetylcephalosporin C synthase

scientific article (publication date: 9 April 2004)

Conversion of Cysteine into Dehydroalanine Enables Access to Synthetic Histones Bearing Diverse Post-Translational Modifications

scientific article published on 13 January 2012

Correction to "Structure-Based in Silico Screening Identifies a Potent Ebolavirus Inhibitor from a Traditional Chinese Medicine Library"

scientific article published on 28 October 2019

Cover Picture: Monitoring Conformational Changes in the NDM-1 Metallo-β-lactamase by19F NMR Spectroscopy (Angew. Chem. Int. Ed. 12/2014)

Crotonase Catalysis Enables Flexible Production of Functionalized Prolines and Carbapenams

article

Crotonases: Nature’s Exceedingly Convertible Catalysts

Crystal Structure of the 2-Oxoglutarate- and Fe(II)-Dependent Lysyl Hydroxylase JMJD6

scientific article

Crystal structure and mechanistic implications of 1-aminocyclopropane-1-carboxylic acid oxidase--the ethylene-forming enzyme.

scientific article

Crystal structure and mechanistic implications of N2-(2-carboxyethyl)arginine synthase, the first enzyme in the clavulanic acid biosynthesis pathway

scientific article

Crystal structure of PHYHD1A, a 2OG oxygenase related to phytanoyl-CoA hydroxylase

scientific article published on 21 April 2011

Crystal structure of a clavaminate synthase-Fe(II)-2-oxoglutarate-substrate-NO complex: evidence for metal centered rearrangements

scientific article

Crystal structure of carbapenem synthase (CarC)

scientific article (publication date: 6 June 2003)

Crystal structure of human persulfide dioxygenase: structural basis of ethylmalonic encephalopathy.

scientific article

Crystal structure of the PHF8 Jumonji domain, an Nepsilon-methyl lysine demethylase

scientific article

Crystal structures of VIM-1 complexes explain active site heterogeneity in VIM-class metallo-β-lactamases

scientific article published on 23 November 2018

Crystal structures of an oligopeptide-binding protein from the biosynthetic pathway of the beta-lactamase inhibitor clavulanic acid

scientific article

Crystal structures of histone demethylase JMJD2A reveal basis for substrate specificity

scientific article

Crystallization and Preliminary X-ray Diffraction Studies on a Recombinant Isopenicillin N Synthase from Cephalosporium acremonium

scientific article published on 01 October 1994

Crystallization and preliminary X-ray diffraction studies on recombinant isopenicillin N synthase from Aspergillus nidulans

scientific article published on May 1995

Crystallographic analyses of isoquinoline complexes reveal a new mode of metallo-β-lactamase inhibition.

scientific article published in May 2017

Crystallographic and mass spectrometric analyses of a tandem GNAT protein from the clavulanic acid biosynthesis pathway

scientific article

Cyclic Boronates Inhibit All Classes of β-Lactamases ⬇️

scientific article published on 23 January 2017

Cyclic boronates as versatile scaffolds for KPC-2 β-lactamase inhibition

scientific article published on 10 January 2020

Cyclobutanone Mimics of Intermediates in Metallo-β-Lactamase Catalysis

scientific article published on 17 December 2017

DNA aptamers for as analytical tools for the quantitative analysis of DNA-dealkylating enzymes

scientific article

DNA modification under mild conditions by Suzuki-Miyaura cross-coupling for the generation of functional probes

scientific article

Deciphering Functions of Intracellular Formaldehyde: Linking Cancer and Aldehyde Metabolism

scientific article

Delta-L-(alpha-aminoadipoyl)-L-cysteinyl-D-valine synthetase: isolation of L-cysteinyl-D-valine, a 'shunt' product, and implications for the order of peptide bond formation

scientific article

Design and synthesis of potent and selective inhibitors of BRD7 and BRD9 bromodomains

scientific article published in 2015

Development and application of a fluoride-detection-based fluorescence assay for γ-butyrobetaine hydroxylase

scientific article

Development of homogeneous luminescence assays for histone demethylase catalysis and binding.

scientific article

Differential sensitivity of hypoxia inducible factor hydroxylation sites to hypoxia and hydroxylase inhibitors

scientific article

Direct analysis of enzyme-catalyzed DNA demethylation

scientific article

Direct sulfonylation of anilines mediated by visible light.

scientific article published on 16 November 2017

Discovery and optimization of small-molecule ligands for the CBP/p300 bromodomains

scientific article (publication date: 2 July 2014)

Discovery of ML324, a JMJD2 demethylase inhibitor with demonstrated antiviral activity

Disruption of dimerization and substrate phosphorylation inhibit factor inhibiting hypoxia-inducible factor (FIH) activity

scientific journal article

Dual-action inhibitors of HIF prolyl hydroxylases that induce binding of a second iron ion.

scientific article

Dynamic combinatorial chemistry employing boronic acids/boronate esters leads to potent oxygenase inhibitors.

scientific article

Dynamic combinatorial mass spectrometry leads to inhibitors of a 2-oxoglutarate-dependent nucleic acid demethylase

scientific article

Dynamic combinatorial mass spectrometry leads to metallo-beta-lactamase inhibitors

scientific article

Dynamic states of the DNA repair enzyme AlkB regulate product release

scientific article published on 11 July 2008

ESI-MS studies on prolyl hydroxylase domain 2 reveal a new metal binding site

scientific article published in April 2008

Ejection of structural zinc leads to inhibition of γ-butyrobetaine hydroxylase

scientific article published on 19 September 2014

Elimination of Rhodnius prolixus in Central America ⬇️

scientific article published on February 22, 2012

Emulsion PCR significantly improves nonequilibrium capillary electrophoresis of equilibrium mixtures-based aptamer selection: allowing for efficient and rapid selection of aptamer to unmodified ABH2 protein

scientific article published on 29 December 2014

Enzymatic synthesis of monocyclic beta-lactams

scientific article published in February 2002

Enzymes of valclavam biosynthesis

scientific article published on 25 July 2002

Epidithiodiketopiperazines block the interaction between hypoxia-inducible factor-1alpha (HIF-1alpha) and p300 by a zinc ejection mechanism

scientific article published on 09 July 2009

Epimerization and desaturation by carbapenem synthase (CarC). A hybrid DFT study

scientific article published in April 2006

Ethylene biosynthesis by 1-aminocyclopropane-1-carboxylic acid oxidase: a DFT study

scientific article published in November 2006

Evaluation of aspirin metabolites as inhibitors of hypoxia-inducible factor hydroxylases

scientific article

Evidence That Two Enzyme-derived Histidine Ligands Are Sufficient for Iron Binding and Catalysis by Factor Inhibiting HIF (FIH)

scientific article

Evidence for a stereoelectronic effect in human oxygen sensing.

scientific article

Evidence for oxidation at C-3 of the flavonoid C-ring during anthocyanin biosynthesis

scientific article published in September 2001

Evidence for the slow reaction of hypoxia-inducible factor prolyl hydroxylase 2 with oxygen

scientific article

Evidence that thienamycin biosynthesis proceeds via C-5 epimerization: ThnE catalyzes the formation of (2S,5S)-trans-carboxymethylproline.

scientific article published in January 2009

Exchange of the valine 2-H in the biosynthesis of L-δ-(α-aminoadipoyl)-L-Cysteinyl-D-valine

article

Exchange of valine-oxygen during the biosynthesis of δ-(L-α-aminoadipoyl)-L-cysteinyl-D-valine

Expanding chemical biology of 2-oxoglutarate oxygenases

scientific article

Expanding the yeast protein arginine methylome

scientific article published on 5 June 2015

Expansion of base excision repair compensates for a lack of DNA repair by oxidative dealkylation in budding yeast

scientific article published on 18 July 2019

Expression in Escherichia coli of a clavaminic acid synthase isozyme: A trifunctional oxygenase involved in clavulanic acid biosynthesis

scientific article published in 1994

Expression of Idh1(R132H) in the Murine Subventricular Zone Stem Cell Niche Recapitulates Features of Early Gliomagenesis

scientific article published on 21 September 2016

Expression, purification and characterization of 1-aminocyclopropane-1-carboxylate oxidase from tomato in Escherichia coli

scientific article

Factor inhibiting hypoxia-inducible factor (FIH) and other asparaginyl hydroxylases

scientific article published in December 2004

Factor-inhibiting hypoxia-inducible factor (FIH) catalyses the post-translational hydroxylation of histidinyl residues within ankyrin repeat domains

scientific article

Fast and forceful refolding of stretched alpha-helical solenoid proteins

scientific article

Fluorinated derivatives of pyridine-2,4-dicarboxylate are potent inhibitors of human 2-oxoglutarate dependent oxygenases

scientific article published on 01 July 2021

Fluoromethylated derivatives of carnitine biosynthesis intermediates--synthesis and applications.

scientific article published on February 2014

Formaldehyde quantification using ampicillin is not selective

scientific article published on 04 December 2019

Frontispiece: Cation-π Interactions Contribute to Substrate Recognition in γ-Butyrobetaine Hydroxylase Catalysis

Generation of a synthetic GlcNAcylated nucleosome reveals regulation of stability by H2A-Thr101 GlcNAcylation

scientific article

Generation, validation and humanisation of a novel insulin resistant cell model.

scientific article published on 23 June 2010

Glucose Metabolism and Oxygen Availability Govern Reactivation of the Latent Human Retrovirus HTLV-1.

scientific article published on 6 September 2017

Glyco- and peptidomimetics from three-component Joullié-Ugi coupling show selective antiviral activity

scientific article

HIF hydroxylase inhibitors decrease cellular oxygen consumption depending on their selectivity

scientific article published on 19 December 2019

HIF prolyl hydroxylase inhibition prior to transient focal cerebral ischaemia is neuroprotective in mice

scientific article

High level expression in Escherichia coli of a fungal gene under the control of strong promoters.

scientific article

High level expression in<i>Escherichia coli</i>of a fungal gene under the control of strong promoters

scientific article published in 1990

Highly selective inhibition of histone demethylases by de novo macrocyclic peptides

scientific article published on 06 April 2017

Histone H2A monoubiquitylation and p38-MAPKs regulate immediate-early gene-like reactivation of latent retrovirus HTLV-1

article

Hitting the Jackpot - development of gas chromatography-mass spectrometry (GC-MS) and other rapid screening methods for the analysis of 18 fentanyl-derived synthetic opioids

scientific article published on 28 January 2020

Human AlkB homologue 5 is a nuclear 2-oxoglutarate dependent oxygenase and a direct target of hypoxia-inducible factor 1α (HIF-1α)

scientific article

Human SNM1A and XPF-ERCC1 collaborate to initiate DNA interstrand cross-link repair

scientific article published on September 2011

Human SNM1A suppresses the DNA repair defects of yeast pso2 mutants

scientific article published on 19 November 2007

Human UTY(KDM6C) Is a Male-specific N -Methyl Lysyl Demethylase

scientific article

Human carnitine biosynthesis proceeds via (2S,3S)-3-hydroxy-Nε-trimethyllysine.

scientific article published on 14 December 2016

Human histone demethylase KDM6B can catalyse sequential oxidations

scientific article published on 01 July 2018

Human oxygen sensing may have origins in prokaryotic elongation factor Tu prolyl-hydroxylation

scientific article

Hydroxamate Inhibitors ofAeromonas hydrophilaAE036 Metallo-B-lactamase

Hydroxylation of methylated CpG dinucleotides reverses stabilisation of DNA duplexes by cytosine 5-methylation

scientific article published on 31 March 2011

Hydroxylation of the eukaryotic ribosomal decoding center affects translational accuracy

scientific article

Hypocalcaemia following thyroidectomy unresponsive to oral therapy.

scientific article published on April 2014

Hypoxia and hypoxia mimetics differentially modulate histone post-translational modifications

scientific article published on 01 July 2020

Hypoxia-dependent sequestration of an oxygen sensor by a widespread structural motif can shape the hypoxic response--a predictive kinetic model

scientific article

Hypoxia-inducible factor (HIF) asparagine hydroxylase is identical to factor inhibiting HIF (FIH) and is related to the cupin structural family

scientific journal article

Hypoxia-inducible factor (HIF) prolyl hydroxylase inhibitors induce autophagy and have a protective effect in an in-vitro ischaemia model

scientific article published on 31 January 2020

Hypoxia-inducible factor asparaginyl hydroxylase (FIH-1) catalyses hydroxylation at the beta-carbon of asparagine-803

scientific article

Hypoxia-inducible factor prolyl hydroxylase 2 has a high affinity for ferrous iron and 2-oxoglutarate

scientific article

Hypoxia-inducible factor prolyl-hydroxylase: purification and assays of PHD2.

scientific article published in January 2007

Identification of a pathogenic FTO mutation by next-generation sequencing in a newborn with growth retardation and developmental delay

scientific article published on 16 September 2015

Identification of the KDM2/7 histone lysine demethylase subfamily inhibitor and its antiproliferative activity

scientific article

Identification of valid housekeeping genes for quantitative RT-PCR analysis of cardiosphere-derived cells preconditioned under hypoxia or with prolyl-4-hydroxylase inhibitors

scientific article

Identifying Small-Molecule Binding Sites for Epigenetic Proteins at Domain-Domain Interfaces.

scientific article published on 26 March 2018

Improved Synthesis of Phosphoramidite-Protected <i>N</i><sup>6</sup>-Methyladenosine via BOP-Mediated S<sub>N</sub>Ar Reaction

scientific article published on 31 December 2020

Improved localisation for 2-hydroxyglutarate detection at 3T using long-TE semi-LASER

scientific article

Improved synthesis of 5-hydroxymethyl-2′-deoxycytidine phosphoramidite using a 2′-deoxyuridine to 2′-deoxycytidine conversion without temporary protecting groups

scientific article published on 24 December 2010

In Silico Fragment-Based Design Identifies Subfamily B1 Metallo-β-lactamase Inhibitors ⬇️

scientific article published on 22 December 2017

In Vitro Enzyme Assays for JmjC-Domain-Containing Lysine Histone Demethylases (JmjC-KDMs)

scientific article published on 01 March 2018

Inactivation of 1-Aminocyclopropane-1-carboxylate Oxidase Involves Oxidative Modifications†

article

Incorporation of oxygen into the succinate co-product of iron(II) and 2-oxoglutarate dependent oxygenases from bacteria, plants and humans

scientific article published in September 2005

Independent Observational Analysis of Ulcer Outcomes for SINBAD and University of Texas Ulcer Scoring Systems

scientific article published on 07 December 2020

Inhibition of 2-oxoglutarate dependent oxygenases ⬇️

scientific article published on March 10, 2011

Inhibition of Histone Demethylases by 4-Carboxy-2,2′-Bipyridyl Compounds

scientific article

Inhibition of TEM-2 beta-lactamase from Escherichia coli by clavulanic acid: observation of intermediates by electrospray ionization mass spectrometry.

scientific article

Inhibition of a viral prolyl hydroxylase

scientific article published on 23 January 2019

Inhibition of the HIF1α-p300 interaction by quinone- and indandione-mediated ejection of structural Zn(II).

scientific article

Inhibition of the histone demethylase JMJD2E by 3-substituted pyridine 2,4-dicarboxylates

scientific article published on 15 November 2010

Inhibition of the histone lysine demethylase JMJD2A by ejection of structural Zn(II).

scientific article published on 28 September 2009

Inhibitor scaffolds for 2-oxoglutarate-dependent histone lysine demethylases

scientific article

Inhibitors of both the N-methyl lysyl- and arginyl-demethylase activities of the JmjC oxygenases

scientific article published in June 2018

Inhibitors of the FEZ-1 metallo-β-lactamase

scientific article published on 18 November 2006

Insights into the Mechanistic Basis of Plasmid-Mediated Colistin Resistance from Crystal Structures of the Catalytic Domain of MCR-1

scientific article published on 06 January 2017

Interaction of Avibactam with Class B Metallo-β-Lactamases

scientific article

Investigating d-lysine stereochemistry for epigenetic methylation, demethylation and recognition.

scientific article published on 29 November 2017

Investigating the contribution of the active site environment to the slow reaction of hypoxia-inducible factor prolyl hydroxylase domain 2 with oxygen

scientific article

Investigating the dependence of the hypoxia-inducible factor hydroxylases (factor inhibiting HIF and prolyl hydroxylase domain 2) on ascorbate and other reducing agents

scientific article

Investigations on recyclisation and hydrolysis in avibactam mediated serine β-lactamase inhibition

scientific article (publication date: 26 April 2016)

Investigations on small molecule inhibitors targeting the histone H3K4 tri-methyllysine binding PHD-finger of JmjC histone demethylases

scientific article published on 19 March 2018

Investigations on the oxygen dependence of a 2-oxoglutarate histone demethylase.

scientific article published in January 2013

Iron-mediated cleavage of C-C bonds in vicinal tricarbonyl compounds in water

scientific article published in January 2009

Is JmjC oxygenase catalysis limited to demethylation?

scientific article published on 20 June 2013

Isocitrate dehydrogenase variants in cancer - Cellular consequences and therapeutic opportunities

scientific article published on 07 August 2020

JMJD5 is a human arginyl C-3 hydroxylase.

scientific article

JMJD6 Is a Druggable Oxygenase That Regulates AR-V7 Expression in Prostate Cancer

scientific article published on 01 February 2021

JMJD6 promotes self-renewal and regenerative capacity of hematopoietic stem cells

scientific article published on 01 February 2021

Jmjd6 catalyses lysyl-hydroxylation of U2AF65, a protein associated with RNA splicing

scientific article

Jumonji domain containing protein 6 (Jmjd6) modulates splicing and specifically interacts with arginine-serine-rich (RS) domains of SR- and SR-like proteins

scientific article published on 9 June 2014

KDM3A coordinates actin dynamics with intraflagellar transport to regulate cilia stability

scientific article published on 28 February 2017

Kinetic Investigations of the Role of Factor Inhibiting Hypoxia-inducible Factor (FIH) as an Oxygen Sensor.

scientific article published on 25 June 2015

Kinetic and Structural Characterization of the First B3 Metallo-β-Lactamase with an Active-Site Glutamic Acid

scientific article published on 26 July 2021

Kinetic and crystallographic studies on deacetoxycephalosporin C synthase (DAOCS)

scientific article

Kinetic parameters of human aspartate/asparagine-β-hydroxylase suggest that it has a possible function in oxygen sensing

scientific article published on 26 February 2020

Kinetic rationale for selectivity toward N- and C-terminal oxygen-dependent degradation domain substrates mediated by a loop region of hypoxia-inducible factor prolyl hydroxylases

scientific article

Kinetics and Mechanisms of Hydrolysis and Aminolysis of Thioxocephalosporins

Kinetics and mechanisms of hydrolysis and aminolysis of thioxocephalosporins

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Kruidenier et al. reply

scientific article published in Nature

Lack of activity of recombinant HIF prolyl hydroxylases (PHDs) on reported non-HIF substrates

scientific article published on 10 September 2019

Linking of 2-Oxoglutarate and Substrate Binding Sites Enables Potent and Highly Selective Inhibition of JmjC Histone Demethylases

Linking of 2-oxoglutarate and substrate binding sites enables potent and highly selective inhibition of JmjC histone demethylases

scientific article

Lysine-241 has a role in coupling 2OG turnover with substrate oxidation during KDM4-catalysed histone demethylation

scientific article published on 14 February 2018

Macular oedema is not predicted by perifoveal single blot haemorrhages

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Mass spectrometric studies on the inhibition of TEM-2 beta-lactamase by clavulanic acid derivatives

scientific article published on 01 February 1997

Mass spectrometry reveals potential of β-lactams as SARS-CoV-2 M inhibitors

scientific article

MeLAD: an integrated resource for metalloenzyme-ligand associations

scientific article published on 01 February 2020

Mechanical anisotropy of ankyrin repeats

scientific article published on 6 March 2012

Mechanism for cyclization reaction by clavaminic acid synthase. Insights from modeling studies

scientific article published on 27 February 2007

Mechanism of Molecular Oxygen Diffusion in a Hypoxia-Sensing Prolyl Hydroxylase Using Multiscale Simulation

scientific article published on 23 January 2020

Mechanisms and structures of crotonase superfamily enzymes--how nature controls enolate and oxyanion reactivity

scientific article published on August 2008

Mechanisms of human histone and nucleic acid demethylases

scientific article published on 10 October 2012

Mechanistic Insights into β-Lactamase-Catalysed Carbapenem Degradation Through Product Characterisation

scientific article published on 20 September 2019

Mechanistic and structural studies of KDM-catalysed demethylation of histone 1 isotype 4 at lysine 26

scientific article published on 14 September 2018

Mechanistic insights into the inhibition of serine proteases by monocyclic lactams

scientific article

Mechanistic studies on the application of DNA aptamers as inhibitors of 2-oxoglutarate-dependent oxygenases

scientific article

Mechanistic studies on three 2-oxoglutarate-dependent oxygenases of flavonoid biosynthesis: anthocyanidin synthase, flavonol synthase, and flavanone 3beta-hydroxylase

scientific article (publication date: 9 January 2004)

Metabolic adaptation to chronic hypoxia in cardiac mitochondria.

scientific article

Metal-catalyzed oxidation and mutagenesis studies on the iron(II) binding site of 1-aminocyclopropane-1-carboxylate oxidase

scientific article published in December 1997

Metampicillin is a cyclic aminal produced by reaction of ampicillin with formaldehyde

scientific article published on 21 October 2020

Methods for converting cysteine to dehydroalanine on peptides and proteins

Methyl 6-amino-6-oxohexa-noate

scientific article published on 4 February 2012

Microbiome-derived carnitine mimics as previously unknown mediators of gut-brain axis communication

scientific article published on 11 March 2020

Modulating carnitine levels by targeting its biosynthesis pathway - selective inhibition of γ-butyrobetaine hydroxylase

scientific article published on May 2014

Modulating the hypoxia-inducible factor signaling pathway: applications from cardiovascular disease to cancer

scientific article published on January 2004

Molecular Basis of Class A β-Lactamase Inhibition by Relebactam

scientific article published on 23 September 2019

Molecular and cellular mechanisms of HIF prolyl hydroxylase inhibitors in clinical trials

scientific article published on 11 September 2017

Molecular dynamics simulations of the acyl-enzyme and the tetrahedral intermediate in the deacylation step of serine proteases

scientific article

Molecular mechanism of the multifunctional enzyme L-delta-(alpha-aminoadipoyl)-L-cysteinyl-D-valine (ACV) synthetase

scientific article published on 01 November 1995

Molecular weight analysis of isopenicillin N synthase by electrospray mass spectrometry

scientific article

Monitoring Conformational Changes in the NDM-1 Metallo-β-lactamase by19F NMR Spectroscopy

Monitoring conformational changes in the NDM-1 metallo-β-lactamase by 19F NMR spectroscopy

scientific article published on 24 February 2014

Monitoring the activity of 2-oxoglutarate dependent histone demethylases by NMR spectroscopy: direct observation of formaldehyde

scientific article published in March 2010

Mortality and hospitalization in patients after amputation: a comparison between patients with and without diabetes

scientific article published on October 2006

Mutagenesis studies on the iron binding ligands of clavaminic acid synthase

scientific article published on December 2000

Mutation analysis of HIF prolyl hydroxylases (PHD/EGLN) in individuals with features of phaeochromocytoma and renal cell carcinoma susceptibility

scientific article

Mutations to metabolic enzymes in cancer herald a need to unify genetics and biochemistry ⬇️

scientific article published on September 1, 2011

NMR analyses on N-hydroxymethylated nucleobases - implications for formaldehyde toxicity and nucleic acid demethylases.

scientific article published in May 2018

NMR-filtered virtual screening leads to non-metal chelating metallo-β-lactamase inhibitors

scientific article published on 14 December 2016

Natural variants modify Klebsiella pneumoniae carbapenemase (KPC) acyl-enzyme conformational dynamics to extend antibiotic resistance

scientific article published on 30 November 2020

New Delhi Metallo-β-Lactamase 1 Catalyzes Avibactam and Aztreonam Hydrolysis.

scientific article published on 2 October 2017

New Structural Insights into the Inhibition of Serine Proteases by Cyclic Peptides from Bacteria ⬇️

scientific article published on October 1, 2003

New developments for prevention of type 1 diabetes: a paradigm shift?

scientific article published on 01 January 2019

Non-Hydrolytic β-Lactam Antibiotic Fragmentation by l,d-Transpeptidases and Serine β-Lactamase Cysteine Variants

scientific article published on 21 January 2019

Non-competitive cyclic peptides for targeting enzyme-substrate complexes.

scientific article published on 23 April 2018

Non-enzymatic chemistry enables 2-hydroxyglutarate-mediated activation of 2-oxoglutarate oxygenases.

scientific article

Noninvasive Quantification of 2-Hydroxyglutarate in Human Gliomas with IDH1 and IDH2 Mutations.

scientific article

Normal tissue radioprotection by amifostine via Warburg-type effects

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Nuclear entry and export of FIH are mediated by HIF1α and exportin1 respectively

scientific article published on 19 November 2018

OGFOD1 catalyzes prolyl hydroxylation of RPS23 and is involved in translation control and stress granule formation

scientific article

ORF17 from the clavulanic acid biosynthesis gene cluster catalyzes the ATP-dependent formation of N-glycyl-clavaminic acid

scientific article

ORF6 from the clavulanic acid gene cluster of Streptomyces clavuligerus has ornithine acetyltransferase activity

scientific article published in April 2002

OS-9

OS-9: another piece in the HIF complex story

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Observations on the Deprotection of Pinanediol and Pinacol Boronate Esters via Fluorinated Intermediates

scientific article published on 01 January 2010

Oligomeric structure of proclavaminic acid amidino hydrolase: evolution of a hydrolytic enzyme in clavulanic acid biosynthesis

scientific article

On the histone lysine methyltransferase activity of fungal metabolite chaetocin.

scientific article published on 25 October 2013

On the pivotal role of PPARα in adaptation of the heart to hypoxia and why fat in the diet increases hypoxic injury.

scientific article published on 21 April 2016

Open science discovery of potent noncovalent SARS-CoV-2 main protease inhibitors

scientific article published on 10 November 2023

Optimal translational termination requires C4 lysyl hydroxylation of eRF1.

scientific article published on 30 January 2014

Optimisation of a triazolopyridine based histone demethylase inhibitor yields a potent and selective KDM2A (FBXL11) inhibitor

scientific article published in December 2014

Oxidation by 2-oxoglutarate oxygenases: non-haem iron systems in catalysis and signalling.

scientific article

Oxidation of deacetylcephalosporin C by deacetoxycephalosporin C/deacetylcephalosporin C synthase

scientific article published on 01 August 1992

Oxidative degradation of bilirubin produces vasoactive compounds

scientific article published on 01 December 2000

Oxygenase catalyzed 5-methylcytosine hydroxylation

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Oxygenase-Catalyzed Desymmetrization ofN,N-Dialkyl-piperidine-4-carboxylic Acids

scientific article (publication date: 6 October 2014)

Oxygenase-Catalyzed Desymmetrization ofN,N-Dialkyl-piperidine-4-carboxylic Acids

Oxygenase-catalyzed ribosome hydroxylation occurs in prokaryotes and humans

scientific article

Oxygenases for oxygen sensing

PHF8, a gene associated with cleft lip/palate and mental retardation, encodes for an Nepsilon-dimethyl lysine demethylase

scientific article

PTP1B controls non-mitochondrial oxygen consumption by regulating RNF213 to promote tumour survival during hypoxia

scientific article published on 20 June 2016

Pan-histone demethylase inhibitors simultaneously targeting Jumonji C and lysine-specific demethylases display high anticancer activities.

scientific article

Penicillin biosynthesis: active substrates derived by methoxy substitution in the valinyl residue of the natural substrate

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Pharmacological inhibition of FTO.

scientific article published on April 2015

Pharmacological targeting of the HIF hydroxylases--A new field in medicine development

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Photoactivable peptides for identifying enzyme–substrate and protein–protein interactions

scientific article published on 13 December 2010

Phylogenetics and sequence analysis--some problems for the unwary

scientific article published on December 2003

Phylogeography and genetic variation of Triatoma dimidiata, the main Chagas disease vector in Central America, and its position within the genus Triatoma

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Physiological and biochemical aspects of hydroxylations and demethylations catalyzed by human 2-oxoglutarate oxygenases ⬇️

scientific article published on August 20, 2010

Plant Growth Regulator Daminozide Is a Selective Inhibitor of Human KDM2/7 Histone Demethylases

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Posttranslational hydroxylation of ankyrin repeats in IkappaB proteins by the hypoxia-inducible factor (HIF) asparaginyl hydroxylase, factor inhibiting HIF (FIH)

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Potent and Selective KDM5 Inhibitor Stops Cellular Demethylation of H3K4me3 at Transcription Start Sites and Proliferation of MM1S Myeloma Cells

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Potent and Selective Triazole-Based Inhibitors of the Hypoxia-Inducible Factor Prolyl-Hydroxylases with Activity in the Murine Brain

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Preclinical Evaluation of Discorhabdins in Antiangiogenic and Antitumor Models

scientific article published on 19 July 2018

Preconditioning of Cardiosphere-Derived Cells With Hypoxia or Prolyl-4-Hydroxylase Inhibitors Increases Stemness and Decreases Reliance on Oxidative Metabolism

scientific article published on 6 March 2015

Probing the penicillin sidechain selectivity of recombinant deacetoxycephalosporin C synthase

scientific article published in May 2001

Profiling interactions of vaborbactam with metallo-β-lactamases

scientific article published on 17 May 2019

Progress in the development and application of small molecule inhibitors of bromodomain-acetyl-lysine interactions

scientific article published on 27 September 2012

Proline 4-hydroxylase: Stereochemical course of the reaction

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Proline-hydroxylated hypoxia-inducible factor 1α (HIF-1α) upregulation in human tumours

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Prolyl hydroxylase 2 inactivation enhances glycogen storage and promotes excessive neutrophilic responses

scientific article published on 14 August 2017

Protein Hydroxylation Catalyzed by 2-Oxoglutarate-dependent Oxygenases

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Proteins of the penicillin biosynthesis pathway

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Pseudomonas expression of an oxygen sensing prolyl hydroxylase homologue regulates neutrophil host responses in vitro and in vivo.

scientific article published on 26 October 2017

Publisher Correction: JMJD5 is a human arginyl C-3 hydroxylase.

scientific article published on 23 April 2018

Publisher Correction: The Jumonji-C oxygenase JMJD7 catalyzes (3S)-lysyl hydroxylation of TRAFAC GTPases

scientific article published on 01 October 2018

Purification and initial characterization of an enzyme with deacetoxycephalosporin C synthetase and hydroxylase activities

scientific article published on August 1987

Purification and initial characterization of proline 4-hydroxylase from Streptomyces griseoviridus P8648: a 2-oxoacid, ferrous-dependent dioxygenase involved in etamycin biosynthesis ⬇️

scientific article published on January 1996

Purified recombinant hARD1 does not catalyse acetylation of Lys532 of HIF-1alpha fragments in vitro

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Quantifying the Binding Interaction between the Hypoxia-Inducible Transcription Factor and the von Hippel-Lindau Suppressor.

scientific article

Quantitative High-Throughput Screening Identifies 8-Hydroxyquinolines as Cell-Active Histone Demethylase Inhibitors

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Quantitative MS-Based Proteomics: Comparing the MCF-7 Cellular Response to Hypoxia and a 2-Oxoglutarate Analogue

scientific article published on 10 January 2020

Rapid Identification of Novel Psychoactive and Other Controlled Substances Using Low-Field 1H NMR Spectroscopy.

scientific article published on 19 April 2019

Rationally engineered flavin-dependent oxidase reveals steric control of dioxygen reduction

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Recent Progress in Histone Demethylase Inhibitors

scientific article published on 28 December 2015

Recommended Guidelines for Developing, Qualifying, and Implementing Complex In Vitro Models (CIVMs) for Drug Discovery

scientific article published on 04 June 2020

Reducing agent mediated non-enzymatic conversion of  2-oxoglutarate to succinate - implications for oxygenase assays

scientific article published on 01 June 2020

Refsum's disease: a peroxisomal disorder affecting phytanic acid alpha-oxidation

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Regulation of Jumonji-domain-containing histone demethylases by hypoxia-inducible factor (HIF)-1alpha

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Reporter ligand NMR screening method for 2-oxoglutarate oxygenase inhibitors

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Research needs for Chagas disease prevention

scientific article published on 19 March 2010

Rh(iii)-Catalyzed directed C–H carbenoid coupling reveals aromatic bisphosphonates inhibiting metallo- and Serine-β-lactamases

Rhodanine hydrolysis leads to potent thioenolate mediated metallo-β-lactamase inhibition

scientific article

Ribosomal oxygenases are structurally conserved from prokaryotes to humans

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Role of Structural Dynamics in Selectivity and Mechanism of Non-heme Fe(II) and 2-Oxoglutarate-Dependent Oxygenases Involved in DNA Repair

scientific article published on 08 May 2020

Role of phytanoyl-CoA 2-hydroxylase in phytanic acid metabolism.

scientific article

Role of the jelly-roll fold in substrate binding by 2-oxoglutarate oxygenases

scientific article

Roles of 2-oxoglutarate oxygenases and isopenicillin N synthase in β-lactam biosynthesis

scientific article published on 01 August 2018

Scottish foot ulcer risk score predicts foot ulcer healing in a regional specialist foot clinic.

scientific article published on 22 May 2007

Section 5(2) Mental Health Act 1983: does teaching make a difference?

scientific article published in July 2006

Selective Inhibitors of a Human Prolyl Hydroxylase (OGFOD1) Involved in Ribosomal Decoding

scientific article published on 08 January 2019

Selective Inhibitors of the JMJD2 Histone Demethylases: Combined Nondenaturing Mass Spectrometric Screening and Crystallographic Approaches

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Selective inhibition of factor inhibiting hypoxia-inducible factor

scientific article published in June 2005

Selective small molecule probes for the hypoxia inducible factor (HIF) prolyl hydroxylases

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Self-hydroxylation of the splicing factor lysyl hydroxylase, JMJD6

Sideromimic Modification of Lactivicin Dramatically Increases Potency against Extensively Drug-Resistant Stenotrophomonas maltophilia Clinical Isolates

scientific article published on 2 May 2016

Signalling hypoxia by HIF hydroxylases

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Small-molecule active pharmaceutical ingredients of approved cancer therapeutics inhibit human aspartate/asparagine-β-hydroxylase

scientific article published on 06 August 2020

Small-molecule-based inhibition of histone demethylation in cells assessed by quantitative mass spectrometry

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Small-molecules that covalently react with a human prolyl hydroxylase – towards activity modulation and substrate capture

scientific article published on 01 January 2019

Stereoselective C-C bond formation catalysed by engineered carboxymethylproline synthases

scientific article published on 3 April 2011

Stereoselective Production of Dimethyl-Substituted Carbapenams via Engineered Carbapenem Biosynthesis Enzymes

Stereoselective preparation of lipidated carboxymethyl-proline/pipecolic acid derivatives via coupling of engineered crotonases with an alkylmalonyl-CoA synthetase

scientific article published on 9 October 2013

Structural Analyses on Intermediates in Serine Protease Catalysis

scientific article published in Journal of Biological Chemistry

Structural Basis of Metallo-β-Lactamase Inhibition by Captopril Stereoisomers

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Structural Investigations of the Inhibition of Escherichia coli AmpC β-Lactamase by Diazabicyclooctanes

scientific article published on 16 November 2020

Structural and Biochemical Characterization of Rm3, a Subclass B3 Metallo-β-Lactamase Identified from a Functional Metagenomic Study.

scientific article published on 18 July 2016

Structural and Evolutionary Basis for the Dual Substrate Selectivity of Human KDM4 Histone Demethylase Family

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Structural and biochemical analyses reveal how ornithine acetyl transferase binds acidic and basic amino acid substrates

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Structural and mechanistic basis of penicillin-binding protein inhibition by lactivicins

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Structural and mechanistic studies of the orf12 gene product from the clavulanic acid biosynthesis pathway

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Structural and mechanistic studies on 2-oxoglutarate-dependent oxygenases and related enzymes

scientific article

Structural and mechanistic studies on N(2)-(2-carboxyethyl)arginine synthase

scientific article

Structural and mechanistic studies on anthocyanidin synthase catalysed oxidation of flavanone substrates: the effect of C-2 stereochemistry on product selectivity and mechanism

scientific article published in August 2005

Structural and mechanistic studies on carboxymethylproline synthase (CarB), a unique member of the crotonase superfamily catalyzing the first step in carbapenem biosynthesis

scientific article

Structural and mechanistic studies on the inhibition of the hypoxia-inducible transcription factor hydroxylases by tricarboxylic acid cycle intermediates

scientific article

Structural and mechanistic studies on the peroxisomal oxygenase phytanoyl-CoA 2-hydroxylase (PhyH).

scientific article published on November 2007

Structural and mechanistic studies on γ-butyrobetaine hydroxylase

scientific article

Structural and stereoelectronic insights into oxygenase-catalyzed formation of ethylene from 2-oxoglutarate.

scientific article published on 18 April 2017

Structural basis for binding of cyclic 2-oxoglutarate analogues to factor-inhibiting hypoxia-inducible factor

scientific article

Structural basis for binding of hypoxia-inducible factor to the oxygen-sensing prolyl hydroxylases

scientific article

Structural basis for inhibition of the fat mass and obesity associated protein (FTO)

scientific article

Structural basis for oxygen degradation domain selectivity of the HIF prolyl hydroxylases.

scientific article

Structural basis for the broad-spectrum inhibition of metallo-beta-lactamases by thiols

scientific article

Structural basis for the interaction of lactivicins with serine beta-lactamases

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Structural basis for the recognition of hydroxyproline in HIF-1 alpha by pVHL

scientific article

Structural basis of metallo-β-lactamase, serine-β-lactamase and penicillin-binding protein inhibition by cyclic boronates ⬇️

scientific article published on 8 August 2016

Structural insights into how 5-hydroxymethylation influences transcription factor binding

scientific article

Structural studies on 2-oxoglutarate oxygenases and related double-stranded beta-helix fold proteins

scientific article

Structural studies on human 2-oxoglutarate dependent oxygenases

scientific article

Structural studies on the reaction of isopenicillin N synthase with the substrate analogue delta-(l-alpha-aminoadipoyl)-l-cysteinyl-d-alpha-aminobutyrate

scientific article (publication date: 15 June 2003)

Structural studies on the reaction of isopenicillin N synthase with the truncated substrate analogues delta-(L-alpha-aminoadipoyl)-L-cysteinyl-glycine and delta-(L-alpha-aminoadipoyl)-L-cysteinyl-D-alanine

scientific article published in May 2005

Structural/mechanistic insights into the efficacy of non-classical β-lactamase inhibitors against extensively drug resistant Stenotrophomonas maltophilia clinical isolates. ⬇️

scientific article published on 6 September 2017

Structure Guided Development of Potent Reversibly Binding Penicillin Binding Protein Inhibitors

scientific article

Structure activity relationship studies on rhodanines and derived enethiol inhibitors of metallo-β-lactamases

scientific article published on 23 February 2018

Structure and Mechanism of a Viral Collagen Prolyl Hydroxylase

scientific article

Structure and mechanism of anthocyanidin synthase from Arabidopsis thaliana

scientific article

Structure of factor-inhibiting hypoxia-inducible factor (HIF) reveals mechanism of oxidative modification of HIF-1 alpha

scientific article

Structure of human RNA N6-methyladenine demethylase ALKBH5 provides insights into its mechanisms of nucleic acid recognition and demethylation

scientific article

Structure of human phytanoyl-CoA 2-hydroxylase identifies molecular mechanisms of Refsum disease

scientific article published on 9 December 2005

Structure of the ribosomal oxygenase OGFOD1 provides insights into the regio- and stereoselectivity of prolyl hydroxylases

scientific article

Structure-Activity Relationship and Crystallographic Studies on 4-Hydroxypyrimidine HIF Prolyl Hydroxylase Domain Inhibitors

scientific article published on 03 December 2019

Structure-Based in Silico Screening Identifies a Potent Ebolavirus Inhibitor from a Traditional Chinese Medicine Library

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Structure-function analysis of phytanoyl-CoA 2-hydroxylase mutations causing Refsum's disease

scientific article

Structure-function relationships of human JmjC oxygenases-demethylases versus hydroxylases

scientific article

Structure-guided design of cell wall biosynthesis inhibitors that overcome β-lactam resistance in Staphylococcus aureus (MRSA)

scientific article

Structures of Human ALKBH5 Demethylase Reveal a Unique Binding Mode for Specific Single-stranded N 6 -Methyladenosine RNA Demethylation

scientific article

Structures of Mycobacterium tuberculosis Penicillin-Binding Protein 3 in Complex with Five β-Lactam Antibiotics Reveal Mechanism of Inactivation

scientific article published on 21 February 2020

Studies of isopenicillin N synthase enzymatic properties using a continuous spectrophotometric assay

scientific article published in November 2000

Studies on deacetoxycephalosporin C synthase support a consensus mechanism for 2-oxoglutarate dependent oxygenases.

scientific article

Studies on enmetazobactam clarify mechanisms of widely used β-lactamase inhibitors

scientific article published on 29 April 2022

Studies on non-haem ferrous-dependent oxygenases and oxidases

scientific article published on February 1997

Studies on phytanoyl-CoA 2-hydroxylase and synthesis of phytanoyl-coenzyme A.

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Studies on spiro[4.5]decanone prolyl hydroxylase domain inhibitors

scientific article published on 01 March 2019

Studies on ternary metallo-beta lactamase-inhibitor complexes using electrospray ionization mass spectrometry

scientific article published on 19 May 2006

Studies on ternary metallo-β lactamase-inhibitor complexes using electrospray ionization mass spectrometry

scientific article published in 2006

Studies on the Glutathione-Dependent Formaldehyde-Activating Enzyme from Paracoccus denitrificans

scientific article published on 16 December 2015

Studies on the Interaction of the Histone Demethylase KDM5B with Tricarboxylic Acid Cycle Intermediates.

scientific article published on 18 August 2017

Studies on the Substrate Selectivity of the Hypoxia-Inducible Factor Prolyl Hydroxylase 2 Catalytic Domain

scientific article published on 26 September 2018

Studies on the active site of deacetoxycephalosporin C synthase

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Studies on the activity of the hypoxia-inducible-factor hydroxylases using an oxygen consumption assay

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Studies on the catalytic domains of multiple JmjC oxygenases using peptide substrates

scientific article published on December 2014

Studies on the exchange of valine-oxygen during the biosynthesis of δ-(L-α-Aminoadipoyl)-L-cysteinyl-D-valine

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Studies on the inhibition of AmpC and other β-lactamases by cyclic boronates

scientific article published in April 2019

Studies on the reaction of glutathione and formaldehyde using NMR.

scientific article published on 24 August 2010

Studies on the reaction of nitric oxide with the hypoxia-inducible factor prolyl hydroxylase domain 2 (EGLN1)

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Studies on the selectivity of proline hydroxylases reveal new substrates including bicycles

scientific article published on 28 October 2019

Studies on the specificity of unprocessed and mature forms of phytanoyl-CoA 2-hydroxylase and mutation of the iron binding ligands

scientific article published in June 2005

Studying the active-site loop movement of the São Paolo metallo-β-lactamase-1†Electronic supplementary information (ESI) available: Procedures for protein expression and purification, 19F-labelling, crystallisation, data collection, and structure de

scientific article published on 4 November 2014

Substrate selectivity analyses of factor inhibiting hypoxia-inducible factor

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Substrate specificity of L-delta-(alpha-aminoadipoyl)-L-cysteinyl-D-valine synthetase from Cephalosporium acremonium: demonstration of the structure of several unnatural tripeptide products

scientific article published on July 1994

Substrate specificity of cloned deacetoxycephalosporin C/deacetylcephalosporin C synthetase

scientific article published on 01 November 1988

Substrate specificity of proline-4-hydroxylase: Chemical and enzymatic synthesis of 2S,3R,4S-epoxyproline

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Sudestada1, a Drosophila ribosomal prolyl-hydroxylase required for mRNA translation, cell homeostasis, and organ growth.

scientific article published on 18 February 2014

Symmetry breaking by enzyme-catalyzed epoxide hydrolysis

Syntheses of [2-13C] and [1,2-13C] labelled α-ketoglutaric acid

scholarly article by Jack E. Baldwin et al published September 1989 in Journal of Labelled Compounds and Radiopharmaceuticals

Synthesis and Biological Evaluation of Tripartin, a Putative KDM4 Natural Product Inhibitor, and 1-Dichloromethylinden-1-ol Analogues

scientific article published on 21 August 2018

Synthesis and conformational analysis of cyclic analogues of inverse γ-turns

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Synthesis and evaluation of 3-(dihydroxyboryl)benzoic acids as D,D-carboxypeptidase R39 inhibitors.

scientific article published in October 2009

Synthesis and evaluation of delta-lactams (piperazones) as elastase inhibitors

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Synthesis of Novel Pyridine-carboxylates as Small-Molecule Inhibitors of Human Aspartate/Asparagine-β-Hydroxylase

scientific article published on 24 April 2020

Synthesis of a bicyclic oxo-γ-lactam from a simple caprolactam derivative

Synthesis of deuterium labelled L- and D-glutamate semialdehydes and their evaluation as substrates for carboxymethylproline synthase (CarB)--implications for carbapenem biosynthesis

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Synthesis of regio- and stereoselectively deuterium-labelled derivatives of L-glutamate semialdehyde for studies on carbapenem biosynthesis.

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Targeting Protein-Protein Interactions in the HIF System

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Targeting histone lysine demethylases - progress, challenges, and the future

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Targeting the Mycobacterium tuberculosis transpeptidase LdtMt2 with cysteine-reactive inhibitors including ebselen

scientific article published on 01 August 2019

Terminally Truncated Isopenicillin N Synthase Generates a Dithioester Product: Evidence for a Thioaldehyde Intermediate during Catalysis and a New Mode of Reaction for Non-Heme Iron Oxidases

scientific article published on 12 July 2017

The 2-Oxoglutarate-Dependent Oxygenase JMJD6 Catalyses Oxidation of Lysine Residues to give 5S-Hydroxylysine Residues

scientific article published on 18 January 2011

The C-4 stereochemistry of leucocyanidin substrates for anthocyanidin synthase affects product selectivity

scientific article published in November 2003

The Chemical Biology of Human Metallo-β-Lactamase Fold Proteins

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The Clinically Used Iron Chelator Deferasirox Is an Inhibitor of Epigenetic JumonjiC Domain-Containing Histone Demethylases

scientific article published on 19 July 2019

The Clinically Used Iron Chelator Deferasirox is an Inhibitor of Epigenetic JumonjiC Domain-Containing Histone Demethylases

scientific article published on 9 July 2019

The Effect of Cysteine Mutations on Recombinant Deacetoxycephalosporin C Synthase from S. clavuligerus

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The FIH hydroxylase is a cellular peroxide sensor that modulates HIF transcriptional activity

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The HIF pathway as a therapeutic target

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The Jumonji-C oxygenase JMJD7 catalyzes (3S)-lysyl hydroxylation of TRAFAC GTPases

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The Mechanism of ACV Synthetase

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The SNM1A DNA repair nuclease

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The Ugi four-component reaction enables expedient synthesis and comparison of photoaffinity probes

The Unusual Bifunctional Catalysis of Epimerization and Desaturation by Carbapenem Synthase

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The broad spectrum 2-oxoglutarate oxygenase inhibitor N-oxalylglycine is present in rhubarb and spinach leaves

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The chemical biology of branched-chain lipid metabolism

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The enzymatic conversion of exomethylene cephalosporin c into deacetyl cephalosporin c and the role of molecular oxygen in cephalosporin c biosynthesis

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The enzymes of β-lactam biosynthesis

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The enzymology of clavam and carbapenem biosynthesis

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The fate of valine-oxygen during penicillin biosynthesis

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The human oxygen sensing machinery and its manipulation

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The hypoxia-inducible transcription factor pathway regulates oxygen sensing in the simplest animal, Trichoplax adhaerens

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The inhibition of factor inhibiting hypoxia-inducible factor (FIH) by β-oxocarboxylic acids

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The inhibition of metallo-beta-lactamase by thioxo-cephalosporin derivatives

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The inhibitor thiomandelic acid binds to both metal ions in metallo-beta-lactamase and induces positive cooperativity in metal binding

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The kinetic properties of various R258 mutants of deacetoxycephalosporin C synthase

scientific article published in March 2003

The methyltransferase METTL9 mediates pervasive 1-methylhistidine modification in mammalian proteomes

scientific article published on 09 February 2021

The most versatile of all reactive intermediates?

The obesity-associated FTO gene encodes a 2-oxoglutarate-dependent nucleic acid demethylase

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The oncometabolite 2-hydroxyglutarate inhibits histone lysine demethylases

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The origin of the β-lactam carbons of clavulanic acid

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The oxygenase Jmjd6--a case study in conflicting assignments

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The polyserine domain of the lysyl-5 hydroxylase Jmjd6 mediates subnuclear localization

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The rising importance of Triatoma rubrofasciata

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The road to avibactam: the first clinically useful non-β-lactam working somewhat like a β-lactam

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The role of PHD2 mutations in the pathogenesis of erythrocytosis

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The role of arginine residues in substrate binding and catalysis by deacetoxycephalosporin C synthase

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The role of iron and 2-oxoglutarate oxygenases in signalling

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The role of sulphur in cephalosporin biosynthesis

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The role of α-ketoglutarate in cephalosporin biosynthesis

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The selectivity and inhibition of AlkB.

scientific article

The structures of the SNM1A and SNM1B/Apollo nuclease domains reveal a potential basis for their distinct DNA processing activities

scientific article published on 17 November 2015

The use of dioxygen by HIF prolyl hydroxylase (PHD1)

scientific article

Therapeutic manipulation of the HIF hydroxylases

scientific article published on April 2010

Therapeutic targeting of oxygen-sensing prolyl hydroxylases abrogates ATF4-dependent neuronal death and improves outcomes after brain hemorrhage in several rodent models

scientific article published on March 2016

Thioester Hydrolysis and CC Bond Formation by Carboxymethylproline Synthase from the Crotonase Superfamily

scientific article published on 01 January 2008

Thiomandelic acid, a broad spectrum inhibitor of zinc beta-lactamases: kinetic and spectroscopic studies

scientific article published on 19 September 2001

Ticks, ivermectin, and experimental Chagas disease

scientific article

Titelbild: Monitoring Conformational Changes in the NDM-1 Metallo-β-lactamase by19F NMR Spectroscopy (Angew. Chem. 12/2014)

Treatment of health-care-associated infections caused by Gram-negative bacteria: a consensus statement

scientific article published on February 2008

Trypanosomiasis control: surmounting diminishing returns

scientific article published on 01 March 2003

Tuning the Transcriptional Response to Hypoxia by Inhibiting Hypoxia-inducible Factor (HIF) Prolyl and Asparaginyl Hydroxylases

scientific article published on 8 August 2016

Use of Methylmalonyl-CoA Epimerase in Enhancing Crotonase Stereoselectivity.

scientific article

Use of cyclic peptides to induce crystallization: case study with prolyl hydroxylase domain 2

scientific article published on 15 December 2020

Use of electrospray mass spectrometry to directly observe an acyl enzyme intermediate in beta-lactamase catalysis

scientific article published on December 1990

Use of ferrous iron by metallo-β-lactamases

scientific article

Use of mass spectrometry to probe the nucleophilicity of cysteinyl residues of prolyl hydroxylase domain 2.

scientific article

Using NMR solvent water relaxation to investigate metalloenzyme-ligand binding interactions

scientific article

Utilization of sterol carrier protein-2 by phytanoyl-CoA 2-hydroxylase in the peroxisomal alpha oxidation of phytanic acid

scientific article published in May 2002

Will morphing boron-based inhibitors beat the β-lactamases?

scientific article published on 18 April 2019

X-ray absorption studies of the ferrous active site of isopenicillin N synthase and related model complexes

article

X-ray crystal structure of ornithine acetyltransferase from the clavulanic acid biosynthesis gene cluster

scientific article

X-ray snapshots of serine protease catalysis reveal a tetrahedral intermediate

scientific article

X-ray structure of a serine protease acyl-enzyme complex at 0.95-A resolution

scientific article

YcfDRM is a thermophilic oxygen-dependent ribosomal protein uL16 oxygenase

scientific article published on 9 March 2018

l-δ-(α-Aminoadipoyl)-l-cysteinyl-d-valine Synthetase: Thioesterification of Valine Is Not Obligatory for Peptide Bond Formation†

scientific article published in 1997

γ-Butyrobetaine hydroxylase catalyses a Stevens type rearrangement

scientific article

δ-L -(α-Aminoadipoyl)-L -cysteinyl-D -valine synthetase: the order of peptide bond formation and timing of the epimerisation reaction

scientific article published on 01 January 1995

“To Cross-Seed or Not To Cross-Seed”: A Pilot Study Using Metallo-β-lactamases

scientific article published on 3 January 2017

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