List of works - Andrew Tym Hattersley

A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity

scientific article

Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index

scientific article (publication date: November 2010)

Genetic studies of body mass index yield new insights for obesity biology

scientific article

Replication of genome-wide association signals in UK samples reveals risk loci for type 2 diabetes

scientific article (publication date: June 2007)

New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk

scientific article

Hundreds of variants clustered in genomic loci and biological pathways affect human height

scientific article

Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes

scientific article

Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes

scientific article

Six new loci associated with body mass index highlight a neuronal influence on body weight regulation

scientific article

Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis

scientific article

Defining the role of common variation in the genomic and biological architecture of adult human height

scientific article

Association scan of 14,500 nonsynonymous SNPs in four diseases identifies autoimmunity variants

scientific article

Common variants near MC4R are associated with fat mass, weight and risk of obesity

scientific article

Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility

scientific article

Genome-wide association study of CNVs in 16,000 cases of eight common diseases and 3,000 shared controls

scientific article

A reference panel of 64,976 haplotypes for genotype imputation

scientific article

Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution

scientific article

New genetic loci link adipose and insulin biology to body fat distribution

scientific article

Genetic variation in GIPR influences the glucose and insulin responses to an oral glucose challenge

scientific journal article

Switching from insulin to oral sulfonylureas in patients with diabetes due to Kir6.2 mutations

scientific article published in August 2006

The genetic architecture of type 2 diabetes

scientific article (publication date: 11 July 2016)

Large-scale association studies of variants in genes encoding the pancreatic beta-cell KATP channel subunits Kir6.2 (KCNJ11) and SUR1 (ABCC8) confirm that the KCNJ11 E23K variant is associated with type 2 diabetes

scientific article published in February 2003

Concept, design and implementation of a cardiovascular gene-centric 50 k SNP array for large-scale genomic association studies

scientific article

Genome-wide association scan meta-analysis identifies three Loci influencing adiposity and fat distribution

scientific article published in June 2009

Hypomethylation of multiple imprinted loci in individuals with transient neonatal diabetes is associated with mutations in ZFP57

scientific article

Novel loci for adiponectin levels and their influence on type 2 diabetes and metabolic traits: a multi-ethnic meta-analysis of 45,891 individuals

scientific article

Insulin gene mutations as a cause of permanent neonatal diabetes

scholarly article

Common variants near ATM are associated with glycemic response to metformin in type 2 diabetes

scientific article

A common variant of HMGA2 is associated with adult and childhood height in the general population

scientific article

Bayesian refinement of association signals for 14 loci in 3 common diseases

scientific article published on 28 October 2012

Activating mutations in Kir6.2 and neonatal diabetes: new clinical syndromes, new scientific insights, and new therapy

scientific article

Mutations in the glucokinase gene of the fetus result in reduced birth weight

scientific article published on July 1, 1998

Common variants in WFS1 confer risk of type 2 diabetes

scientific article published on July 2007

Mutations in PTF1A cause pancreatic and cerebellar agenesis

scientific article

Assessing the combined impact of 18 common genetic variants of modest effect sizes on type 2 diabetes risk

scientific article published on 30 June 2008

Genetic cause of hyperglycaemia and response to treatment in diabetes

scientific article (publication date: 18 October 2003)

Clinical implications of a molecular genetic classification of monogenic beta-cell diabetes

scientific article published on 26 February 2008

Common variation in the FTO gene alters diabetes-related metabolic traits to the extent expected given its effect on BMI

scientific article

Rare and low-frequency coding variants alter human adult height

scientific article (publication date: February 2017)

Rfx6 directs islet formation and insulin production in mice and humans

scientific article

Regulation of Fto/Ftm gene expression in mice and humans

scientific article

Linkage of type 2 diabetes to the glucokinase gene

scientific article published on May 30, 1992

Permanent neonatal diabetes due to mutations in KCNJ11 encoding Kir6.2: patient characteristics and initial response to sulfonylurea therapy

scientific article published in October 2004

Genetic fine mapping and genomic annotation defines causal mechanisms at type 2 diabetes susceptibility loci

scientific article

Combining information from common type 2 diabetes risk polymorphisms improves disease prediction

scientific article published in October 2006

Activating germline mutations in STAT3 cause early-onset multi-organ autoimmune disease

scientific article

Insulin mutation screening in 1,044 patients with diabetes: mutations in the INS gene are a common cause of neonatal diabetes but a rare cause of diabetes diagnosed in childhood or adulthood

article

An Expanded Genome-Wide Association Study of Type 2 Diabetes in Europeans

scientific article published on 31 May 2017

Fine-mapping type 2 diabetes loci to single-variant resolution using high-density imputation and islet-specific epigenome maps

scientific article published on 08 October 2018

Variants in ADCY5 and near CCNL1 are associated with fetal growth and birth weight

scientific article

List of works by Andrew Tym Hattersley

A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity

Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index

Genetic studies of body mass index yield new insights for obesity biology

Replication of genome-wide association signals in UK samples reveals risk loci for type 2 diabetes

New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk

Hundreds of variants clustered in genomic loci and biological pathways affect human height

Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes

Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes

Six new loci associated with body mass index highlight a neuronal influence on body weight regulation

Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis

Defining the role of common variation in the genomic and biological architecture of adult human height

Association scan of 14,500 nonsynonymous SNPs in four diseases identifies autoimmunity variants

Common variants near MC4R are associated with fat mass, weight and risk of obesity

Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility

Genome-wide association study of CNVs in 16,000 cases of eight common diseases and 3,000 shared controls

A reference panel of 64,976 haplotypes for genotype imputation

Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution

New genetic loci link adipose and insulin biology to body fat distribution

Genetic variation in GIPR influences the glucose and insulin responses to an oral glucose challenge

Switching from insulin to oral sulfonylureas in patients with diabetes due to Kir6.2 mutations

The genetic architecture of type 2 diabetes

Large-scale association studies of variants in genes encoding the pancreatic beta-cell KATP channel subunits Kir6.2 (KCNJ11) and SUR1 (ABCC8) confirm that the KCNJ11 E23K variant is associated with type 2 diabetes

Concept, design and implementation of a cardiovascular gene-centric 50 k SNP array for large-scale genomic association studies

Genome-wide association scan meta-analysis identifies three Loci influencing adiposity and fat distribution

Hypomethylation of multiple imprinted loci in individuals with transient neonatal diabetes is associated with mutations in ZFP57

Novel loci for adiponectin levels and their influence on type 2 diabetes and metabolic traits: a multi-ethnic meta-analysis of 45,891 individuals

Insulin gene mutations as a cause of permanent neonatal diabetes

Common variants near ATM are associated with glycemic response to metformin in type 2 diabetes

A common variant of HMGA2 is associated with adult and childhood height in the general population

Bayesian refinement of association signals for 14 loci in 3 common diseases

Activating mutations in Kir6.2 and neonatal diabetes: new clinical syndromes, new scientific insights, and new therapy

Mutations in the glucokinase gene of the fetus result in reduced birth weight

Common variants in WFS1 confer risk of type 2 diabetes

Mutations in PTF1A cause pancreatic and cerebellar agenesis

Assessing the combined impact of 18 common genetic variants of modest effect sizes on type 2 diabetes risk

Genetic cause of hyperglycaemia and response to treatment in diabetes

Clinical implications of a molecular genetic classification of monogenic beta-cell diabetes

Common variation in the FTO gene alters diabetes-related metabolic traits to the extent expected given its effect on BMI

Rare and low-frequency coding variants alter human adult height

Rfx6 directs islet formation and insulin production in mice and humans

Regulation of Fto/Ftm gene expression in mice and humans

Linkage of type 2 diabetes to the glucokinase gene

Permanent neonatal diabetes due to mutations in KCNJ11 encoding Kir6.2: patient characteristics and initial response to sulfonylurea therapy

Genetic fine mapping and genomic annotation defines causal mechanisms at type 2 diabetes susceptibility loci

Combining information from common type 2 diabetes risk polymorphisms improves disease prediction

Activating germline mutations in STAT3 cause early-onset multi-organ autoimmune disease

Insulin mutation screening in 1,044 patients with diabetes: mutations in the INS gene are a common cause of neonatal diabetes but a rare cause of diabetes diagnosed in childhood or adulthood

An Expanded Genome-Wide Association Study of Type 2 Diabetes in Europeans

Fine-mapping type 2 diabetes loci to single-variant resolution using high-density imputation and islet-specific epigenome maps

Variants in ADCY5 and near CCNL1 are associated with fetal growth and birth weight