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List of works by Roderick MacKinnon

A Gating Charge Transfer Center in Voltage Sensors

scientific article

A gating model for the archeal voltage-dependent K(+) channel KvAP in DPhPC and POPE:POPG decane lipid bilayers

scientific article published on 27 May 2009

A membrane-access mechanism of ion channel inhibition by voltage sensor toxins from spider venom

scientific article

A mutant KcsA K(+) channel with altered conduction properties and selectivity filter ion distribution

scientific article published in May 2004

Activation mechanism of a human SK-calmodulin channel complex elucidated by cryo-EM structures

scientific article published on 01 May 2018

Atomic structure of a voltage-dependent K+ channel in a lipid membrane-like environment

scientific article

Calibrated measurement of gating-charge arginine displacement in the KvAP voltage-dependent K+ channel

scientific article published in November 2005

Chemistry of ion coordination and hydration revealed by a K+ channel-Fab complex at 2.0 A resolution

scientific article

Construction of a cyclic nucleotide-gated KcsA K+ channel

scientific article published in July 2005

Cooperative regulation by G proteins and Na(+) of neuronal GIRK2 K(+) channels

scientific article published on 13 April 2016

Cryo-EM Structure of a KCNQ1/CaM Complex Reveals Insights into Congenital Long QT Syndrome

scientific article published in June 2017

Cryo-EM Structure of the Open Human Ether-à-go-go-Related K+ Channel hERG.

scientific article

Cryo-EM analysis of PIP2 regulation in mammalian GIRK channels

scientific article published on 26 August 2020

Cryo-EM structure of the KvAP channel reveals a non-domain-swapped voltage sensor topology

scientific article published on 22 November 2019

Cryo-EM structure of the open high-conductance Ca2+-activated K+ channel

scientific article

Cryo-electron microscopy structure of the Slo2.2 Na(+)-activated K(+) channel

scientific article published on 05 October 2015

Crystal Structure of the Eukaryotic Strong Inward-Rectifier K+ Channel Kir2.2 at 3.1 A Resolution

scientific article

Crystal Structure of the Human K2P TRAAK, a Lipid- and Mechano-Sensitive K + Ion Channel ⬇️

scientific article published on January 27, 2012

Crystal Structure of the Mammalian GIRK2 K+ Channel and Gating Regulation by G Proteins, PIP2, and Sodium

scientific article

Crystal structure and mechanism of a calcium-gated potassium channel

scientific article

Crystal structure of a Kir3.1-prokaryotic Kir channel chimera

scientific article

Crystal structures of a complexed and peptide-free membrane protein-binding domain: molecular basis of peptide recognition by PDZ

scientific article

Domain-swapped chain connectivity and gated membrane access in a Fab-mediated crystal of the human TRAAK K + channel ⬇️

scientific article published on January 22, 2013

Electron microscopic analysis of KvAP voltage-dependent K+ channels in an open conformation

scientific article published on August 2004

Energetic optimization of ion conduction rate by the K+ selectivity filter

scientific article

Functional analysis of Kv1.2 and paddle chimera Kv channels in planar lipid bilayers

scientific article published on 7 July 2008

Functional analysis of an archaebacterial voltage-dependent K+ channel

scientific article

Functional reconstitution of purified human Hv1 H+ channels

scientific article

Gating the selectivity filter in ClC chloride channels

scientific article (publication date: 4 April 2003)

Inferred motions of the S3a helix during voltage-dependent K+ channel gating

scientific article published on 10 June 2008

Ion binding affinity in the cavity of the KcsA potassium channel

scientific article published in May 2004

Mechanistic basis for low threshold mechanosensitivity in voltage-dependent K+ channels

scientific article

Mechanosensitivity is mediated directly by the lipid membrane in TRAAK and TREK1 K+ channels

scientific article published on 18 February 2014

Molecular basis of signaling specificity between GIRK channels and GPCRs

scientific article published on 10 December 2018

Molecular mechanism of proton transport in CLC Cl - /H + exchange transporters ⬇️

scientific article published on July 2, 2012

Molecular structure of human KATP in complex with ATP and ADP.

scientific article published on 29 December 2017

Molecular structures of the human Slo1 K channel in complex with β4

scientific article published on 9 December 2019

Nobel Lecture. Potassium channels and the atomic basis of selective ion conduction

scientific article published in April 2004

Nothing automatic about ion-channel structures.

scientific article published in March 2002

Novel cell-free high-throughput screening method for pharmacological tools targeting K+ channels

scientific article published on 18 April 2016

Open structure of the Ca2+ gating ring in the high-conductance Ca2+-activated K+ channel

scientific article

Phosphatidic acid modulation of Kv channel voltage sensor function

scientific article

Phospholipids and the origin of cationic gating charges in voltage sensors

scientific article published in Nature

Physical mechanism for gating and mechanosensitivity of the human TRAAK K+ channel

scientific article

Piezo's membrane footprint and its contribution to mechanosensitivity

scientific article published on 27 November 2018

Piezo1 forms a slowly-inactivating mechanosensory channel in mouse embryonic stem cells

scientific article published on 22 August 2018

Potassium channel receptor site for the inactivation gate and quaternary amine inhibitors

scientific article

Potassium channels

scientific article published on November 2003

Potassium channels and the atomic basis of selective ion conduction (Nobel Lecture).

scientific article published in August 2004

Pulsed electron-electron double-resonance determination of spin-label distances and orientations on the tetrameric potassium ion channel KcsA.

scientific article published on October 2009

Quantitative analysis of mammalian GIRK2 channel regulation by G proteins, the signaling lipid PIP2 and Na+ in a reconstituted system

scientific article

Regulation of Eag1 gating by its intracellular domains

scientific article published on 06 September 2019

Semisynthesis of a functional K+ channel

scientific article published in May 2004

Solution Structure and Phospholipid Interactions of the Isolated Voltage-Sensor Domain from KvAP ⬇️

scientific article published on September 21, 2010

Structural Titration of Slo2.2, a Na+-Dependent K+ Channel

scientific article published on 18 January 2017

Structural and functional consequences of an amide-to-ester substitution in the selectivity filter of a potassium channel

scientific article published on September 2006

Structural and thermodynamic properties of selective ion binding in a K+ channel

scientific article

Structural basis for gating the high-conductance Ca2+-activated K+ channel

scientific article published on 14 December 2016

Structural basis of PIP2 activation of the classical inward rectifier K+ channel Kir2.2

scientific article

Structural basis of inward rectification: cytoplasmic pore of the G protein-gated inward rectifier GIRK1 at 1.8 A resolution

scientific article

Structure of a CLC chloride ion channel by cryo-electron microscopy

scientific article published on 21 December 2016

Structure of a Eukaryotic CLC Transporter Defines an Intermediate State in the Transport Cycle ⬇️

scientific article published on September 30, 2010

Structure of a voltage-dependent K+ channel beta subunit

scientific article

Structure of the CLC-1 chloride channel from Homo sapiens.

scientific article

Structure of the KvAP voltage-dependent K+ channel and its dependence on the lipid membrane

scientific article

Structure of the RCK domain from the E. coli K+ channel and demonstration of its presence in the human BK channel

scientific article

Structure of the cytoplasmic beta subunit-T1 assembly of voltage-dependent K+ channels

scientific article

Structure of the human BK channel Ca2+-activation apparatus at 3.0 A resolution

scientific article

Structure of the voltage-gated K⁺ channel Eag1 reveals an alternative voltage sensing mechanism

scientific article

Structure-based membrane dome mechanism for Piezo mechanosensitivity

scientific article published on 12 December 2017

Structures of the Human HCN1 Hyperpolarization-Activated Channel

scientific journal article

The GIRK1 subunit potentiates G protein activation of cardiac GIRK1/4 hetero-tetramers

scientific article published on 13 April 2016

The New York Consortium on Membrane Protein Structure (NYCOMPS): a high-throughput platform for structural genomics of integral membrane proteins

scientific article

The Occupancy of Ions in the K+ Selectivity Filter: Charge Balance and Coupling of Ion Binding to a Protein Conformational Change Underlie High Conduction Rates ⬇️

scientific article published on November 7, 2003

The Structure of the Potassium Channel: Molecular Basis of K + Conduction and Selectivity ⬇️

scientific article published on April 3, 1998

The mechanosensitive ion channel TRAAK is localized to the mammalian node of Ranvier

scientific article published on 01 November 2019

The open pore conformation of potassium channels

scientific article published on May 2002

The principle of gating charge movement in a voltage-dependent K+ channel ⬇️

scientific article published on May 1, 2003

Two separate interfaces between the voltage sensor and pore are required for the function of voltage-dependent K(+) channels

scientific article

Voltage-dependent K+ channel gating and voltage sensor toxin sensitivity depend on the mechanical state of the lipid membrane

scholarly article

X-ray structure of a ClC chloride channel at 3.0 A reveals the molecular basis of anion selectivity

scientific article

X-ray structure of a voltage-dependent K+ channel

scientific article

X-ray structure of the mammalian GIRK2–βγ G-protein complex

scientific article

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