List of works - John M. Sedivy

A comparison of oncogene-induced senescence and replicative senescence: implications for tumor suppression and aging

scientific article

A functional screen for Myc-responsive genes reveals serine hydroxymethyltransferase, a major source of the one-carbon unit for cell metabolism

scientific journal article

A link between the accumulation of DNA damage and loss of multi-potency of human mesenchymal stromal cells

scientific article published on December 2010

Abolition of cyclin-dependent kinase inhibitor p16Ink4a and p21Cip1/Waf1 functions permits Ras-induced anchorage-independent growth in telomerase-immortalized human fibroblasts

scientific article

Accumulation of senescent cells in mitotic tissue of aging primates

scientific article

Active Degradation Explains the Distribution of Nuclear Proteins during Cellular Senescence

scientific article published on 26 June 2015

Age-associated increase in heterochromatic marks in murine and primate tissues

scientific article

Cellular senescence and organismal aging

scientific article published on 12 April 2008

Correlation analysis reveals the emergence of coherence in the gene expression dynamics following system perturbation

scientific article

DNA damage markers in dermal fibroblasts in vitro reflect chronological donor age.

scientific article published on 30 January 2016

Do senescence markers correlate in vitro and in situ within individual human donors?

scientific article published in February 2018

Engineering the serine/threonine protein kinase Raf-1 to utilise an orthogonal analogue of ATP substituted at the N6 position

scientific article published in January 2004

Epigenetic control of aging

scientific article

Gene targeting and somatic cell genetics--a rebirth or a coming of age?

scientific article

Global regulation of nucleotide biosynthetic genes by c-Myc

scientific article

How to learn new and interesting things from model systems based on "exotic" biological species

scientific article (publication date: 17 November 2009)

Human Genomics. Sleeping dogs of the genome

scientific article

Interventions to Slow Aging in Humans: Are We Ready?

scientific article

Involvement of the INK4a/Arf gene locus in senescence

scientific article

Kinetic profiling of the c-Myc transcriptome and bioinformatic analysis of repressed gene promoters

scientific article

Loss of protooncogene c-Myc function impedes G1 phase progression both before and after the restriction point

scientific article

Loss of retinoblastoma but not p16 function allows bypass of replicative senescence in human fibroblasts ⬇️

scientific article published on October 17, 2003

Microarray analysis of glial cells resistant to JCV infection suggests a correlation between viral infection and inflammatory cytokine gene expression

scientific article

Molecular characterization of human telomerase reverse transcriptase-immortalized human fibroblasts by gene expression profiling: activation of the epiregulin gene

scientific article

NFAT4 is required for JC virus infection of glial cells

scientific article

Nuclear protein accumulation in cellular senescence and organismal aging revealed with a novel single-cell resolution fluorescence microscopy assay ⬇️

scientific article published on October 1, 2011

Phosphatidylenthanolamine Binding Protein aka Raf Kinase Inhibitor Protein: A Brief History of Its Discovery and the Remarkable Diversity of Biological Functions

scientific article published on January 1, 2011

Phosphorylation of the cell cycle inhibitor p21Cip1/WAF1 by Pim-1 kinase

scientific article (publication date: 16 December 2002)

Postnatal liver growth and regeneration are independent of c-myc in a mouse model of conditional hepatic c-myc deletion

scientific article

Proteomic profiling of Myc-associated proteins

scientific article

Raf kinase inhibitory protein knockout mice: expression in the brain and olfaction deficit

scientific article published on 11 December 2006

Real-time imaging of transcriptional activation in live cells reveals rapid up-regulation of the cyclin-dependent kinase inhibitor gene CDKN1A in replicative cellular senescence

scientific article published on 01 December 2003

Reconstructing networks of pathways via significance analysis of their intersections

scientific article

Reduced c-Myc signaling triggers telomere-independent senescence by regulating Bmi-1 and p16(INK4a).

scholarly article

Reduced expression of MYC increases longevity and enhances healthspan

scientific article

Regulation of RKIP function by Helicobacter pylori in gastric cancer

scientific article

Regulation of gene expression in hepatic cells by the mammalian Target of Rapamycin (mTOR).

scientific article

Regulation of growth arrest in senescence: telomere damage is not the end of the story

scientific article

Reorganization of chromosome architecture in replicative cellular senescence

scientific article (publication date: February 2016)

Requirement for p53 and p21 to sustain G2 arrest after DNA damage

scientific article (publication date: 20 November 1998)

SLC1A5 glutamine transporter is a target of MYC and mediates reduced mTORC1 signaling and increased fatty acid oxidation in long-lived Myc hypomorphic mice.

scientific article published on 25 March 2019

Signaling crossroads: the function of Raf kinase inhibitory protein in cancer, the central nervous system and reproduction

scientific article

Somatic cell knockouts of tumor suppressor genes

scientific article published on January 2003

Stress response gene ATF3 is a target of c-myc in serum-induced cell proliferation

scientific journal article

Targeted inactivation of p53 in human cells does not result in aneuploidy

scientific article published on 01 February 2002

Telomere shortening triggers senescence of human cells through a pathway involving ATM, p53, and p21(CIP1), but not p16(INK4a)

scientific article

The dark side of circulating nucleic acids

scientific article

The number of p16INK4a positive cells in human skin reflects biological age.

scientific article published on 11 June 2012

The oncogene c-Myc coordinates regulation of metabolic networks to enable rapid cell cycle entry

scientific journal article

The proto-oncogene c-myc acts through the cyclin-dependent kinase (Cdk) inhibitor p27(Kip1) to facilitate the activation of Cdk4/6 and early G(1) phase progression

scientific journal article

Transcriptional landscape of repetitive elements in normal and cancer human cells

scientific article

Widespread expression of the Supv3L1 mitochondrial RNA helicase in the mouse

scientific article

c-Myc localization within the nucleus: evidence for association with the PML nuclear body

scientific journal article

p21-Mediated nuclear retention of cyclin B1-Cdk1 in response to genotoxic stress

scientific article

List of works by John M. Sedivy

A comparison of oncogene-induced senescence and replicative senescence: implications for tumor suppression and aging

A functional screen for Myc-responsive genes reveals serine hydroxymethyltransferase, a major source of the one-carbon unit for cell metabolism

A link between the accumulation of DNA damage and loss of multi-potency of human mesenchymal stromal cells

Abolition of cyclin-dependent kinase inhibitor p16Ink4a and p21Cip1/Waf1 functions permits Ras-induced anchorage-independent growth in telomerase-immortalized human fibroblasts

Accumulation of senescent cells in mitotic tissue of aging primates

Active Degradation Explains the Distribution of Nuclear Proteins during Cellular Senescence

Age-associated increase in heterochromatic marks in murine and primate tissues

Cellular senescence and organismal aging

Correlation analysis reveals the emergence of coherence in the gene expression dynamics following system perturbation

DNA damage markers in dermal fibroblasts in vitro reflect chronological donor age.

Do senescence markers correlate in vitro and in situ within individual human donors?

Engineering the serine/threonine protein kinase Raf-1 to utilise an orthogonal analogue of ATP substituted at the N6 position

Epigenetic control of aging

Gene targeting and somatic cell genetics--a rebirth or a coming of age?

Global regulation of nucleotide biosynthetic genes by c-Myc

How to learn new and interesting things from model systems based on "exotic" biological species

Human Genomics. Sleeping dogs of the genome

Interventions to Slow Aging in Humans: Are We Ready?

Involvement of the INK4a/Arf gene locus in senescence

Kinetic profiling of the c-Myc transcriptome and bioinformatic analysis of repressed gene promoters

Loss of protooncogene c-Myc function impedes G1 phase progression both before and after the restriction point

Loss of retinoblastoma but not p16 function allows bypass of replicative senescence in human fibroblasts ⬇️

Microarray analysis of glial cells resistant to JCV infection suggests a correlation between viral infection and inflammatory cytokine gene expression

Molecular characterization of human telomerase reverse transcriptase-immortalized human fibroblasts by gene expression profiling: activation of the epiregulin gene

NFAT4 is required for JC virus infection of glial cells

Nuclear protein accumulation in cellular senescence and organismal aging revealed with a novel single-cell resolution fluorescence microscopy assay ⬇️

Phosphatidylenthanolamine Binding Protein aka Raf Kinase Inhibitor Protein: A Brief History of Its Discovery and the Remarkable Diversity of Biological Functions

Phosphorylation of the cell cycle inhibitor p21Cip1/WAF1 by Pim-1 kinase

Postnatal liver growth and regeneration are independent of c-myc in a mouse model of conditional hepatic c-myc deletion

Proteomic profiling of Myc-associated proteins

Raf kinase inhibitory protein knockout mice: expression in the brain and olfaction deficit

Real-time imaging of transcriptional activation in live cells reveals rapid up-regulation of the cyclin-dependent kinase inhibitor gene CDKN1A in replicative cellular senescence

Reconstructing networks of pathways via significance analysis of their intersections

Reduced c-Myc signaling triggers telomere-independent senescence by regulating Bmi-1 and p16(INK4a).

Reduced expression of MYC increases longevity and enhances healthspan

Regulation of RKIP function by Helicobacter pylori in gastric cancer

Regulation of gene expression in hepatic cells by the mammalian Target of Rapamycin (mTOR).

Regulation of growth arrest in senescence: telomere damage is not the end of the story

Reorganization of chromosome architecture in replicative cellular senescence

Requirement for p53 and p21 to sustain G2 arrest after DNA damage

SLC1A5 glutamine transporter is a target of MYC and mediates reduced mTORC1 signaling and increased fatty acid oxidation in long-lived Myc hypomorphic mice.

Signaling crossroads: the function of Raf kinase inhibitory protein in cancer, the central nervous system and reproduction

Somatic cell knockouts of tumor suppressor genes

Stress response gene ATF3 is a target of c-myc in serum-induced cell proliferation

Targeted inactivation of p53 in human cells does not result in aneuploidy

Telomere shortening triggers senescence of human cells through a pathway involving ATM, p53, and p21(CIP1), but not p16(INK4a)

The dark side of circulating nucleic acids

The number of p16INK4a positive cells in human skin reflects biological age.

The oncogene c-Myc coordinates regulation of metabolic networks to enable rapid cell cycle entry

The proto-oncogene c-myc acts through the cyclin-dependent kinase (Cdk) inhibitor p27(Kip1) to facilitate the activation of Cdk4/6 and early G(1) phase progression

Transcriptional landscape of repetitive elements in normal and cancer human cells

Widespread expression of the Supv3L1 mitochondrial RNA helicase in the mouse

c-Myc localization within the nucleus: evidence for association with the PML nuclear body

p21-Mediated nuclear retention of cyclin B1-Cdk1 in response to genotoxic stress