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List of works by Arlan G. Richardson

A Novel mouse model of enhanced proteostasis: Full-length human heat shock factor 1 transgenic mice ⬇️

scientific article published on October 13, 2010

A cross-sectional study of male and female C57BL/6Nia mice suggests lifespan and healthspan are not necessarily correlated

scientific article published on 02 October 2016

A new mouse model of frailty: the Cu/Zn superoxide dismutase knockout mouse.

scientific article

A new role for oxidative stress in aging: The accelerated aging phenotype in Sod1-/- mice is correlated to increased cellular senescence

scientific article published on 2 November 2016

A novel approach for screening the proteome for changes in protein conformation

scientific article published in March 2006

A strategy for the ubiquitous overexpression of human catalase and CuZn superoxide dismutase genes in transgenic mice

scientific article

Absence of genomic hypomethylation or regulation of cytosine-modifying enzymes with aging in male and female mice

scientific article published on 13 July 2016

Accelerated sarcopenia in Cu/Zn superoxide dismutase knockout mice.

scientific article published on 2 July 2018

Adaptive changes in structure of skeletal muscles from adult Sod1 homozygous knockout mice

scientific article published on 16 November 2006

Aging and cancer: can mTOR inhibitors kill two birds with one drug? ⬇️

scientific article published on March 11, 2011

Alterations in mitochondrial function, hydrogen peroxide release and oxidative damage in mouse hind-limb skeletal muscle during aging

scientific article published on 06 January 2006

Attenuation of leukocyte-endothelium interaction by antioxidant enzymes

scientific article published on 01 August 2003

Attenuation of liver insoluble protein carbonyls: indicator of a longevity determinant? ⬇️

scientific article published on May 6, 2011

Base excision repair deficiency caused by polymerase beta haploinsufficiency: accelerated DNA damage and increased mutational response to carcinogens ⬇️

scientific article published on September 15, 2003

Biomarkers of aging: from primitive organisms to humans

scientific article

Bisulfite oligonucleotide-capture sequencing for targeted base- and strand-specific absolute 5-methylcytosine quantitation

scientific article published on 18 April 2016

Bring Back the Rat!

scientific article published on 01 February 2020

Caloric restriction and genomic stability

article published in 2007

Caloric restriction mitigates age-associated hippocampal differential CG and non-CG methylation

scientific article published on 16 March 2018

Calorie restriction alleviates the age-related decrease in neural progenitor cell division in the aging brain.

scientific article published on June 2013

Calorie restriction prevents age-related changes in the intestinal microbiota

scientific article published on 10 March 2021

Cancer cachexia in a mouse model of oxidative stress

scientific article published on 12 September 2020

Caspase-2 deficiency enhances aging-related traits in mice

scientific article published on 22 December 2006

Catalase transgenic mice: characterization and sensitivity to oxidative stress

scientific article published in February 2004

Characterization of transgenic mice that overexpress both copper zinc superoxide dismutase and catalase

scientific article published on 01 March 2006

Chronic Rapamycin Restores Brain Vascular Integrity and Function Through NO Synthase Activation and Improves Memory in Symptomatic Mice Modeling Alzheimer’s Disease ⬇️

scientific article published on June 26, 2013

Cloning and characterization of a testis and brain-specific isoform of mouse 3'-phosphoinositide-dependent protein kinase-1, mPDK-1 beta

scientific article

Combined treatment of rapamycin and dietary restriction has a larger effect on the transcriptome and metabolome of liver

scientific article

Comparative proteomics: characterization of a two-dimensional gel electrophoresis system to study the effect of aging on mitochondrial proteins

scientific article published on 01 January 2003

Comparison of Whole Body SOD1 Knockout with Muscle-Specific SOD1 Knockout Mice Reveals a Role for Nerve Redox Signaling in Regulation of Degenerative Pathways in Skeletal Muscle

scientific article

Complex I generated, mitochondrial matrix-directed superoxide is released from the mitochondria through voltage dependent anion channels ⬇️

scientific article published on May 18, 2012

Conditional knockout of Mn-SOD targeted to type IIB skeletal muscle fibers increases oxidative stress and is sufficient to alter aerobic exercise capacity.

scientific article published on 23 September 2009

Correction: Inhibition of mTOR by Rapamycin Abolishes Cognitive Deficits and Reduces Amyloid-β Levels in a Mouse Model of Alzheimer's Disease.

scientific article published on 18 November 2011

Correction: Inhibition of mTOR by Rapamycin Abolishes Cognitive Deficits and Reduces Amyloid-β Levels in a Mouse Model of Alzheimer's Disease.

scientific article published on 27 December 2011

CuZnSOD gene deletion targeted to skeletal muscle leads to loss of contractile force but does not cause muscle atrophy in adult mice

scientific article published on 31 May 2013

Cyclophilin D over-expression increases mitochondrial complex III activity and accelerates supercomplex formation

scientific article published on December 2016

Decreased in vitro mitochondrial function is associated with enhanced brain metabolism, blood flow, and memory in Surf1-deficient mice

scientific article published on 10 July 2013

Denervation-induced skeletal muscle atrophy is associated with increased mitochondrial ROS production

scientific article published on 20 June 2007

Detection and quantification of protein disulfides in biological tissues a fluorescence-based proteomic approach.

scientific article

Detection of protein carbonyls in aging liver tissue: A fluorescence-based proteomic approach

scientific article published on 26 September 2006

Dietary Restriction Does Not Protect the Nigrostriatal Dopaminergic Pathway of Older Animals From Low-Dose MPTP-Induced Neurotoxicity ⬇️

scientific article published on May 1, 2003

Dietary restriction attenuates age-associated muscle atrophy by lowering oxidative stress in mice even in complete absence of CuZnSOD.

scientific article

Dietary restriction attenuates the accelerated aging phenotype of Sod1−/− mice ⬇️

scientific article published on February 28, 2013

Dietary restriction but not rapamycin extends disease onset and survival of the H46R/H48Q mouse model of ALS

scientific article (publication date: August 2012)

Dietary restriction reduces atherosclerosis and oxidative stress in the aorta of apolipoprotein E-deficient mice

scientific article published in April 2002

Does reduced IGF-1R signaling in Igf1r+/- mice alter aging?

scientific article

Downregulation of Grb2 contributes to the insulin-sensitizing effect of calorie restriction

scientific article published on 24 February 2009

Early postnatal administration of growth hormone increases tuberoinfundibular dopaminergic neuron numbers in Ames dwarf mice

scientific article

Edward J. Masoro, Scientist and Friend

scientific article published on 01 October 2020

Effect of aging and caloric restriction on the mitochondrial proteome

scientific article published on 01 March 2007

Effect of rapamycin on aging and age-related diseases-past and future

scientific article published on 10 October 2020

Effects of age and caloric restriction on lipid peroxidation: measurement of oxidative stress by F2-isoprostane levels

scientific article published in July 2005

Effects of transgenic methionine sulfoxide reductase A (MsrA) expression on lifespan and age-dependent changes in metabolic function in mice

scientific article

Embryonic fibroblasts from Gpx4+/- mice: a novel model for studying the role of membrane peroxidation in biological processes

scientific article published in November 2003

Enhancing mitochondrial respiration suppresses tumor promoter TPA-induced PKM2 expression and cell transformation in skin epidermal JB6 cells.

scientific article published on 14 June 2011

Food restriction attenuates age-related increase in the sensitivity of endothelial cells to oxidized lipids

scientific article published on April 2004

Formation of 3-nitrotyrosines in carbonic anhydrase III is a sensitive marker of oxidative stress in skeletal muscle

scientific article published on April 2007

GAPDH is conformationally and functionally altered in association with oxidative stress in mouse models of amyotrophic lateral sclerosis

scientific article published on 6 August 2008

Genetic mouse models of extended lifespan

scientific article

Geroscience: linking aging to chronic disease

scientific article

Glutathione peroxidase 4 differentially regulates the release of apoptogenic proteins from mitochondria

scientific article published on 15 May 2009

Glutathione peroxidase 4 protects cortical neurons from oxidative injury and amyloid toxicity

scientific article published in July 2006

Gpx4 ablation in adult mice results in a lethal phenotype accompanied by neuronal loss in brain ⬇️

scientific article published on March 6, 2012

Gpx4 protects mitochondrial ATP generation against oxidative damage

scientific article published on 21 March 2007

Haploinsufficiency in DNA polymerase beta increases cancer risk with age and alters mortality rate

scientific article published in August 2006

Health Effects of Long-Term Rapamycin Treatment: The Impact on Mouse Health of Enteric Rapamycin Treatment from Four Months of Age throughout Life

scientific article published on 15 May 2015

Hepatic genes altered in expression by food restriction are not influenced by the low plasma glucose level in young male GLUT4 transgenic mice

scientific article

Hepatic response to oxidative injury in long-lived Ames dwarf mice

scientific article

Housing density does not influence the longevity effect of calorie restriction

scientific article published on 01 December 2005

How longevity research can lead to therapies for Alzheimer's disease: The rapamycin story

scientific article published on 3 December 2014

Increased superoxide in vivo accelerates age-associated muscle atrophy through mitochondrial dysfunction and neuromuscular junction degeneration

scientific article

Inducible cell-specific mouse models for paired epigenetic and transcriptomic studies of microglia and astroglia

scientific article published on 19 November 2020

Inducing Autophagy by Rapamycin Before, but Not After, the Formation of Plaques and Tangles Ameliorates Cognitive Deficits ⬇️

scientific article published on September 28, 2011

Inhibition of mTOR by rapamycin abolishes cognitive deficits and reduces amyloid-beta levels in a mouse model of Alzheimer's disease

scientific article

Is Rapamycin a Dietary Restriction Mimetic?

scientific article published on 01 January 2020

Is the oxidative stress theory of aging dead?

scientific article

Isocitrate dehydrogenase 1 is downregulated during early skin tumorigenesis which can be inhibited by overexpression of manganese superoxide dismutase ⬇️

scientific article published on June 7, 2012

Lack of methionine sulfoxide reductase A in mice increases sensitivity to oxidative stress but does not diminish life span

scientific article published on June 2009

Life-long reduction in MnSOD activity results in increased DNA damage and higher incidence of cancer but does not accelerate aging

scientific article (publication date: 16 December 2003)

Lifelong rapamycin administration ameliorates age‐dependent cognitive deficits by reducing IL‐1β and enhancing NMDA signaling ⬇️

scientific article published on February 1, 2012

Lifelong reduction in complex IV induces tissue-specific metabolic effects but does not reduce lifespan or healthspan in mice

scientific article published on 25 April 2018

Lifespan extension in genetically modified mice

scientific article published on 22 May 2009

Lipid peroxidation up-regulates BACE1 expression in vivo: a possible early event of amyloidogenesis in Alzheimer's disease

scientific article published on 02 August 2008

Liver specific expression of Cu/ZnSOD extends the lifespan of Sod1 null mice

scientific article published on 31 January 2016

Long-lived ames dwarf mice are resistant to chemical stressors

scientific article

Longer lifespan in male mice treated with a weakly estrogenic agonist, an antioxidant, an α-glucosidase inhibitor or a Nrf2-inducer.

scientific article published on 16 June 2016

Measures of Healthspan as Indices of Aging in Mice-A Recommendation.

scientific article published on 22 August 2015

Metabolic consequences of long-term rapamycin exposure on common marmoset monkeys (Callithrix jacchus)

scientific article

Methionine oxidation and aging

scientific article

Methionine sulfoxide reductase A affects insulin resistance by protecting insulin receptorfunction ⬇️

scientific article published on October 23, 2012

Mice deficient in both Mn superoxide dismutase and glutathione peroxidase-1 have increased oxidative damage and a greater incidence of pathology but no reduction in longevity

scientific article published on 23 September 2009

Mice fed rapamycin have an increase in lifespan associated with major changes in the liver transcriptome

scientific article

Minimal effects of dietary restriction on neuroendocrine carcinogenesis in Rb+/- mice

scientific article published in February 2003

Mitochondrial oxidative stress impairs contractile function but paradoxically increases muscle mass via fibre branching

scientific article published on 01 February 2019

MnSOD deficiency has a differential effect on disease progression in two different ALS mutant mouse models

scientific article

MnSOD deficiency results in elevated oxidative stress and decreased mitochondrial function but does not lead to muscle atrophy during aging

scientific article

MnSOD overexpression reduces fibrosis and pro-apoptotic signaling in the aging mouse heart

scientific article published on 11 July 2014

Molecular changes in transcription and metabolic pathways underlying muscle atrophy in the CuZnSOD null mouse model of sarcopenia

scientific article published on 12 May 2020

Molecular events in matrix protein metabolism in the aging kidney

scientific article published on 19 October 2012

Molecular interplay between mammalian target of rapamycin (mTOR), amyloid-beta, and Tau: effects on cognitive impairments

scientific article

MsrA Overexpression Targeted to the Mitochondria, but Not Cytosol, Preserves Insulin Sensitivity in Diet-Induced Obese Mice

scientific article

Multiple deficiencies in antioxidant enzymes in mice result in a compound increase in sensitivity to oxidative stress

scientific journal article

Muscle mitochondrial catalase expression prevents neuromuscular junction disruption, atrophy, and weakness in a mouse model of accelerated sarcopenia

scientific article published on 24 September 2021

Necroptosis increases with age and is reduced by dietary restriction.

scientific article published on 25 April 2018

Neuron specific reduction in CuZnSOD is not sufficient to initiate a full sarcopenia phenotype.

scientific article published on 15 April 2015

Neuron-specific deletion of CuZnSOD leads to an advanced sarcopenic phenotype in older mice

scientific article published on 04 September 2020

Neuron-specific expression of CuZnSOD prevents the loss of muscle mass and function that occurs in homozygous CuZnSOD-knockout mice

scientific article published on 30 December 2013

Neuronal mitochondrial amelioration by feeding acetyl-L-carnitine and lipoic acid to aged rats

scientific article published on 28 March 2008

Obesity in Aging Exacerbates Neuroinflammation, Dysregulating Synaptic Function-Related Genes and Altering Eicosanoid Synthesis in the Mouse Hippocampus: Potential Role in Impaired Synaptic Plasticity and Cognitive Decline.

scientific article published in February 2019

Obesity-induced oxidative stress, accelerated functional decline with age and increased mortality in mice

scientific article published on 3 January 2015

Overexpression of Mn superoxide dismutase does not increase life span in mice

scientific article published on 24 July 2009

Overexpression of antioxidant enzymes in diaphragm muscle does not alter contraction-induced fatigue or recovery

scientific article

Overexpression of human SOD1 improves survival of mice susceptible to endotoxic shock ⬇️

scientific article published on July 24, 2012

Oxidative damage associated with obesity is prevented by overexpression of CuZn- or Mn-superoxide dismutase

scientific article published on 18 July 2013

Oxidative stress and diabetes: What can we learn about insulin resistance from antioxidant mutant mouse models? ⬇️

scientific article published on October 20, 2011

Oxidative stress-induced dysregulation of excitation-contraction coupling contributes to muscle weakness

scientific article published on 02 August 2018

PGC-1alpha-induced mitochondrial alterations in 3T3 fibroblast cells

scientific article published on April 2007

PGC-1α protects neurons and alters disease progression in an amyotrophic lateral sclerosis mouse model

scientific article published on 01 December 2011

Plasma protein biomarkers of the geriatric syndrome of frailty

scientific article

Preparing for an Aging World: Engaging Biogerontologists, Geriatricians, and the Society

scientific article published on 29 September 2015

Processing of data generated by 2-dimensional gel electrophoresis for statistical analysis: missing data, normalization, and statistics

scientific article

Prolonged ethanol administration depletes mitochondrial DNA in MnSOD-overexpressing transgenic mice, but not in their wild type littermates

scientific article

Protein stability and resistance to oxidative stress are determinants of longevity in the longest-living rodent, the naked mole-rat.

scholarly article

Proteomic Screening of Glycoproteins in Human Plasma for Frailty Biomarkers ⬇️

scientific article published on January 4, 2012

Raising the antioxidant levels within mouse muscle fibres does not affect contraction-induced injury

scientific article

Rapamycin Extends Life and Health in C57BL/6 Mice ⬇️

scientific article published on May 16, 2013

Rapamycin Increases Mortality in db/db Mice, a Mouse Model of Type 2 Diabetes

scientific article published on 05 October 2015

Rapamycin rescues vascular, metabolic and learning deficits in apolipoprotein E4 transgenic mice with pre-symptomatic Alzheimer's disease

scientific article published on 31 December 2015

Rapamycin selectively alters serum chemistry in diabetic mice ⬇️

scientific article published on April 23, 2012

Rapamycin, anti-aging, and avoiding the fate of Tithonus

scientific article published on August 2013

Rapamycin-induced insulin resistance is mediated by mTORC2 loss and uncoupled from longevity

scientific article

Rapamycin-induced metabolic defects are reversible in both lean and obese mice

scientific article

Rapamycin-mediated mouse lifespan extension: Late-life dosage regimes with sex-specific effects

scientific article published on 04 November 2020

Reduction in Reactive Oxygen Species Production by Mitochondria From Elderly Subjects With Normal and Impaired Glucose Tolerance ⬇️

scientific article published on June 15, 2011

Reduction in glutathione peroxidase 4 increases life span through increased sensitivity to apoptosis

scientific article

Reduction of glucose intolerance with high fat feeding is associated with anti-inflammatory effects of thioredoxin 1 overexpression in mice ⬇️

scientific article published on May 17, 2012

Reduction of mitochondrial H2O2 by overexpressing peroxiredoxin 3 improves glucose tolerance in mice

scientific article published on 5 September 2008

Reduction of pressor response to vasoconstrictor agents by overexpression of catalase in mice

scientific article published on January 2003

Reproducibility, sources of variability, pooling, and sample size: important considerations for the design of high-density oligonucleotide array experiments

scientific article published in April 2004

Retardation of atherosclerosis by overexpression of catalase or both Cu/Zn-superoxide dismutase and catalase in mice lacking apolipoprotein E.

scientific article published on 4 November 2004

Revisiting the genomic hypomethylation hypothesis of aging.

scientific article published on 24 January 2018

Role of DNA methylation in the dietary restriction mediated cellular memory.

scientific article published on 5 May 2017

Role of nerve-muscle interactions and reactive oxygen species in regulation of muscle proteostasis with ageing

scientific article published on 9 August 2017

Role of superoxide-nitric oxide interactions in the accelerated age-related loss of muscle mass in mice lacking Cu,Zn superoxide dismutase

scientific article

Science fact and the SENS agenda. What can we reasonably expect from ageing research?

scientific article

Senescent Cells Contribute to the Physiological Remodeling of Aged Lungs

scientific article published on 7 January 2015

Sexually divergent DNA methylation patterns with hippocampal aging

scientific article published on 25 September 2017

Short form glutathione peroxidase 4 is the essential isoform required for survival and somatic mitochondrial functions

scientific article published on 10 September 2009

Short-term rapamycin treatment in mice has few effects on the transcriptome of white adipose tissue compared to dietary restriction.

scientific article

Short-term treatment with rapamycin and dietary restriction have overlapping and distinctive effects in young mice

scientific article published on 8 May 2012

Significant life extension by ten percent dietary restriction

scientific article published on 22 December 2015

Simultaneous assessment of cognitive function, circadian rhythm, and spontaneous activity in aging mice

scientific article

Skeletal muscle weakness due to deficiency of CuZn-superoxide dismutase is associated with loss of functional innervation

scientific article published on 7 September 2011

Stress kinases: Altered in fibroblasts and liver of dwarf mice

Superoxide-mediated oxidative stress accelerates skeletal muscle atrophy by synchronous activation of proteolytic systems

scientific article published on 26 May 2020

Suppression of atherogenesis by overexpression of glutathione peroxidase-4 in apolipoprotein E-deficient mice

scientific article published on 2 October 2007

Targeting cPLA2 derived lipid hydroperoxides as a potential intervention for sarcopenia

scientific article published on 18 August 2020

Testing efficacy of administration of the antiaging drug rapamycin in a nonhuman primate, the common marmoset

scientific article

The Geropathology Grading Platform demonstrates that mice null for Cu/Zn-superoxide dismutase show accelerated biological aging

scientific article published on 24 February 2018

The Sam and Ann Barshop Center for Longevity and Aging Studies. Interview by Vicki Glaser

scientific article published in January 2003

The Sam and Ann Barshop Center for Longevity and Aging Studies: the University of Texas Health Science Center at San Antonio

scientific article published on 01 August 2002

The age-related failure of adaptive responses to contractile activity in skeletal muscle is mimicked in young mice by deletion of Cu,Zn superoxide dismutase

scientific article

The development of a specific pathogen free (SPF) barrier colony of marmosets (Callithrix jacchus) for aging research

scientific article published on 7 December 2017

The effect of gonadectomy and estradiol on sensitivity to oxidative stress.

scientific article published on January 2009

The in vivo gene expression signature of oxidative stress

scientific article

The inherent challenges of classifying senescence-Response

scientific article

The long lifespan of two bat species is correlated with resistance to protein oxidation and enhanced protein homeostasis

scientific article published on 24 February 2009

The overexpression of major antioxidant enzymes does not extend the lifespan of mice

scientific article published on 11 December 2008

The role of DNA methylation in epigenetics of aging

The role of insulin and insulin-like growth factor-I in mammalian ageing

scientific article published in September 2004

The role of macromolecular damage in aging and age-related disease

scientific article published in June 2014

The role of oxidative damage and stress in aging.

scientific article

The selenoprotein GPX4 is essential for mouse development and protects from radiation and oxidative damage insults

scientific journal article

Thioredoxin 1 Overexpression Extends Mainly the Earlier Part of Life Span in Mice ⬇️

scientific article published on August 26, 2011

Thioredoxin 2 haploinsufficiency in mice results in impaired mitochondrial function and increased oxidative stress

scientific article published on 7 December 2007

To help aging populations, classify organismal senescence

scientific article

Transgenic mice overexpressing glutathione peroxidase 4 are protected against oxidative stress-induced apoptosis

scientific article published on 20 October 2004

Trends in oxidative aging theories

scientific article (publication date: 15 August 2007)

Update on the oxidative stress theory of aging: does oxidative stress play a role in aging or healthy aging?

scientific article

Use of Nerve Conduction Velocity to Assess Peripheral Nerve Health in Aging Mice

scientific article

Use of Transgenic Mice in Aging Research

scientific article published on 01 January 1997

Whole body overexpression of PGC-1alpha has opposite effects on hepatic and muscle insulin sensitivity

scientific article published on 10 February 2009

You Have Come A Long Way Baby: Five Decades of Research on the Biology of Aging from the Perspective of a Researcher Studying Aging

scientific article published on 25 August 2020

mTOR: Alzheimer's disease prevention for APOE4 carriers

scientific article published on 30 June 2016

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