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List of works by David Siderovski

5′-Capping enzymes are targeted to pre-mRNA by binding to the phosphorylated carboxy-terminal domain of RNA polymerase II ⬇️

scientific article published on December 15, 1997

A G protein γ subunit-like domain shared between RGS11 and other RGS proteins specifies binding to G β5 subunits ⬇️

scientific article published on October 27, 1998

A Non-Canonical Function of Gβ as a Subunit of E3 Ligase in Targeting GRK2 Ubiquitylation

scientific article published on 14 May 2015

A P-loop Mutation in Gα Subunits Prevents Transition to the Active State: Implications for G-protein Signaling in Fungal Pathogenesis

scientific article

A Set of Human Putative Lymphocyte G0/G1Switch Genes Includes Genes Homologous to Rodent Cytokine and Zinc Finger Protein-Encoding Genes ⬇️

scientific article published on October 1, 1990

A bifunctional Galphai/Galphas modulatory peptide that attenuates adenylyl cyclase activity

scientific article published on October 2005

A capture coupling method for the covalent immobilization of hexahistidine tagged proteins for surface plasmon resonance

scientific article published on January 2010

A crystallographic view of interactions between Dbs and Cdc42: PH domain-assisted guanine nucleotide exchange

scientific article

A direct fluorescence-based assay for RGS domain GTPase accelerating activity

scientific article

A high throughput fluorescence polarization assay for inhibitors of the GoLoco motif/G-alpha interaction

scientific article

A homogeneous method to measure nucleotide exchange by α-subunits of heterotrimeric G-proteins using fluorescence polarization

scientific article published on 27 July 2010

A new family of regulators of G-protein-coupled receptors?

scientific article

A point mutation to Galphai selectively blocks GoLoco motif binding: direct evidence for Galpha.GoLoco complexes in mitotic spindle dynamics

scientific article

A role for Regulator of G protein Signaling-12 (RGS12) in the balance between myoblast proliferation and differentiation

scientific article published on 13 August 2019

A seven-transmembrane RGS protein that modulates plant cell proliferation.

scientific article

Analysis of Interactions between Regulator of G-Protein Signaling-14 and Microtubules

scientific article published on 01 January 2004

Application of RGS box proteins to evaluate G-protein selectivity in receptor-promoted signaling.

scientific article published in January 2004

Assays of complex formation between RGS protein G gamma subunit-like domains and G beta subunits

scientific article

Chemerin-activated functions of CMKLR1 are regulated by G protein-coupled receptor kinase 6 (GRK6) and β-arrestin 2 in inflammatory macrophages

scientific article published on 18 December 2018

Chronic olanzapine treatment causes differential expression of genes in frontal cortex of rats as revealed by DNA microarray technique

scientific article published on 11 January 2006

Cloning of a retinally abundant regulator of G-protein signaling (RGS-r/RGS16): genomic structure and chromosomal localization of the human gene

scientific article

Comment on "A G protein coupled receptor is a plasma membrane receptor for the plant hormone abscisic acid".

scientific article

Computational Design of the Sequence and Structure of a Protein-Binding Peptide ⬇️

scientific article published on March 9, 2011

Cooperative interaction between the DNA-binding domains of PU.1 and IRF4.

scientific article published in June 1998

Correction: Exome Sequencing in 53 Sporadic Cases of Schizophrenia Identifies 18 Putative Candidate Genes

scientific article published on 21 October 2015

Cortical localization of the Galpha protein GPA-16 requires RIC-8 function during C. elegans asymmetric cell division

scientific article published on 14 September 2005

Covalent immobilization of histidine-tagged proteins for surface plasmon resonance

scientific article published on 23 February 2006

Crystal structure of the multifunctional Gβ5–RGS9 complex

scientific article

D2 dopamine receptor activation of potassium channels is selectively decoupled by Galpha-specific GoLoco motif peptides.

scientific article published on March 2005

Development of full sweet, umami, and bitter taste responsiveness requires Regulator of G protein Signaling-21 (RGS21).

scientific article published on 26 April 2018

Differential G-alpha interaction capacities of the GoLoco motifs in Rap GTPase activating proteins

scientific article published on 01 September 2006

Differential expression of regulator of G-protein signaling R12 subfamily members during mouse development

scientific article published in October 2005

Entamoeba histolytica RacC selectively engages p21-activated kinase effectors

scientific article

Entamoeba histolytica Rho1 Regulates Actin Polymerization through a Divergent, Diaphanous-Related Formin ⬇️

scientific article published on October 23, 2012

Evaluating modulators of "Regulator of G-protein Signaling" (RGS) proteins

scientific article published on March 2012

Exome sequencing in 53 sporadic cases of schizophrenia identifies 18 putative candidate genes

scientific article

Functional relevance of the disulfide-linked complex of the N-terminal PDZ domain of InaD with NorpA

scientific article

G Protein signaling modulator-3 inhibits the inflammasome activity of NLRP3

scientific article

G alpha selectivity and inhibitor function of the multiple GoLoco motif protein GPSM2/LGN

scientific article published on 01 September 2005

G beta association and effector interaction selectivities of the divergent G gamma subunit G gamma(13)

scientific article (publication date: 28 December 2001)

G protein signaling in the parasite Entamoeba histolytica ⬇️

scientific article published on March 22, 2013

G-protein alpha subunit interaction and guanine nucleotide dissociation inhibitor activity of the dual GoLoco motif protein PCP-2 (Purkinje cell protein-2).

scientific article

G-protein signaling modulator-3 regulates heterotrimeric G-protein dynamics through dual association with Gβ and Gαi protein subunits

scientific article published on 13 December 2011

G-protein signaling modulator-3, a gene linked to autoimmune diseases, regulates monocyte function and its deficiency protects from inflammatory arthritis

scientific journal article

GPCR high throughput screening (part 1)

scientific article published on 01 June 2008

GTPase Activating Specificity of RGS12 and Binding Specificity of an Alternatively Spliced PDZ (PSD-95/Dlg/ZO-1) Domain ⬇️

scientific article published on July 10, 1998

GTPase acceleration as the rate-limiting step in Arabidopsis G protein-coupled sugar signaling

scholarly article

Galpha12/13- and rho-dependent activation of phospholipase C-epsilon by lysophosphatidic acid and thrombin receptors

scientific article published on 22 March 2006

Gbeta gamma isoforms selectively rescue plasma membrane localization and palmitoylation of mutant Galphas and Galphaq

scientific article (publication date: 29 June 2001)

Genetic deletion of Rgs12 in mice affects serotonin transporter expression and function in vivo and ex vivo

scientific article published on 25 August 2020

Genetic variations in GPSM3 associated with protection from rheumatoid arthritis affect its transcript abundance

scientific article published on 28 January 2016

Genome-scale analysis reveals Sst2 as the principal regulator of mating pheromone signaling in the yeast Saccharomyces cerevisiae.

scientific article

Ggamma-like (GGL) domains: new frontiers in G-protein signaling and beta-propeller scaffolding.

scientific article

Guanine nucleotide dissociation inhibitor activity of the triple GoLoco motif protein G18: alanine-to-aspartate mutation restores function to an inactive second GoLoco motif.

scientific article published on March 2004

Heterotrimeric G-protein Signaling Is Critical to Pathogenic Processes in Entamoeba histolytica ⬇️

scientific article published on November 15, 2012

High-affinity immobilization of proteins using biotin- and GST-based coupling strategies

scientific article

Induction of regulator of G-protein signaling 2 expression by long-acting β2-adrenoceptor agonists and glucocorticoids in human airway epithelial cells.

scientific article

Inhibition of dopamine transporter activity by G protein βγ subunits

scientific article

Integrating energy calculations with functional assays to decipher the specificity of G protein-RGS protein interactions.

scientific article

LGN regulates mitotic spindle orientation during epithelial morphogenesis

scientific article

Leukemia-associated Rho guanine nucleotide exchange factor promotes G alpha q-coupled activation of RhoA.

scientific article

Mammalian inscuteable regulates spindle orientation and cell fate in the developing retina

scientific article published on November 2005

Minimal determinants for binding activated G alpha from the structure of a G alpha(i1)-peptide dimer

scientific article published on September 2006

Modulating platelet reactivity through control of RGS18 availability.

scientific article

Negative regulation of PKB/Akt-dependent cell survival by the tumor suppressor PTEN

scientific journal article

Novel behavioral assays of spontaneous and precipitated THC withdrawal in mice

scientific article published on 07 July 2018

PB1 domain interaction of p62/sequestosome 1 and MEKK3 regulates NF-kappaB activation

scientific article

Preclinical Testing of Nalfurafine as an Opioid-sparing Adjuvant that Potentiates Analgesia by the Mu Opioid Receptor-targeting Agonist Morphine

scientific article published on 06 September 2019

Profound block in thymocyte development in mice lacking p56lck

scientific article

Protective Roles for RGS2 in a Mouse Model of House Dust Mite-Induced Airway Inflammation.

scientific article

Purification and in vitro functional analyses of RGS12 and RGS14 GoLoco motif peptides.

scientific article published in January 2004

Purification and in vitro functional analysis of the Arabidopsis thaliana regulator of G-protein signaling-1.

scientific article published in January 2004

Quantitative Analysis of the Effect of Phosphoinositide Interactions on the Function of Dbl Family Proteins

scientific article published in Journal of Biological Chemistry

RGS12 interacts with the SNARE-binding region of the Cav2.2 calcium channel

scientific article published on 9 November 2004

RIC-8 is required for GPR-1/2-dependent Galpha function during asymmetric division of C. elegans embryos

scientific article

RNA interference screen for RGS protein specificity at muscarinic and protease-activated receptors reveals bidirectional modulation of signaling

scientific article

Random mutagenesis of the human immunodeficiency virus type-1 trans-activator of transcription (HIV-1 Tat) ⬇️

scientific article published on October 25, 1992

Receptor-mediated activation of heterotrimeric G-proteins: current structural insights.

scientific article published on 12 April 2007

Receptor-selective effects of endogenous RGS3 and RGS5 to regulate mitogen-activated protein kinase activation in rat vascular smooth muscle cells

scientific journal article

Reduction of GPSM3 expression akin to the arthritis-protective SNP rs204989 differentially affects migration in a neutrophil model

scientific article published on 16 June 2016

Regulation of T cell activation, anxiety, and male aggression by RGS2.

scientific article

Regulation of protease-activated receptor 1 signaling by the adaptor protein complex 2 and R4 subfamily of regulator of G protein signaling proteins

scientific article published on 02 December 2013

Regulation of the subcellular localization of the G-protein subunit regulator GPSM3 through direct association with 14-3-3 protein ⬇️

scientific article published on July 26, 2012

Regulator of G protein signaling-12 modulates the dopamine transporter in ventral striatum and locomotor responses to psychostimulants

scientific article published in January 2018

Regulator of G-protein signaling 14 (RGS14) is a selective H-Ras effector

scientific journal article

Regulator of G-protein signaling-2 mediates vascular smooth muscle relaxation and blood pressure

scientific article

Regulators of G-Protein Signaling and Their Gα Substrates: Promises and Challenges in Their Use as Drug Discovery Targets ⬇️

scientific article published on July 7, 2011

Regulators of G-protein signalling as new central nervous system drug targets.

scientific article

Return of the GDI: the GoLoco motif in cell division.

scientific article

Rgs1 regulates multiple Galpha subunits in Magnaporthe pathogenesis, asexual growth and thigmotropism.

scientific article published on 25 January 2007

Ric-8 controls Drosophila neural progenitor asymmetric division by regulating heterotrimeric G proteins

scientific article published in November 2005

Role of the pleckstrin homology domain in intersectin-L Dbl homology domain activation of Cdc42 and signaling

scientific article published on April 2003

Selective role for RGS12 as a Ras/Raf/MEK scaffold in nerve growth factor-mediated differentiation

scientific article

Single Nucleotide Polymorphisms in Chemosensory Pathway Genes GNB3, TAS2R19, and TAS2R38 Are Associated with Chronic Rhinosinusitis

scientific article published on 28 May 2019

State-selective binding peptides for heterotrimeric G-protein subunits: novel tools for investigating G-protein signaling dynamics.

scientific article published on June 2008

Structural Determinants of G-protein   Subunit Selectivity by Regulator of G-protein Signaling 2 (RGS2)

scientific article

Structural Determinants of RGS-RhoGEF Signaling Critical to Entamoeba histolytica Pathogenesis

scientific article

Structural Determinants of Ubiquitin Conjugation in Entamoeba histolytica ⬇️

scientific article published on December 3, 2012

Structural and evolutionary division of phosphotyrosine binding (PTB) domains.

scientific article

Structural basis for the selective activation of Rho GTPases by Dbl exchange factors

scientific article

Structural determinants for GoLoco-induced inhibition of nucleotide release by Galpha subunits

scientific article published on 25 April 2002

Structural determinants underlying the temperature-sensitive nature of a Galpha mutant in asymmetric cell division of Caenorhabditis elegans

scientific article

Structural diversity in the RGS domain and its interaction with heterotrimeric G protein  -subunits

scientific article

Structure of Galpha(i1) bound to a GDP-selective peptide provides insight into guanine nucleotide exchange

scientific article published in July 2005

Telomerase-associated protein TEP1 is not essential for telomerase activity or telomere length maintenance in vivo

scientific article (publication date: November 2000)

The G betagamma dimer as a novel source of selectivity in G-protein signaling: GGL-ing at convention.

scientific article published in August 2004

The R6A-1 peptide binds to switch II of Galphai1 but is not a GDP-dissociation inhibitor

scientific article

The RGS protein inhibitor CCG-4986 is a covalent modifier of the RGS4 Galpha-interaction face

scientific article

The effect of RGS12 on PDGFbeta receptor signalling to p42/p44 mitogen activated protein kinase in mammalian cells

scientific article published on 7 October 2005

The mitochondrial proteins NLRX1 and TUFM form a complex that regulates type I interferon and autophagy.

scientific article

The stability of tastant detection by mouse lingual chemosensory tissue requires Regulator of G protein Signaling-21 (RGS21)

scientific article published on 01 January 2021

The telomerase reverse transcriptase is limiting and necessary for telomerase function in vivo.

scientific article published on November 2000

Tiam1 mediates Ras activation of Rac by a PI(3)K-independent mechanism

scientific article

Translation of polarity cues into asymmetric spindle positioning in Caenorhabditis elegans embryos

scientific article

Two Galpha(i1) rate-modifying mutations act in concert to allow receptor-independent, steady-state measurements of RGS protein activity

scientific article

Unique structural and nucleotide exchange features of the Rho1 GTPase of Entamoeba histolytica.

scientific article

β2-Adrenoceptor agonist-induced RGS2 expression is a genomic mechanism of bronchoprotection that is enhanced by glucocorticoids

scientific article published on 11 November 2011

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