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List of works by Jan Vijg

"Best-Guess" MRAD Provides Robust Evidence for a Limit to Human Lifespan: Reply to de Grey (Rejuvenation Res. 2017;20:261-262).

scientific article published on 6 October 2017

A Compendium of Age-Related PheWAS and GWAS Traits for Human Genetic Association Studies, Their Networks and Genetic Correlations

publication published on 01 June 2021

A direct comparison of interphase FISH versus low-coverage single cell sequencing to detect aneuploidy reveals respective strengths and weaknesses

scientific article published on 19 July 2019

A dual-activation, adenoviral-based system for the controlled induction of DNA double-strand breaks by the restriction endonuclease SacI.

scientific article

A high-fidelity method for genomic sequencing of single somatic cells reveals a very high mutational burden

scientific article

A model system for analyzing somatic mutations in Drosophila melanogaster

scientific article published on 15 April 2007

A new progeroid syndrome reveals that genotoxic stress suppresses the somatotroph axis

scientific article

A review of the biomedical innovations for healthy longevity

scientific article

A strategy for the ubiquitous overexpression of human catalase and CuZn superoxide dismutase genes in transgenic mice

scientific article

ARDD 2020: from aging mechanisms to interventions

scientific article published on 30 December 2020

Accelerated aging pathology in ad libitum fed Xpd(TTD) mice is accompanied by features suggestive of caloric restriction

scientific article published on 22 August 2005

Accelerating aging by mouse reverse genetics: a rational approach to understanding longevity

scientific article (publication date: April 2004)

Accurate identification of single-nucleotide variants in whole-genome-amplified single cells

scientific article published on 20 March 2017

Age- and temperature-dependent somatic mutation accumulation in Drosophila melanogaster

scientific article

Age-related mutation accumulation at a lacZ reporter locus in normal and tumor tissues of Trp53-deficient mice.

scientific article published in February 2002

Age-related somatic mutations in the cancer genome

scientific article

Age-related telomere attrition causes aberrant gene expression in sub-telomeric regions

scientific article published on 21 May 2021

Aging alters the apoptotic response to genotoxic stress ⬇️

scientific article published on January 1, 2002

Aging and genome maintenance

scientific article

Aging and genome maintenance: lessons from the mouse?

scientific article (publication date: 28 February 2003)

Aging and p53: getting it straight. A commentary on a recent paper by Gentry and Venkatachalam

scientific article published on 01 December 2005

Aging and the Inevitable Limit to Human Life Span

scientific article

Aging genomes: a necessary evil in the logic of life

scientific article

Aging on a different scale--chronological versus pathology-related aging

scientific article published on October 2013

Aging--lost in translation?

scientific article published on 01 December 2009

Aging. Genomic priorities in aging

scientific article

Aging: a sirtuin shake-up?

scientific article published on 01 November 2008

An essential role for senescent cells in optimal wound healing through secretion of PDGF-AA

scientific article

Analysis of individual cells identifies cell-to-cell variability following induction of cellular senescence

scientific article published on 11 July 2017

Attenuation of leukocyte-endothelium interaction by antioxidant enzymes

scientific article published on 01 August 2003

Bleomycin-induced genome structural variations in normal, non-tumor cells

scientific article published in Scientific Reports

Broad segmental progeroid changes in short-lived Ercc1(-/Δ7) mice

scientific article

Catalase transgenic mice: characterization and sensitivity to oxidative stress

scientific article published in February 2004

Cell Replacement to Reverse Brain Aging: Challenges, Pitfalls, and Opportunities

scientific article published on 8 March 2018

Centenarians as super-controls to assess the biological relevance of genetic risk factors for common age-related diseases: a proof of principle on type 2 diabetes

scientific article published on May 2013

Characterization of transgenic mice that overexpress both copper zinc superoxide dismutase and catalase

scientific article published on 01 March 2006

Chromatin unbound

scientific article published in Nature

Chromosomal aneuploidy in the aging brain

scientific article

Chromosome-specific accumulation of aneuploidy in the aging mouse brain

scientific article

Clonally expanded mtDNA point mutations are abundant in individual cells of human tissues

scientific article

Combined oral benzo[a]pyrene and inhalatory ozone exposure have no effect on lung tumor development in DNA repair-deficient Xpa mice

scientific article

Comparative analysis of genome maintenance genes in naked mole rat, mouse, and human

scientific article published on 28 January 2015

Comparative genetics of longevity and cancer: insights from long-lived rodents

scientific article

Comparison of DNA- and RNA-based methods for detection of truncating BRCA1 mutations

scientific article published on July 2002

Comprehensive and accurate mutation scanning of theCFTR gene by two-dimensional DNA electrophoresis

article

Comprehensive microRNA profiling in B-cells of human centenarians by massively parallel sequencing ⬇️

scientific article published on July 31, 2012

Comprehensive transcriptional landscape of aging mouse liver

scientific article

Controlled induction of DNA double-strand breaks in the mouse liver induces features of tissue ageing

scientific article

Corrigendum to “What evidence is there for the existence of individual genes with antagonistic pleiotropic effects?” [Mechanisms of Ageing and Development 126 (2005) 421–429]

article

DNA damage and ageing: new-age ideas for an age-old problem

scientific article

DNA damage in normally and prematurely aged mice ⬇️

scientific article published on April 24, 2013

DNA repair in species with extreme lifespan differences

scientific article

DNA structure-induced genomic instability in vivo

scientific article published on 09 December 2008

Deep biomarkers of human aging: Application of deep neural networks to biomarker development

scientific article

Deficiency of the DNA repair protein nibrin increases the basal but not the radiation induced mutation frequency in vivo.

scientific article published on 11 July 2014

Deletion of individual Ku subunits in mice causes an NHEJ-independent phenotype potentially by altering apurinic/apyrimidinic site repair

scientific article published on 23 January 2014

Deletion of p66Shc in mice increases the frequency of size-change mutations in the lacZ transgene

scientific article

Detection and analysis of somatic mutations at a lacZ reporter locus in higher organisms: application to Mus musculus and Drosophila melanogaster

scientific article published on January 2007

Detection by denaturing gradient gel electrophoresis of pncA mutations associated with pyrazinamide resistance in Mycobacterium tuberculosis isolates from the United States-Mexico border region

scientific article published on June 2005

Detection of rpoB mutations associated with rifampin resistance in Mycobacterium tuberculosis using denaturing gradient gel electrophoresis

scientific article published on June 2005

Development and validation of a targeted next generation DNA sequencing panel outperforming whole exome sequencing for the identification of clinically relevant genetic variants

scientific article published on 26 October 2017

Development of a Method to Implement Whole-Genome Bisulfite Sequencing of cfDNA from Cancer Patients and a Mouse Tumor Model

scientific article published on 23 January 2018

Development of a Targeted Multi-Disorder High-Throughput Sequencing Assay for the Effective Identification of Disease-Causing Variants.

scientific article published on 27 July 2015

Differences between germline and somatic mutation rates in humans and mice

scientific article

Direct mutation analysis by high-throughput sequencing: from germline to low-abundant, somatic variants

scientific article published on 12 October 2011

Direct, genome-wide assessment of DNA mutations in single cells.

scientific article published on 15 November 2011

Do DNA Double-Strand Breaks Drive Aging?

scientific article

Does damage to DNA and other macromolecules play a role in aging? If so, how?

scientific article published on 19 February 2009

Does premature aging of the mtDNA mutator mouse prove that mtDNA mutations are involved in natural aging?

scientific article

Dong et al. reply

scientific article published in June 2017

Dong et al. reply

journal article; published in Nature on 2017-06-29

Dong et al. reply

scientific article published on 01 June 2017

Dong et al. reply

article published in 2017

Dong et al. reply

Editorial

Editorial overview: Molecular and genetic bases of disease: the double life of DNA.

scientific article published on June 2014

Effect of Ames dwarfism and caloric restriction on spontaneous DNA mutation frequency in different mouse tissues

scientific article published on 13 May 2008

Effect of Ku80 deficiency on mutation frequencies and spectra at a LacZ reporter locus in mouse tissues and cells

scientific article

Epigenetic factors in aging and longevity

scientific article published on 19 September 2009

Evidence for a limit to human lifespan

scientific article

FOXO3a acts to suppress DNA double-strand break-induced mutations

scientific article published on 28 July 2020

Fast mitochondrial DNA isolation from mammalian cells for next-generation sequencing

scientific article published on September 2013

Four-color FISH for the detection of low-level aneuploidy in interphase cells

scientific article published in January 2014

Functional genomics of ageing

scientific article

Genetic analysis reveals an intrinsic property of the germinal center B cells to generate A:T mutations

scientific article published on 17 June 2008

Genetic evidence for common pathways in human age-related diseases

scientific article

Genetics of extreme human longevity to guide drug discovery for healthy ageing

scientific article published on 27 July 2020

Genetics of longevity and aging

scientific article

Genome Instability and Aging ⬇️

scientific article published on January 1, 2013

Genome Scanning of Human Breast Carcinomas Using Micro- and Minisatellite Core Probes

Genome dynamics in aging mice

scientific article published on November 2002

Genome instability, cancer and aging

scientific article

Genome instability: a conserved mechanism of ageing?

scientific article

Genome instability: cancer or aging?

scientific article published on 21 May 2007

Genome-wide quantitative analysis of DNA methylation from bisulfite sequencing data

scientific article

Genome-wide, Single-Cell DNA Methylomics Reveals Increased Non-CpG Methylation during Human Oocyte Maturation.

scientific article published on 19 June 2017

Global, integrated analysis of methylomes and transcriptomes from laser capture microdissected bronchial and alveolar cells in human lung

scientific article published on 21 February 2018

Haploinsufficiency in DNA polymerase beta increases cancer risk with age and alters mortality rate

scientific article published in August 2006

High preservation of CpG cytosine methylation patterns at imprinted gene loci in liver and brain of aged mice

scientific article

High-throughput sequencing in mutation detection: A new generation of genotoxicity tests?

scientific article

Homeostatic imbalance between apoptosis and cell renewal in the liver of premature aging Xpd mice

scientific journal article

INK4 locus of the tumor-resistant rodent, the naked mole rat, expresses a functional p15/p16 hybrid isoform

scientific article

Impact of genome instability on transcription regulation of aging and senescence

scientific article

Impact papers on aging in 2009.

scientific article

Improved transposon-based library preparation for the Ion Torrent platform

scientific article

In silico Pathway Activation Network Decomposition Analysis (iPANDA) as a method for biomarker development.

scientific article

Increased cell-to-cell variation in gene expression in ageing mouse heart

scientific article

Increased genomic instability is not a prerequisite for shortened lifespan in DNA repair deficient mice

scientific article published on 10 February 2006

Innovating aging: promises and pitfalls on the road to life extension

scientific article

Interventions to Slow Aging in Humans: Are We Ready?

scientific article

Interview with Jan Vijg, Ph.D. [Interviewed by Vicki Glaser].

scientific article published in October 2010

Intra-organ variation in age-related mutation accumulation in the mouse

scientific article

Ku80 deletion suppresses spontaneous tumors and induces a p53-mediated DNA damage response

scientific article

Large genome rearrangements as a primary cause of aging

scientific article

Life spanning murine gene expression profiles in relation to chronological and pathological aging in multiple organs

scientific article published on 14 July 2013

Lifespan extension by dietary restriction is not linked to protection against somatic DNA damage in Drosophila melanogaster

scientific article

Loss of the bloom syndrome helicase increases DNA ligase 4-independent genome rearrangements and tumorigenesis in aging Drosophila

scientific article published on 19 December 2011

MPHASYS: a mouse phenotype analysis system

scientific article

Maintaining genetic integrity in aging: a zero sum game

scientific article

Measuring Genome Instability in Aging – A Mini-Review ⬇️

scientific article published on December 10, 2011

Mechanisms and consequences of aneuploidy and chromosome instability in the aging brain

scientific article

Mechanisms of cancer resistance in long-lived mammals

scientific article published on 5 April 2018

Mitochondrial DNA mutations and aging: a case closed?

scientific article published on 01 April 2007

Mitochondrial DNA mutations and aging: devils in the details?

scientific article published on 26 December 2008

Mouse models for xeroderma pigmentosum group A and group C show divergent cancer phenotypes

scientific article

Mutant frequencies and spectra depend on growth state and passage number in cells cultured from transgenic lacZ-plasmid reporter mice

scientific article published on 26 August 2005

Mutation and catastrophe in the aging genome.

scientific article

Mutation frequencies and spectra in DNA polymerase eta-deficient mice

scientific article published in April 2008

Mutational fingerprints of aging ⬇️

scientific article published on January 15, 2002

Myc-dependent genome instability and lifespan in Drosophila

scientific article

New Insights into Bioactive Compounds of Traditional Chinese Medicines for Insulin Resistance Based on Signaling Pathways

scientific article published on 17 September 2019

Nuclear Genomic Instability and Aging

scientific article published on 01 June 2018

On key lesions and all that: a tribute to Paul Lohman

scientific article

Organ-specific increase in mutation accumulation and apoptosis rate in CuZn-superoxide dismutase-deficient mice

scientific journal article

Oxygen accelerates the accumulation of mutations during the senescence and immortalization of murine cells in culture

scientific article published on December 2003

Pathogenic Mechanisms of Somatic Mutation and Genome Mosaicism in Aging

scientific article published on 01 July 2020

Puzzles, promises and a cure for ageing

scientific article published on August 2008

Quantitative detection of low-abundance somatic structural variants in normal cells by high-throughput sequencing

scientific article

RAD51 mutants cause replication defects and chromosomal instability

scientific journal article

Rapid mitochondrial DNA isolation method for direct sequencing

scientific article published in January 2015

Rebuttal to Miller: 'Accelerated aging': a primrose path to insight?'

scientific article (publication date: April 2004)

Reduction of pressor response to vasoconstrictor agents by overexpression of catalase in mice

scientific article published on January 2003

SCCNV: A Software Tool for Identifying Copy Number Variation From Single-Cell Whole-Genome Sequencing

scientific article published on 16 November 2020

SIRT6 Is Responsible for More Efficient DNA Double-Strand Break Repair in Long-Lived Species

scientific article published on 01 April 2019

SNP discovery in associating genetic variation with human disease phenotypes

scientific article

SNP'ing for longevity

scientific article published on 6 May 2009

Searching for genetic determinants of human aging and longevity: opportunities and challenges ⬇️

scientific article published on January 1, 2002

Sensitivity of primary fibroblasts in culture to atmospheric oxygen does not correlate with species lifespan.

scientific article published on 07 May 2016

Single-cell genome-wide bisulfite sequencing uncovers extensive heterogeneity in the mouse liver methylome

scientific article published on 05 July 2016

Single-cell transcriptogenomics reveals transcriptional exclusion of ENU-mutated alleles

scientific article

Single-cell whole-genome sequencing reveals the functional landscape of somatic mutations in B lymphocytes across the human lifespan

scientific article

Single-cell, locus-specific bisulfite sequencing (SLBS) for direct detection of epimutations in DNA methylation patterns

scientific article

SomaMutDB: a database of somatic mutations in normal human tissues

scientific article published on 01 January 2022

Somatic Mutagenesis in Mammals and Its Implications for Human Disease and Aging

scientific article published on 13 September 2018

Somatic mutations, genome mosaicism, cancer and aging

scientific article

Systems-level analysis of human aging genes shed new light on mechanisms of aging.

scientific article published on 14 May 2016

The Essence of Aging

scientific article published on 22 September 2015

The Future of Human Longevity: Time for a Reality Check

scientific article published on 22 August 2017

The Long and Short of Fertility and Longevity ⬇️

scientific article published on September 8, 2010

The dark side of circulating nucleic acids

scientific article

The demographic and biomedical case for late-life interventions in aging

scientific article published on July 2010

The overexpression of major antioxidant enzymes does not extend the lifespan of mice

scientific article published on 11 December 2008

The progeroid phenotype of Ku80 deficiency is dominant over DNA-PKCS deficiency

scientific article published in 2014

The role of DNA damage and repair in aging: new approaches to an old problem

scientific article published on 29 February 2008

The second international conference "genetics of aging and longevity".

scientific article published on May 2012

Time, tumours and telomeres. Meeting on Cancer and Aging

scientific article published on May 2006

Transcripts of aging

scientific article published on June 2004

Turning anti-ageing genes against cancer

scientific article published in November 2008

What evidence is there for the existence of individual genes with antagonistic pleiotropic effects?

scientific article

Whole Chromosome Instability induces senescence and promotes SASP.

scientific article published on 12 October 2016

Whole chromosome aneuploidy in the brain of Bub1bH/H and Ercc1-/Δ7 mice

scientific article published on 17 December 2015

Whole genome sequencing of glioblastoma multiforme identifies multiple structural variations involved in EGFR activation

scientific article

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