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List of works by Bruce Spiegelman

"The adipocyte: a multifunctional cell".

scientific article published in December 2006

A PGC-1α isoform induced by resistance training regulates skeletal muscle hypertrophy

scientific article

A PGC1-α-dependent myokine that drives brown-fat-like development of white fat and thermogenesis

scientific journal article

A chemical screen probing the relationship between mitochondrial content and cell size

scientific article

A conversation with Bruce Spiegelman. Interviewed by Ushma Neill

scientific article published in May 2013

A creatine-driven substrate cycle enhances energy expenditure and thermogenesis in beige fat.

scientific article

A functional peroxisome proliferator-activated receptor-gamma ligand-binding domain is not required for adipogenesis

scientific article

A fundamental system of cellular energy homeostasis regulated by PGC-1alpha

scholarly article

A novel therapeutic approach to treating obesity through modulation of TGFβ signaling

scientific article published on May 2012

A phase II study of troglitazone, an activator of the PPARgamma receptor, in patients with chemotherapy-resistant metastatic colorectal cancer

scientific article published in September 2002

APC-dependent suppression of colon carcinogenesis by PPARgamma

scientific journal article

Abnormal glucose homeostasis in skeletal muscle-specific PGC-1alpha knockout mice reveals skeletal muscle-pancreatic beta cell crosstalk

scientific article

Adaptive thermogenesis in adipocytes: is beige the new brown?

scientific article

Adipsin is an adipokine that improves β cell function in diabetes

scientific article

An ERK/Cdk5 axis controls the diabetogenic actions of PPARγ.

scientific article

An autoregulatory loop controls peroxisome proliferator-activated receptor gamma coactivator 1alpha expression in muscle

scientific article

Anti-diabetic drugs inhibit obesity-linked phosphorylation of PPARgamma by Cdk5.

scientific article

Appearance and disappearance of the mRNA signature characteristic of Treg cells in visceral adipose tissue: age, diet, and PPARγ effects

scientific article

Attenuated PGC-1α Isoforms following Endurance Exercise with Blood Flow Restriction

scientific article published in September 2016

Banting Lecture 2012: Regulation of adipogenesis: toward new therapeutics for metabolic disease

scientific article published on June 2013

Bioenergetic analysis of peroxisome proliferator-activated receptor gamma coactivators 1alpha and 1beta (PGC-1alpha and PGC-1beta) in muscle cells

scientific article published on 6 May 2003

Biological control through regulated transcriptional coactivators

scientific article

Brown Adipose Tissue Controls Skeletal Muscle Function via the Secretion of Myostatin

scholarly article by Xingxing Kong published in October 2018

Brown and Beige Fat: Molecular Parts of a Thermogenic Machine

scientific article

Brown and Beige Fat: Physiological Roles beyond Heat Generation

scientific article published on October 2015

C/EBPalpha induces adipogenesis through PPARgamma: a unified pathway

scientific article

C/EBPβ Controls Exercise-Induced Cardiac Growth and Protects against Pathological Cardiac Remodeling ⬇️

scientific article published on December 23, 2010

CACHEXIA & BROWN FAT: A BURNING ISSUE IN CANCER.

scientific article published on September 2016

CITED4 induces physiologic hypertrophy and promotes functional recovery after ischemic injury

scientific article published on June 2016

Cell biology of fat storage

scientific article

Characterization of the peroxisome proliferator activated receptor coactivator 1 alpha (PGC 1alpha) expression in the murine brain

scientific article

Combined training enhances skeletal muscle mitochondrial oxidative capacity independent of age

scientific article

Complementary action of the PGC-1 coactivators in mitochondrial biogenesis and brown fat differentiation

scientific article published on May 2006

Coordination of p300-mediated chromatin remodeling and TRAP/mediator function through coactivator PGC-1alpha

scientific article

Crosstalk between KCNK3-Mediated Ion Current and Adrenergic Signaling Regulates Adipose Thermogenesis and Obesity

scientific article

Defects in energy homeostasis in Leigh syndrome French Canadian variant through PGC-1alpha/LRP130 complex

scientific article

Detection and Quantitation of Circulating Human Irisin by Tandem Mass Spectrometry

scientific article

Disorder-to-order transition underlies the structural basis for the assembly of a transcriptionally active PGC-1α/ERRγ complex ⬇️

scientific article published on November 2, 2011

Do Adipocytes Emerge from Mural Progenitors?

scientific article published in May 2017

Erralpha and Gabpa/b specify PGC-1alpha-dependent oxidative phosphorylation gene expression that is altered in diabetic muscle

scientific article

Erratum: correction: CREB regulates hepatic gluconeogenesis through the coactivator PGC-1

scientific article published in Nature

Exercise induces hippocampal BDNF through a PGC-1α/FNDC5 pathway

scientific article

FGF21 regulates PGC-1α and browning of white adipose tissues in adaptive thermogenesis

scientific article published on February 2012

Fat cells directly sense temperature to activate thermogenesis

scientific article published on July 2013

G protein-coupled receptor 56 regulates mechanical overload-induced muscle hypertrophy

scientific article

Gene expression-based screening identifies microtubule inhibitors as inducers of PGC-1alpha and oxidative phosphorylation

scholarly article

Genetic Depletion of Adipocyte Creatine Metabolism Inhibits Diet-Induced Thermogenesis and Drives Obesity

scientific article published on October 2017

Genetic Depletion of Adipocyte Creatine Metabolism Inhibits Diet-Induced Thermogenesis and Drives Obesity

scientific article published on 23 August 2017

Genetic analysis of adipogenesis through peroxisome proliferator-activated receptor gamma isoforms

scientific article published on 27 August 2002

Hic-5 regulates an epithelial program mediated by PPARgamma

scientific journal article

Hyperlipidemic effects of dietary saturated fats mediated through PGC-1beta coactivation of SREBP.

scientific article

Hypomorphic mutation of PGC-1beta causes mitochondrial dysfunction and liver insulin resistance

scientific article published on December 2006

Initiation of myoblast to brown fat switch by a PRDM16-C/EBP-beta transcriptional complex

scientific article

Integrated Regulation of Hepatic Metabolism by Fibroblast Growth Factor 21 (FGF21) in Vivo ⬇️

scientific article published on June 28, 2011

International Union of Pharmacology. LXI. Peroxisome proliferator-activated receptors

scientific article

Irisin ERKs the fat.

scientific article published on February 2014

Irisin and the therapeutic benefits of exercise. ⬇️

scientific article published in June 2012

Krox20 stimulates adipogenesis via C/EBPbeta-dependent and -independent mechanisms

scientific article

Lysine-specific demethylase 1 promotes brown adipose tissue thermogenesis via repressing glucocorticoid activation

scientific article published on 26 August 2016

Meteorin-like is a hormone that regulates immune-adipose interactions to increase beige fat thermogenesis

scientific journal article

Mitochondrial Patch Clamp of Beige Adipocytes Reveals UCP1-Positive and UCP1-Negative Cells Both Exhibiting Futile Creatine Cycling

scientific article

Mitochondrial ROS regulate thermogenic energy expenditure and sulfenylation of UCP1

scientific journal article

Mitochondrial reactive oxygen species and adipose tissue thermogenesis: Bridging physiology and mechanisms

scientific article published on 24 August 2017

Modulation of PGC-1 coactivator pathways in brown fat differentiation through LRP130.

scientific article published on 26 August 2008

Molecular mechanisms of cancer development in obesity ⬇️

scientific article published on November 24, 2011

Muscle-specific PPARgamma-deficient mice develop increased adiposity and insulin resistance but respond to thiazolidinediones

scientific article

Muscle-specific expression of PPARgamma coactivator-1alpha improves exercise performance and increases peak oxygen uptake

scientific article published on 31 January 2008

NR4A orphan nuclear receptors as mediators of CREB-dependent neuroprotection

scientific journal article

Noncanonical agonist PPARγ ligands modulate the response to DNA damage and sensitize cancer cells to cytotoxic chemotherapy

scientific article published on 2 January 2018

Nutrient control of glucose homeostasis through a complex of PGC-1alpha and SIRT1

scientific article (publication date: 3 March 2005)

Nutritional regulation of hepatic heme biosynthesis and porphyria through PGC-1alpha

scientific article published in August 2005

PGC-1alpha negatively regulates hepatic FGF21 expression by modulating the heme/Rev-Erb(alpha) axis

scientific article

PGC-1alpha protects skeletal muscle from atrophy by suppressing FoxO3 action and atrophy-specific gene transcription

scholarly article

PGC-1alpha regulates a HIF2alpha-dependent switch in skeletal muscle fiber types

scientific journal article

PGC-1beta in the regulation of hepatic glucose and energy metabolism

scientific journal article

PPAR{delta} agonism activates fatty acid oxidation via PGC-1{alpha} but does not increase mitochondrial gene expression and function

scientific article published on 12 May 2009

PRDM16 controls a brown fat/skeletal muscle switch

scientific article

PTH/PTHrP Receptor Mediates Cachexia in Models of Kidney Failure and Cancer

scientific article

Paradoxical effects of increased expression of PGC-1alpha on muscle mitochondrial function and insulin-stimulated muscle glucose metabolism

scholarly article

Peroxisome Proliferator-activated Receptor γ Coactivator 1β (PGC-1β), A Novel PGC-1-related Transcription Coactivator Associated with Host Cell Factor ⬇️

scientific article (publication date: 18 January 2002)

Peroxisome proliferator-activated receptor gamma coactivator 1 coactivators, energy homeostasis, and metabolism

scientific article

Peroxisome proliferator-activated receptor-gamma coactivator 1 alpha (PGC-1 alpha): transcriptional coactivator and metabolic regulator

scientific article

Prdm16 determines the thermogenic program of subcutaneous white adipose tissue in mice ⬇️

scientific article published on December 1, 2010

QnAs with Bruce M. Spiegelman

scientific article published on 14 November 2011

RETRACTED: Activation of the PPAR/PGC-1alpha pathway prevents a bioenergetic deficit and effectively improves a mitochondrial myopathy phenotype

retracted scientific article published on September 2008

Regulation of hepatic fasting response by PPARgamma coactivator-1alpha (PGC-1): requirement for hepatocyte nuclear factor 4alpha in gluconeogenesis

scholarly article

Regulation of the brown and white fat gene programs through a PRDM16/CtBP transcriptional complex

scientific journal article

Response to Comment on Wu and Spiegelman. Irisin ERKs the fat. Diabetes 2014;63:381-383.

scientific article published in September 2014

Retracted: Increased muscle PGC-1α expression protects from sarcopenia and metabolic disease during aging

retracted scientific article

Retraction Notice to: Activation of the PPAR/PGC-1α Pathway Prevents a Bioenergetic Deficit and Effectively Improves a Mitochondrial Myopathy Phenotype

scientific article published on December 2016

Retrograde influence of muscle fibers on their innervation revealed by a novel marker for slow motoneurons

scientific article

Rosiglitazone versus placebo for men with prostate carcinoma and a rising serum prostate-specific antigen level after radical prostatectomy and/or radiation therapy

scientific article published in October 2004

Se-Jin Lee, myostatin discoverer, elected to the National Academy of Science ⬇️

scientific article published on June 7, 2012

Sensitivity of lipid metabolism and insulin signaling to genetic alterations in hepatic peroxisome proliferator-activated receptor-gamma coactivator-1alpha expression

scientific article published on 14 April 2009

Separation of the gluconeogenic and mitochondrial functions of PGC-1{alpha} through S6 kinase

scientific article

Suppression of beta cell energy metabolism and insulin release by PGC-1alpha

scientific article published on July 2003

Suppression of mitochondrial respiration through recruitment of p160 myb binding protein to PGC-1alpha: modulation by p38 MAPK

scientific article

Synergy between PPARgamma ligands and platinum-based drugs in cancer

scientific article published on May 2007

TAZ, a transcriptional modulator of mesenchymal stem cell differentiation

scientific article

TRPV4 is a regulator of adipose oxidative metabolism, inflammation, and energy homeostasis

scientific journal article

Targeted elimination of peroxisome proliferator-activated receptor gamma in beta cells leads to abnormalities in islet mass without compromising glucose homeostasis

scientific article published on October 2003

The Cancer Drug Dasatinib Increases PGC-1α in Adipose Tissue but Has Adverse Effects on Glucose Tolerance in Obese Mice

scientific article

The Secreted Enzyme PM20D1 Regulates Lipidated Amino Acid Uncouplers of Mitochondria

scientific journal article

The future of brown adipose tissues in the treatment of type 2 diabetes

scientific article published on 9 May 2015

The orphan nuclear receptor SHP regulates PGC-1alpha expression and energy production in brown adipocytes

scientific article

The perils of putting career before all else

scientific article published in March 2002

The role of exercise and PGC1alpha in inflammation and chronic disease

scientific article published on July 2008

The transcriptional coactivator PGC-1beta drives the formation of oxidative type IIX fibers in skeletal muscle

scientific article published on January 2007

The unfolded protein response mediates adaptation to exercise in skeletal muscle through a PGC-1α/ATF6α complex

scientific article

Thrap3 docks on phosphoserine 273 of PPARγ and controls diabetic gene programming

scientific article

Time window expansion for HDX analysis of an intrinsically disordered protein

scientific article published on 25 July 2013

Transcription coactivator TRAP220 is required for PPAR gamma 2-stimulated adipogenesis

scientific article

Transcriptional coactivator PGC-1 alpha controls the energy state and contractile function of cardiac muscle

scientific article

Transcriptional control of brown adipocyte development and physiological function--of mice and men.

scientific article published on April 2009

Transcriptional control of brown fat determination by PRDM16

scientific journal article

Transcriptional control of brown fat development

scientific article published on April 2010

Transcriptional control of mitochondrial energy metabolism through the PGC1 coactivators.

scientific article published on January 2007

Transcriptional control of preadipocyte determination by Zfp423.

scientific article

Transducer of regulated CREB-binding proteins (TORCs) induce PGC-1alpha transcription and mitochondrial biogenesis in muscle cells

scientific article

Transverse aortic constriction leads to accelerated heart failure in mice lacking PPAR-gamma coactivator 1alpha

scholarly article

Tumour-derived PTH-related protein triggers adipose tissue browning and cancer cachexia

scientific article published on 13 July 2014

UCP1 deficiency causes brown fat respiratory chain depletion and sensitizes mitochondria to calcium overload-induced dysfunction

scientific article

Use of the peroxisome proliferator-activated receptor (PPAR) gamma ligand troglitazone as treatment for refractory breast cancer: a phase II study

scientific article published in June 2003

What we talk about when we talk about fat.

scientific article published on January 2014

Zfp423 Expression Identifies Committed Preadipocytes and Localizes to Adipose Endothelial and Perivascular Cells ⬇️

scientific article published on February 8, 2012

miR-222 is necessary for exercise-induced cardiac growth and protects against pathological cardiac remodeling

scientific article

p38 mitogen-activated protein kinase is the central regulator of cyclic AMP-dependent transcription of the brown fat uncoupling protein 1 gene

scientific article published in April 2004

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