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List of works by Thomas Waldmann

31st Annual Meeting and Associated Programs of the Society for Immunotherapy of Cancer (SITC 2016): part one

scientific article (publication date: November 2016)

90Y-Daclizumab (Anti-CD25), High-Dose Carmustine, Etoposide, Cytarabine, and Melphalan Chemotherapy and Autologous Hematopoietic Stem Cell Transplant Yielded Sustained Complete Remissions in 4 Patients with Recurrent Hodgkin's Lymphoma

scientific article published on 09 April 2020

90Y-daclizumab, an anti-CD25 monoclonal antibody, provided responses in 50% of patients with relapsed Hodgkin's lymphoma

scientific article

A First-in-Human Phase 1 Study of Subcutaneous Outpatient Recombinant Human IL-15 (rhIL-15) in Adults with Advanced Solid Tumors.

scientific article published on 4 December 2017

A biophysical approach to IL-2 and IL-15 receptor function: localization, conformation and interactions

scientific article published on 31 January 2008

A double-masked, randomized study to investigate the safety and efficacy of daclizumab to treat the ocular complications related to Behçet's disease

scientific article

A gain-of-function CCR4 mutations in adult T-cell leukemia/lymphoma (ATL) enhance the chemotactic abilities and P13K/AKT activation.

scientific article

A multi-valent vaccinia virus-based tuberculosis vaccine molecularly adjuvanted with interleukin-15 induces robust immune responses in mice

scientific article published on 06 February 2009

A new domain in the Toll/IL-1R domain-containing adaptor inducing interferon-β factor protein amino terminus is important for tumor necrosis factor-α receptor-associated factor 3 association, protein stabilization and interferon signaling

scientific article

A pilot study of CTLA-4 blockade after cancer vaccine failure in patients with advanced malignancy

article

Adult T-cell leukemia cells overexpress Wnt5a and promote osteoclast differentiation ⬇️

scientific article published on 09 May 2013

Analysis of Human Natural Killer Cell Metabolism

scientific article published on 22 June 2020

Antibody-based therapy of leukaemia

scientific article published on 30 September 2009

Antibody-mediated blockade of IL-15 reverses the autoimmune intestinal damage in transgenic mice that overexpress IL-15 in enterocytes

scientific article

Application of a macromolecular contrast agent for detection of alterations of tumor vessel permeability induced by radiation

scientific article published on 01 November 2004

Augmented efficacy of brentuximab vedotin combined with ruxolitinib and/or Navitoclax in a murine model of human Hodgkin's lymphoma

scientific article published on 25 January 2016

Autocrine/paracrine cytokine stimulation of leukemic cell proliferation in smoldering and chronic adult T-cell leukemia ⬇️

scientific article published on September 21, 2010

Bench-to-bedside translation of Interleukin-15 for immunotherapy: principles and challenges

scientific article published on 01 May 2020

Burkitt lymphoma pathogenesis and therapeutic targets from structural and functional genomics

scientific article published on 12 August 2012

CITN-06: a Phase I/expansion trial of alt-803, an IL-15 superagonist, in patients with advanced melanoma.

scientific article

CITN11-02 interim trial results: subcutaneous administration of recombinant human IL-15 (rhIL-15) is associated with expansion of peripheral blood CD56+ NK cells and CD8+ T cells.

scientific article published on 4 November 2015

CITN11-02 interim trial results: subcutaneous administration of recombinant human IL-15 (rhil-15) is associated with robust expansion of peripheral blood CD56+ NK cells

scientific article published on 6 November 2014

CP-690,550, a therapeutic agent, inhibits cytokine-mediated Jak3 activation and proliferation of T cells from patients with ATL and HAM/TSP

scientific article

Cardiac involvement with human T-cell lymphotrophic virus type-1-associated adult T-cell leukemia/lymphoma: The NIH experience

scientific article published in March 2008

Central memory self/tumor-reactive CD8+ T cells confer superior antitumor immunity compared with effector memory T cells

scientific article

Chimeric antigen receptor modified T cells that target chemokine receptor CCR4 as a therapeutic modality for T-cell malignancies.

scientific article

Clinical manufacturing of recombinant human interleukin 15. I. Production cell line development and protein expression in E. coli with stop codon optimization ⬇️

scientific article published on December 9, 2011

Clinical trial of a humanized anti-IL-2/IL-15 receptor β chain in HAM/TSP

scientific article published on 05 July 2019

Clinical trial of a humanized monoclonal anti-IL15Rβ (CD122), in HTLV-1 associated myelopathy/ tropical spastic paraparesis (HAM/TSP).

scientific article published on 7 January 2014

Co-expression of Interleukin-15 Enhances the Protective Immune Responses Induced by Immunization with a Murine Malaria MVA-Based Vaccine Encoding the Circumsporozoite Protein

scientific article published on 27 October 2015

Coadministration of HIV vaccine vectors with vaccinia viruses expressing IL-15 but not IL-2 induces long-lasting cellular immunity

scholarly article

Colorectal carcinoma rearranges cell surface protein topology and density in CD4+ T cells

article published in 2007

Combination of 9-aminoacridine with Campath-1H provides effective therapy for a murine model of adult T-cell leukemia

scientific article

Combination therapy for adult T-cell leukemia-xenografted mice: flavopiridol and anti-CD25 monoclonal antibody

scientific article published on 21 September 2004

Complete Remissions of Adult T-cell Leukemia with Anti-CD25 Recombinant Immunotoxin LMB-2 and Chemotherapy to Block Immunogenicity

scientific article published on 8 September 2015

Cytokine receptor signaling is required for the survival of ALK- anaplastic large cell lymphoma, even in the presence of JAK1/STAT3 mutations

scientific article published on 29 March 2017

Cytokines in the Treatment of Cancer

scientific article published on 11 June 2018

Dendritic cell-derived interleukin-15 is crucial for therapeutic cancer vaccine potency

scientific article

Detection of channel proximity by nanoparticle-assisted delaying of toxin binding; a combined patch-clamp and flow cytometric energy transfer study

scientific article published on March 2005

Detection of lymph node involvement in hematologic malignancies using micromagnetic resonance lymphangiography with a gadolinum-labeled dendrimer nanoparticle

scientific article

Detection of receptor trimers on the cell surface by flow cytometric fluorescence energy homotransfer measurements

Development of a highly efficacious vaccinia-based dual vaccine against smallpox and anthrax, two important bioterror entities ⬇️

scientific article published on October 4, 2010

Development of an IL-15–autocrine CD8 T-cell leukemia in IL-15–transgenic mice requires the cis expression of IL-15Rα ⬇️

scientific article published on February 8, 2011

Development of antibodies and chimeric molecules for cancer immunotherapy

scientific article

Development of smallpox vaccine candidates with integrated interleukin-15 that demonstrate superior immunogenicity, efficacy, and safety in mice

scientific article

Disorders of the JAK/STAT Pathway in T Cell Lymphoma Pathogenesis: Implications for Immunotherapy

scientific article published on 9 February 2017

Distinct pathways involving the FK506-binding proteins 12 and 12.6 underlie IL-2-versus IL-15-mediated proliferation of T cells ⬇️

scientific article published on November 6, 2003

EBV-related lymphoproliferative disease complicating therapy with the anti-CD2 monoclonal antibody, siplizumab, in patients with T-cell malignancies

scientific article published on 17 March 2009

Effective therapy of murine models of human leukemia and lymphoma with radiolabeled anti-CD30 antibody, HeFi-1

scientific article

Effective treatment of a murine model of adult T-cell leukemia using 211At-7G7/B6 and its combination with unmodified anti-Tac (daclizumab) directed toward CD25

scientific article published on 28 March 2006

Effective treatment of a murine model of adult T-cell leukemia using depsipeptide and its combination with unmodified daclizumab directed toward CD25.

scientific article published on 23 October 2008

Effective treatment of established human breast tumor xenografts in immunodeficient mice with a single dose of the alpha-emitting radioisotope astatine-211 conjugated to anti-HER2/neu diabodies

scientific article published on February 2008

Elevated serum-soluble interleukin-2 receptor levels in patients with anaplastic large cell lymphoma

scientific article

Emerging Therapies: Spectrum of Applications of Monoclonal Antibody Therapy

scientific article published on January 1, 2000

Engagement of lymphoma T cell receptors causes accelerated growth and the secretion of an NK cell-inhibitory factor

scientific article published on 11 September 2020

Enhanced efficacy of JAK1 inhibitor with mTORC1/C2 targeting in smoldering/chronic adult T cell leukemia

scientific article published on 22 October 2020

Essential role of the linear ubiquitin chain assembly complex and TAK1 kinase in A20 mutant Hodgkin lymphoma

scientific article published on 02 November 2020

Exploiting synthetic lethality for the therapy of ABC diffuse large B cell lymphoma

scientific article

FERM domain mutations induce gain of function in JAK3 in adult T-cell leukemia/lymphoma ⬇️

scientific article published on August 5, 2011

First-in-human trial of rhIL-15 and haploidentical natural killer cell therapy for advanced acute myeloid leukemia

scientific article published on 01 July 2019

GPI-microdomains (membrane rafts) and signaling of the multi-chain interleukin-2 receptor in human lymphoma/leukemia T cell lines

scientific article published on February 2002

Gain-of-function CCR4 mutations in adult T cell leukemia/lymphoma

scientific article

Gene expression profiling of ATL patients: compilation of disease-related genes and evidence for TCF4 involvement in BIRC5 gene expression and cell viability

scientific article published on 08 January 2009

Gene regulation and suppression of type I interferon signaling by STAT3 in diffuse large B cell lymphoma

scientific article published on 2 January 2018

Herceptin-geldanamycin immunoconjugates: pharmacokinetics, biodistribution, and enhanced antitumor activity

scientific article published on February 2004

High-dose humanized anti-IL-2 receptor alpha antibody (daclizumab) for the treatment of active, non-infectious uveitis

scientific article published on 20 June 2008

Highly persistent and effective prime/boost regimens against tuberculosis that use a multivalent modified vaccine virus Ankara-based tuberculosis vaccine with interleukin-15 as a molecular adjuvant

scientific article

Humanized anti-interleukin-2 (IL-2) receptor alpha therapy: long-term results in uveitis patients and preliminary safety and activity data for establishing parameters for subcutaneous administration

scientific article published in November 2003

IFN regulatory factor 4 participates in the human T cell lymphotropic virus type I-mediated activation of the IL-15 receptor alpha promoter

scientific article published in June 2002

IL-15 adjuvanted multivalent vaccinia-based universal influenza vaccine requires CD4+ T cells for heterosubtypic protection

scientific article

IL-15 administered by continuous infusion to rhesus macaques induces massive expansion of CD8+ T effector memory population in peripheral blood ⬇️

scientific article published on November 8, 2011

IL-15 as a mediator of CD4+ help for CD8+ T cell longevity and avoidance of TRAIL-mediated apoptosis

scholarly article

IL-15 enhances the in vivo antitumor activity of tumor-reactive CD8+ T cells

scientific article

IL-15 expands unconventional CD8alphaalphaNK1.1+ T cells but not Valpha14Jalpha18+ NKT cells

scientific article published on June 2008

IL-15 in the Combination Immunotherapy of Cancer

scientific article published on 19 May 2020

IL-15 serves as a costimulator in determining the activity of autoreactive CD8 T cells in an experimental mouse model of graft-versus-host-like disease

scientific article published on July 2008

IL-15/IL-15Ralpha-mediated avidity maturation of memory CD8+ T cells.

scholarly article

IL-15Ralpha recycles and presents IL-15 In trans to neighboring cells

scientific article (publication date: November 2002)

IL-2 and IL-15 blockade by BNZ-1, an inhibitor of selective γ-chain cytokines, decreases leukemic T-cell viability

scholarly article by T Tiffany Wang et al published 23 October 2018 in Leukemia

IL-2 and IL-15 receptor alpha-subunits are coexpressed in a supramolecular receptor cluster in lipid rafts of T cells

scientific article

IL-21-driven neoplasms in SJL mice mimic some key features of human angioimmunoblastic T-cell lymphoma

scientific article

IL15 and T-cell Stemness in T-cell-Based Cancer Immunotherapy

scientific article

IL15 by Continuous Intravenous Infusion to Adult Patients with Solid Tumors in a Phase I Trial Induced Dramatic NK-Cell Subset Expansion

scientific article published on 29 May 2019

IL15 infusion of cancer patients expands the subpopulation of cytotoxic CD56bright NK cells and increases NK cell cytokine release capabilities

scientific article published on 25 August 2017

ITK and IL-15 support two distinct subsets of CD8+ T cells

scholarly article

Identification of a γc Receptor Antagonist That Prevents Reprogramming of Human Tissue-resident Cytotoxic T Cells by IL15 and IL21

scientific article published on 14 October 2019

Increased serum soluble IL-15Rα levels in T-cell large granular lymphocyte leukemia ⬇️

scientific article published on November 2, 2011

Induction of the IL-9 gene by HTLV-I Tax stimulates the spontaneous proliferation of primary adult T-cell leukemia cells by a paracrine mechanism

scientific article published on 13 March 2008

Insulin-dependent diabetes induced by pancreatic beta cell expression of IL-15 and IL-15Rα ⬇️

scientific article published on July 31, 2013

Interleukin-15 (dys)regulation of lymphoid homeostasis: Implications for therapy of autoimmunity and cancer

scientific article published on 01 January 2020

Interleukin-15 Constrains Mucosal T Helper 17 Cell Generation: Influence of Mononuclear Phagocytes

scientific article published on 23 November 2015

Interleukin-15 biology and its therapeutic implications in cancer ⬇️

scientific article published on October 25, 2011

Interleukin-15 combined with an anti-CD40 antibody provides enhanced therapeutic efficacy for murine models of colon cancer

scholarly article

Interleukin-2 activity can be fine tuned with engineered receptor signaling clamps.

scientific article

Janus Kinase Inhibitor Tofacitinib Shows Potent Efficacy in a Mouse Model of Autoimmune Lymphoproliferative Syndrome (ALPS).

scientific article published on 9 October 2015

Leukemia/lymphoma development in IL-15-deficient TCR-transgenic mice

scientific article published on 4 November 2015

Loss of cytotoxicity and gain of cytokine production in murine tumor-activated NK cells

scientific article

Lymphatic drainage imaging of breast cancer in mice by micro-magnetic resonance lymphangiography using a nano-size paramagnetic contrast agent

scientific article published in May 2004

MTS dye based colorimetric CTLL-2 cell proliferation assay for product release and stability monitoring of interleukin-15: assay qualification, standardization and statistical analysis

scientific article published on 30 July 2009

Markedly additive antitumor activity with the combination of a selective survivin suppressant YM155 and alemtuzumab in adult T-cell leukemia ⬇️

scientific article published on January 15, 2013

Membrane Potential Distinctly Modulates Mobility and Signaling of IL-2 and IL-15 Receptors in T Cells

scientific article published on 10 May 2018

Micro-magnetic resonance lymphangiography in mice using a novel dendrimer-based magnetic resonance imaging contrast agent

scientific article published on 01 January 2003

Modifications in synthesis strategy improve the yield and efficacy of geldanamycin-herceptin immunoconjugates

scientific article published on July 2002

NK cells prevent T cell lymphoma development in T cell receptor-transgenic mice

scientific article published on 27 February 2020

NK cells protect TCR-transgenic mice from developing fetal leukemia

scientific article published on 6 November 2014

Nanometer-scale organization of the alpha subunits of the receptors for IL2 and IL15 in human T lymphoma cells

scientific article published on March 2008

Overcoming CD4 deficiency to induce long-lived memory CD8+ CTL.

scientific article

Paracrine and Transpresentation Functions of IL-15 Are Mediated by Diverse Splice Versions of IL-15Rα in Human Monocytes and Dendritic Cells ⬇️

scientific article published on October 16, 2012

Phase 1 trial of IL-15 trans presentation blockade using humanized Mik-Beta-1 mAb in patients with T-cell large granular lymphocytic leukemia ⬇️

scientific article published on December 3, 2012

Phase 1/2 study of alemtuzumab with dose-adjusted EPOCH in untreated aggressive T and NK cell lymphomas

scientific article published on 10 January 2019

Phase I dose escalation study of the anti-CD2 monoclonal antibody, siplizumab, with DA-EPOCH-R in aggressive peripheral T-cell lymphomas.

scientific article published on 16 October 2017

Phase II Study of Alemtuzumab (CAMPATH-1) in Patients with HTLV-1-Associated Adult T-cell Leukemia/lymphoma

scientific article

Preassociation of IL-15 with IL-15R alpha-IgG1-Fc enhances its activity on proliferation of NK and CD8+/CD44high T cells and its antitumor action

scientific article published on February 2008

Preclinical and phase I clinical trial of blockade of IL-15 using Mikbeta1 monoclonal antibody in T cell large granular lymphocyte leukemia

scientific article

Preparation and in vivo evaluation of a novel stabilized linker for 211At labeling of protein

scientific article published on 2 May 2006

Preparation and in vivo evaluation of novel linkers for 211At labeling of proteins.

scientific article

Protection by universal influenza vaccine is mediated by memory CD4 T cells

scientific article published on 07 June 2018

Protective-antigen (PA) based anthrax vaccines confer protection against inhalation anthrax by precluding the establishment of a systemic infection ⬇️

scientific article published on June 20, 2013

Radiation therapy for the management of patients with HTLV-1-associated adult T-cell leukemia/lymphoma.

scientific article

Radioimmunotherapy of A431 xenografted mice with pretargeted B3 antibody-streptavidin and (90)Y-labeled 1,4,7,10-tetraazacyclododecane-N,N',N",N"'-tetraacetic acid (DOTA)-biotin.

scientific article published in October 2002

Rapid progression of adult T-cell leukemia/lymphoma as tumor-infiltrating Tregs after PD-1 blockade

scientific article published on 01 October 2019

Receptor-directed therapy of T-cell leukemias and lymphomas

scientific article published on April 2008

Redistribution, hyperproliferation, activation of natural killer cells and CD8 T cells, and cytokine production during first-in-human clinical trial of recombinant human interleukin-15 in patients with cancer

scientific article

Regulation of IFN regulatory factor 4 expression in human T cell leukemia virus-I-transformed T cells

scientific article (publication date: 15 September 2002)

Regulation of normal B-cell differentiation and malignant B-cell survival by OCT2.

scientific article published on 18 March 2016

Results From a First-in-Human Study of BNZ-1, a Selective Multicytokine Inhibitor Targeting Members of the Common Gamma (γc) Family of Cytokines

scientific article published on 29 August 2019

Role of trans-cellular IL-15 presentation in the activation of NK cell-mediated killing, which leads to enhanced tumor immunosurveillance

scientific article published on 14 September 2004

Safety (toxicity), pharmacokinetics, immunogenicity, and impact on elements of the normal immune system of recombinant human IL-15 in rhesus macaques

scientific article

Safety, efficacy, and pharmacokinetics/pharmacodynamics of daclizumab (anti-CD25) in patients with adult T-cell leukemia/lymphoma

scientific article

Selective Dependence of H2-M3–Restricted CD8 Responses on IL-15 ⬇️

scientific article published on February 6, 2012

Selective targeting of JAK/STAT signaling is potentiated by Bcl-xL blockade in IL-2-dependent adult T-cell leukemia

scientific article

Selective targeting of JAK/STAT signaling is potentiated by Bcl-xL blockade in IL-2-dependent adult T-cell leukemia.

scientific article

Smallpox vaccine with integrated IL-15 demonstrates enhanced in vivo viral clearance in immunodeficient mice and confers long term protection against a lethal monkeypox challenge in cynomolgus monkeys

scientific article

Superior T memory stem cell persistence supports long-lived T cell memory

scientific article published on 2 January 2013

Survival adjustment of mature dendritic cells by IL-15.

scientific article

Systemic radioimmunotherapy using a monoclonal antibody, anti-Tac directed toward the alpha subunit of the IL-2 receptor armed with the alpha-emitting radionuclides (212)Bi or (211)At

scientific article published in April 2004

Targeting the HTLV-I-Regulated BATF3/IRF4 Transcriptional Network in Adult T Cell Leukemia/Lymphoma

scientific article published on 26 July 2018

The IL-15/IL-15Ralpha on cell surfaces enables sustained IL-15 activity and contributes to the long survival of CD8 memory T cells

scholarly article

The role of interleukin-15 in inflammation and immune responses to infection: implications for its therapeutic use ⬇️

scientific article published on October 25, 2011

Tofacitinib, a Janus Kinase Inhibitor Demonstrates Efficacy in an IL-15 Transgenic Mouse Model that Recapitulates Pathologic Manifestations of Celiac Disease ⬇️

scientific article published on December 28, 2012

Trans-endocytosis of intact IL-15Rα-IL-15 complex from presenting cells into NK cells favors signaling for proliferation

scientific article published on 23 December 2019

Transient and persistent effects of IL-15 on lymphocyte homeostasis in nonhuman primates

scientific article

Vaccinia virus-based multivalent H5N1 avian influenza vaccines adjuvanted with IL-15 confer sterile cross-clade protection in mice

scientific article

Viral Activation of Interleukin-15 (IL-15): Characterization of a Virus-Inducible Element in the IL-15 Promoter Region

miR-155 augments CD8+ T-cell antitumor activity in lymphoreplete hosts by enhancing responsiveness to homeostatic γc cytokines.

scientific article

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