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List of works by Thomas Waldmann

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IL-15Ralpha recycles and presents IL-15 In trans to neighboring cells

scientific article (publication date: November 2002)
Central memory self/tumor-reactive CD8+ T cells confer superior antitumor immunity compared with effector memory T cells

scientific article
Burkitt lymphoma pathogenesis and therapeutic targets from structural and functional genomics

scientific article published on 12 August 2012
IL-15 enhances the in vivo antitumor activity of tumor-reactive CD8+ T cells

scientific article
Exploiting synthetic lethality for the therapy of ABC diffuse large B cell lymphoma

scientific article
Redistribution, hyperproliferation, activation of natural killer cells and CD8 T cells, and cytokine production during first-in-human clinical trial of recombinant human interleukin-15 in patients with cancer

scientific article
Superior T memory stem cell persistence supports long-lived T cell memory

scientific article published on 2 January 2013
Interleukin-15 biology and its therapeutic implications in cancer

scientific article published on October 25, 2011
Preassociation of IL-15 with IL-15R alpha-IgG1-Fc enhances its activity on proliferation of NK and CD8+/CD44high T cells and its antitumor action

scientific article published on February 2008
Role of trans-cellular IL-15 presentation in the activation of NK cell-mediated killing, which leads to enhanced tumor immunosurveillance

scientific article published on 14 September 2004
Coadministration of HIV vaccine vectors with vaccinia viruses expressing IL-15 but not IL-2 induces long-lasting cellular immunity

scholarly article
IL-15 as a mediator of CD4+ help for CD8+ T cell longevity and avoidance of TRAIL-mediated apoptosis

scholarly article
A pilot study of CTLA-4 blockade after cancer vaccine failure in patients with advanced malignancy

article
IL-15/IL-15Ralpha-mediated avidity maturation of memory CD8+ T cells.

scholarly article
Safety (toxicity), pharmacokinetics, immunogenicity, and impact on elements of the normal immune system of recombinant human IL-15 in rhesus macaques

scientific article
The IL-15/IL-15Ralpha on cell surfaces enables sustained IL-15 activity and contributes to the long survival of CD8 memory T cells

scholarly article
ITK and IL-15 support two distinct subsets of CD8+ T cells

scholarly article
Interleukin-15 combined with an anti-CD40 antibody provides enhanced therapeutic efficacy for murine models of colon cancer

scholarly article
Lymphatic drainage imaging of breast cancer in mice by micro-magnetic resonance lymphangiography using a nano-size paramagnetic contrast agent

scientific article published in May 2004
Antibody-mediated blockade of IL-15 reverses the autoimmune intestinal damage in transgenic mice that overexpress IL-15 in enterocytes

scientific article
Humanized anti-interleukin-2 (IL-2) receptor alpha therapy: long-term results in uveitis patients and preliminary safety and activity data for establishing parameters for subcutaneous administration

scientific article published in November 2003
IL-2 and IL-15 receptor alpha-subunits are coexpressed in a supramolecular receptor cluster in lipid rafts of T cells

scientific article
Transient and persistent effects of IL-15 on lymphocyte homeostasis in nonhuman primates

scientific article
Gain-of-function CCR4 mutations in adult T cell leukemia/lymphoma

scientific article published on December 8, 2014
Interleukin-2 activity can be fine tuned with engineered receptor signaling clamps.

scientific article
Survival adjustment of mature dendritic cells by IL-15.

scientific article
GPI-microdomains (membrane rafts) and signaling of the multi-chain interleukin-2 receptor in human lymphoma/leukemia T cell lines

scientific article published on February 2002
High-dose humanized anti-IL-2 receptor alpha antibody (daclizumab) for the treatment of active, non-infectious uveitis

scientific article published on 20 June 2008
CP-690,550, a therapeutic agent, inhibits cytokine-mediated Jak3 activation and proliferation of T cells from patients with ATL and HAM/TSP

scientific article
miR-155 augments CD8+ T-cell antitumor activity in lymphoreplete hosts by enhancing responsiveness to homeostatic γc cytokines.

scientific article
Gene expression profiling of ATL patients: compilation of disease-related genes and evidence for TCF4 involvement in BIRC5 gene expression and cell viability

scientific article published on 08 January 2009
IL-15 administered by continuous infusion to rhesus macaques induces massive expansion of CD8+ T effector memory population in peripheral blood

scientific article published on November 8, 2011
The role of interleukin-15 in inflammation and immune responses to infection: implications for its therapeutic use

scientific article published on October 25, 2011
FERM domain mutations induce gain of function in JAK3 in adult T-cell leukemia/lymphoma

scientific article published on August 5, 2011
Cytokine receptor signaling is required for the survival of ALK- anaplastic large cell lymphoma, even in the presence of JAK1/STAT3 mutations

scientific article published on 29 March 2017
Vaccinia virus-based multivalent H5N1 avian influenza vaccines adjuvanted with IL-15 confer sterile cross-clade protection in mice

scientific article
A double-masked, randomized study to investigate the safety and efficacy of daclizumab to treat the ocular complications related to Behçet's disease

scientific article
Nanometer-scale organization of the alpha subunits of the receptors for IL2 and IL15 in human T lymphoma cells

scientific article published on March 2008
Preclinical and phase I clinical trial of blockade of IL-15 using Mikbeta1 monoclonal antibody in T cell large granular lymphocyte leukemia

scientific article
Selective targeting of JAK/STAT signaling is potentiated by Bcl-xL blockade in IL-2-dependent adult T-cell leukemia

scientific article
Disorders of the JAK/STAT Pathway in T Cell Lymphoma Pathogenesis: Implications for Immunotherapy

scientific article published on 9 February 2017
Micro-magnetic resonance lymphangiography in mice using a novel dendrimer-based magnetic resonance imaging contrast agent

scientific article published on 01 January 2003
Induction of the IL-9 gene by HTLV-I Tax stimulates the spontaneous proliferation of primary adult T-cell leukemia cells by a paracrine mechanism

scientific article published on 13 March 2008
Application of a macromolecular contrast agent for detection of alterations of tumor vessel permeability induced by radiation

scientific article published on 01 November 2004
Detection of lymph node involvement in hematologic malignancies using micromagnetic resonance lymphangiography with a gadolinum-labeled dendrimer nanoparticle

scientific article
Highly Persistent and Effective Prime/Boost Regimens against Tuberculosis That Use a Multivalent Modified Vaccine Virus Ankara-Based Tuberculosis Vaccine with Interleukin-15 as a Molecular Adjuvant

scientific article published on March 31, 2010
IL15 and T-cell Stemness in T-cell-Based Cancer Immunotherapy

scientific article
Regulation of IFN regulatory factor 4 expression in human T cell leukemia virus-I-transformed T cells

scientific article (publication date: 15 September 2002)
Safety, efficacy, and pharmacokinetics/pharmacodynamics of daclizumab (anti-CD25) in patients with adult T-cell leukemia/lymphoma

scientific article published on September 28, 2014
EBV-related lymphoproliferative disease complicating therapy with the anti-CD2 monoclonal antibody, siplizumab, in patients with T-cell malignancies

scientific article published on 17 March 2009

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