List of works - Ethan M. Shevach

A Self-Reactive TCR Drives the Development of Foxp3+ Regulatory T Cells That Prevent Autoimmune Disease ⬇️

scientific article published on June 20, 2011

Absence of signaling into CD4⁺ cells via C3aR and C5aR enables autoinductive TGF-β1 signaling and induction of Foxp3⁺ regulatory T cells.

scientific article

Activated CD4+CD25+ T cells selectively kill B lymphocytes

scientific article published on 17 January 2006

Analysis of adhesion molecules, target cells, and role of IL-2 in human FOXP3+ regulatory T cell suppressor function

scientific article

Application of IL-2 therapy to target T regulatory cell function ⬇️

scientific article published on August 30, 2012

Autoantibodies in scurfy mice and IPEX patients recognize keratin 14.

scientific article published on 11 February 2010

CCR5-dependent homing of naturally occurring CD4+ regulatory T cells to sites of Leishmania major infection favors pathogen persistence

scientific article

CD4(+)CD25(+) immunoregulatory T cells: gene expression analysis reveals a functional role for the glucocorticoid-induced TNF receptor

scientific article

CD4(+)CD25(+) regulatory T cells can mediate suppressor function in the absence of transforming growth factor beta1 production and responsiveness

scientific article

CD4+ CD25+ suppressor T cells: more questions than answers

scientific article

CD4+ FoxP3+ regulatory T cells confer infectious tolerance in a TGF-beta-dependent manner

scientific article

CD4+CD25+ regulatory T cells control Leishmania major persistence and immunity

scientific article

Coexpression of TIGIT and FCRL3 identifies Helios+ human memory regulatory T cells.

scientific article

Constitutive presentation of a natural tissue autoantigen exclusively by dendritic cells in the draining lymph node

scientific article

Control of T cell activation by CD4+CD25+ suppressor T cells

scientific article published on January 1, 2003

Cutting Edge: IL-2 is essential for TGF-beta-mediated induction of Foxp3+ T regulatory cells

scientific article

Cutting Edge: Inhibition of the Interaction of NK Inhibitory Receptors with MHC Class I Augments Antiviral and Antitumor Immunity

scientific article published on 29 June 2020

Cutting edge: antigen-specific TGF beta-induced regulatory T cells suppress Th17-mediated autoimmune disease

scientific article published on December 2008

Cutting edge: depletion of CD4+CD25+ regulatory T cells is necessary, but not sufficient, for induction of organ-specific autoimmune disease

scientific article

Endogenous mouse mammary tumor viruses (mtv): new roles for an old virus in cancer, infection, and immunity

scientific article

Engagement of TLR2 does not reverse the suppressor function of mouse regulatory T cells, but promotes their survival

scientific article

Engineered antigen-specific human regulatory T cells: immunosuppression of FVIII-specific T- and B-cell responses

scientific article

Eos Is Redundant for Regulatory T Cell Function but Plays an Important Role in IL-2 and Th17 Production by CD4+ Conventional T Cells

scientific article published on 10 June 2015

Expression of Helios, an Ikaros transcription factor family member, differentiates thymic-derived from peripherally induced Foxp3+ T regulatory cells

scientific article

Foxp3-mediated inhibition of Akt inhibits Glut1 (glucose transporter 1) expression in human T regulatory cells

scientific article

Generation of pathogenic T(H)17 cells in the absence of TGF-β signalling

scientific article

Helios Controls a Limited Subset of Regulatory T Cell Functions

scientific article

Helios Deficiency Predisposes the Differentiation of CD4+Foxp3- T Cells into Peripherally Derived Regulatory T Cells

scientific article published on 05 June 2019

IFN-α/β receptor signaling promotes regulatory T cell development and function under stress conditions

scientific article

IL-2 Controls the Stability of Foxp3 Expression in TGF-β–Induced Foxp3+ T Cells In Vivo ⬇️

scientific article published on April 27, 2011

In vivo expansion of CD4CD45RO-CD25 T cells expressing foxP3 in IL-2-treated HIV-infected patients

scientific article

Induction of FOXP3 expression in naive human CD4+FOXP3 T cells by T-cell receptor stimulation is transforming growth factor-beta dependent but does not confer a regulatory phenotype

scientific article

Inhibition of the function of the FcgammaRIIB by a monoclonal antibody to thymic shared antigen-1, a Ly-6 family antigen

scientific article

Monitoring regulatory T cells in clinical samples: consensus on an essential marker set and gating strategy for regulatory T cell analysis by flow cytometry

scientific article published on 28 June 2015

Naturally-occurring CD4+CD25+ immunoregulatory T cells: central players in the arena of peripheral tolerance

scientific article published on April 2004

Neuroprotective autoimmunity: naturally occurring CD4+CD25+ regulatory T cells suppress the ability to withstand injury to the central nervous system

scientific article

Nonredundant roles for Stat5a/b in directly regulating Foxp3

scientific article published on 16 January 2007

Oligodeoxynucleotides stabilize Helios-expressing Foxp3+ human T regulatory cells during in vitro expansion

scientific article published on 31 January 2012

Recognition of a new ARTC1 peptide ligand uniquely expressed in tumor cells by antigen-specific CD4+ regulatory T cells

scientific article

Regulatory T cells mediate specific suppression by depleting peptide-MHC class II from dendritic cells

scientific article published on 14 January 2019

Regulatory T-cell expansion during chronic viral infection is dependent on endogenous retroviral superantigens

scientific article

Release of active TGF-β1 from the latent TGF-β1/GARP complex on T regulatory cells is mediated by integrin β8

scientific article

Retinoic acid inhibits Th17 polarization and enhances FoxP3 expression through a Stat-3/Stat-5 independent signaling pathway

scientific article

SAMHD1 Posttranscriptionally Controls the Expression of Foxp3 and Helios in Human T Regulatory Cells

scientific article published on 13 August 2018

T-cell-expressed proprotein convertase furin is essential for maintenance of peripheral immune tolerance

scientific article

TCR signaling fuels T(reg) cell suppressor function

scientific article

TGF-beta-induced Foxp3+ regulatory T cells rescue scurfy mice

scientific article published on July 2008

TNF downmodulates the function of human CD4+CD25hi T-regulatory cells

scientific article published on 14 March 2006

Th1, Th2, and Th17 effector T cell-induced autoimmune gastritis differs in pathological pattern and in susceptibility to suppression by regulatory T cells

scientific article published on August 2008

The Deubiquitinase CYLD Targets Smad7 Protein to Regulate Transforming Growth Factor β (TGF-β) Signaling and the Development of Regulatory T Cells ⬇️

scientific article published on September 19, 2011

The Resurrection of T Cell-Mediated Suppression ⬇️

scientific article published on April 1, 2011

The lifestyle of naturally occurring CD4+ CD25+ Foxp3+ regulatory T cells

scientific article

The role of platelet and endothelial GARP in thrombosis and hemostasis

scientific article

The role of suppressor T cells in regulation of immune responses

scientific article

Transcriptome profiling of human FoxP3+ regulatory T cells

scientific article published on 10 December 2015

Type I interferon signaling attenuates regulatory T cell function in viral infection and in the tumor microenvironment.

scientific article published on 19 April 2018

List of works by Ethan M. Shevach

A Self-Reactive TCR Drives the Development of Foxp3+ Regulatory T Cells That Prevent Autoimmune Disease ⬇️

Absence of signaling into CD4⁺ cells via C3aR and C5aR enables autoinductive TGF-β1 signaling and induction of Foxp3⁺ regulatory T cells.

Activated CD4+CD25+ T cells selectively kill B lymphocytes

Analysis of adhesion molecules, target cells, and role of IL-2 in human FOXP3+ regulatory T cell suppressor function

Application of IL-2 therapy to target T regulatory cell function ⬇️

Autoantibodies in scurfy mice and IPEX patients recognize keratin 14.

CCR5-dependent homing of naturally occurring CD4+ regulatory T cells to sites of Leishmania major infection favors pathogen persistence

CD4(+)CD25(+) immunoregulatory T cells: gene expression analysis reveals a functional role for the glucocorticoid-induced TNF receptor

CD4(+)CD25(+) regulatory T cells can mediate suppressor function in the absence of transforming growth factor beta1 production and responsiveness

CD4+ CD25+ suppressor T cells: more questions than answers

CD4+ FoxP3+ regulatory T cells confer infectious tolerance in a TGF-beta-dependent manner

CD4+CD25+ regulatory T cells control Leishmania major persistence and immunity

Coexpression of TIGIT and FCRL3 identifies Helios+ human memory regulatory T cells.

Constitutive presentation of a natural tissue autoantigen exclusively by dendritic cells in the draining lymph node

Control of T cell activation by CD4+CD25+ suppressor T cells

Cutting Edge: IL-2 is essential for TGF-beta-mediated induction of Foxp3+ T regulatory cells

Cutting Edge: Inhibition of the Interaction of NK Inhibitory Receptors with MHC Class I Augments Antiviral and Antitumor Immunity

Cutting edge: antigen-specific TGF beta-induced regulatory T cells suppress Th17-mediated autoimmune disease

Cutting edge: depletion of CD4+CD25+ regulatory T cells is necessary, but not sufficient, for induction of organ-specific autoimmune disease

Endogenous mouse mammary tumor viruses (mtv): new roles for an old virus in cancer, infection, and immunity

Engagement of TLR2 does not reverse the suppressor function of mouse regulatory T cells, but promotes their survival

Engineered antigen-specific human regulatory T cells: immunosuppression of FVIII-specific T- and B-cell responses

Eos Is Redundant for Regulatory T Cell Function but Plays an Important Role in IL-2 and Th17 Production by CD4+ Conventional T Cells

Expression of Helios, an Ikaros transcription factor family member, differentiates thymic-derived from peripherally induced Foxp3+ T regulatory cells

Foxp3-mediated inhibition of Akt inhibits Glut1 (glucose transporter 1) expression in human T regulatory cells

Generation of pathogenic T(H)17 cells in the absence of TGF-β signalling

Helios Controls a Limited Subset of Regulatory T Cell Functions

Helios Deficiency Predisposes the Differentiation of CD4+Foxp3- T Cells into Peripherally Derived Regulatory T Cells

IFN-α/β receptor signaling promotes regulatory T cell development and function under stress conditions

IL-2 Controls the Stability of Foxp3 Expression in TGF-β–Induced Foxp3+ T Cells In Vivo ⬇️

In vivo expansion of CD4CD45RO-CD25 T cells expressing foxP3 in IL-2-treated HIV-infected patients

Induction of FOXP3 expression in naive human CD4+FOXP3 T cells by T-cell receptor stimulation is transforming growth factor-beta dependent but does not confer a regulatory phenotype

Inhibition of the function of the FcgammaRIIB by a monoclonal antibody to thymic shared antigen-1, a Ly-6 family antigen

Monitoring regulatory T cells in clinical samples: consensus on an essential marker set and gating strategy for regulatory T cell analysis by flow cytometry

Naturally-occurring CD4+CD25+ immunoregulatory T cells: central players in the arena of peripheral tolerance

Neuroprotective autoimmunity: naturally occurring CD4+CD25+ regulatory T cells suppress the ability to withstand injury to the central nervous system

Nonredundant roles for Stat5a/b in directly regulating Foxp3

Oligodeoxynucleotides stabilize Helios-expressing Foxp3+ human T regulatory cells during in vitro expansion

Recognition of a new ARTC1 peptide ligand uniquely expressed in tumor cells by antigen-specific CD4+ regulatory T cells

Regulatory T cells mediate specific suppression by depleting peptide-MHC class II from dendritic cells

Regulatory T-cell expansion during chronic viral infection is dependent on endogenous retroviral superantigens

Release of active TGF-β1 from the latent TGF-β1/GARP complex on T regulatory cells is mediated by integrin β8

Retinoic acid inhibits Th17 polarization and enhances FoxP3 expression through a Stat-3/Stat-5 independent signaling pathway

SAMHD1 Posttranscriptionally Controls the Expression of Foxp3 and Helios in Human T Regulatory Cells

T-cell-expressed proprotein convertase furin is essential for maintenance of peripheral immune tolerance

TCR signaling fuels T(reg) cell suppressor function

TGF-beta-induced Foxp3+ regulatory T cells rescue scurfy mice

TNF downmodulates the function of human CD4+CD25hi T-regulatory cells

Th1, Th2, and Th17 effector T cell-induced autoimmune gastritis differs in pathological pattern and in susceptibility to suppression by regulatory T cells

The Deubiquitinase CYLD Targets Smad7 Protein to Regulate Transforming Growth Factor β (TGF-β) Signaling and the Development of Regulatory T Cells ⬇️

The Resurrection of T Cell-Mediated Suppression ⬇️

The lifestyle of naturally occurring CD4+ CD25+ Foxp3+ regulatory T cells

The role of platelet and endothelial GARP in thrombosis and hemostasis

The role of suppressor T cells in regulation of immune responses

Transcriptome profiling of human FoxP3+ regulatory T cells

Type I interferon signaling attenuates regulatory T cell function in viral infection and in the tumor microenvironment.