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List of works by Alexander Rudensky

A Distinct Function of Regulatory T Cells in Tissue Protection

scientific article

A Mutation in the Transcription Factor Foxp3 Drives T Helper 2 Effector Function in Regulatory T Cells

scientific article published on 29 January 2019

A Single miRNA-mRNA Interaction Affects the Immune Response in a Context- and Cell-Type-Specific Manner

scientific article

A comparative encyclopedia of DNA elements in the mouse genome

scientific article

A critical role for regulatory T cell-mediated control of inflammation in the absence of commensal microbiota

scientific article

A distal Foxp3 enhancer enables interleukin-2 dependent thymic Treg cell lineage commitment for robust immune tolerance

scientific article published on 09 April 2021

A function for interleukin 2 in Foxp3-expressing regulatory T cells

scientific journal article

A mechanism for expansion of regulatory T-cell repertoire and its role in self-tolerance

scientific article published on 25 November 2015

A narrow circle of mutual friends

scientific article published on 01 May 2011

A nonimmune function of T cells in promoting lung tumor progression

scientific article published on 16 October 2017

A role for cathepsin L and cathepsin S in peptide generation for MHC class II presentation

scientific article published on March 2002

A unified atlas of CD8 T cell dysfunctional states in cancer and infection

scientific article published on 22 April 2021

A well adapted regulatory contrivance: regulatory T cell development and the forkhead family transcription factor Foxp3.

scientific article

Altering the distribution of Foxp3(+) regulatory T cells results in tissue-specific inflammatory disease

scientific article

An N-Terminal Mutation of the Foxp3 Transcription Factor Alleviates Arthritis but Exacerbates Diabetes ⬇️

scientific article published on May 10, 2012

An NF-κB-microRNA regulatory network tunes macrophage inflammatory responses.

scientific article

An essential role for the IL-2 receptor in Treg cell function ⬇️

scientific article published on 05 September 2016

An intersection between the self-reactive regulatory and nonregulatory T cell receptor repertoires

scientific journal article

Analysis of the underlying cellular mechanisms of anti-CD154-induced graft tolerance: the interplay of clonal anergy and immune regulation

scientific article published in July 2005

Antigen receptor repertoire profiling from RNA-seq data.

scientific article published in October 2017

Antigen-specific dose-dependent system for the study of an inheritable and reversible phenotype in mouse CD4+ T cells

scientific article published on 01 December 2002

Author Correction: An NF-κB-microRNA regulatory network tunes macrophage inflammatory responses

scientific article published in Nature Communications

Autocrine Transforming Growth Factor-β1 Promotes In Vivo Th17 Cell Differentiation ⬇️

scientific article published on March 25, 2011

BRCT-domain protein BRIT1 influences class switch recombination.

scientific article

Bacterial metabolism of bile acids promotes generation of peripheral regulatory T cells

scientific article published on 15 April 2020

Basophils Promote Tumor Rejection via Chemotaxis and Infiltration of CD8+ T Cells

scientific article

CD4+ regulatory T cells control TH17 responses in a Stat3-dependent manner.

scientific article

CD49b defines functionally mature Treg cells that survey skin and vascular tissues

article

CXCR4+ Treg cells control serum IgM levels and natural IgM autoantibody production by B-1 cells in the bone marrow

scientific article published on 07 June 2022

Cathepsin L regulates CD4+ T cell selection independently of its effect on invariant chain: a role in the generation of positively selecting peptide ligands

scientific article

Cathepsin S controls MHC class II-mediated antigen presentation by epithelial cells in vivo

scientific article published in February 2005

Cellular mechanisms of fatal early-onset autoimmunity in mice with the T cell-specific targeting of transforming growth factor-beta receptor

scientific journal article

Characterization of mouse and human B7-H3 genes

scientific journal article

Comparative analysis of murine T-cell receptor repertoires.

scientific article

Conceiving the Inconceivable: The Function of Aire in Immune Tolerance to Peripheral Tissue-Restricted Antigens in the Thymus

scientific article published on 01 January 2021

Continuous requirement for the TCR in regulatory T cell function

scientific article

Control of immune homeostasis by naturally arising regulatory CD4+ T cells

scientific article published on December 2003

Control of inflammation by integration of environmental cues by regulatory T cells

scientific article published on March 2013

Control of regulatory T cell lineage commitment and maintenance

scientific article

Control of the inheritance of regulatory T cell identity by a cis element in the Foxp3 locus

scientific article published on August 2014

Coordination of early protective immunity to viral infection by regulatory T cells

scientific article

Corrigendum: Stability and function of regulatory T cells expressing the transcription factor T-bet

scientific article published on 20 September 2017

Crystal structure of MHC class II I-Ab in complex with a human CLIP peptide: prediction of an I-Ab peptide-binding motif

scientific article (publication date: 28 February 2003)

Cutting edge: TCR stimulation is sufficient for induction of Foxp3 expression in the absence of DNA methyltransferase 1.

scientific article

Cutting edge: depletion of Foxp3+ cells leads to induction of autoimmunity by specific ablation of regulatory T cells in genetically targeted mice

scientific article published on 01 December 2009

DNA methylation secures CD4(+) and CD8(+) T cell lineage borders

scientific article published on 01 July 2015

Deletion of CTLA-4 on regulatory T cells during adulthood leads to resistance to autoimmunity.

scientific article

Developmental regulation of Foxp3 expression during ontogeny.

scientific article

Dicer-dependent microRNA pathway safeguards regulatory T cell function

scientific article

Differential cell-intrinsic regulations of germinal center B and T cells by miR-146a and miR-146b

scientific article published in Nature Communications

Differential regulation of cathepsin S and cathepsin L in interferon gamma-treated macrophages

scientific article

Differentiation of regulatory Foxp3+ T cells in the thymic cortex

scholarly article

Distinct Requirements of CHD4 during B Cell Development and Antibody Response

article

Distinct dendritic cell populations sequentially present antigen to CD4 T cells and stimulate different aspects of cell-mediated immunity

scientific article published on 01 July 2003

Dual TCR T cells: gaining entry into the periphery

scientific article published on 01 February 2002

Editorial overview: The value of commitment in the lymphocyte world

scientific article published on 01 June 2019

Editorial overview: lymphocyte development

scientific article published on 9 April 2009

Effect of decreasing the affinity of the class II-associated invariant chain peptide on the MHC class II peptide repertoire in the presence or absence of H-2M.

scientific article published in April 2004

Effects of the administration of high-dose interleukin-2 on immunoregulatory cell subsets in patients with advanced melanoma and renal cell cancer

scientific article published on 01 April 2007

Enforcing T cell innocence

scientific article published on 01 January 2020

Expansion and function of Foxp3-expressing T regulatory cells during tuberculosis

scientific article

Extrathymic generation of regulatory T cells in placental mammals mitigates maternal-fetal conflict

scientific article (publication date: 6 July 2012)

Extrathymically Generated Regulatory T Cells Establish a Niche for Intestinal Border-Dwelling Bacteria and Affect Physiologic Metabolite Balance.

scientific article published on 29 May 2018

Extrathymically generated regulatory T cells control mucosal TH2 inflammation ⬇️

scientific article published on February 8, 2012

FOXP3 and NFAT: partners in tolerance

scientific article

FXR mediates T cell-intrinsic responses to reduced feeding during infection

scientific article published on 14 December 2020

Feedback control of regulatory T cell homeostasis by dendritic cells in vivo

scientific article published on 10 August 2009

FoxP3 and Ezh2 regulate Tfr cell suppressive function and transcriptional program

scientific article published on 31 January 2019

Foxp3 and dominant tolerance

scientific article published in September 2005

Foxp3 exploits a pre-existent enhancer landscape for regulatory T cell lineage specification

scientific article

Foxp3 in control of the regulatory T cell lineage

scientific article published on May 2007

Foxp3 programs the development and function of CD4+CD25+ regulatory T cells

scientific article (publication date: April 2003)

Foxp3-dependent microRNA155 confers competitive fitness to regulatory T cells by targeting SOCS1 protein

scientific article

Foxp3-dependent programme of regulatory T-cell differentiation

scientific article published in Nature

Foxp3: a genetic foundation for regulatory T cell differentiation and function

scientific article published on 01 July 2020

Function of miR-146a in controlling Treg cell-mediated regulation of Th1 responses

scientific article

G protein-coupled receptor 83 is dispensable for the development and function of regulatory T cells.

scientific article

Genetic and epigenetic variation in the lineage specification of regulatory T cells

scientific article

Genome-wide analysis of Foxp3 target genes in developing and mature regulatory T cells.

scientific article published on 21 January 2007

Hallmarks of Tissue-Resident Lymphocytes

scientific article published on March 2016

Helminth secretions induce de novo T cell Foxp3 expression and regulatory function through the TGF-β pathway

scientific article

Homeostasis and anergy of CD4(+)CD25(+) suppressor T cells in vivo

scientific article published on 10 December 2001

IL-2 production by self-reactive CD4 thymocytes scales regulatory T cell generation in the thymus

scientific article published on 21 August 2019

IL-2-dependent adaptive control of NK cell homeostasis

scientific article published on 6 May 2013

IL-2-dependent tuning of NK cell sensitivity for target cells is controlled by regulatory T cells

scientific article

IPS-1 Is Essential for the Control of West Nile Virus Infection and Immunity

scientific article

Immigration in science

scientific article published on 01 November 2020

Immune homeostasis enforced by co-localized effector and regulatory T cells

scientific article

Importance of group X-secreted phospholipase A2 in allergen-induced airway inflammation and remodeling in a mouse asthma model

scientific article

In Situ Maturation and Tissue Adaptation of Type 2 Innate Lymphoid Cell Progenitors

scientific article published on 30 September 2020

In vivo analysis of dendritic cell development and homeostasis

scientific article

In vivo sites and cellular mechanisms of T reg cell-mediated suppression

scientific article

Inflammation-induced repression of chromatin bound by the transcription factor Foxp3 in regulatory T cells

scientific article

Inflammatory adaptation in barrier tissues

scientific article published in 2021

Inhibition of miR-146a prevents enterovirus-induced death by restoring the production of type I interferon.

scientific article published on January 2014

Interactions between innate and adaptive lymphocytes.

scientific article

Interleukin-10 signaling in regulatory T cells is required for suppression of Th17 cell-mediated inflammation

scientific article

Interplay between regulatory T cells and PD-1 in modulating T cell exhaustion and viral control during chronic LCMV infection

scientific article

Intraclonal competition limits the fate determination of regulatory T cells in the thymus

scientific article

Lack of Foxp3 function and expression in the thymic epithelium

scientific article

Lysosomal cysteine proteases regulate antigen presentation

scientific article

Maintenance of the Foxp3-dependent developmental program in mature regulatory T cells requires continued expression of Foxp3.

scientific article published on 14 January 2007

Mechanisms of donor-specific transfusion tolerance: preemptive induction of clonal T-cell exhaustion via indirect presentation

scientific article published on 15 May 2003

Memory of Inflammation in Regulatory T Cells

scientific article published on 3 August 2016

Metabolites produced by commensal bacteria promote peripheral regulatory T-cell generation

scientific article (publication date: 19 December 2013)

Microbial metabolites control gut inflammatory responses

scientific article published on 16 January 2014

Molecular aspects of regulatory T cell development

scientific article published on April 2004

Molecular orchestration of differentiation and function of regulatory T cells

scientific article published on June 2009

Mouse TCRalphabeta+CD8alphaalpha intraepithelial lymphocytes express genes that down-regulate their antigen reactivity and suppress immune responses

scientific article published in April 2007

Mouse Watch: A Cautionary Tale

scientific article published on 01 July 2019

Mouse regulatory DNA landscapes reveal global principles of cis-regulatory evolution

scientific article

Natural Genetic Variation Reveals Key Features of Epigenetic and Transcriptional Memory in Virus-Specific CD8 T Cells

scientific article published on 23 April 2019

Nemo-like Kinase Drives Foxp3 Stability and Is Critical for Maintenance of Immune Tolerance by Regulatory T Cells

Neuropilin 1 is expressed on thymus-derived natural regulatory T cells, but not mucosa-generated induced Foxp3+ T reg cells

scientific article

Novel Foxo1-dependent transcriptional programs control T(reg) cell function

scientific article

Nuclear receptor LXRβ controls fitness and functionality of activated T cells

scientific article published on 01 April 2021

Pillars Article: Foxp3 Programs the Development and Function of CD4+CD25+ Regulatory T Cells. Nat. Immunol. 2003. 4: 330-336.

scientific article published in February 2017

Positive selection of self-MHC-reactive T cells by individual peptide-MHC class II complexes

scientific article

Proteolytic processing of dynamin by cytoplasmic cathepsin L is a mechanism for proteinuric kidney disease

scientific article published in August 2007

Recognition of the peripheral self by naturally arising CD25+ CD4+ T cell receptors

scientific article published on 01 August 2004

Regulation of immunity by self-reactive T cells

scientific article

Regulation of thymic epithelium by keratinocyte growth factor

scientific article published in November 2002

Regulatory T Cells Exhibit Distinct Features in Human Breast Cancer

scientific article published in November 2016

Regulatory T Cells: Differentiation and Function

scientific article

Regulatory T cell ablation causes acute T cell lymphopenia

scientific article published on 23 January 2014

Regulatory T cell lineage specification by the forkhead transcription factor foxp3

scientific journal article

Regulatory T cell-derived interleukin-10 limits inflammation at environmental interfaces

scientific article

Regulatory T cells and Foxp3 ⬇️

scientific article published on May 1, 2011

Regulatory T cells expressing interleukin 10 develop from Foxp3+ and Foxp3- precursor cells in the absence of interleukin 10

scientific article published on 12 August 2007

Regulatory T cells prevent catastrophic autoimmunity throughout the lifespan of mice

scientific article (publication date: February 2007)

Regulatory T cells: mechanisms of differentiation and function

scientific article (publication date: 2012)

Regulatory T cells: recommendations to simplify the nomenclature.

scientific article published in April 2013

Regulatory T-cell suppressor program co-opts transcription factor IRF4 to control T(H)2 responses

scientific article

Reigning in regulatory T-cell function

scientific article published on 01 July 2015

Robust Antitumor Responses Result from Local Chemotherapy and CTLA-4 Blockade.

scientific article published on 16 January 2018

Role of conserved non-coding DNA elements in the Foxp3 gene in regulatory T-cell fate

scientific article

Roles for cathepsins S, L, and B in insulitis and diabetes in the NOD mouse

scientific article

Roles of Regulatory T Cells in Tissue Pathophysiology and Metabolism

scientific article published on 10 October 2019

Runx-CBFbeta complexes control expression of the transcription factor Foxp3 in regulatory T cells

scientific article published on 20 September 2009

Single-Cell Map of Diverse Immune Phenotypes in the Breast Tumor Microenvironment

scientific article published on 28 June 2018

Single-cell analysis of normal and FOXP3-mutant human T cells: FOXP3 expression without regulatory T cell development

scholarly article

Spatiotemporal regulation of peripheral T cell tolerance

scientific article published on 04 May 2023

Stability and function of regulatory T cells expressing the transcription factor T-bet

scientific article published on 7 June 2017

Stability of the regulatory T cell lineage in vivo.

scientific article

Stage-specific regulation of natural killer cell homeostasis and response against viral infection by microRNA-155

scientific article published on 9 April 2013

Synthesis, stabilization, and characterization of the MR1 ligand precursor 5-amino-6-D-ribitylaminouracil (5-A-RU).

scientific article

T cell receptor signalling in the control of regulatory T cell differentiation and function

scientific article

T reg Cells in Cancer: A Case of Multiple Personality Disorder ⬇️

scientific article published on December 12, 2012

T reg cell-intrinsic requirements for ST2 signaling in health and neuroinflammation

scientific article published on 01 February 2021

TGF-beta-induced Foxp3 inhibits T(H)17 cell differentiation by antagonizing RORgammat function

scientific article

TGF-beta1 maintains suppressor function and Foxp3 expression in CD4+CD25+ regulatory T cells

scientific article

TGFbeta signalling in control of T-cell-mediated self-reactivity

scientific article published on June 2007

Targeting of inducible costimulator (ICOS) expressed on alloreactive T cells down-regulates graft-versus-host disease (GVHD) and facilitates engraftment of allogeneic bone marrow (BM).

scientific article published on 23 December 2004

Th17 and regulatory T cells in mediating and restraining inflammation

scientific article

Th17 cells express interleukin-10 receptor and are controlled by Foxp3⁻ and Foxp3+ regulatory CD4+ T cells in an interleukin-10-dependent manner

scientific article

The Balance Between Donor T Cell Anergy and Suppression Versus Lethal Graft-Versus-Host Disease Is Determined by Host Conditioning

scientific article published on 01 November 2002

The Cell-Intrinsic Circadian Clock Is Dispensable for Lymphocyte Differentiation and Function

scientific article published on 21 May 2015

The RNAseIII enzyme Drosha is critical in T cells for preventing lethal inflammatory disease

scientific journal article

The Transcription Factor Foxp3 Shapes Regulatory T Cell Identity by Tuning the Activity of trans-Acting Intermediaries

scientific article published on 06 November 2020

The aryl hydrocarbon receptor controls cell-fate decisions in B cells.

scientific article published on 23 December 2016

The effect of cellular context on miR-155-mediated gene regulation in four major immune cell types

scientific article published on 17 September 2018

The effects of commensal microbiota on immune cell subsets and inflammatory responses

scientific article published on January 2012

The lysosomal cysteine proteases in MHC class II antigen presentation

scientific article

The nuclear orphan receptor Nr4a2 induces Foxp3 and regulates differentiation of CD4+ T cells ⬇️

scientific article

The plasticity and stability of regulatory T cells

scientific article published on 17 May 2013

The role of the transcription factor Foxp3 in the development of regulatory T cells

scientific article

Therapeutic use of regulatory T cells for graft-versus-host disease

scientific article published on 16 August 2019

Thymic development and peripheral homeostasis of regulatory T cells.

scientific article published on 15 February 2007

Thymocyte expression of cathepsin L is essential for NKT cell development

scientific article published on 7 October 2002

Tissue residency of innate lymphoid cells in lymphoid and nonlymphoid organs

scientific article

Transcription factor Foxp1 regulates Foxp3 chromatin binding and coordinates regulatory T cell function

scientific article published on 14 January 2019

Transcription factor Foxp3 and its protein partners form a complex regulatory network

scientific article

Transcriptional Basis of Mouse and Human Dendritic Cell Heterogeneity

scientific article published on 24 October 2019

Transcriptional control of regulatory T-cell differentiation

scientific article published on January 2013

Transcriptome-wide miR-155 binding map reveals widespread noncanonical microRNA targeting

scientific article

Transient regulatory T cell ablation deters oncogene-driven breast cancer and enhances radiotherapy

scientific article published on 14 October 2013

Tregs control the development of symptomatic West Nile virus infection in humans and mice

scientific article

ZFP36 RNA-binding proteins restrain T cell activation and anti-viral immunity.

scientific article

miR-23∼27∼24 clusters control effector T cell differentiation and function

scientific article published on February 2016

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