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List of works by Karl Claxton

A Comprehensive Algorithm for Approval of Health Technologies With, Without, or Only in Research: The Key Principles for Informing Coverage Decisions

scientific article published on 11 May 2016

A Cost-Effectiveness Analysis of Intradiscal Electrothermal Therapy Compared with Circumferential Lumbar Fusion

scientific article published on 12 September 2017

A Framework for Addressing Structural Uncertainty in Decision Models

scientific article published on 20 May 2011

A Pilot Study of Value of Information Analysis to Support Research Recommendations for NICE

A rational framework for decision making by the National Institute For Clinical Excellence (NICE).

scientific article published on August 2002

Addressing adoption and research design decisions simultaneously: the role of value of sample information analysis

scientific article

An iterative Bayesian approach to health technology assessment: application to a policy of preoperative optimization for patients undergoing major elective surgery

scientific article published on September 2006

Appraising the value of evidence generation activities: an HIV modelling study

article

Assessing the economic challenges posed by orphan drugs: a comment on Drummond et al

scientific article published on 01 January 2007

Assessing the value of human papillomavirus vaccination in Gavi-eligible low-income and middle-income countries

scientific article published on 01 October 2020

Budget allocation and the revealed social rate of time preference for health ⬇️

scientific article published on March 24, 2011

Budgetary policies and available actions: a generalisation of decision rules for allocation and research decisions

scientific article published on 16 December 2009

Cancer Drugs Fund requires further reform

scientific article

Causes for concern: is NICE failing to uphold its responsibilities to all NHS patients?

scientific article published on January 2015

Characterising Uncertainty in the Assessment of Medical Devices and Determining Future Research Needs.

scientific article published on February 2017

Characterizing structural uncertainty in decision analytic models: a review and application of methods

scientific article published on July 2009

Comment: Positive tails and normative dogs

scientific article published on 02 August 2018

Comprehensive decision-analytic model and Bayesian value-of-information analysis: pentoxifylline in the treatment of chronic venous leg ulcers

scientific article

Continuing the multiple sclerosis risk sharing scheme is unjustified

scientific article published on 3 June 2010

Cost-effectiveness of enhanced external counterpulsation (EECP) for the treatment of stable angina in the United Kingdom.

scientific article published on April 2010

Country-Level Cost-Effectiveness Thresholds: Initial Estimates and the Need for Further Research

scientific article published on December 2016

Coverage with evidence development, only in research, risk sharing, or patient access scheme? A framework for coverage decisions

scientific article published on 30 March 2012

Decision analysis for resource allocation in health care

scientific article published on October 2008

Developing a Value Framework: The Need to Reflect the Opportunity Costs of Funding Decisions

scientific article published on February 2017

Dimensions of design space: a decision-theoretic approach to optimal research design.

scientific article published on 15 July 2009

Discounting and cost-effectiveness in NICE - stepping back to sort out a confusion

scientific article published on January 2006

Discounting and decision making in the economic evaluation of health-care technologies

scientific article published on 12 May 2010

Discounting in Economic Evaluations.

scientific article published in July 2018

Efficiency, equity, and budgetary policies: informing decisions using mathematical programming.

scientific article published in March 2007

Eliciting distributions to populate decision analytic models

scientific article published on 22 March 2010

Establishing the cost-effectiveness of new pharmaceuticals under conditions of uncertainty--when is there sufficient evidence?

scientific article published on 01 July 2005

Estimating Social Variation in the Health Effects of Changes in Health Care Expenditure

scientific article published on 15 February 2020

Estimating health opportunity costs in low-income and middle-income countries: a novel approach and evidence from cross-country data

article

Estimating the Marginal Productivity of the English National Health Service From 2003 to 2012

scientific article published on 18 June 2019

Evidence synthesis, parameter correlation and probabilistic sensitivity analysis

scientific article

Experiences of Structured Elicitation for Model-Based Cost-Effectiveness Analyses.

scientific article

Exploring the Research Decision Space: The Expected Value of Information for Sequential Research Designs

scientific article published on 29 December 2009

Exploring uncertainty in cost-effectiveness analysis

scientific article published in January 2008

Good practice guidelines for decision-analytic modelling in health technology assessment: a review and consolidation of quality assessment

scientific article

Health Opportunity Costs: Assessing the Implications of Uncertainty Using Elicitation Methods with Experts

scientific article published on 22 May 2020

How to design the cost-effectiveness appraisal process of new healthcare technologies to maximise population health: A conceptual framework

scientific article published on 22 August 2017

How to estimate the health benefits of additional research and changing clinical practice

scientific article

Identifying research priorities: the value of information associated with repeat screening for age-related macular degeneration

scientific article published on 01 January 2008

Incorporation of uncertainty in health economic modelling studies

article

International Society for Pharmacoeconomics and Outcomes Research Comments on the American Society of Clinical Oncology Value Framework

scientific article published on 13 June 2016

Methods for assessing the cost-effectiveness of public health interventions: key challenges and recommendations

scientific article published on 25 August 2009

Methods for the estimation of the National Institute for Health and Care Excellence cost-effectiveness threshold

scientific article published on February 2015

Methods to assess cost-effectiveness and value of further research when data are sparse: negative-pressure wound therapy for severe pressure ulcers

scientific article

Methods to elicit experts' beliefs over uncertain quantities: application to a cost effectiveness transition model of negative pressure wound therapy for severe pressure ulceration

scientific article published on 11 July 2011

Methods to place a value on additional evidence are illustrated using a case study of corticosteroids after traumatic brain injury

scientific article published on 17 September 2015

Modelling the cost effectiveness of interferon beta and glatiramer acetate in the management of multiple sclerosis. Commentary: evaluating disease modifying treatments in multiple sclerosis.

scientific article

OFT, VBP: QED?

scientific article published on June 2007

Orphan drugs and the NHS: should we value rarity?

scientific article

Policy: Development goals should enable decision-making.

scientific article published in July 2015

Pre-operative optimisation employing dopexamine or adrenaline for patients undergoing major elective surgery: a cost-effectiveness analysis

scientific article published on 26 March 2002

Preventive strategies for group B streptococcal and other bacterial infections in early infancy: cost effectiveness and value of information analyses

scientific article

Probabilistic analysis and computationally expensive models: Necessary and required?

scientific article published on 01 July 2006

Probabilistic sensitivity analysis for NICE technology assessment: not an optional extra

scientific article published on 01 April 2005

Real economics needs to reflect real decisions: a response to Johnson

scientific article published on 01 February 2012

Resolving the "Cost-Effective but Unaffordable" Paradox: Estimating the Health Opportunity Costs of Nonmarginal Budget Impacts

scientific article published on 04 January 2018

Rights, responsibilities and NICE: a rejoinder to Harris

scientific article published on August 2007

Searching for a threshold, not setting one: the role of the National Institute for Health and Clinical Excellence

scientific article published on 01 January 2007

Should patients have a greater role in valuing health states?

scientific article published on 01 January 2005

Sins of omission and obfuscation: IQWIG's guidelines on economic evaluation methods

scientific article published on 01 October 2010

Social value and individual choice: The value of a choice-based decision-making process in a collectively funded health system.

scientific article

Supporting the development of a health benefits package in Malawi.

scientific article

The International Decision Support Initiative Reference Case for Economic Evaluation: An Aid to Thought.

scientific article published on December 2016

The NICE cost-effectiveness threshold: what it is and what that means

scientific article published on January 2008

The Value of Further Research: The Added Value of Individual-Participant Level Data

scientific article published on 01 June 2019

The Value of Innovation

The authors’ reply

The half-life of truth: what are appropriate time horizons for research decisions?

scientific article published on 30 April 2008

The heterogeneity of schizophrenia in disease states

scientific article published in November 2004

The impact of NHS expenditure on health outcomes in England: Alternative approaches to identification in all-cause and disease specific models of mortality

scientific article published on 02 April 2018

The value of clinical information : an economic approach to research priority setting. ⬇️

doctoral thesis

The value of heterogeneity for cost-effectiveness subgroup analysis: conceptual framework and application

scientific article

The value of implementation and the value of information: combined and uneven development

scientific article published in January 2008

Understanding Harris' understanding of CEA: is cost effective resource allocation undone? ⬇️

scientific article published in January 2013

Unifying Research and Reimbursement Decisions: Case Studies Demonstrating the Sequence of Assessment and Judgments Required

scientific article published on 13 August 2015

Unrelated Future Costs and Unrelated Future Benefits: Reflections on NICE Guide to the Methods of Technology Appraisal.

scientific article

Using value of information analysis to inform publicly funded research priorities.

scientific article published on January 2005

Value based pricing for NHS drugs: an opportunity not to be missed?

scientific article

Value for money and the Quality and Outcomes Framework in primary care in the UK NHS.

scientific article

Value of information and value of implementation: application of an analytic framework to inform resource allocation decisions in metastatic hormone-refractory prostate cancer

scientific article published on 24 July 2008

When Is Evidence Sufficient?

article

When does NICE recommend the use of health technologies within a programme of evidence development? : a systematic review of NICE guidance

scientific article published on February 2013

When is enough evidence enough? - Using systematic decision analysis and value-of-information analysis to determine the need for further evidence.

scientific article

Whither trial-based economic evaluation for health care decision making?

scientific article published on July 2006

Why licensing authorities need to consider the net value of new drugs in assigning review priorities: addressing the tension between licensing and reimbursement

scientific article published on January 2008

Wound healing and TIME; new concepts and scientific applications

scientific article

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