List of works by William Charles Earnshaw

3D-CLEM Reveals that a Major Portion of Mitotic Chromosomes Is Not Chromatin

scientific article

A DHODH inhibitor increases p53 synthesis and enhances tumor cell killing by p53 degradation blockage.

scientific article published on 16 March 2018

A cellular poison cupboard

scientific article published in Nature

A dominant mutant of inner centromere protein (INCENP), a chromosomal protein, disrupts prometaphase congression and cytokinesis

scientific article

A dynamic connection between centromeres and ND10 proteins

scientific article

A map of the centromere (primary constriction) in vertebrate chromosomes at metaphase

scientific article published on 01 January 1989

A neocentromere in the DAZ region of the human Y chromosome

article

A new assay for measuring chromosome instability (CIN) and identification of drugs that elevate CIN in cancer cells

scientific article

A new generation of human artificial chromosomes for functional genomics and gene therapy

scientific article

A pathway for mitotic chromosome formation.

scientific article published on 18 January 2018

A perfect funeral with no corpse

scientific article

A portable BRCA1-HAC (human artificial chromosome) module for analysis of BRCA1 tumor suppressor function.

scientific article

A promoter-hijack strategy for conditional shutdown of multiply spliced essential cell cycle genes

scientific article

A super-resolution map of the vertebrate kinetochore

scientific article

APC/CCdh1 is required for the termination of chromosomal passenger complex activity upon mitotic exit

scientific article published on 15 September 2020

Acetylation of core histones in response to HDAC inhibitors is diminished in mitotic HeLa cells

scientific article

Activation of Multiple Interleukin-1β Converting Enzyme Homologues in Cytosol and Nuclei of HL-60 Cells during Etoposide-induced Apoptosis

scientific article published in Journal of Biological Chemistry

An intrinsic S/G2 checkpoint enforced by ATR

scientific article published on 01 August 2018

Analysis of Caspase Activation During Apoptosis

article

Analysis of Scc1-deficient cells defines a key metaphase role of vertebrate cohesin in linking sister kinetochores

scientific article

Analysis of anticentromere autoantibodies using cloned autoantigen CENP-B.

scientific article

Analysis of the distribution of the INCENPs throughout mitosis reveals the existence of a pathway of structural changes in the chromosomes during metaphase and early events in cleavage furrow formation ⬇️

scientific article published on April 1, 1991

Antibodies to topoisomerase I in sera from patients with scleroderma.

scientific article published on June 1987

Anticentromere Autoantibodies

article

Apoptosis-associated caspase activation assays

scientific article published on March 2008

Apoptosis: lessons from in vitro systems

article

Apoptotic phosphorylation of histone H2B is mediated by mammalian sterile twenty kinase

scientific article (publication date: 16 May 2003)

Assembly of nucleosomes: the reaction involving X. laevis nucleoplasmin.

scientific article

Assembly of the head of bacteriophage P22: x-ray diffraction from heads, proheads and related structures.

scientific article

Aurora B Overexpression Causes Aneuploidy and p21Cip1 Repression during Tumor Development

scientific article

Aurora-B phosphorylation in vitro identifies a residue of survivin that is essential for its localization and binding to inner centromere protein (INCENP) in vivo

scientific article

Aurora-C kinase is a novel chromosomal passenger protein that can complement Aurora-B kinase function in mitotic cells

scientific article

Autoantibodies against the chromosomal passenger protein INCENP found in a patient with Graham Little-Piccardi-Lassueur syndrome

scientific article published on 12 January 2007

Auxin-induced rapid degradation of inhibitor of caspase-activated DNase (ICAD) induces apoptotic DNA fragmentation, caspase activation, and cell death: a cell suicide module

scientific article

Auxin/AID versus conventional knockouts: distinguishing the roles of CENP-T/W in mitotic kinetochore assembly and stability

scientific article published on January 2016

Biochemical mechanism of apoptotic execution.

scientific article published on May 2000

Borealin: a novel chromosomal passenger required for stability of the bipolar mitotic spindle

scientific article

Breaking the HAC Barrier: histone H3K9 acetyl/methyl balance regulates CENP-A assembly

scientific article

Building mitotic chromosomes

scientific article published on 23 October 2010

CAD/DFF40 nuclease is dispensable for high molecular weight DNA cleavage and stage I chromatin condensation in apoptosis.

scientific article

CDC27Hs colocalizes with CDC16Hs to the centrosome and mitotic spindle and is essential for the metaphase to anaphase transition

scientific article

CELL BIOLOGY: Keeping Survivin Nimble at Centromeres in Mitosis

scientific article published in Science

CENP-32 is required to maintain centrosomal dominance in bipolar spindle assembly

scientific journal article

CENP-A and the CENP nomenclature: response to Talbert and Henikoff

scientific article

CENP-A is required for accurate chromosome segregation and sustained kinetochore association of BubR1.

scientific article

CENP-C and CENP-I are key connecting factors for kinetochore and CENP-A assembly

scientific article

CENP-C binds the alpha-satellite DNA in vivo at specific centromere domains

scientific article (publication date: June 2002)

CENP-C is required for maintaining proper kinetochore size and for a timely transition to anaphase.

scientific article

CENP-C, an autoantigen in scleroderma, is a component of the human inner kinetochore plate

scientific article

CENP-E, a novel human centromere-associated protein required for progression from metaphase to anaphase

scientific article

CENP-I is essential for centromere function in vertebrate cells

scientific article

CENP-V is required for centromere organization, chromosome alignment and cytokinesis

scientific article

Caspase-6 gene disruption reveals a requirement for lamin A cleavage in apoptotic chromatin condensation

scientific article published on April 2002

Caspase-7 gene disruption reveals an involvement of the enzyme during the early stages of apoptosis

scientific article published on 28 October 2003

Caspase-mediated cleavage of DNA topoisomerase I at unconventional sites during apoptosis

scientific article

Cell division, growth and death

Centromere and kinetochore structure.

scientific article

Centromeric inactivation in a dicentric human Y;21 translocation chromosome ⬇️

scientific article published on September 1, 1997

Centrosome amplification induced by DNA damage occurs during a prolonged G2 phase and involves ATM.

scientific article

Characterization of Caspase Processing and Activation in HL-60 Cell Cytosol Under Cell-free Conditions

scientific article published in Journal of Biological Chemistry

Characterization of neo-centromeres in marker chromosomes lacking detectable alpha-satellite DNA.

scientific article published on August 1997

Chk1 is required for spindle checkpoint function.

scientific article published in February 2007

Chromatin-associated Protein Phosphatase 1 Regulates Aurora-B and Histone H3 Phosphorylation

scientific article published in Journal of Biological Chemistry

Chromokinesin KIF4A teams up with Stathmin 1 to regulate abscission in a SUMO-dependent manner

scientific article published on 26 June 2020

Chromosomal passengers

scientific article published on 01 September 2001

Chromosomal passengers and the (aurora) ABCs of mitosis

scientific article (publication date: February 2001)

Chromosomal passengers: Toward an integrated view of mitosis

article

Chromosomal passengers: conducting cell division

scientific article (publication date: October 2007)

Chromosomal passengers: the four-dimensional regulation of mitotic events

scientific article published on 4 September 2004

Chromosome engineering allows the efficient isolation of vertebrate neocentromeres.

scientific article

Cleavage furrows formed between centrosomes lacking an intervening spindle and chromosomes contain microtubule bundles, INCENP, and CHO1 but not CENP-E.

scientific article published on February 1999

Cleavage of lamin A by Mch2 alpha but not CPP32: multiple interleukin 1 beta-converting enzyme-related proteases with distinct substrate recognition properties are active in apoptosis

scientific article

Cleavage of poly(ADP-ribose) polymerase by a proteinase with properties like ICE

scientific article (publication date: 22 September 1994)

Co-localization of centromere activity, proteins and topoisomerase II within a subdomain of the major human X alpha-satellite array

scientific article

Comparison of apoptosis in wild-type and Fas-resistant cells: chemotherapy-induced apoptosis is not dependent on Fas/Fas ligand interactions ⬇️

scientific article published on August 1, 1997

Condensin I associates with structural and gene regulatory regions in vertebrate chromosomes

scientific article

Condensin I interacts with the PARP-1-XRCC1 complex and functions in DNA single-strand break repair

scientific article

Condensin and Repo-Man-PP1 co-operate in the regulation of chromosome architecture during mitosis

scientific article published on 24 September 2006

Condensin is required for nonhistone protein assembly and structural integrity of vertebrate mitotic chromosomes

scientific article

Condensin regulates the stiffness of vertebrate centromeres

scientific article

Condensin: Architect of mitotic chromosomes

scientific article published on January 2009

Contrasting roles of condensin I and condensin II in mitotic chromosome formation

scientific article

Correction: The Chromosomal Passenger Complex Activates Polo Kinase at Centromeres.

scientific article

CrmA/SPI-2 Inhibition of an Endogenous ICE-related Protease Responsible for Lamin A Cleavage and Apoptotic Nuclear Fragmentation

scientific article published in Journal of Biological Chemistry

Cytogenetic survey in systemic sclerosis: correlation of aneuploidy with the presence of anticentromere antibodies

scientific article published on 01 January 1993

DArk bleaching of rhodopsin by organic mercurial ⬇️

scientific article published on August 15, 1973

DNA arrangement in isometric phage heads ⬇️

scientific article published on August 18, 1977

DNA content of a functioning chicken kinetochore

scientific article

De novo formation and epigenetic maintenance of centromere chromatin

scientific article published on 15 January 2019

Death receptor-induced apoptosis reveals a novel interplay between the chromosomal passenger complex and CENP-C during interphase

scientific article

Deconstructing Survivin: comprehensive genetic analysis of Survivin function by conditional knockout in a vertebrate cell line

scientific article

Deducing protein function by forensic integrative cell biology

scientific article (publication date: December 2013)

Detection of DNA Cleavage in Apoptotic Cells

article

Detection of anticentromere antibodies using cloned autoantigen cenp-Bl

scientific article published on 01 December 1987

Development of a novel HAC-based "gain of signal" quantitative assay for measuring chromosome instability (CIN) in cancer cells

scientific article

Differential Localization of ICAD-L and ICAD-S in Cells Due to Removal of a C-Terminal NLS from ICAD-L by Alternative Splicing

article

Direct and indirect association of the small GTPase ran with nuclear pore proteins and soluble transport factors: studies in Xenopus laevis egg extracts.

scientific article published on September 1996

Discovering centromere proteins: from cold white hands to the A, B, C of CENPs

scientific article published on 20 May 2015

Disruption of centromere assembly during interphase inhibits kinetochore morphogenesis and function in mitosis

scientific article published on 01 September 1991

Down-regulation of HP1Hsalpha expression is associated with the metastatic phenotype in breast cancer

scientific article published on 01 July 2000

Drosophila Incenp is required for cytokinesis and asymmetric cell division during development of the nervous system

scientific article published on 28 February 2006

Dual roles of Incenp crucial to the assembly of the acentrosomal metaphase spindle in female meiosis

scientific article

Effects of full-length borealin on the composition and protein-protein interaction activity of a binary chromosomal passenger complex

scientific article published on February 2009

Efficiency of de novo centromere formation in human artificial chromosomes

scientific article published on March 2002

Epigenetic engineering reveals a balance between histone modifications and transcription in kinetochore maintenance

scientific article

Epigenetic engineering shows H3K4me2 is required for HJURP targeting and CENP-A assembly on a synthetic human kinetochore

scientific article

Epigenetic engineering shows that a human centromere resists silencing mediated by H3K27me3/K9me3

scientific article

Epigenetic engineering: histone H3K9 acetylation is compatible with kinetochore structure and function

scientific article published on January 2012

Essential roles of Drosophila inner centromere protein (INCENP) and aurora B in histone H3 phosphorylation, metaphase chromosome alignment, kinetochore disjunction, and chromosome segregation

scientific article (publication date: 14 May 2001)

Essential roles of KIF4 and its binding partner PRC1 in organized central spindle midzone formation

scientific article

FREQUENCY OF AUTOANTIBODIES TO A MAJOR EPITOPE ON THE CARBOXYL TERMINAL FRAGMENT OF CENP-B IN PATIENTS WITH AUTOIMMUNE DISEASE

scientific article published on 01 May 1995

Formation of spindle poles by dynein/dynactin-dependent transport of NuMA

scientific article

Functional analysis after rapid degradation of condensins and 3D-EM reveals chromatin volume is uncoupled from chromosome architecture in mitosis.

scientific article published on 19 January 2018

Functional complementation of a genetic deficiency with human artificial chromosomes.

scientific article published on 10 July 2001

Further evidence that CENP-C is a necessary component of active centromeres: studies of a dic(X; 15) with simultaneous immunofluorescence and FISH

article

Generation of a Synthetic Human Chromosome with Two Centromeric Domains for Advanced Epigenetic Engineering Studies.

scientific article published on 22 March 2018

Generation of a conditionally self-eliminating HAC gene delivery vector through incorporation of a tTAVP64 expression cassette.

scientific article published on 20 February 2015

Genetic analysis of the short splice variant of the inhibitor of caspase-activated DNase (ICAD-S) in chicken DT40 cells.

scientific article

Genetic and epigenetic regulation of centromeres: a look at HAC formation.

scientific article

Gradient of increasing Aurora B kinase activity is required for cells to execute mitosis

scientific article published on 18 October 2010

Granzyme B/Perforin-Mediated Apoptosis of Jurkat Cells Results in Cleavage of Poly(ADP-ribose) Polymerase to the 89-kDa Apoptotic Fragment and Less Abundant 64-kDa Fragment

article

H3K9me3 maintenance on a Human Artificial Chromosome is required for segregation but not centromere epigenetic memory

scientific article published on 23 June 2020

HACking the centromere chromatin code: insights from human artificial chromosomes.

scientific article published on July 2012

HP1α targets the chromosomal passenger complex for activation at heterochromatin before mitotic entry.

scientific article published on 21 February 2018

Hierarchical inactivation of a synthetic human kinetochore by a chromatin modifier

scientific article published on 05 August 2009

High titers of autoantibodies to topoisomerase I (Scl-70) in sera from scleroderma patients

scientific article published on 01 February 1986

Histone H4 Lys 20 monomethylation of the CENP-A nucleosome is essential for kinetochore assembly

scientific article

Histones synthesized for use in early development of Xenopus laevis are stored as a complex with antigenic properties similar to those of the octamer core of nucleosomes.

scientific article

How do kinetochores CLASP dynamic microtubules?

scientific article

Human Artificial Chromosome with Regulated Centromere: A Tool for Genome and Cancer Studies

article

Human CLASP1 is an outer kinetochore component that regulates spindle microtubule dynamics

scientific article

Human INCENP colocalizes with the Aurora-B/AIRK2 kinase on chromosomes and is overexpressed in tumour cells

scientific article (publication date: May 2001)

Human artificial chromosome (HAC) vector with a conditional centromere for correction of genetic deficiencies in human cells

scientific article

Human artificial chromosome with a conditional centromere for gene delivery and gene expression.

scientific article

Human artificial chromosome-based gene delivery vectors for biomedicine and biotechnology

scientific article published on 30 January 2014

Human autoantibody to topoisomerase II.

scientific article

ICAD/DFF Regulator of Apoptotic Nuclease Is Nuclear

article

ICE-related proteases in apoptosis.

scientific article published on February 1996

INCENP and Aurora B promote meiotic sister chromatid cohesion through localization of the Shugoshin MEI-S332 in Drosophila

scientific article published in July 2006

INCENP at the kinase crossroads

article

INCENP binds directly to tubulin and requires dynamic microtubules to target to the cleavage furrow

scientific article (publication date: 15 January 2001)

INCENP centromere and spindle targeting: identification of essential conserved motifs and involvement of heterochromatin protein HP1

scientific article

INCENP is required for proper targeting of Survivin to the centromeres and the anaphase spindle during mitosis

scientific article

INCENP loss from an inactive centromere correlates with the loss of sister chromatid cohesion.

scientific article

INCENP-aurora B interactions modulate kinase activity and chromosome passenger complex localization

scientific article

INCENP?aurora B interactions modulate kinase activity and chromosome passenger complex localization.

scientific article published in February 2010

Identification of a family of human centromere proteins using autoimmune sera from patients with scleroderma

scientific article

Identification of a subdomain of CENP-B that is necessary and sufficient for localization to the human centromere ⬇️

scientific article published on March 1, 1992

Identification of overlapping DNA-binding and centromere-targeting domains in the human kinetochore protein CENP-C.

scientific article published on July 1996

Idiotypic Analysis of Human Anticentromere Autoantibodies

article

Idiotypic analysis of human anti-topoisomerase I autoantibodies.

scientific article published on January 1991

Immunolocalization of CENP-A suggests a distinct nucleosome structure at the inner kinetochore plate of active centromeres

scientific article published on 01 November 1997

In vitro BioID: mapping the CENP-A microenvironment with high temporal and spatial resolution

scientific article published on 20 March 2019

In vivo functional dissection of human inner kinetochore protein CENP-C

scientific article

In vivo phosphorylation of the 170-kDa form of eukaryotic DNA topoisomerase II. Cell cycle analysis.

scientific article published in September 1989

Inactivation of a human kinetochore by specific targeting of chromatin modifiers

scientific article published on April 2008

Induction of apoptosis by cancer chemotherapy.

scientific article

Interphase-specific association of intrinsic centromere protein CENP-C with HDaxx, a death domain-binding protein implicated in Fas-mediated cell death

scientific article

Isolation of mitotic chromosomes from vertebrate cells and characterization of their proteome by mass spectrometry

scientific article published on 12 April 2018

Isotype analysis of the anti–CENP-B anticentromere autoantibody: Evidence for restricted clonality

article

KAT7/HBO1/MYST2 Regulates CENP-A Chromatin Assembly by Antagonizing Suv39h1-Mediated Centromere Inactivation.

scientific article published on June 2016

Ki-67 and the Chromosome Periphery Compartment in Mitosis.

scientific article published on 21 August 2017

Ki-67 is a PP1-interacting protein that organises the mitotic chromosome periphery.

scientific article

Kinetochore localisation of the DNA damage response component 53BP1 during mitosis

scientific journal article

Lack of correlation between caspase activation and caspase activity assays in paclitaxel-treated MCF-7 breast cancer cells

scientific article

Longitudinal Study of Anticentromere and Antitopoisomerase-I Isotypes

article

MAST/Orbit has a role in microtubule-kinetochore attachment and is essential for chromosome alignment and maintenance of spindle bipolarity

scientific article

Making the Auroras glow: regulation of Aurora A and B kinase function by interacting proteins

scientific article published on December 2009

Mammalian CLASP1 and CLASP2 cooperate to ensure mitotic fidelity by regulating spindle and kinetochore function

scientific article published on 16 August 2006

Mammalian Centromeres: DNA Sequence, Protein Composition, and Role in Cell Cycle Progression

article

Mammalian caspases: structure, activation, substrates, and functions during apoptosis

scientific article (publication date: June 1999)

Mapping DNA within the mammalian kinetochore.

scientific article

Mapping the invisible chromatin transactions of prophase chromosome remodeling

scientific article published on 31 January 2022

Method to Assemble Genomic DNA Fragments or Genes on Human Artificial Chromosome with Regulated Kinetochore Using a Multi-Integrase System

scientific article

Mio depletion links mTOR regulation to Aurora A and Plk1 activation at mitotic centrosomes

scientific article published on 29 June 2015

Mitotic chromosome formation and the condensin paradox

scientific article published on May 2004

Mitotic chromosome structure.

scientific article published on November 1988

Mitotic chromosomes are compacted laterally by KIF4 and condensin and axially by topoisomerase IIα

scientific article published on 19 November 2012

Mitotic post-translational modifications of histones promote chromatin compaction in vitro

scientific article published on September 2017

Modelling of the small-angle X-ray diffraction arising from the surface lattices of phages lambda and P22

scientific article published on June 15, 1979

Molecular analysis of the INCENPs (inner centromere proteins): separate domains are required for association with microtubules during interphase and with the central spindle during anaphase.

scientific article

Molecular and genetic analysis of condensin function in vertebrate cells

scientific article published on 14 May 2008

Molecular basis for Cdk1-regulated timing of Mis18 complex assembly and CENP-A deposition.

scientific article published on 4 April 2017

Molecular cloning of a human homologue of Drosophila heterochromatin protein HP1 using anti-centromere autoantibodies with anti-chromo specificity.

scientific article

Mps1 Phosphorylates Its N-Terminal Extension to Relieve Autoinhibition and Activate the Spindle Assembly Checkpoint.

scientific article published on 20 February 2018

Mutations in pericentrin cause Seckel syndrome with defective ATR-dependent DNA damage signaling

scientific article published on 23 December 2007

Nano Random Forests to mine protein complexes and their relationships in quantitative proteomics data

scientific article

Nap1 regulates proper CENP-B binding to nucleosomes

scientific article published on 15 January 2013

Neocentromeres

article

New faces for the new year

scientific article published on 01 January 1997

Novel components of human mitotic chromosomes identified by proteomic analysis of the chromosome scaffold fraction

scientific article published on 18 December 2004

Organization of synthetic alphoid DNA array in human artificial chromosome (HAC) with a conditional centromere

scientific article published on December 2012

PREditOR: a synthetic biology approach to removing heterochromatin from cells

scientific article published on 06 December 2016

Panspecies small-molecule disruptors of heterochromatin-mediated transcriptional gene silencing

scientific article

Phosphorylated forms of activated caspases are present in cytosol from HL-60 cells during etoposide-induced apoptosis

scientific article published on 01 November 1998

Polo kinase regulates the localization and activity of the chromosomal passenger complex in meiosis and mitosis in Drosophila melanogaster

scientific article

Protecting a transgene expression from the HAC-based vector by different chromatin insulators

scientific article published on 16 May 2013

Proteomic analysis of human metaphase chromosomes reveals topoisomerase II alpha as an Aurora B substrate

scientific article

Proteomics Analysis with a Nano Random Forest Approach Reveals Novel Functional Interactions Regulated by SMC Complexes on Mitotic Chromosomes

scientific article published on 26 May 2016

Publisher Correction: A DHODH inhibitor increases p53 synthesis and enhances tumor cell killing by p53 degradation blockage.

scientific article published on 22 May 2018

Purification of the Death Substrate Poly(ADP-ribose) Polymerase

article

RNAi analysis reveals an unexpected role for topoisomerase II in chromosome arm congression to a metaphase plate

scientific article published in December 2003

Re-engineering an alphoid(tetO)-HAC-based vector to enable high-throughput analyses of gene function

scientific article published on 4 April 2013

Reed-Sternberg cells form by abscission failure in the presence of functional Aurora B kinase

scientific article (publication date: 2015)

Regulation of both apoptosis and cell survival by the v-Src oncoprotein.

scientific article published on August 2000

Replication of alpha-satellite DNA arrays in endogenous human centromeric regions and in human artificial chromosome

scientific article

Repo-Man coordinates chromosomal reorganization with nuclear envelope reassembly during mitotic exit.

scientific article

Repo-Man-PP1: a link between chromatin remodelling and nuclear envelope reassembly

scientific article published on March 2012

Reverse genetics of essential genes in tissue-culture cells: 'dead cells talking'.

scientific article

Role of factors downstream of caspases in nuclear disassembly during apoptotic execution.

scientific article

Role of nonhistone proteins in the chromosomal events of mitosis

scientific article

Role of the Centromere/Kinetochore in Cell Cycle Control

scientific article published on 01 January 1991

SUMOylation modulates the function of Aurora-B kinase

scientific article

ScII: an abundant chromosome scaffold protein is a member of a family of putative ATPases with an unusual predicted tertiary structure.

scientific article

Scc1/Rad21/Mcd1 is required for sister chromatid cohesion and kinetochore function in vertebrate cells

scientific article (publication date: December 2001)

Seh1 targets GATOR2 and Nup153 to mitotic chromosomes.

scientific article published on 3 April 2018

Sgt1 is required for human kinetochore assembly

scientific article

Shugoshin: a centromeric guardian senses tension

scientific article

Silver staining the chromosome scaffold

scientific article

Specific destruction of kinetochore protein CENP-C and disruption of cell division by herpes simplex virus immediate-early protein Vmw110.

scientific article published on March 1999

Specification of kinetochore-forming chromatin by the histone H3 variant CENP-A

scientific article

Stepwise unfolding supports a subunit model for vertebrate kinetochores

scientific article

Structural studies of bacteriophage lambda heads and proheads by small angle X-ray diffraction

scientific article

Structure and assembly of the capsid of bacteriophage P22

scientific article published on November 30, 1976

Structure of phage P22 coat protein aggregates formed in the absence of the scaffolding protein

scientific article

Structure of the human centromere at metaphase.

scientific article published on May 1990

Studies of the lamin proteinase reveal multiple parallel biochemical pathways during apoptotic execution

scientific article

Super-resolution fluorescence microscopy as a tool to study the nanoscale organization of chromosomes

scientific article

Survivin is required for stable checkpoint activation in taxol-treated HeLa cells

scientific article

Synthesis of novel caspase inhibitors for characterization of the active caspase proteome in vitro and in vivo

scientific article

Systematic Analysis of Compounds Specifically Targeting Telomeres and Telomerase for Clinical Implications in Cancer Therapy

scientific article published on 30 August 2018

TD-60 links RalA GTPase function to the CPC in mitosis.

scientific article published on 9 July 2015

Targeting the INCENP IN-box-Aurora B interaction to inhibit CPC activity in vivo.

scientific article

The Dawn of Aurora Kinase Research: From Fly Genetics to the Clinic

scientific article

The INCENPs: Structural and Functional Analysis of a Family of Chromosome Passenger Proteins

scientific article published on 01 January 1993

The Inner Centromere Protein (INCENP) Coil Is a Single α-Helix (SAH) Domain That Binds Directly to Microtubules and Is Important for Chromosome Passenger Complex (CPC) Localization and Function in Mitosis. ⬇️

scientific article

The SMC proteins and the coming of age of the chromosome scaffold hypothesis.

scientific article

The centromere: chromatin foundation for the kinetochore machinery

scientific article

The centromere: hub of chromosomal activities.

scientific article

The chromosomal passenger complex (CPC): from easy rider to the godfather of mitosis

scientific article published on December 2012

The chromosomal passenger complex activates Polo kinase at centromeres

scientific article

The chromosomal passenger complex: one for all and all for one.

scientific article

The dynamic kinetochore-microtubule interface

scientific article

The kinetochore is part of the metaphase chromosome scaffold.

scientific article

The pinheads and fuzzbrains go haywire. Chromosome Structure and Segregation sponsored by the American Society for Cell Biology, Airlie, VA, USA, September 8-12, 1989

scientific article published on 01 December 1989

The protein composition of mitotic chromosomes determined using multiclassifier combinatorial proteomics

scientific article

The size of the bacteriophage T4 head in solution with comments about the dimension of virus particles as visualized by electron microscopy

scientific article

The structural organization of DNA packaged within the heads of T4 wild-type, isometric and giant bacteriophages

scientific article

The structure and dynamics of ring chromosomes in human neoplastic and non-neoplastic cells

article

Three distinct stages of apoptotic nuclear condensation revealed by time-lapse imaging, biochemical and electron microscopy analysis of cell-free apoptosis

scientific article

Three human chromosomal autoantigens are recognized by sera from patients with anti-centromere antibodies

scientific article

Three related centromere proteins are absent from the inactive centromere of a stable isodicentric chromosome

article

Three-dimensional topology of the SMC2/SMC4 subcomplex from chicken condensin I revealed by cross-linking and molecular modelling

scientific article

Topoisomerase II is a structural component of mitotic chromosome scaffolds.

scientific article

Transition from caspase-dependent to caspase-independent mechanisms at the onset of apoptotic execution.

scientific article

Transmission of a fully functional human neocentromere through three generations

scientific article

Trashing the genome: the role of nucleases during apoptosis

scientific article

Two Interlinked Bistable Switches Govern Mitotic Control in Mammalian Cells

scientific article published on 15 November 2018

Two differentially spliced forms of topoisomerase IIalpha and beta mRNAs are conserved between birds and humans.

scientific article

Untangling the role of DNA topoisomerase II in mitotic chromosome structure and function.

scientific article published on February 1997

Use of DT40 conditional-knockout cell lines to study chromosomal passenger protein function

scientific article published on December 2010

Use of Mass Spectrometry to Study the Centromere and Kinetochore

scientific article published on January 2017

Use of molecular cloning methods to map the distribution of epitopes on topoisomerase I (Scl-70) recognized by sera of scleroderma patients

scientific article published on 01 October 1990

Using human artificial chromosomes to study centromere assembly and function

scientific article

Vascular smooth muscle cell polyploidization involves changes in chromosome passenger proteins and an endomitotic cell cycle

article

Vertebrate cells genetically deficient for Cdc14A or Cdc14B retain DNA damage checkpoint proficiency but are impaired in DNA repair

scientific article

Visualization of centromere proteins CENP-B and CENP-C on a stable dicentric chromosome in cytological spreads

scientific article published on 01 June 1989

When is a centromere not a kinetochore?

scientific article published on May 1991

Whole-proteome genetic analysis of dependencies in assembly of a vertebrate kinetochore.

scientific article published on 14 December 2015

p150TSP, a conserved nuclear phosphoprotein that contains multiple tetratricopeptide repeats and binds specifically to SH2 domains

scientific journal article

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