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List of works by Sarah Spiegel

"Inside-out" signaling of sphingosine-1-phosphate: therapeutic targets

scientific article

A Serotype 5/3 Adenovirus Expressing MDA-7/IL-24 Infects Renal Carcinoma Cells and Promotes Toxicity of Agents That Increase Ros and Ceramide Levels ⬇️

scientific article published on November 30, 2010

A chicken-or-egg conundrum in apoptosis: which comes first? Ceramide or PKCdelta?

scientific article

A novel acylglycerol kinase that produces lysophosphatidic acid modulates cross talk with EGFR in prostate cancer cells

scientific article

A novel role for mitochondrial sphingosine-1-phosphate produced by sphingosine kinase-2 in PTP-mediated cell survival during cardioprotection.

scientific article

A rapid and sensitive method to measure secretion of sphingosine-1-phosphate

scientific article

A real-time high-throughput fluorescence assay for sphingosine kinases

scientific article

A selective sphingosine kinase 1 inhibitor integrates multiple molecular therapeutic targets in human leukemia.

scientific article published on 29 May 2008

A specific ceramide kinase assay to measure cellular levels of ceramide

scientific article

A specific sphingosine kinase 1 inhibitor attenuates airway hyperresponsiveness and inflammation in a mast cell–dependent murine model of allergic asthma ⬇️

scientific article published on August 30, 2012

ABCC1-Exported Sphingosine-1-phosphate, Produced by Sphingosine Kinase 1, Shortens Survival of Mice and Patients with Breast Cancer

scientific article published on 9 March 2018

Aberrant ORM (yeast)-like protein isoform 3 (ORMDL3) expression dysregulates ceramide homeostasis in cells and ceramide exacerbates allergic asthma in mice

scientific article

Active, phosphorylated fingolimod inhibits histone deacetylases and facilitates fear extinction memory

scientific article

Alkaline ceramidase 1 is essential for mammalian skin homeostasis and regulating whole-body energy expenditure

scientific article published on 29 April 2016

Aminoacylase 1 is a sphingosine kinase 1-interacting protein

scientific article published on June 2004

An improved syngeneic orthotopic murine model of human breast cancer progression

scientific article

Apoptosis induces expression of sphingosine kinase 1 to release sphingosine-1-phosphate as a "come-and-get-me" signal

scientific article published on 24 March 2008

Arabidopsis sphingosine kinase and the effects of phytosphingosine-1-phosphate on stomatal aperture

scientific article published on 21 January 2005

Autocrine and paracrine roles of sphingosine-1-phosphate

scientific article published on 29 September 2007

Autophagy Induced by Deficiency of Sphingosine-1-phosphate Phosphohydrolase 1 Is Switched to Apoptosis by Calpain-mediated Autophagy-related Gene 5 (Atg5) Cleavage ⬇️

scientific article published on November 3, 2011

Biological characterization of 3-(2-amino-ethyl)-5-[3-(4-butoxyl-phenyl)-propylidene]-thiazolidine-2,4-dione (K145) as a selective sphingosine kinase-2 inhibitor and anticancer agent

scientific article

CERAMIDE IN APOPTOSIS AND OXIDATIVE STRESS IN ALLERGIC INFLAMMATION AND ASTHMA

scientific article published on 29 October 2020

Ca2+/calmodulin-dependent translocation of sphingosine kinase: role in plasma membrane relocation but not activation.

scientific article published on February 2003

Carnitine palmitoyltransferase 1A functions to repress FoxO transcription factors to allow cell cycle progression in ovarian cancer

scientific article published on 24 December 2015

Caspase-, cathepsin-, and PERK-dependent regulation of MDA-7/IL-24-induced cell killing in primary human glioma cells

scientific article published on February 2008

Ceramide 1-phosphate, a mediator of phagocytosis

scientific article

Ceramide kinase mediates cytokine- and calcium ionophore-induced arachidonic acid release

scientific article (publication date: 3 October 2003)

Ceramide kinase regulates growth and survival of A549 human lung adenocarcinoma cells

scientific article published on 25 January 2007

Ceramide kinase, a novel lipid kinase. Molecular cloning and functional characterization

scientific article

Ceramide plays a prominent role in MDA-7/IL-24-induced cancer-specific apoptosis.

scientific article

Ceramide-induced cell death in primary neuronal cultures: upregulation of ceramide levels during neuronal apoptosis

scientific article

Characterization of murine sphingosine-1-phosphate phosphohydrolase

scientific journal article

Cloning and characterization of a protein kinase A anchoring protein (AKAP)-related protein that interacts with and regulates sphingosine kinase 1 activity

scientific article

Coadministration of histone deacetylase inhibitors and perifosine synergistically induces apoptosis in human leukemia cells through Akt and ERK1/2 inactivation and the generation of ceramide and reactive oxygen species

scientific article

Conjugated Bile Acids Activate the Sphingosine–1–Phosphate Receptor 2 in Primary Rodent Hepatocytes ⬇️

scientific article published on November 30, 2011

Conjugated bile acid-activated S1P receptor 2 is a key regulator of sphingosine kinase 2 and hepatic gene expression

scientific article

Conjugated bile acids promote ERK1/2 and AKT activation via a pertussis toxin-sensitive mechanism in murine and human hepatocytes

scientific article

Copper dependence of angioproliferation in pulmonary arterial hypertension in rats and humans

scientific article

Cross-talk at the crossroads of sphingosine-1-phosphate, growth factors, and cytokine signaling

scientific article published on 2 April 2008

Cross-talk between LPA1 and epidermal growth factor receptors mediates up-regulation of sphingosine kinase 1 to promote gastric cancer cell motility and invasion.

scientific article published on August 2008

Deoxycholic acid activates the c-Jun N-terminal kinase pathway via FAS receptor activation in primary hepatocytes. Role of acidic sphingomyelinase-mediated ceramide generation in FAS receptor activation

scientific article

Development of small-molecule inhibitors of sphingosine-1-phosphate signaling ⬇️

scientific article published on August 27, 2011

Differential regulation of autophagy and cell viability by ceramide species

scientific article

Differential transactivation of sphingosine-1-phosphate receptors modulates NGF-induced neurite extension

scientific journal article

Distinct roles of sphingosine kinases 1 and 2 in human mast-cell functions

scientific article

EGF regulates plasminogen activator inhibitor-1 (PAI-1) by a pathway involving c-Src, PKCdelta, and sphingosine kinase 1 in glioblastoma cells

scientific article published on 12 September 2007

Editorial for BBRC lipidomics special issue

article

Effect of a membrane-targeted sphingosine kinase 1 on cell proliferation and survival.

scientific article published on June 2005

Essential role for sphingosine kinases in neural and vascular development

scientific journal article

Essential roles of sphingosine-1-phosphate receptor 2 in human mast cell activation, anaphylaxis, and pulmonary edema

scientific article

Estradiol induces export of sphingosine 1-phosphate from breast cancer cells via ABCC1 and ABCG2.

scientific article

Export and functions of sphingosine-1-phosphate.

scientific article published on 04 March 2009

Expression of SphK1 impairs degranulation and motility of RBL-2H3 mast cells by desensitizing S1P receptors

scientific article published in March 2005

Extracellular and Intracellular Actions of Sphingosine-1-Phosphate ⬇️

scientific article published on January 1, 2010

FTY720/fingolimod increases NPC1 and NPC2 expression and reduces cholesterol and sphingolipid accumulation in Niemann-Pick type C mutant fibroblasts

scientific article published on 12 January 2017

Fenretinide Causes Emphysema, Which Is Prevented by Sphingosine 1-Phoshate ⬇️

scientific article published on January 11, 2013

Filamin A Expression Negatively Regulates Sphingosine-1-Phosphate-Induced NF-κB Activation in Melanoma Cells by Inhibition of Akt Signaling

scientific article published on 9 November 2015

Filamin A links sphingosine kinase 1 and sphingosine-1-phosphate receptor 1 at lamellipodia to orchestrate cell migration

scientific article

Fingolimod augments Pemetrexed killing of non-small cell lung cancer and overcomes resistance to ERBB inhibition

scientific article published on 02 November 2018

Functions of the multifaceted family of sphingosine kinases and some close relatives

scientific article

Generation and metabolism of bioactive sphingosine-1-phosphate

scientific article published in August 2004

Genome-wide in vivo screen identifies novel host regulators of metastatic colonization

scientific article published on 4 January 2017

Genotype-dependent effects of TGF-β1 on mast cell function: targeting the Stat5 pathway

scientific journal article

Glycosphingolipids and cell death

scientific article published on January 2004

Hepatic apolipoprotein M (apoM) overexpression stimulates formation of larger apoM/sphingosine 1-phosphate-enriched plasma high density lipoprotein.

scientific article published on 06 December 2013

Host sphingosine kinase 1 worsens pancreatic cancer peritoneal carcinomatosis

scientific article published on 9 July 2016

IL-4 and TGF-beta 1 counterbalance one another while regulating mast cell homeostasis

scientific article published on 19 March 2010

In Memoriam: Roscoe Owen Brady (1923-2016)

scientific article published on 17 August 2016

Innate immune agonist, dsRNA, induces apoptosis in ovarian cancer cells and enhances the potency of cytotoxic chemotherapeutics ⬇️

scientific article published on April 24, 2012

Interleukin-1 regulates the expression of sphingosine kinase 1 in glioblastoma cells

scientific article published on 11 December 2008

International Union of Basic and Clinical Pharmacology. LXXVIII. Lysophospholipid receptor nomenclature

scientific article

Interstitial Fluid Sphingosine-1-Phosphate in Murine Mammary Gland and Cancer and Human Breast Tissue and Cancer Determined by Novel Methods

scientific article published on 19 May 2016

Involvement of sphingosine kinase 2 in p53-independent induction of p21 by the chemotherapeutic drug doxorubicin

scientific article published on November 2007

Involvement of sphingosine kinase in TNF-alpha-stimulated tetrahydrobiopterin biosynthesis in C6 glioma cells

scientific article published on 28 January 2002

Involvement of sphingosine kinase in plant cell signalling

scientific article published on 28 June 2008

Is tail vein injection a relevant breast cancer lung metastasis model?

scientific article published on August 2013

K63-linked polyubiquitination of transcription factor IRF1 is essential for IL-1-induced production of chemokines CXCL10 and CCL5.

scientific article published on 26 January 2014

Lipid mediators of angiogenesis and the signalling pathways they initiate

scientific article

Lyn but not Fyn kinase controls IgG-mediated systemic anaphylaxis

scientific article published on 26 March 2012

Lysophosphatidic acid stimulates gastric cancer cell proliferation via ERK1-dependent upregulation of sphingosine kinase 1 transcription.

scientific article

Lysophospholipid receptor nomenclature review: IUPHAR Review 8.

scientific article

Lysophospholipid receptors in the nervous system

scientific article

MDA-7/IL-24-induced cell killing in malignant renal carcinoma cells occurs by a ceramide/CD95/PERK-dependent mechanism

scientific article

Measurement of mammalian sphingosine-1-phosphate phosphohydrolase activity in vitro and in vivo

scientific article

Memo has a novel role in S1P signaling and is [corrected] crucial for vascular development

scientific article

Mice deficient in sphingosine kinase 1 are rendered lymphopenic by FTY720.

scientific article published on 30 September 2004

Modulation of adaptive immune responses by sphingosine-1-phosphate

scientific article published in October 2004

Molecular mechanism of sphingosine-1-phosphate action in Duchenne muscular dystrophy

scientific article published on 25 September 2013

Murine model of long-term obstructive jaundice

scientific article

Network modelling reveals the mechanism underlying colitis-associated colon cancer and identifies novel combinatorial anti-cancer targets

scientific article

Neuropeptide Y induces migration, proliferation, and tube formation of endothelial cells bimodally via Y1, Y2, and Y5 receptors

scientific article

New insights into functions of the sphingosine-1-phosphate transporter SPNS2

scientific article published on 17 January 2019

Niemann-Pick type C disease: The atypical sphingolipidosis

scientific article published on 28 August 2018

Non-alcoholic fatty liver disease: Insights from sphingolipidomics

scholarly article by David J Montefusco published in October 2018

Novel Sphingolipid-Based Cancer Therapeutics in the Personalized Medicine Era

scientific article published on 19 June 2018

Novel role of sphingosine kinase 1 as a mediator of neurotrophin-3 action in oligodendrocyte progenitors

scientific journal article

ORMDL proteins regulate ceramide levels during sterile inflammation

scientific article published on 16 June 2016

ORMDL3 and allergic asthma: From physiology to pathology

scientific article published on 31 July 2019

OSU-03012 stimulates PKR-like endoplasmic reticulum-dependent increases in 70-kDa heat shock protein expression, attenuating its lethal actions in transformed cells

scientific article published on 08 January 2008

PDE5 inhibitors enhance celecoxib killing in multiple tumor types

scientific article

PERK-dependent regulation of MDA-7/IL-24-induced autophagy in primary human glioma cells

scientific article published on 13 February 2008

PERK-dependent regulation of ceramide synthase 6 and thioredoxin play a key role in mda-7/IL-24-induced killing of primary human glioblastoma multiforme cells

scientific article

Pleiotropic actions of sphingosine-1-phosphate

scientific article

Preferential signaling and induction of allergy-promoting lymphokines upon weak stimulation of the high affinity IgE receptor on mast cells.

scientific article

Recycling of sphingosine is regulated by the concerted actions of sphingosine-1-phosphate phosphohydrolase 1 and sphingosine kinase 2.

scientific article

Regulation and functions of sphingosine kinases in the brain

scientific article published on 29 April 2008

Regulation of fibroblast functions by lysophospholipid mediators: potential roles in wound healing

scientific article published on September 2007

Regulation of histone acetylation in the nucleus by sphingosine-1-phosphate.

scientific article

Resection of the primary tumor improves survival in metastatic breast cancer by reducing overall tumor burden.

scientific article published on 13 March 2013

Revisiting the sphingolipid rheostat: Evolving concepts in cancer therapy

scientific article

Role of ABCC1 in export of sphingosine-1-phosphate from mast cells

scientific article

Role of Sphingosine Kinase 1 and Sphingosine-1-Phosphate Axis in Hepatocellular Carcinoma

scientific article published on 19 July 2019

Role of sphingosine kinase 1 and sphingosine-1-phosphate in CD40 signaling and IgE class switching

scientific article

Role of sphingosine kinase 2 in cell migration toward epidermal growth factor

scientific article

Role of sphingosine-1-phosphate phosphatase 1 in epidermal growth factor-induced chemotaxis.

scientific article

Role of sphingosine-1-phosphate phosphohydrolase 1 in the regulation of resistance artery tone

scientific article published on 26 June 2008

Shooting the messenger: oxidative stress regulates sphingosine-1-phosphate

scientific article published on 01 January 2007

Sorafenib and pemetrexed toxicity in cancer cells is mediated via SRC-ERK signaling

scientific article published on 07 June 2012

SphK1 and SphK2, sphingosine kinase isoenzymes with opposing functions in sphingolipid metabolism

scientific article

Sphingolipid metabolites in inflammatory disease

scientific article

Sphingolipid signalling in Arabidopsis guard cells involves heterotrimeric G proteins

scientific article

Sphingosine 1-phosphate and ceramide 1-phosphate: expanding roles in cell signaling

scientific article

Sphingosine 1-phosphate in neural signalling and function

scientific article published on April 2007

Sphingosine 1-phosphate signaling: providing cells with a sense of direction

scientific article

Sphingosine 1-phosphate, a key cell signaling molecule

scientific article

Sphingosine 1-phosphate, present in serum-derived lipoproteins, activates matriptase

scientific article (publication date: 22 March 2002)

Sphingosine and Sphingosine Kinase 1 Involvement in Endocytic Membrane Trafficking

scientific article published on 3 January 2017

Sphingosine and its analog, the immunosuppressant 2-amino-2-(2-[4-octylphenyl]ethyl)-1,3-propanediol, interact with the CB1 cannabinoid receptor

scientific article

Sphingosine kinase 1

scientific article (publication date: 8 November 2007)

Sphingosine kinase 1 activation by estrogen receptor α36 contributes to tamoxifen resistance in breast cancer

scientific article published on 12 October 2018

Sphingosine kinase 1 in breast cancer

scientific article published on 16 October 2017

Sphingosine kinase 1 is required for migration, proliferation and survival of MCF-7 human breast cancer cells

scientific article published on October 2005

Sphingosine kinase activity counteracts ceramide-mediated cell death in human melanoma cells: role of Bcl-2 expression

scientific article published in January 2005

Sphingosine kinase and sphingosine-1-phosphate in liver pathobiology

scientific article

Sphingosine kinase functionally links elevated transmural pressure and increased reactive oxygen species formation in resistance arteries

scientific article published on 13 February 2006

Sphingosine kinase modulates microvascular tone and myogenic responses through activation of RhoA/Rho kinase

scientific article

Sphingosine kinase type 1 induces G12/13-mediated stress fiber formation, yet promotes growth and survival independent of G protein-coupled receptors

scientific article published on 8 September 2003

Sphingosine kinase type 1 promotes estrogen-dependent tumorigenesis of breast cancer MCF-7 cells

scientific article

Sphingosine kinase type 2 activation by ERK-mediated phosphorylation

scientific article published on 20 February 2007

Sphingosine kinase type 2 is a putative BH3-only protein that induces apoptosis

scientific article published on 30 June 2003

Sphingosine kinase, sphingosine-1-phosphate, and apoptosis

scientific article

Sphingosine kinase: a closer look at last

scientific article published on May 2013

Sphingosine kinases and sphingosine-1-phosphate are critical for transforming growth factor beta-induced extracellular signal-regulated kinase 1 and 2 activation and promotion of migration and invasion of esophageal cancer cells

scientific article published on 21 April 2008

Sphingosine kinases, sphingosine 1-phosphate, apoptosis and diseases

scientific article

Sphingosine kinases, sphingosine-1-phosphate and sphingolipidomics

scientific article

Sphingosine kinases: a novel family of lipid kinases

scientific article

Sphingosine-1-phosphate and estrogen signaling in breast cancer

scientific article

Sphingosine-1-phosphate and interleukin-1 independently regulate plasminogen activator inhibitor-1 and urokinase-type plasminogen activator receptor expression in glioblastoma cells: implications for invasiveness

scientific article published on September 2008

Sphingosine-1-phosphate and lipid phosphohydrolases

scientific article

Sphingosine-1-phosphate and the immunosuppressant, FTY720-phosphate, regulate detrusor muscle tone

scientific article published on 20 April 2007

Sphingosine-1-phosphate in allergic responses, asthma and anaphylaxis

scientific article

Sphingosine-1-phosphate in chronic intestinal inflammation and cancer

scientific article

Sphingosine-1-phosphate in the lymphatic fluid determined by novel methods

scientific article published on 22 December 2016

Sphingosine-1-phosphate induces development of functionally mature chymase-expressing human mast cells from hematopoietic progenitors

scientific article published on 17 June 2009

Sphingosine-1-phosphate inhibits IL-1-induced expression of C-C motif ligand 5 via c-Fos-dependent suppression of IFN-β amplification loop

scientific article

Sphingosine-1-phosphate is a missing cofactor for the E3 ubiquitin ligase TRAF2

scientific article

Sphingosine-1-phosphate links persistent STAT3 activation, chronic intestinal inflammation, and development of colitis-associated cancer.

scientific article published on 27 December 2012

Sphingosine-1-phosphate phosphatase 2 promotes disruption of mucosal integrity, and contributes to ulcerative colitis in mice and humans

scientific article published on 29 April 2016

Sphingosine-1-phosphate phosphohydrolase in regulation of sphingolipid metabolism and apoptosis

scientific journal article

Sphingosine-1-phosphate phosphohydrolase regulates endoplasmic reticulum-to-golgi trafficking of ceramide

scientific article

Sphingosine-1-phosphate produced by sphingosine kinase 1 promotes breast cancer progression by stimulating angiogenesis and lymphangiogenesis.

scientific article

Sphingosine-1-phosphate receptors mediate neuromodulatory functions in the CNS

scientific article

Sphingosine-1-phosphate signaling and its role in disease ⬇️

scientific article published on October 14, 2011

Sphingosine-1-phosphate stimulates contraction of human airway smooth muscle cells

scientific article published in October 2003

Sphingosine-1-phosphate synthesis and functions in mast cells

scientific article published on December 2008

Sphingosine-1-phosphate: dual messenger functions

scientific article

Sphingosine-1-phosphate: the Swiss army knife of sphingolipid signaling

scientific article

Sphingosine‐1‐phosphate produced by sphingosine kinase 2 in mitochondria interacts with prohibitin 2 to regulate complex IV assembly and respiration ⬇️

scientific article published on October 19, 2010

Spinster 2, a sphingosine-1-phosphate transporter, plays a critical role in inflammatory and autoimmune diseases

scientific article

Spns2, a transporter of phosphorylated sphingoid bases, regulates their blood and lymph levels, and the lymphatic network

scientific journal article

Structure of the First Sphingosine 1-Phosphate Receptor ⬇️

scientific article published on May 22, 2012

TP53 is required for BECN1- and ATG5-dependent cell death induced by sphingosine kinase 1 inhibition

scientific article published on 25 January 2018

Targeted lipidomics: signaling lipids and drugs of abuse

scientific article

Targeting SphK1 as a new strategy against cancer

scientific article published on August 2008

Targeting sphingosine kinase 1 inhibits Akt signaling, induces apoptosis, and suppresses growth of human glioblastoma cells and xenografts

scientific article published on September 2009

Targeting sphingosine-1-phosphate in hematologic malignancies

scientific article

Targeting sphingosine-1-phosphate: a novel avenue for cancer therapeutics

scientific article

Targeting the S1P/S1PR1 axis mitigates cancer-induced bone pain and neuroinflammation

scientific article published on 31 May 2017

Targeting the SphK1/S1P/S1PR1 axis that links obesity, chronic inflammation and breast cancer metastasis.

scientific article

Targeting the sphingosine-1-phosphate axis in cancer, inflammation and beyond

scientific article

The G Protein-Coupled Receptor GPR4 Suppresses ERK Activation in a Ligand-Independent Manner ⬇️

scientific article (publication date: 28 October 2003)

The ORMDL3 Asthma Gene Regulates ICAM1 and has Multiple Effects on Cellular Inflammation

article

The S1P2 receptor negatively regulates platelet-derived growth factor-induced motility and proliferation.

scientific article

The histone deacetylase inhibitor LAQ824 induces human leukemia cell death through a process involving XIAP down-regulation, oxidative injury, and the acid sphingomyelinase-dependent generation of ceramide

scientific article

The histone deacetylase inhibitor MS-275 interacts synergistically with fludarabine to induce apoptosis in human leukemia cells.

scientific article published in April 2004

The immunomodulator FTY720 has a direct cytoprotective effect in oligodendrocyte progenitors

scientific article

The immunosuppressant FTY720 is phosphorylated by sphingosine kinase type 2 ⬇️

scientific article published on November 6, 2003

The immunosuppressant drug FTY720 inhibits cytosolic phospholipase A2 independently of sphingosine-1-phosphate receptors

scientific article

The lipid phosphatase LPP3 regulates extra-embryonic vasculogenesis and axis patterning

scientific journal article

The outs and the ins of sphingosine-1-phosphate in immunity ⬇️

scientific article published on May 6, 2011

The potential of histone deacetylase inhibitors in Niemann - Pick type C disease

scientific article published on 23 September 2013

The role of sphingosine-1-phosphate and its receptors in asthma

scientific article published on March 2008

The role of sphingosine-1-phosphate in smooth muscle contraction

scientific article

The roles of sphingosine-1-phosphate in asthma

scientific article

The sphingosine-1-phosphate/sphingosine-1-phosphate receptor 2 axis regulates early airway T-cell infiltration in murine mast cell-dependent acute allergic responses.

scientific article

Transactivation of sphingosine-1-phosphate receptors by FcepsilonRI triggering is required for normal mast cell degranulation and chemotaxis

scientific article

Uncleaved ApoM signal peptide is required for formation of large ApoM/sphingosine 1-phosphate (S1P)-enriched HDL particles

scientific article

VEGF Potentiates GD3-Mediated Immunosuppression by Human Ovarian Cancer Cells

scientific article published on 13 April 2016

Vorinostat and sorafenib increase CD95 activation in gastrointestinal tumor cells through a Ca(2+)-de novo ceramide-PP2A-reactive oxygen species-dependent signaling pathway

scientific article published on 14 July 2010

Vorinostat and sorafenib increase ER stress, autophagy and apoptosis via ceramide-dependent CD95 and PERK activation

scientific article published on 12 October 2008

Why is effective treatment of asthma so difficult? An integrated systems biology hypothesis of asthma

scientific article

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