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List of works by Deborah Ashby

A Bayesian approach to probabilistic sensitivity analysis in structured benefit-risk assessment

scientific article published on 28 January 2015

A first-in-human study of the novel HIV-fusion inhibitor C34-PEG4-Chol

scientific article published on 25 August 2017

A randomised, double-blind, placebo-controlled trial of repeated nebulisation of non-viral cystic fibrosis transmembrane conductance regulator (CFTR) gene therapy in patients with cystic fibrosis

scientific article

A systematic review of chronic fatigue, its syndromes and ethnicity: prevalence, severity, co-morbidity and coping

scientific article

A systematic review of pain drawing literature: should pain drawings be used for psychologic screening?

scientific article published on June 2006

Adjusting for publication bias: modelling the selection process

scientific article published on May 2004

Advice to use topical or oral ibuprofen for chronic knee pain in older people: randomised controlled trial and patient preference study

scientific article

An analysis of papers published in the British and European Journals of Orthodontics.

scientific article published on August 1996

An efficacy and mechanism evaluation study of Levosimendan for the Prevention of Acute oRgan Dysfunction in Sepsis (LeoPARDS): protocol for a randomized controlled trial.

scientific article

Antibody prevalence for SARS-CoV-2 following the peak of the pandemic in England: REACT2 study in 100,000 adults

scientific article

Antidepressant treatment and the risk of fatal and non-fatal self harm in first episode depression: nested case-control study

scientific article

Antidepressants and suicide: what is the balance of benefit and harm

scientific article published on July 2004

Attenuated Salmonella typhimurium SL3261 as a vaccine vector for recombinant antigen in rabbits.

scientific article published on 23 March 2005

Azithromycin for Acute Exacerbations of Asthma : The AZALEA Randomized Clinical Trial

scientific article published on 19 September 2016

Balancing benefit and risk of medicines: a systematic review and classification of available methodologies

scientific article published on 13 May 2014

Bayesian statistics in medicine: a 25 year review

scientific article published on November 2006

Benefit-risk assessment in a post-market setting: a case study integrating real-life experience into benefit-risk methodology.

scientific article published on 5 July 2014

Cardiovascular MRI in clinical trials: expanded applications through novel surrogate endpoints

scientific article

Challenges and methodology in the incorporation of biomarkers in cancer clinical trials

scientific article published on 21 December 2016

Challenges in evaluating surgical innovation

scientific article

Changes in Cerebral Function Parameters with Maraviroc Intensified Antiretroviral Therapy in Treatment Naïve HIV-Positive Individuals; A Randomised Controlled Study.

scientific article published on 12 February 2018

Changes in physiological, functional and structural markers of cystic fibrosis lung disease with treatment of a pulmonary exacerbation

scientific article

Chronic fatigue syndrome in an ethnically diverse population: the influence of psychosocial adversity and physical inactivity

scientific article

Clinical and laboratory evaluation of SARS-CoV-2 lateral flow assays for use in a national COVID-19 seroprevalence survey

scientific article published on 12 August 2020

Cumulative flying time and risk of venous thromboembolism

scientific article published on 08 October 2011

Cytokines in severe respiratory syncytial virus bronchiolitis

scientific article published in June 2002

DELTA guidance on choosing the target difference and undertaking and reporting the sample size calculation for a randomised controlled trial

DELTA2 guidance on choosing the target difference and undertaking and reporting the sample size calculation for a randomised controlled trial

scientific article published in the British Medical Journal

Developing a Bayesian adaptive design for a phase I clinical trial: a case study for a novel HIV treatment

scientific article

Developing routinely recorded clinical data from electronic patient records as a national resource to improve neonatal health care: the Medicines for Neonates research programme

scientific article published on 24 September 2019

Dicing with Death: Chance, Risk and Health.

scientific article published in July 2004

Diet and colorectal cancer: an investigation of the lectin/galactose hypothesis

scientific article (publication date: June 2002)

Dietetic management of people with cystic fibrosis.

scientific article

Effect of Early Vasopressin vs Norepinephrine on Kidney Failure in Patients With Septic Shock: The VANISH Randomized Clinical Trial

scientific article published on August 2016

Effectiveness of financial incentives to improve adherence to maintenance treatment with antipsychotics: cluster randomised controlled trial

scientific article published on 07 October 2013

Effects of targeted delivery of propionate to the human colon on appetite regulation, body weight maintenance and adiposity in overweight adults

scientific article

Emergency department treatments and physiotherapy for acute whiplash: a pragmatic, two-step, randomised controlled trial

scientific article published in The Lancet

Establishing causality in the assessment of safety of medicines for children

scientific article published on 12 September 2008

Evaluation and stages of surgical innovations

scientific article published in The Lancet

Exploiting relationships between outcomes in Bayesian multivariate network meta-analysis with an application to relapsing-remitting multiple sclerosis

scientific article published on 16 July 2020

External data required timely response by the Trial Steering-Data Monitoring Committee for the NALoxone InVEstigation (N-ALIVE) pilot trial

scientific article published in March 2017

Financial incentives to improve adherence to anti-psychotic maintenance medication in non-adherent patients - a cluster randomised controlled trial (FIAT)

scientific article published on 28 September 2009

For debate: is the evidence for the efficacy of cholinesterase inhibitors in the symptomatic treatment of Alzheimer's disease convincing or not?

scientific article published on 6 February 2008

Genetic Loci associated with C-reactive protein levels and risk of coronary heart disease

scientific article

High and increasing prevalence of SARS-CoV-2 swab positivity in England during end September beginning October 2020: REACT-1 round 5 updated report

scientific article

High prevalence but low impact of data extraction and reporting errors were found in Cochrane systematic reviews

scientific article

High prevalence of SARS-CoV-2 swab positivity and increasing R number in England during October 2020: REACT-1 round 6 interim report

High prevalence of SARS-CoV-2 swab positivity in England during September 2020: interim report of round 5 of REACT-1 study

scientific article

Increasing SARS-CoV-2 antibody prevalence in England at the start of the second wave: REACT-2 Round 4 cross-sectional study in 160,000 adults

scientific article

Informed patient consent to participation in cluster randomized trials: an empirical exploration of trials in primary care.

scientific article published on January 2005

Internal and external validity of cluster randomised trials: systematic review of recent trials

scientific article

Intravenous versus oral antibiotics for eradication of Pseudomonas aeruginosa in cystic fibrosis (TORPEDO-CF): a randomised controlled trial

scientific article published on 01 October 2020

Introduction: Current trends in research and regulation of microbial-based cleaning products

scientific article published on 2 April 2018

Is it exposure to cigarette smoke or to smokers which increases the risk of meningococcal disease in teenagers?

scientific article published on 04 January 2006

Kisspeptin-54 triggers egg maturation in women undergoing in vitro fertilization

scientific article

Lack of effect of influenza immunisation on anticoagulant control in patients on long-term warfarin

scientific article published in July 2007

Lessons for cluster randomized trials in the twenty-first century: a systematic review of trials in primary care

scientific article

Levosimendan for the Prevention of Acute Organ Dysfunction in Sepsis.

scientific article published on 5 October 2016

Levosimendan in septic shock in patients with biochemical evidence of cardiac dysfunction: a subgroup analysis of the LeoPARDS randomised trial

scientific article published on 19 August 2019

Levosimendan to prevent acute organ dysfunction in sepsis: the LeoPARDS RCT

scientific article published on 16 November 2018

Literature review of visual representation of the results of benefit-risk assessments of medicinal products

scientific article

Managing Injuries of the Neck Trial (MINT): design of a randomised controlled trial of treatments for whiplash associated disorders.

scientific article

Meeting report: 1st international functional metagenomics workshop may 7-8, 2012, st. Jacobs, ontario, Canada

scientific article

Metformin does not affect cancer risk: a cohort study in the U.K. Clinical Practice Research Datalink analyzed like an intention-to-treat trial

scientific article

Monitoring: Bayesian Data Monitoring in Clinical Trials

No surgical innovation without evaluation: the IDEAL recommendations

scientific article published in September 2009

Nutritional Evaluation and Optimisation in Neonates (NEON) trial of amino acid regimen and intravenous lipid composition in preterm parenteral nutrition: a randomised double-blind controlled trial

scientific article

Nutritional Evaluation and Optimisation in Neonates: a randomized, double-blind controlled trial of amino acid regimen and intravenous lipid composition in preterm parenteral nutrition.

scientific article published on 20 April 2016

Oral protein energy supplements for children with cystic fibrosis: CALICO multicentre randomised controlled trial

scientific article published on 8 February 2006

Oral steroids for long-term use in cystic fibrosis

scientific article (published 2015-12-09)

Oral steroids for long-term use in cystic fibrosis

scientific article (published 2013-06-24)

Oral steroids for long-term use in cystic fibrosis

scientific article

Pharmacokinetics, adverse effects and tolerability of a novel analogue of human pancreatic polypeptide, PP 1420.

scientific article published on February 2012

Practical help for specifying the target difference in sample size calculations for RCTs: the DELTA2 five-stage study, including a workshop

article by Jonathan A. Cook et al published 1 October 2019 in Health Technology Assessment

Prokinetics prescribing in paediatrics: evidence on cisapride, domperidone, and metoclopramide

scientific article published on April 2015

Protocol for a randomised controlled trial of VAsopressin versus Noradrenaline as Initial therapy in Septic sHock (VANISH).

scientific article

REACT-1 round 10 report: Level prevalence of SARS-CoV-2 swab-positivity in England during third national lockdown in March 2021

scientific article

REACT-1 round 13 interim report: acceleration of SARS-CoV-2 Delta epidemic in the community in England during late June and early July 2021

scientific article

REACT-1 round 6 updated report: high prevalence of SARS-CoV-2 swab positivity with reduced rate of growth in England at the start of November 2020

scientific article

REACT-1 round 7 interim report: fall in prevalence of swab-positivity in England during national lockdown

scientific article

REACT-1 round 7 updated report: regional heterogeneity in changes in prevalence of SARS-CoV-2 infection during the second national COVID-19 lockdown in England

scientific article

REACT-1 round 8 final report: high average prevalence with regional heterogeneity of trends in SARS-CoV-2 infection in the community in England during January 2021

scientific article

REACT-1 round 8 interim report: SARS-CoV-2 prevalence during the initial stages of the third national lockdown in England

scientific article

REACT-1 round 9 final report: Continued but slowing decline of prevalence of SARS-CoV-2 during national lockdown in England in February 2021

scientific article

REACT-1 round 9 interim report: downward trend of SARS-CoV-2 in England in February 2021 but still at high prevalence

scientific article

Recommendations for benefit-risk assessment methodologies and visual representations

scientific article

Repeated nebulisation of non-viral CFTR gene therapy in patients with cystic fibrosis: a randomised, double-blind, placebo-controlled, phase 2b trial.

scientific article

Republished paper: Where errors occur in the preparation and administration of intravenous medicines: a systematic review and Bayesian analysis

scientific article published on December 2010

Respiratory syncytial virus bronchiolitis: disease severity, interleukin-8, and virus genotype

scientific article published in May 2002

Resurgence of SARS-CoV-2 in England: detection by community antigen surveillance

scientific article

Resurgence of SARS-CoV-2: Detection by community viral surveillance

scientific article

Rituximab versus cyclophosphamide for the treatment of connective tissue disease-associated interstitial lung disease (RECITAL): study protocol for a randomised controlled trial.

scientific article

Sample size for cluster randomized trials: effect of coefficient of variation of cluster size and analysis method

scientific article published on 30 August 2006

Selective serotonin reuptake inhibitors (SSRIs) and suicide in adults: meta-analysis of drug company data from placebo controlled, randomised controlled trials submitted to the MHRA's safety review

scientific article

Smooth muscle cholinergic denervation hypersensitivity in diverticular disease

scientific article

Suicidal behaviour and SSRIs: updated meta-analysis

scientific article published on June 2006

Supplementation of iron in pulmonary hypertension: Rationale and design of a phase II clinical trial in idiopathic pulmonary arterial hypertension

scientific article published on January 2013

Survival of very preterm infants admitted to neonatal care in England 2008-2014: time trends and regional variation

scientific article published on 7 September 2017

Systematic reviews and lifelong diseases

scientific article

TOIB Study. Are topical or oral ibuprofen equally effective for the treatment of chronic knee pain presenting in primary care: a randomised controlled trial with patient preference study. [ISRCTN79353052].

scientific article

The Interaction of Vasopressin and Corticosteroids in Septic Shock

scientific article published on 01 June 2014

The cardiopulmonary effects of vasopressin compared with norepinephrine in septic shock

scientific article published in September 2012

The use of routinely collected patient data for research: a critical review

scientific article

Thrombosis prevention trial: compliance with warfarin treatment and investigation of a retained effect

scientific article (publication date: 23 June 2003)

Transcriptomic Signatures in Sepsis and a Differential Response to Steroids: From the VANISH Randomized Trial

scientific article published on 01 April 2019

Transient dynamics of SARS-CoV-2 as England exited national lockdown

scientific article

Twin peaks: The Omicron SARS-CoV-2 BA.1 and BA.2 epidemics in England

scientific article published on 24 May 2022

Ursodeoxycholic acid for cystic fibrosis-related liver disease

scientific article (published 2014-12-15)

Ursodeoxycholic acid for cystic fibrosis-related liver disease

scientific article

Ursodeoxycholic acid for cystic fibrosis-related liver disease

Usability and acceptability of home-based self-testing for SARS-CoV-2 antibodies for population surveillance

scientific article published on 12 August 2020

Using disease registries for pharmacoepidemiological research: a case study of data from a cystic fibrosis registry

scientific article published on September 1, 2003

Vaccine uptake and SARS-CoV-2 antibody prevalence among 207,337 adults during May 2021 in England: REACT-2 study

scientific article

Variations in primary open-angle glaucoma prevalence by age, gender, and race: a Bayesian meta-analysis

scientific article published on October 2006

Vasopressin in septic shock: an individual patient data meta-analysis of randomised controlled trials

scientific article published on 06 May 2019

Weighing benefit–risk of medicines: concepts and approaches

article published in 2011

Where errors occur in the preparation and administration of intravenous medicines: a systematic review and Bayesian analysis.

scientific article published on 11 January 2010

Where's the utility in Bayesian data-monitoring of clinical trials?

scientific article