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List of works by Peter Hegemann

"Vision" in single-celled algae.

scientific article published on June 2004

A Streptomyces rimosus aphVIII gene coding for a new type phosphotransferase provides stable antibiotic resistance to Chlamydomonas reinhardtii.

scientific article

A blue-light photoreceptor mediates the feedback regulation of photosynthesis

scientific article published on 14 September 2016

A photochromic histidine kinase rhodopsin (HKR1) that is bimodally switched by ultraviolet and blue light

scientific article published on October 2012

A set of engineered Escherichia coli expression strains for selective isotope and reactivity labeling of amino acid side chains and flavin cofactors

scientific article

A synthetic gene coding for the green fluorescent protein (GFP) is a versatile reporter in Chlamydomonas reinhardtii

scientific article

Absorption and Emission Spectroscopic Investigation of Thermal Dynamics and Photo-Dynamics of the Rhodopsin Domain of the Rhodopsin-Guanylyl Cyclase from the Nematophagous Fungus Catenaria anguillulae

scientific article published on 5 October 2017

Absorption and Emission Spectroscopic Investigation of the Thermal Dynamics of the Archaerhodopsin 3 Based Fluorescent Voltage Sensor Archon2

scientific article published on 08 September 2020

Absorption and Emission Spectroscopic Investigation of the Thermal Dynamics of the Archaerhodopsin 3 Based Fluorescent Voltage Sensor QuasAr1 ⬇️

scientific article published on 21 August 2019

Absorption and emission spectroscopic characterisation of combined wildtype LOV1-LOV2 domain of phot from Chlamydomonas reinhardtii.

scientific article published in October 2005

Absorption and emission spectroscopic characterization of BLUF protein Slr1694 from Synechocystis sp. PCC6803 with roseoflavin cofactor

scientific article published on 8 August 2009

Absorption and emission spectroscopic characterization of blue-light receptor Slr1694 from Synechocystis sp. PCC6803.

scientific article published on 22 September 2006

Absorption and emission spectroscopic characterization of photo-dynamics of photoactivated adenylyl cyclase mutant bPAC-Y7F of Beggiatoa sp.

scientific article published on 7 August 2014

Abstracts from the 8th International Conference on cGMP Generators, Effectors and Therapeutic Implications : Bamberg, Germany. 23-25 June, 2017

article

Active cortical dendrites modulate perception.

scientific article

Active site structure and absorption spectrum of channelrhodopsin-2 wild-type and C128T mutant

Adventure beyond borders of scientific fields with optogenetics ⬇️

scientific article published on January 1, 2013

Algal sensory photoreceptors

scientific article

All-trans retinal constitutes the functional chromophore in Chlamydomonas rhodopsin

scientific article published on December 1991

Altered <i>N</i>-glycan composition impacts flagella mediated adhesion in <i>Chlamydomonas reinhardtii</i>

scientific article published on 10 December 2020

An Efficient Visual Screen for CRISPR/Cas9 Activity in Arabidopsis thaliana

scientific article

An improved chloride-conducting channelrhodopsin for light-induced inhibition of neuronal activity in vivo.

scientific article

Anion-conducting channelrhodopsins with tuned spectra and modified kinetics engineered for optogenetic manipulation of behavior.

scientific article published on 2 November 2017

Author Correction: Anion-conducting channelrhodopsins with tuned spectra and modified kinetics engineered for optogenetic manipulation of behavior.

scientific article published on 14 March 2018

Bi-stable neural state switches

scientific article

BiPOLES is an optogenetic tool developed for bidirectional dual-color control of neurons

scientific article

Bimodal activation of different neuron classes with the spectrally red-shifted channelrhodopsin chimera C1V1 in Caenorhabditis elegans

scientific article (publication date: 2012)

Biophysics of Channelrhodopsin

scientific article published on June 2015

Biotechnology: Programming genomes with light

scientific article

Bistable retinal schiff base photodynamics of histidine kinase rhodopsin HKR1 from Chlamydomonas reinhardtii

scientific article published on 8 March 2014

Blue light induces global and localized conformational changes in the kinase domain of full-length phototropin

scientific article published in February 2010

Channelrhodopsin engineering and exploration of new optogenetic tools

scientific article published on 20 December 2010

Channelrhodopsin-1 Phosphorylation Changes with Phototactic Behavior and Responds to Physiological Stimuli in Chlamydomonas

scientific article published on 12 March 2019

Channelrhodopsin-1 initiates phototaxis and photophobic responses in chlamydomonas by immediate light-induced depolarization

scientific article

Channelrhodopsin-1: a light-gated proton channel in green algae.

scientific article

Channelrhodopsin-2, a directly light-gated cation-selective membrane channel

scientific article

Channelrhodopsins of Volvox carteri are photochromic proteins that are specifically expressed in somatic cells under control of light, temperature, and the sex inducer.

scientific article published on 29 July 2009

Channelrhodopsins: directly light-gated cation channels

scientific article

Characterization of a flavin radical product in a C57M mutant of a LOV1 domain by electron paramagnetic resonance

scientific article

Chlamyrhodopsin represents a new type of sensory photoreceptor.

scientific article

Collective exchange processes reveal an active site proton cage in bacteriorhodopsin

scientific article published on 03 January 2020

Color tuning in binding pocket models of the chlamydomonas-type channelrhodopsins

scientific article published on 28 November 2011

Color-tuned channelrhodopsins for multiwavelength optogenetics ⬇️

scientific article published on July 27, 2012

Complex Photochemistry within the Green-Absorbing Channelrhodopsin ReaChR.

scientific article published on March 2017

Control of phobic behavioral responses by rhodopsin-induced photocurrents in Chlamydomonas ⬇️

scientific article published on September 1, 1997

Controlling fertilization and cAMP signaling in sperm by optogenetics.

scientific article

Conversion of a light-driven proton pump into a light-gated ion channel

scientific article published on 24 November 2015

Conversion of channelrhodopsin into a light-gated chloride channel.

scientific article

Crystal structure of the channelrhodopsin light-gated cation channel

scientific article

Crystal structure of the red light-activated channelrhodopsin Chrimson

scientific article published in Nature Communications

Crystal structures and molecular mechanism of a light-induced signaling switch: The Phot-LOV1 domain from Chlamydomonas reinhardtii

scientific article

Desensitization and Dark Recovery of the Photoreceptor Current in Chlamydomonas reinhardtii

scientific article published on 01 October 1997

Design of a light-gated proton channel based on the crystal structure of Coccomyxa rhodopsin

scientific article published on 19 March 2019

Direct measurement of cytosolic calcium and pH in living Chlamydomonas reinhardtii cells

scientific article published on 01 March 1999

Dual photoisomerization on distinct potential energy surfaces in a UV absorbing rhodopsin

scientific article published on 30 May 2020

Dynamics of voltage profile in enzymatic ion transporters, demonstrated in electrokinetics of proton pumping rhodopsin

scientific article published on 11 July 2008

Early formation of the ion-conducting pore in channelrhodopsin-2.

scientific article published on 23 December 2014

Electrical properties, substrate specificity and optogenetic potential of the engineered light-driven sodium pump eKR2.

scientific article

Engineered Passive Potassium Conductance in the KR2 Sodium Pump

scientific article published on 09 April 2019

Engineering of a red-light-activated human cAMP/cGMP-specific phosphodiesterase.

scientific article

Enzymerhodopsins: novel photoregulated catalysts for optogenetics

scientific article published on 05 April 2019

Erratum: Synthetic retinal analogs modify the spectral and kinetic characteristics of microbial rhodopsin optogenetic tools

scientific article published on 25 February 2015

Evidence for a light-induced H(+) conductance in the eye of the green alga Chlamydomonas reinhardtii

scientific article published on February 2002

Evolution of the channelrhodopsin photocycle model

scientific article published on April 2010

Fast manipulation of cellular cAMP level by light in vivo

scientific article

Fast noninvasive activation and inhibition of neural and network activity by vertebrate rhodopsin and green algae channelrhodopsin

scientific article published on 23 November 2005

Fast, repetitive light-activation of CaV3.2 using channelrhodopsin 2.

scientific article published on May 2010

From channelrhodopsins to optogenetics

scientific article published on 22 January 2013

Functional variations among LOV domains as revealed by FT-IR difference spectroscopy

scientific article

Féry Infrared Spectrometer for Single-Shot Analysis of Protein Dynamics

scientific article published on 02 December 2019

Genetically encoded calcium indicators for multi-color neural activity imaging and combination with optogenetics

scientific article

Genome of Acanthamoeba castellanii highlights extensive lateral gene transfer and early evolution of tyrosine kinase signaling

scientific article

Gloeobacter rhodopsin, limitation of proton pumping at high electrochemical load

scientific article

Glu 87 of channelrhodopsin-1 causes pH-dependent color tuning and fast photocurrent inactivation

scientific article published on 19 January 2009

H+ -pumping rhodopsin from the marine alga Acetabularia.

scientific article

Heterogeneity of the Transmembrane Protein Conformation in Purple Membranes Identified by Infrared Nanospectroscopy

scientific article published on 27 September 2017

High-efficiency channelrhodopsins for fast neuronal stimulation at low light levels

scientific article

Hindered rotation of a cofactor methyl group as a probe for protein-cofactor interaction

scientific article published in July 2010

Hydrogen bond switching among flavin and amino acid side chains in the BLUF photoreceptor observed by ultrafast infrared spectroscopy

scientific article published on 15 August 2008

Hydrogen-bond switching through a radical pair mechanism in a flavin-binding photoreceptor

scholarly article

Identification of Rad51 protein from Chlamydomonas reinhardtii: recombinational characteristics

scientific article

Identification of a Natural Green Light Absorbing Chloride Conducting Channelrhodopsin from Proteomonas sulcata

scientific article published on 6 January 2016

In channelrhodopsin-2 Glu-90 is crucial for ion selectivity and is deprotonated during the photocycle

scientific article

In vitro identification of rhodopsin in the green alga Chlamydomonas

scientific article published in April 1991

In vivo generation of flavoproteins with modified cofactors

scientific article published on 11 November 2008

Introduction to the Symposium-in Print: Blue light effects

scientific article published in May 2011

Ion Selectivity and Competition in Channelrhodopsins ⬇️

scientific article published on July 2, 2013

Irreversible photoreduction of flavin in a mutated Phot-LOV1 domain

scientific article published in August 2003

Isolation and characterization of the retinal-binding component of halorhodopsin.

scientific article published on January 1982

Key residues for the light regulation of the blue light-activated adenylyl cyclase from Beggiatoa sp.

scientific article published on 28 July 2014

Lateral Gene Transfer of Anion-Conducting Channelrhodopsins between Green Algae and Giant Viruses

scientific article published on 09 October 2020

Light modulation of cellular cAMP by a small bacterial photoactivated adenylyl cyclase, bPAC, of the soil bacterium Beggiatoa

scientific article

Light-Dark Adaptation of Channelrhodopsin Involves Photoconversion between the all-trans and 13-cis Retinal Isomers

scientific article

Light-Induced Rearrangement of the β5 Strand in the BLUF Photoreceptor SyPixD (Slr1694).

scientific article published on 17 November 2015

Light-dark Adaptation of Channelrhodopsin C128T Mutant ⬇️

scientific article published on February 25, 2013

Light-generated paramagnetic intermediates in BLUF domains

scientific article published on 28 January 2011

Light-regulated adsorption and desorption of <i>Chlamydomonas</i> cells at surfaces

Mechanistic insights in light-induced cAMP production by photoactivated adenylyl cyclase alpha (PACalpha).

scientific article published on November 2009

MerMAIDs: a family of metagenomically discovered marine anion-conducting and intensely desensitizing channelrhodopsins

scientific article published on 25 July 2019

Microbial and animal rhodopsins: structures, functions, and molecular mechanisms.

scientific article published on 23 December 2013

Microbial opsins: a family of single-component tools for optical control of neural activity

scientific article published on 01 March 2011

Modeling light-induced currents in the eye of Chlamydomonas reinhardtii

scientific article published in September 2002

Modulation of Light Energy Transfer from Chromophore to Protein in the Channelrhodopsin ReaChR

scientific article published on 10 July 2020

Molecular determinants of proton selectivity and gating in the red-light activated channelrhodopsin Chrimson.

scientific article published on 30 August 2017

Monitoring dynamic expression of nuclear genes in Chlamydomonas reinhardtii by using a synthetic luciferase reporter gene

scientific article published in August 2004

Monitoring light-induced structural changes of Channelrhodopsin-2 by UV-visible and Fourier transform infrared spectroscopy.

scientific article published on 16 October 2008

Multiple photocycles of channelrhodopsin

scientific article published on 16 September 2005

NeoR, a near-infrared absorbing rhodopsin

scientific article published on 10 November 2020

Neocortical excitation/inhibition balance in information processing and social dysfunction ⬇️

scientific article (publication date: 27 July 2011)

New Concepts for Presynaptic Optogenetics

Nuclear gene targeting in Chlamydomonas as exemplified by disruption of the PHOT gene

scientific article published on 10 December 2008

Nuclear gene targeting in Chlamydomonas using engineered zinc-finger nucleases.

scientific article published on 29 January 2013

Nuclear-gene targeting by using single-stranded DNA avoids illegitimate DNA integration in Chlamydomonas reinhardtii

scientific article published on July 2005

Of ion pumps, sensors and channels — Perspectives on microbial rhodopsins between science and history

scientific article

On the reaction mechanism of adduct formation in LOV domains of the plant blue-light receptor phototropin

scientific article published in September 2004

Opsin evolution: out of wild green yonder?

scientific article published in April 2000

Optogenetic Tools for Subcellular Applications in Neuroscience

scientific article published in November 2017

Optogenetic acidification of synaptic vesicles and lysosomes

scientific article published on 9 November 2015

Optogenetic approaches addressing extracellular modulation of neural excitability

scientific article published on 5 April 2016

Optogenetic modulation of an adenylate cyclase in Toxoplasma gondii demonstrates a requirement of the parasite cAMP for host-cell invasion and stage differentiation. ⬇️

scientific article published on 22 March 2013

Optogenetics: 10 years after ChR2 in neurons--views from the community

scientific article published on August 2015

Phot-LOV1: photocycle of a blue-light receptor domain from the green alga Chlamydomonas reinhardtii

scientific article published on February 2003

Photo-reduction of flavin mononucleotide to semiquinone form in LOV domain mutants of blue-light receptor phot from Chlamydomonas reinhardtii.

scientific article published on 10 January 2007

Photoactivated cyclases: In memoriam Masakatsu Watanabe

scientific article published on 13 August 2015

Photoactivation of channelrhodopsin

scientific article

Photoadduct Formation from the FMN Singlet Excited State in the LOV2 Domain of Chlamydomonas reinhardtii Phototropin.

scientific article published on 21 October 2016

Photochemical chromophore isomerization in histidine kinase rhodopsin HKR1.

scientific article published on 31 March 2015

Photocycle Dynamics of the Archaerhodopsin 3 Based Fluorescent Voltage Sensor QuasAr1

scientific article published on 25 December 2019

Photodynamics of the small BLUF protein BlrB from Rhodobacter sphaeroides.

scientific article published on 21 February 2006

Photophobic responses and phototaxis in Chlamydomonas are triggered by a single rhodopsin photoreceptor

scientific article

Photophysical characterisation and photo-cycle dynamics of LOV1-His domain of phototropin from Chlamydomonas reinhardtii with roseoflavin monophosphate cofactor

scientific article published on 3 July 2010

Photoreactions of the Histidine Kinase Rhodopsin Ot-HKR from the Marine Picoalga Ostreococcus tauri

scientific article published on 21 March 2019

Photoreceptor current and photoorientation in chlamydomonas mediated by 9-demethylchlamyrhodopsin

scientific article

Phototropin influence on eyespot development and regulation of phototactic behavior in Chlamydomonas reinhardtii.

scientific article published on 30 November 2012

Picosecond events in the photochemical cycle of the light-driven chloride-pump halorhodopsin

scientific article published on January 1985

Potassium Channel-Based Two Component Optogenetic Tool for Silencing of Excitable Cells

article published in 2018

Potassium channel-based optogenetic silencing

scientific article published in Nature Communications

Probing visual transduction in a plant cell: Optical recording of rhodopsin-induced structural changes from Chlamydomonas reinhardtii

scientific article published on November 1990

Proton transfer reactions in the red light-activatable channelrhodopsin variant ReaChR and their relevance for its function.

scientific article published on 28 June 2017

Reaction dynamics of the chimeric channelrhodopsin C1C2.

scientific article

Reconstitution of halorhodopsin in black lipid membranes

scientific article published on 01 January 1984

Recording of blue light-induced energy and volume changes within the wild-type and mutated phot-LOV1 domain from Chlamydomonas reinhardtii

scientific article published in February 2004

Rectification of the channelrhodopsin early conductance.

scientific article published on September 2011

Red-shifted optogenetic excitation: a tool for fast neural control derived from Volvox carteri

scientific article

Redox properties of LOV domains: chemical versus photochemical reduction, and influence on the photocycle.

scientific article published in December 2007

Removal of mismatched bases from synthetic genes by enzymatic mismatch cleavage

scientific article

Reversible bleaching of Chlamydomonas reinhardtii rhodopsin in vivo

scientific article published on 01 July 1988

Rhodopsin-cyclases for photocontrol of cGMP/cAMP and 2.3 Å structure of the adenylyl cyclase domain.

scientific article published on 24 May 2018

Rhodopsin-regulated calcium currents in Chlamydomonas

scientific article published in Nature

Single photon detection by an archaebacterium

scientific article published on 01 February 1988

Spectroscopic characterization of flavin mononucleotide bound to the LOV1 domain of Phot1 from Chlamydomonas reinhardtii

scientific article

Streptomyces rimosus aminoglycoside-3'-phosphotransferase VIII: comparisons with aminoglycoside-3'-phosphotransferases of aminoglycoside-producing strains with eukaryotic protein kinases

scientific article published in January 2002

Structural foundations of optogenetics: Determinants of channelrhodopsin ion selectivity

scientific article

Structural model of channelrhodopsin

scientific article published on 11 January 2012

Synthetic retinal analogues modify the spectral and kinetic characteristics of microbial rhodopsin optogenetic tools.

scientific article published on 15 December 2014

Targeting of Photoreceptor Genes in Chlamydomonas reinhardtii via Zinc-Finger Nucleases and CRISPR/Cas9.

scientific article published on 4 October 2017

The abundant retinal protein of the Chlamydomonas eye is not the photoreceptor for phototaxis and photophobic responses ⬇️

scientific article published on November 1, 2001

The branched photocycle of the slow-cycling channelrhodopsin-2 mutant C128T.

scientific article published on 25 March 2010

The chromophore structure of the long-lived intermediate of the C128T channelrhodopsin-2 variant

scientific article published on 13 November 2011

The chromoprotein of halorhodopsin is the light-driven electrogenic chloride pump in halobacterium halobiumt

scientific article published on 01 December 1984

The femtosecond-to-second photochemistry of red-shifted fast-closing anion channelrhodopsin PsACR1.

scientific article published on 10 November 2017

The form and function of channelrhodopsin

scientific article

The halo-opsin gene. I. Identification and isolation

scientific article

The hydrogen-bond switch reaction of the Blrb Bluf domain of Rhodobacter sphaeroides

scientific article published on 31 May 2011

The microbial opsin family of optogenetic tools

scientific article

The nature of rhodopsin-triggered photocurrents in Chlamydomonas. I. Kinetics and influence of divalent ions

scientific article

The nature of rhodopsin-triggered photocurrents in Chlamydomonas. II. Influence of monovalent ions

scientific article published in February 1996

The phot LOV2 domain and its interaction with LOV1.

scientific article

The photochemistry of the light-, oxygen-, and voltage-sensitive domains in the algal blue light receptor phot

scientific article

The photocycle of the chloride pump halorhodopsin. I: Azide-catalyzed deprotonation of the chromophore is a side reaction of photocycle intermediates inactivating the pump.

scientific article published on September 1985

The photocycle of the chloride pump halorhodopsin. II: Quantum yields and a kinetic model.

scientific article published on September 1985

The rhodopsin-guanylyl cyclase of the aquatic fungus Blastocladiella emersonii enables fast optical control of cGMP signaling

scientific article

The role of calcium in Chlamydomonas photomovement responses as analysed by calcium channel inhibitors

scientific article published on 01 September 1990

The role of key amino acids in the photoactivation pathway of the Synechocystis Slr1694 BLUF domain

scientific article published in December 2009

The two parallel photocycles of the Chlamydomonas sensory photoreceptor histidine kinase rhodopsin 1.

scientific article published on 13 July 2017

Time-resolved infrared spectroscopic techniques as applied to channelrhodopsin

scientific article (publication date: 2015)

Time-resolved serial femtosecond crystallography reveals early structural changes in channelrhodopsin

scientific article

Tip-Enhanced Infrared Difference-Nanospectroscopy of the Proton Pump Activity of Bacteriorhodopsin in Single Purple Membrane Patches

scientific article published on 17 April 2019

Towards an identification of chemically different flavin radicals by means of theirg-tensor

Towards an understanding of channelrhodopsin function: simulations lead to novel insights of the channel mechanism.

scientific article published on 30 January 2013

Tracking Pore Hydration in Channelrhodopsin by Site-Directed Infrared-Active Azido Probes

scientific article published on 19 February 2019

Two light-activated conductances in the eye of the green alga Volvox carteri

scientific article

Two open states with progressive proton selectivities in the branched channelrhodopsin-2 photocycle

scientific article published on March 2010

Ultrafast optogenetic control.

scientific article

Unfolding of the C-Terminal Jα Helix in the LOV2 Photoreceptor Domain Observed by Time-Resolved Vibrational Spectroscopy.

scientific article published on 18 August 2016

Unifying photocycle model for light adaptation and temporal evolution of cation conductance in channelrhodopsin-2

scientific article published on 19 April 2019

Upgrading a microplate reader for photobiology and all-optical experiments

scientific article published in February 2015

Vibrational spectroscopy of an algal Phot-LOV1 domain probes the molecular changes associated with blue-light reception

scientific article

Vision in microalgae ⬇️

scientific article published on January 1, 1997

Volvoxrhodopsin, a light-regulated sensory photoreceptor of the spheroidal green alga Volvox carteri

scientific article published in August 1999

Whole-cell Patch-clamp Recordings for Electrophysiological Determination of Ion Selectivity in Channelrhodopsins.

scientific article

WiChR, a highly potassium-selective channelrhodopsin for low-light one- and two-photon inhibition of excitable cells

scientific article published in 2022

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