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List of works by Dario S. Zamboni

A Dual Role for P2X7 Receptor during Porphyromonas gingivalis Infection

scientific article

A method for generation of bone marrow-derived macrophages from cryopreserved mouse bone marrow cells

scientific article

A novel pathway for inducible nitric-oxide synthase activation through inflammasomes

scientific article

A parent-of-origin effect determines the susceptibility of a non-informative F1 population to Trypanosoma cruzi infection in vivo

scientific article

AIM2 Engages Active but Unprocessed Caspase-1 to Induce Noncanonical Activation of the NLRP3 Inflammasome.

scientific article

Absence of NOD2 receptor predisposes to intestinal inflammation by a deregulation in the immune response in hosts that are unable to control gut dysbiosis

scholarly article by Patrícia Reis de Souza et al published October 2018 in Immunobiology

Activation of NLRC4 by flagellated bacteria triggers caspase-1-dependent and -independent responses to restrict Legionella pneumophila replication in macrophages and in vivo.

scientific article published on 11 November 2011

Anti-metastatic immunotherapy based on mucosal administration of flagellin and immunomodulatory P10.

scientific article published on 16 September 2014

Author Correction: Caspase-8 mediates inflammation and disease in rodent malaria

scientific article published on 03 November 2020

Autophagy downstream of endosomal Toll-like receptor signaling in macrophages is a key mechanism for resistance to Leishmania major infection

scientific article published on 12 June 2017

Beneficial effects of colchicine for moderate to severe COVID-19: a randomised, double-blinded, placebo-controlled clinical trial

COVID‐19 bimodal clinical and pathological phenotypes

Caspase-1 but Not Caspase-11 Is Required for NLRC4-Mediated Pyroptosis and Restriction of Infection by Flagellated Legionella Species in Mouse Macrophages and In Vivo.

scientific article published on 31 July 2015

Caspase-1 is involved in the genesis of inflammatory hypernociception by contributing to peripheral IL-1β maturation

scientific article published on 4 October 2010

Caspase-11-dependent IL-1α release boosts Th17 immunity against Paracoccidioides brasiliensis

scientific article published on 19 August 2019

Caspase-8 mediates inflammation and disease in rodent malaria

scientific article published on 14 September 2020

Coxiella burnetii express type IV secretion system proteins that function similarly to components of the Legionella pneumophila Dot/Icm system

scientific article published in August 2003

Critical role of ASC inflammasomes and bacterial type IV secretion system in caspase-1 activation and host innate resistance to Brucella abortus infection

scientific article published on 4 March 2013

Cytosolic detection of flagellin: a deadly twist

scientific article published on 01 June 2006

Dectin-1 Activation during Leishmania amazonensis Phagocytosis Prompts Syk-Dependent Reactive Oxygen Species Production To Trigger Inflammasome Assembly and Restriction of Parasite Replication

scientific article

Disease severity and mortality can be independently regulated in a mouse model of experimental graft versus host disease

scientific article

Efferocytosis of SARS-CoV-2-infected dying cells impairs macrophage anti-inflammatory functions and clearance of apoptotic cells

scientific article published on 6 June 2022

Expression and activity of NOD1 and NOD2/RIPK2 signalling in mononuclear cells from patients with rheumatoid arthritis.

scientific article published on 23 July 2015

Flagellin-deficient Legionella mutants evade caspase-1- and Naip5-mediated macrophage immunity

scientific article

Gasdermin-D activation by SARS-CoV-2 triggers NET and mediate COVID-19 immunopathology

Gasdermin-D and Caspase-7 are the key Caspase-1/8 substrates downstream of the NAIP5/NLRC4 inflammasome required for restriction of Legionella pneumophila

scientific article published on 28 June 2019

Genetic control of natural resistance of mouse macrophages to Coxiella burnetii infection in vitro: macrophages from restrictive strains control parasitophorous vacuole maturation

scientific article published on April 2004

Guanylate-binding protein 5 licenses caspase-11 for Gasdermin-D mediated host resistance to Brucella abortus infection

scientific article published on 27 December 2018

Gut microbiota translocation to the pancreatic lymph nodes triggers NOD2 activation and contributes to T1D onset

scientific article published on 20 June 2016

Hemolysis-induced lethality involves inflammasome activation by heme

scientific article

Heparin prevents in vitro glycocalyx shedding induced by plasma from COVID-19 patients

scientific article published on 27 March 2021

IFN-γ plays a unique role in protection against low virulent Trypanosoma cruzi strain.

scientific article

IL-18 triggered by the Nlrp3 inflammasome induces host innate resistance in a pulmonary model of fungal infection

scientific article published on 30 March 2015

IL-1β production by intermediate monocytes is associated with immunopathology in cutaneous leishmaniasis

scientific article

IL-33 contributes to sepsis-induced long-term immunosuppression by expanding the regulatory T cell population.

scientific article published on 4 April 2017

Identification and functional characterization of K(+) transporters encoded by Legionella pneumophila kup genes.

scientific article published on 2 August 2013

Immunity to protozoan parasites.

scientific article published on 3 May 2012

Infection of Vero cells with Coxiella burnetii phase II: relative intracellular bacterial load and distribution estimated by confocal laser scanning microscopy and morphometry.

scientific article

Inflammasome Activation in Legionella-Infected Macrophages

scientific article published on 01 January 2019

Inflammasome activation is critical to the protective immune response during chemically induced squamous cell carcinoma.

scientific article

Inflammasome activation is reactive oxygen species dependent and mediates irinotecan-induced mucositis through IL-1β and IL-18 in mice.

scientific article published in July 2014

Inflammasome biology taught by Legionella pneumophila

scientific article published on 20 December 2016

Inflammasome-dependent Mechanisms Involved in Sensing and Restriction of Bacterial Replication

scientific article published on 6 September 2017

Inflammasome-derived IL-1β production induces nitric oxide-mediated resistance to Leishmania

scientific article published on 9 June 2013

Inflammasomes and Leishmania: in good times or bad, in sickness or in health

scientific article published on 20 June 2019

Inflammasomes are activated in response to SARS-CoV-2 infection and are associated with COVID-19 severity in patients

scientific article published on 01 March 2021

Inflammasomes in host response to protozoan parasites.

scientific article

Inhibition of caspase-1 or gasdermin-D enable caspase-8 activation in the Naip5/NLRC4/ASC inflammasome

scientific article

Inhibition of inflammasome activation by Coxiella burnetii type IV secretion system effector IcaA.

scientific article

Inhibition of inflammasome activation by a clinical strain of Klebsiella pneumoniae impairs efferocytosis and leads to bacterial dissemination

scientific article published on 05 December 2018

Innate Immunity to Legionella Pneumophila ⬇️

scientific article published on May 16, 2011

Innate immune activation and subversion of Mammalian functions by leishmania lipophosphoglycan.

scientific article published on 22 February 2012

Interleukin 1 receptor-driven neutrophil recruitment accounts to MyD88-dependent pulmonary clearance of legionella pneumophila infection in vivo

scientific article

Intrinsic expression of Nod2 in CD4+ T lymphocytes is not necessary for the development of cell-mediated immunity and host resistance to Toxoplasma gondii.

scientific article published on 10 November 2011

Joint NOD2/RIPK2 signaling regulates IL-17 axis and contributes to the development of experimental arthritis

scientific article

Legionella longbeachae Is Immunologically Silent and Highly Virulent In Vivo.

scientific article

Leishmania Lipophosphoglycan Triggers Caspase-11 and the Non-canonical Activation of the NLRP3 Inflammasome

scientific article published on 01 January 2019

Leishmania RNA virus exacerbates Leishmaniasis by subverting innate immunity via TLR3-mediated NLRP3 inflammasome inhibition

scientific article published on 21 November 2019

Macrophage priming is dispensable for NLRP3 inflammasome activation and restriction of Leishmania amazonensis replication

scientific article published on 07 May 2019

Malaria-induced NLRP12/NLRP3-dependent caspase-1 activation mediates inflammation and hypersensitivity to bacterial superinfection.

scientific article published on 16 January 2014

Microbicidal property of B1 cell derived mononuclear phagocyte

scientific article

Mitochondrial DNA Activates the NLRP3 Inflammasome and Predisposes to Type 1 Diabetes in Murine Model

scientific article published on 27 February 2017

Mitochondrial DNA and TLR9 activation contribute to SARS-CoV-2-induced endothelial cell damage

scientific article published on 25 November 2021

Molecular basis of carrageenan-induced cytokines production in macrophages

scientific article published on 07 September 2020

Mouse resident peritoneal macrophages partially control in vitro infection with Coxiella burnetii phase II.

scientific article published on May 2002

Murine Alveolar Macrophages Are Highly Susceptible to Replication of Coxiella burnetii Phase II In Vitro

scientific article published on 13 June 2016

MyD88-, but not Nod1- and/or Nod2-deficient mice, show increased susceptibility to polymicrobial sepsis due to impaired local inflammatory response

scientific journal article

NALP3: a key player in caspase-1 activation

scientific article published on January 2006

NLRC4 biology in immunity and inflammation

scientific article published on 12 June 2020

NLRP12 Attenuates Inflammatory Bone Loss in Experimental Apical Periodontitis

scientific article published on 25 January 2019

NLRP12 controls arthritis severity by acting as a checkpoint inhibitor of Th17 cell differentiation

scientific article published on 07 July 2020

NLRP3 Inflammasome Mediates Aldosterone-Induced Vascular Damage

scientific article published on November 2016

NLRP3 inflammasome-mediated neutrophil recruitment and hypernociception depend on leukotriene B4 in a murine model of gout

article

NOD-Like Receptor P3 Inflammasome Controls Protective Th1/Th17 Immunity against Pulmonary Paracoccidioidomycosis

scientific article

NOD1 and NOD2 Signaling in Infection and Inflammation.

scientific article

NOD1 in the modulation of host-microbe interactions and inflammatory bone resorption in the periodontal disease model.

scientific article published in August 2016

NOD2 contributes to Porphyromonas gingivalis-induced bone resorption.

scientific article

NOD2-RIP2-Mediated Signaling Helps Shape Adaptive Immunity in Visceral Leishmaniasis.

scientific article

Nitric oxide partially controls Coxiella burnetii phase II infection in mouse primary macrophages

scientific article

Nucleotide-binding oligomerization domain-1 and -2 play no role in controlling Brucella abortus infection in mice

scientific article published on 30 November 2011

Nucleotide-binding oligomerization domain-2 (NOD2) regulates type-1 cytokine responses to Mycobacterium avium but is not required for host control of infection

scientific article published on 27 March 2015

Nucleotide-binding oligomerization domain-containing protein 2 prompts potent inflammatory stimuli during Neospora caninum infection

scientific article published on 05 July 2016

Opposing roles of LTB4 and PGE2 in regulating the inflammasome-dependent scorpion venom-induced mortality.

scientific article published on 23 February 2016

Peripheral NLCR4 inflammasome participates in the genesis of acute inflammatory pain

scientific article published on 01 March 2015

Phagocytosis of apoptotic cells increases the susceptibility of macrophages to infection with Coxiella burnetii phase II through down-modulation of nitric oxide production

scientific article published on April 2004

Phosphoinositide-3 kinase gamma regulates caspase-1 activation and leukocyte recruitment in acute murine gout

scientific article published on 08 August 2019

Pivotal role of Toll-like receptors 2 and 4, its adaptor molecule MyD88, and inflammasome complex in experimental tubule-interstitial nephritis

scientific article (publication date: 2011)

Pore formation triggered by Legionella spp. is an Nlrc4 inflammasome-dependent host cell response that precedes pyroptosis

scientific article published on 4 January 2010

Primary Role for Toll-Like Receptor-Driven Tumor Necrosis Factor Rather than Cytosolic Immune Detection in Restricting Coxiella burnetii Phase II Replication within Mouse Macrophages

scientific article published on 19 January 2016

Pro-inflammatory Ca++-activated K+ channels are inhibited by hydroxychloroquine

scientific article published on 15 May 2017

Protein methyltransferase 7 deficiency in Leishmania major increases neutrophil associated pathology in murine model

scientific article published on 02 March 2021

Publisher Correction: Leishmania RNA virus exacerbates Leishmaniasis by subverting innate immunity via TLR3-mediated NLRP3 inflammasome inhibition

scientific article published on 07 January 2020

Recognition of Legionella pneumophila nucleic acids by innate immune receptors

scientific article

Relevance of the myeloid differentiation factor 88 (MyD88) on RANKL, OPG, and nod expressions induced by TLR and IL-1R signaling in bone marrow stromal cells

scientific article published in February 2015

Role of NOD2 and RIP2 in host-microbe interactions with Gram-negative bacteria: insights from the periodontal disease model.

scientific article published on 7 September 2016

Role of regulatory T cells in long-term immune dysfunction associated with severe sepsis

scientific article published in August 2010

SARS-CoV-2 triggered neutrophil extracellular traps (NETs) mediate COVID-19 pathology

scientific article published on 9 June 2020

SARS-CoV-2-triggered neutrophil extracellular traps mediate COVID-19 pathology

scientific article published on 01 December 2020

Stimulation of toll-like receptor 2 by Coxiella burnetii is required for macrophage production of pro-inflammatory cytokines and resistance to infection.

scientific article

Systems analysis of subjects acutely infected with the Chikungunya virus

scientific article published in June 2019

The Birc1e cytosolic pattern-recognition receptor contributes to the detection and control of Legionella pneumophila infection

scientific article published on 29 January 2006

The Inhibition of Inflammasome by Brazilian Propolis (EPP-AF)

scientific article published on 16 April 2013

The NLRP3 inflammasome contributes to host protection during Sporothrix schenckii infection.

scientific article published on 31 January 2017

The NLRP3 inflammasome is involved with the pathogenesis of Mayaro virus

scientific article published on 03 September 2019

The NOD2 signaling in peripheral macrophages contributes to neuropathic pain development

scientific article published on 01 January 2019

The Nlrc4 Inflammasome Contributes to Restriction of Pulmonary Infection by Flagellated Legionella spp. that Trigger Pyroptosis.

scientific article

The P2X7 Receptor Mediates Toxoplasma gondii Control in Macrophages through Canonical NLRP3 Inflammasome Activation and Reactive Oxygen Species Production

scientific article published on 12 October 2017

The global response to the COVID-19 pandemic: how have immunology societies contributed?

scientific article published on 10 September 2020

The host control of a clinical isolate strain of P. aeruginosa infection is independent of Nod-1 but depends on MyD88.

scientific article published on 15 February 2018

The mouse as a model for pulmonary legionella infection.

scientific article published in January 2013

The pattern recognition receptors Nod1 and Nod2 account for neutrophil recruitment to the lungs of mice infected with Legionella pneumophila

scientific article published on 2 June 2010

The use of a heterogeneously controlled mouse population reveals a significant correlation of acute phase parasitemia with mortality in Chagas disease.

scientific article

When the going gets tough: scientists' personal challenges

scientific article published on 01 October 2014

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