List of works by Ton Schumacher

A Traceless Selection: Counter-selection System That Allows Efficient Generation of Transposon and CRISPR-modified T-cell Products

scientific article published on 22 March 2016

A committed tissue-resident memory T cell precursor within the circulating CD8+ effector T cell pool

scientific article published on 01 October 2020

A liquid biopsy for cancer immunotherapy

scientific article published on 01 April 2016

A mouse model that is immunologically tolerant to reporter and modifier proteins

scientific article published on 29 May 2020

A transcriptionally and functionally distinct PD-1+ CD8+ T cell pool with predictive potential in non-small-cell lung cancer treated with PD-1 blockade

scientific article published on 11 June 2018

A viral peptide can mimic an endogenous peptide for allorecognition of a major histocompatibility complex class I product ⬇️

scientific article published on June 1, 1992

Acquired Immune Resistance Follows Complete Tumor Regression without Loss of Target Antigens or IFNγ Signaling.

scientific article

Acquired and intrinsic resistance in cancer immunotherapy

scientific article

Adoptive cellular therapy: a race to the finish line.

scientific article published on March 2015

Adoptive therapy with redirected primary regulatory T cells results in antigen-specific suppression of arthritis

scientific article

Adoptive transfer of T-cell immunity

scientific article

Alloreactive cytotoxic T cells provide means to decipher the immunopeptidome and reveal a plethora of tumor-associated self-epitopes.

scientific article published on 16 December 2013

Alpha beta T cell receptor transfer to gamma delta T cells generates functional effector cells without mixed TCR dimers in vivo.

scientific article published in January 2009

Altered peptide ligands revisited: vaccine design through chemically modified HLA-A2-restricted T cell epitopes

scientific article published on 13 October 2014

An early HIV mutation within an HLA-B*57-restricted T cell epitope abrogates binding to the killer inhibitory receptor 3DL1.

scientific article published on 23 March 2011

Anti-CTLA-4 therapy broadens the melanoma-reactive CD8+ T cell response.

scientific article published on September 2014

Anti-Inflammatory Drugs Remodel the Tumor Immune Environment to Enhance Immune Checkpoint Blockade Efficacy

publication published on 24 May 2021

Antigen Identification for Orphan T Cell Receptors Expressed on Tumor-Infiltrating Lymphocytes.

scientific article published on 20 December 2017

Antigen bias in T cell cross-priming

scientific article

Antigen design enhances the immunogenicity of Semliki Forest virus-based therapeutic human papillomavirus vaccines.

scientific article

Antigen receptor repertoire profiling from RNA-seq data.

scientific article published in October 2017

Antigen-specific TIL therapy for melanoma: a flexible platform for personalized cancer immunotherapy.

scientific article published on 7 November 2013

Apoptosis threshold set by Noxa and Mcl-1 after T cell activation regulates competitive selection of high-affinity clones.

scientific article

Assembly and intracellular transport of major histocompatibility complex molecules ⬇️

scientific article published on August 1, 1991

Assessing T lymphocyte function and differentiation by genetically encoded reporter systems.

scientific article published on 10 June 2015

Augmenting Immunotherapy Impact by Lowering Tumor TNF Cytotoxicity Threshold

scientific article published on 11 July 2019

Augmenting Immunotherapy Impact by Lowering Tumor TNF Cytotoxicity Threshold

scientific article published on 01 January 2020

Author Correction: Lineage tracing of acute myeloid leukemia reveals the impact of hypomethylating agents on chemoresistance selection

scientific article published on 26 November 2019

Author Correction: Replicative history marks transcriptional and functional disparity in the CD8+ T cell memory pool

correction of a scholarly article

Author Correction: Tissue patrol by resident memory CD8+ T cells in human skin

scientific article published on 24 March 2020

Autotaxin impedes anti-tumor immunity by suppressing chemotaxis and tumor infiltration of CD8 + T cells

B cells and tertiary lymphoid structures promote immunotherapy response

scientific article published on 15 January 2020

BRAF(V600E) Kinase Domain Duplication Identified in Therapy-Refractory Melanoma Patient-Derived Xenografts

scientific article published on 16 June 2016

Barcoding reveals complex clonal behavior in patient-derived xenografts of metastatic triple negative breast cancer

scientific article published in Nature Communications

Barriers to chimerism after major histocompatibility complex-mismatched stem cell transplantation: a potential role for heterologous immunity.

scientific article published on 13 April 2014

Behavior and function of tissue-resident memory T cells

scientific article published on January 2012

Biomarkers in cancer immunotherapy

scientific article published on 01 January 2015

Breadth and Dynamics of HLA-A2- and HLA-B7-Restricted CD8+ T Cell Responses against Nonstructural Viral Proteins in Acute Human Tick-Borne Encephalitis Virus Infection

scientific article published on 02 July 2018

Broad Cytotoxic Targeting of Acute Myeloid Leukemia by Polyclonal Delta One T Cells

scientific article published on 20 March 2019

Bystander hyperactivation of preimmune CD8+ T cells in chronic HCV patients

scientific article published on 14 November 2015

CANCER IMMUNOLOGY. The "cancer immunogram".

scientific article

CD4 memory T cells survive and proliferate but fail to differentiate in the absence of CD40

scientific article

CD8+ T cell states in human cancer: insights from single-cell analysis

scientific article published on 05 February 2020

CD8+ T cell tolerance and cancer immunotherapy

scientific article

Cancer Neoantigens

scientific article published on 14 December 2018

Cancer immunology. Mutational landscape determines sensitivity to PD-1 blockade in non-small cell lung cancer

scientific article (publication date: 3 April 2015)

Cancer immunotherapy

scientific article published on 12 April 2013

Case Report of a Fatal Serious Adverse Event Upon Administration of T Cells Transduced With a MART-1-specific T-cell Receptor

scientific article published on 21 April 2015

Cellular barcoding: a technical appraisal.

scientific article published on July 2014

Characterization of the CD8+ T cell responses directed against respiratory syncytial virus during primary and secondary infection in C57BL/6 mice

scientific article published on 30 May 2006

Checkpoint blockade cancer immunotherapy targets tumour-specific mutant antigens

scientific article

Class I major histocompatibility complexes loaded by a periodate trigger

scientific article

Combination of targeted therapy and immunotherapy in melanoma

scientific article published on 17 August 2011

Conditional MHC class I ligands and peptide exchange technology for the human MHC gene products HLA-A1, -A3, -A11, and -B7

scholarly article

Correction: Preventing tumor escape by targeting a post-proteasomal trimming independent epitope

scientific article published on 17 January 2017

DNA Vaccines and Intradermal Vaccination by DNA Tattooing ⬇️

scientific article published on January 1, 2012

Defining 'T cell exhaustion'

scientific article published on 30 September 2019

Definition of Proteasomal Peptide Splicing Rules for High-Efficiency Spliced Peptide Presentation by MHC Class I Molecules

scientific article published on 23 September 2015

Determining lineage pathways from cellular barcoding experiments

scientific article published on 6 February 2014

Development of adoptive cell therapy for cancer: a clinical perspective.

scientific article published on June 2010

Discovering naturally processed antigenic determinants that confer protective T cell immunity

scientific article published on April 2013

Discovery of low-affinity preproinsulin epitopes and detection of autoreactive CD8 T-cells using combinatorial MHC multimers.

scientific article published in June 2011

Dissecting T cell lineage relationships by cellular barcoding

scientific article published on 22 September 2008

Dissection of T-cell Antigen Specificity in Human Melanoma

scientific article published on 06 February 2012

Diverse and heritable lineage imprinting of early haematopoietic progenitors.

scientific article published on 3 April 2013

Dysfunctional CD8 T Cells Form a Proliferative, Dynamically Regulated Compartment within Human Melanoma

scientific article published on 27 December 2018

Dysfunctional CD8 T Cells Form a Proliferative, Dynamically Regulated Compartment within Human Melanoma

scientific article published on 01 April 2020

Editorial overview: Cancer immunology: genomics & biomarkers: Cancer immunity through the prism of genomics and proteomics

scientific article published on 06 August 2016

Effective postexposure treatment of retrovirus-induced disease with immunostimulatory DNA containing CpG motifs

scientific article

Enhanced immunogenicity of mitochondrial-localized proteins in cancer cells

scientific article published on 23 March 2020

Epstein-Barr virus gp42 is posttranslationally modified to produce soluble gp42 that mediates HLA class II immune evasion.

scientific article

Erratum: Corrigendum: Signatures of mutational processes in human cancer

scientific article published in Nature

Generation of Tumor-Reactive T Cells by Co-culture of Peripheral Blood Lymphocytes and Tumor Organoids

scientific article published on 09 August 2018

Genomics- and Transcriptomics-Based Patient Selection for Cancer Treatment With Immune Checkpoint Inhibitors: A Review

scientific article

Glutaminyl cyclase is an enzymatic modifier of the CD47- SIRPα axis and a target for cancer immunotherapy

scientific article published on 04 March 2019

Guidelines for the use of flow cytometry and cell sorting in immunological studies

scientific article published on October 2017

HLA micropolymorphisms strongly affect peptide-MHC multimer-based monitoring of antigen-specific CD8+ T cell responses

scientific article published on 16 December 2013

HPV16 E7 DNA tattooing: safety, immunogenicity, and clinical response in patients with HPV-positive vulvar intraepithelial neoplasia.

scientific article

Heterogeneous differentiation patterns of individual CD8+ T cells.

scientific article published on 14 March 2013

High sensitivity of cancer exome-based CD8 T cell neo-antigen identification

scientific article

High-throughput T-cell epitope discovery through MHC peptide exchange

scientific article

High-throughput identification of antigen-specific TCRs by TCR gene capture

scientific article

High-throughput identification of potential minor histocompatibility antigens by MHC tetramer-based screening: feasibility and limitations

scientific article

Human cancer regression antigens

scientific article published on 06 April 2013

Identification of CMTM6 and CMTM4 as PD-L1 protein regulators.

scientific article

Identification of the optimal combination dosing schedule of neoadjuvant ipilimumab plus nivolumab in macroscopic stage III melanoma (OpACIN-neo): a multicentre, phase 2, randomised, controlled trial

scientific article published on 31 May 2019

Immune induction strategies in metastatic triple-negative breast cancer to enhance the sensitivity to PD-1 blockade: the TONIC trial

scientific article published on 13 May 2019

Immunotherapeutic strategies: the melanoma example

scientific article published on July 2009

Induction of neoantigen-reactive T cells from healthy donors

scientific article published on 17 May 2019

Interference with T cell receptor–HLA-DR interactions by Epstein–Barr virus gp42 results in reduced T helper cell recognition ⬇️

scientific article published on September 22, 2003

Intra- and inter-tumor heterogeneity in a vemurafenib-resistant melanoma patient and derived xenografts

scientific article

Intradermal vaccination by DNA tattooing.

scientific article published in January 2014

Intravital imaging of fluorescent markers and FRET probes by DNA tattooing

scientific article

Intravital microscopy through an abdominal imaging window reveals a pre-micrometastasis stage during liver metastasis

scientific article published in October 2012

Key Parameters of Tumor Epitope Immunogenicity Revealed Through a Consortium Approach Improve Neoantigen Prediction

scientific article published on 02 October 2020

Lactate dehydrogenase as a selection criterion for ipilimumab treatment in metastatic melanoma.

scientific article published on 8 March 2014

Lineage tracing of acute myeloid leukemia reveals the impact of hypomethylating agents on chemoresistance selection

scientific article published on 01 November 2019

Lipopolysaccharide contamination in intradermal DNA vaccination: toxic impurity or adjuvant?

scientific article published on 02 July 2009

Loss of p53 triggers WNT-dependent systemic inflammation to drive breast cancer metastasis

scientific article published on 31 July 2019

Low and variable tumor reactivity of the intratumoral TCR repertoire in human cancers

scientific article published on 03 December 2018

MHC multimer technology: current status and future prospects

scientific article

MHC-based detection of antigen-specific CD8+ T cell responses.

scientific article published on 23 February 2010

Manufacture of gene-modified human T-cells with a memory stem/central memory phenotype.

scientific article

Mapping the life histories of T cells.

scientific article published on 06 August 2010

Mechanisms of induction of primary virus-specific cytotoxic T lymphocyte responses

scientific article published on November 1, 1992

Mismatch Repair-Deficient Cancers Are Targets for Anti-PD-1 Therapy.

scientific article

Mixed functional characteristics correlating with TCR-ligand koff -rate of MHC-tetramer reactive T cells within the naive T-cell repertoire.

scientific article published on 25 August 2013

Modular nucleic acid assembled p/MHC microarrays for multiplexed sorting of antigen-specific T cells.

scientific article published on July 2009

Mutations Associated with Acquired Resistance to PD-1 Blockade in Melanoma

scientific article published on 13 July 2016

Nab2 regulates secondary CD8+ T-cell responses through control of TRAIL expression

scientific article published on 29 November 2011

Neoadjuvant immunotherapy leads to pathological responses in MMR-proficient and MMR-deficient early-stage colon cancers

scientific article published on 06 April 2020

Neoadjuvant immunotherapy with nivolumab and ipilimumab induces major pathological responses in patients with head and neck squamous cell carcinoma

scientific article published on 22 December 2021

Neoadjuvant nivolumab, ipilimumab, and celecoxib in MMR-proficient and MMR-deficient colon cancers: Final clinical analysis of the NICHE study.

scientific article published on 06 June 2022

Neoadjuvant versus adjuvant ipilimumab plus nivolumab in macroscopic stage III melanoma

scientific article published on 08 October 2018

Neoantigen landscape dynamics during human melanoma-T cell interactions

scientific article published on 27 June 2016

Neoantigens encoded in the cancer genome

scientific article published on 9 August 2016

Neoantigens in cancer immunotherapy.

scientific article

On the role of melanoma-specific CD8+ T-cell immunity in disease progression of advanced-stage melanoma patients

scientific article published on 01 July 2004

One naive T cell, multiple fates in CD8+ T cell differentiation.

scientific article

Optimization of intradermal vaccination by DNA tattooing in human skin

scientific article

Pairing of T-cell receptor chains via emulsion PCR.

scientific article

Parallel detection of antigen-specific T cell responses by combinatorial encoding of MHC multimers

article

Parallel detection of antigen-specific T-cell responses by multidimensional encoding of MHC multimers.

scientific article

Parallel in vivo and in vitro melanoma RNAi dropout screens reveal synthetic lethality between hypoxia and DNA damage response inhibition.

scientific article published on 6 November 2014

Peptide Splicing in the Proteasome Creates a Novel Type of Antigen with an Isopeptide Linkage.

scientific article published on 23 September 2015

Peptide selection by MHC class I molecules ⬇️

scientific article published on April 25, 1991

Preclinical development of T cell receptor gene therapy

scientific article published on 25 March 2009

Preclinical development of highly effective and safe DNA vaccines directed against HPV 16 E6 and E7.

scientific article published on 27 April 2011

Preferred size of peptides that bind to H-2 Kb is sequence dependent

scientific article published on June 1, 1992

Preoperative ipilimumab plus nivolumab in locoregionally advanced urothelial cancer: the NABUCCO trial

scientific article published on 12 October 2020

Preventing tumor escape by targeting a post-proteasomal trimming independent epitope.

scientific article published on 03 October 2016

Primary T cell expansion and differentiation in vivo requires antigen presentation by B cells.

scientific article published in March 2006

Prospects and limitations of T cell receptor gene therapy

scientific article

Publisher Correction: Barcoding reveals complex clonal behavior in patient-derived xenografts of metastatic triple negative breast cancer

scientific article published on 24 April 2019

Publisher Correction: Immune induction strategies in metastatic triple-negative breast cancer to enhance the sensitivity to PD-1 blockade: the TONIC trial

scientific article published on 01 July 2019

Quorum Regulation via Nested Antagonistic Feedback Circuits Mediated by the Receptors CD28 and CTLA-4 Confers Robustness to T Cell Population Dynamics

scientific article published on 11 February 2020

RNA interference targeting programmed death receptor-1 improves immune functions of tumor-specific T cells

scientific article published on 27 March 2010

RNAi-mediated TCR knockdown prevents autoimmunity in mice caused by mixed TCR dimers following TCR gene transfer

scientific article published on 22 July 2014

Radiotherapy and Cisplatin Increase Immunotherapy Efficacy by Enabling Local and Systemic Intratumoral T-cell Activity

scientific article published on 19 February 2019

Rational design of DNA vaccines for the induction of human papillomavirus type 16 E6- and E7-specific cytotoxic T-cell responses

scientific article published on 31 October 2012

Regulation and Function of the PD-L1 Checkpoint.

scientific article published in March 2018

Replicative history marks transcriptional and functional disparity in the CD8+ T cell memory pool

scholarly article

Replicative history marks transcriptional and functional disparity in the CD8+ T cell memory pool

preprint

Reproducibility of Illumina platform deep sequencing errors allows accurate determination of DNA barcodes in cells.

scientific article

SLFN11 can sensitize tumor cells towards IFN-γ-mediated T cell killing

scientific article published on 12 February 2019

Segmentation of occluded hematopoietic stem cells from tracking

scientific article

Selective BRAF inhibition decreases tumor-resident lymphocyte frequencies in a mouse model of human melanoma

scientific article

Shielding the cationic charge of nanoparticle-formulated dermal DNA vaccines is essential for antigen expression and immunogenicity

scientific article published on 12 September 2009

Shift from systemic to site-specific memory by tumor-targeted IL-2.

scientific article published on May 2004

Simultaneous detection of circulating autoreactive CD8+ T-cells specific for different islet cell-associated epitopes using combinatorial MHC multimers.

scientific article

Single cell behavior in T cell differentiation

scientific article published on 20 March 2014

Single-cell analysis of regions of interest (SCARI) using a photosensitive tag

scientific article published on 09 September 2021

Single-cell perforin and granzyme expression reveals the anatomical localization of effector CD8+ T cells in influenza virus-infected mice.

scholarly article

Specificity and affinity motifs for Grb2 SH2-ligand interactions

scientific article

Subtle CXCR3-Dependent Chemotaxis of CTLs within Infected Tissue Allows Efficient Target Localization.

scientific article published on 2 November 2015

Synthetic peptide libraries in the determination of T cell epitopes and peptide binding specificity of class I molecules

scientific article published on June 1, 1992

Synthetic vehicles for DNA vaccination

scientific article published on January 2010

T Cell Dysfunction in Cancer.

scientific article published in April 2018

T Cell Fate at the Single-Cell Level.

scientific article published on 11 December 2015

T Cells Redirected to a Minor Histocompatibility Antigen Instruct Intratumoral TNFα Expression and Empower Adoptive Cell Therapy for Solid Tumors.

scientific article

T cell immunity. Functional heterogeneity of human memory CD4⁺ T cell clones primed by pathogens or vaccines

scientific article

T cell memory. Skin-resident memory CD8⁺ T cells trigger a state of tissue-wide pathogen alert.

scientific article

T cell receptor fingerprinting enables in-depth characterization of the interactions governing recognition of peptide-MHC complexes

scientific article published on 19 November 2018

T cells targeted to TdT kill leukemic lymphoblasts while sparing normal lymphocytes

scientific article published on 06 December 2021

T-cell receptor gene therapy of established tumors in a murine melanoma model

scientific article

T-cell-receptor gene therapy

scientific article

TCR gene therapy of spontaneous prostate carcinoma requires in vivo T cell activation.

scientific article published on August 2008

TCR repertoires of intratumoral T-cell subsets

scientific article published on January 2014

TCR transgenes and transgene cassettes for TCR gene therapy: status in 2008.

scientific article published on 03 February 2009

TIL therapy broadens the tumor-reactive CD8(+) T cell compartment in melanoma patients.

scientific article

Targeting B cell leukemia with highly specific allogeneic T cells with a public recognition motif

scientific article published on 16 September 2010

Targeting of cancer neoantigens with donor-derived T cell receptor repertoires

scientific article

Technologies for MHC class I immunoproteomics

scientific article published on 08 June 2010

Temporal effects of gamma interferon deficiency on the course of Friend retrovirus infection in mice

scientific article

Testing for HLA/peptide tetramer-binding to the T cell receptor complex on human T lymphocytes.

scientific article published on 10 May 2012

The Branching Point in Erythro-Myeloid Differentiation

scientific article published on December 2015

The CD47-SIRPα Immune Checkpoint

scientific article published on 01 May 2020

The Human Cell Atlas

scientific article

The development of standard samples with a defined number of antigen-specific T cells to harmonize T cell assays: a proof-of-principle study

scientific article

The immune system strikes back: cellular immune responses against indoleamine 2,3-dioxygenase

scientific article published on 7 September 2009

Tissue patrol by resident memory CD8+ T cells in human skin

scientific article published on 20 May 2019

Tissue-resident memory CD8+ T cells continuously patrol skin epithelia to quickly recognize local antigen.

scientific article

Towards error-free profiling of immune repertoires.

scientific article published on 04 May 2014

Transposon leads to contamination of clinical pDNA vaccine.

scientific article published on 23 May 2013

Tumor exome analysis reveals neoantigen-specific T-cell reactivity in an ipilimumab-responsive melanoma

scientific article published on 16 September 2013

Tumor infiltrating lymphocytes (TIL) therapy in metastatic melanoma: boosting of neoantigen-specific T cell reactivity and long-term follow-up

scientific article published on 01 August 2020

Tumor organoid-T-cell coculture systems

scientific article published on 18 December 2019

Tumor rejection induced by CD70-mediated quantitative and qualitative effects on effector CD8+ T cell formation

scientific article

Tumor-Infiltrating Lymphocyte Therapy or Ipilimumab in Advanced Melanoma

scientific article published on 8 December 2022

UV-induced ligand exchange in MHC class I protein crystals

scientific article

pMHC Multiplexing Strategy to Detect High Numbers of T Cell Responses in Parallel.

scientific article

γδ T cells are effectors of immunotherapy in cancers with HLA class I defects

scientific article published in 2023

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