List of works - Shitij Kapur

Psychosis as a state of aberrant salience: a framework linking biology, phenomenology, and pharmacology in schizophrenia

scientific article

The dopamine hypothesis of schizophrenia: version III--the final common pathway

scientific article

Schizophrenia

scholarly article about schizophrenia

Grand challenges in global mental health

scientific article

Does fast dissociation from the dopamine d(2) receptor explain the action of atypical antipsychotics?: A new hypothesis

scientific article

Why has it taken so long for biological psychiatry to develop clinical tests and what to do about it?

scientific article published on 7 August 2012

Relationship between dopamine D(2) occupancy, clinical response, and side effects: a double-blind PET study of first-episode schizophrenia

scientific article

The nature of dopamine dysfunction in schizophrenia and what this means for treatment

scientific article published on August 2012

CNVs conferring risk of autism or schizophrenia affect cognition in controls

scientific article (publication date: 18 December 2013)

Opposite effects of delta-9-tetrahydrocannabinol and cannabidiol on human brain function and psychopathology

scientific article

Half a century of antipsychotics and still a central role for dopamine D2 receptors

scientific article published on October 2003

Direct activation of the ventral striatum in anticipation of aversive stimuli

scientific article

Antipsychotic dosing in preclinical models is often unrepresentative of the clinical condition: a suggested solution based on in vivo occupancy

scientific article published on 20 February 2003

From dopamine to salience to psychosis--linking biology, pharmacology and phenomenology of psychosis.

scientific article

Delayed-onset hypothesis of antipsychotic action: a hypothesis tested and rejected

scientific article published in December 2003

Functional brain maps of retrieval mode and recovery of episodic information.

scientific article

NMDA receptor antagonists ketamine and PCP have direct effects on the dopamine D(2) and serotonin 5-HT(2)receptors-implications for models of schizophrenia

scientific article

Functional role of the prefrontal cortex in retrieval of memories: a PET study

scientific article published on 01 October 1995

Cannabidiol inhibits THC-elicited paranoid symptoms and hippocampal-dependent memory impairment

scientific article

Dopamine D(2) receptors and their role in atypical antipsychotic action: still necessary and may even be sufficient

scientific article

Dopamine Synthesis Capacity in Patients With Treatment-Resistant Schizophrenia

scientific article published on November 1, 2012

Antipsychotic treatment resistance in schizophrenia associated with elevated glutamate levels but normal dopamine function

scientific article published on 25 July 2013

Radiosynthesis and evaluation of [11C]-(+)-4-propyl-3,4,4a,5,6,10b-hexahydro-2H-naphtho[1,2-b][1,4]oxazin-9-ol as a potential radiotracer for in vivo imaging of the dopamine D2 high-affinity state with positron emission tomography.

scientific article published in June 2005

An automated method for the extraction of regional data from PET images

scientific article published on 21 June 2006

Mechanisms underlying psychosis and antipsychotic treatment response in schizophrenia: insights from PET and SPECT imaging.

scientific article published on January 2009

The acute effects of synthetic intravenous Delta9-tetrahydrocannabinol on psychosis, mood and cognitive functioning

scientific article

Atypical antipsychotics: new directions and new challenges in the treatment of schizophrenia

scientific article

Role of the dopaminergic system in depression

scientific article

Evidence for impaired cortical inhibition in schizophrenia using transcranial magnetic stimulation

scientific article

Dopamine D(2) receptor occupancy is a common mechanism underlying animal models of antipsychotics and their clinical effects

scientific article published in November 2001

Increased dopamine D2 receptor binding after long-term treatment with antipsychotics in humans: a clinical PET study

scientific article

Dopamine specifically inhibits forebrain neural stem cell proliferation, suggesting a novel effect of antipsychotic drugs.

scientific article published in June 2005

Schizophrenia: more dopamine, more D2 receptors

scientific article

The formation of abnormal associations in schizophrenia: neural and behavioral evidence

scientific article published on 2 May 2007

"Breakthrough" dopamine supersensitivity during ongoing antipsychotic treatment leads to treatment failure over time

scientific article

Differential effects of aripiprazole on D(2), 5-HT(2), and 5-HT(1A) receptor occupancy in patients with schizophrenia: a triple tracer PET study.

scientific article

Elevation of prolactin levels by atypical antipsychotics

scientific article published in January 2002

The D2 dopamine receptor occupancy of risperidone and its relationship to extrapyramidal symptoms: a PET study.

scientific article published on 01 January 1995

Separate brain regions code for salience vs. valence during reward prediction in humans

scientific article published in April 2007

Negative symptoms have greater impact on functioning than positive symptoms in schizophrenia: analysis of CATIE data

scientific article

Alterations of the brain reward system in antipsychotic naïve schizophrenia patients

scientific article published on 13 March 2012

The effect of paroxetine on 5-HT(2A) receptors in depression: an [(18)F]setoperone PET imaging study

scientific article

Specific and generalized neuropsychological deficits: a comparison of patients with various first-episode psychosis presentations

scientific article published in December 2009

Early response to antipsychotic drug therapy as a clinical marker of subsequent response in the treatment of schizophrenia

scientific article

The amphetamine-induced sensitized state as a model of schizophrenia

scientific article published on 28 August 2007

An algorithm-based approach to first-episode schizophrenia: response rates over 3 prospective antipsychotic trials with a retrospective data analysis

scientific article

Dissociation between in vivo occupancy and functional antagonism of dopamine D2 receptors: comparing aripiprazole to other antipsychotics in animal models

scientific article published on 30 November 2005

Dopaminergic function in cannabis users and its relationship to cannabis-induced psychotic symptoms.

scientific article published on 29 June 2013

Binding characteristics and sensitivity to endogenous dopamine of [11C]-(+)-PHNO, a new agonist radiotracer for imaging the high-affinity state of D2 receptors in vivo using positron emission tomography.

scientific article

The neural correlates of intentional learning of verbal materials: a PET study in humans.

scientific article

List of works by Shitij Kapur

Psychosis as a state of aberrant salience: a framework linking biology, phenomenology, and pharmacology in schizophrenia

The dopamine hypothesis of schizophrenia: version III--the final common pathway

Schizophrenia

Grand challenges in global mental health

Does fast dissociation from the dopamine d(2) receptor explain the action of atypical antipsychotics?: A new hypothesis

Why has it taken so long for biological psychiatry to develop clinical tests and what to do about it?

Relationship between dopamine D(2) occupancy, clinical response, and side effects: a double-blind PET study of first-episode schizophrenia

The nature of dopamine dysfunction in schizophrenia and what this means for treatment

CNVs conferring risk of autism or schizophrenia affect cognition in controls

Opposite effects of delta-9-tetrahydrocannabinol and cannabidiol on human brain function and psychopathology

Half a century of antipsychotics and still a central role for dopamine D2 receptors

Direct activation of the ventral striatum in anticipation of aversive stimuli

Antipsychotic dosing in preclinical models is often unrepresentative of the clinical condition: a suggested solution based on in vivo occupancy

From dopamine to salience to psychosis--linking biology, pharmacology and phenomenology of psychosis.

Delayed-onset hypothesis of antipsychotic action: a hypothesis tested and rejected

Functional brain maps of retrieval mode and recovery of episodic information.

NMDA receptor antagonists ketamine and PCP have direct effects on the dopamine D(2) and serotonin 5-HT(2)receptors-implications for models of schizophrenia

Functional role of the prefrontal cortex in retrieval of memories: a PET study

Cannabidiol inhibits THC-elicited paranoid symptoms and hippocampal-dependent memory impairment

Dopamine D(2) receptors and their role in atypical antipsychotic action: still necessary and may even be sufficient

Dopamine Synthesis Capacity in Patients With Treatment-Resistant Schizophrenia

Antipsychotic treatment resistance in schizophrenia associated with elevated glutamate levels but normal dopamine function

Radiosynthesis and evaluation of [11C]-(+)-4-propyl-3,4,4a,5,6,10b-hexahydro-2H-naphtho[1,2-b][1,4]oxazin-9-ol as a potential radiotracer for in vivo imaging of the dopamine D2 high-affinity state with positron emission tomography.

An automated method for the extraction of regional data from PET images

Mechanisms underlying psychosis and antipsychotic treatment response in schizophrenia: insights from PET and SPECT imaging.

The acute effects of synthetic intravenous Delta9-tetrahydrocannabinol on psychosis, mood and cognitive functioning

Atypical antipsychotics: new directions and new challenges in the treatment of schizophrenia

Role of the dopaminergic system in depression

Evidence for impaired cortical inhibition in schizophrenia using transcranial magnetic stimulation

Dopamine D(2) receptor occupancy is a common mechanism underlying animal models of antipsychotics and their clinical effects

Increased dopamine D2 receptor binding after long-term treatment with antipsychotics in humans: a clinical PET study

Dopamine specifically inhibits forebrain neural stem cell proliferation, suggesting a novel effect of antipsychotic drugs.

Schizophrenia: more dopamine, more D2 receptors

The formation of abnormal associations in schizophrenia: neural and behavioral evidence

"Breakthrough" dopamine supersensitivity during ongoing antipsychotic treatment leads to treatment failure over time

Differential effects of aripiprazole on D(2), 5-HT(2), and 5-HT(1A) receptor occupancy in patients with schizophrenia: a triple tracer PET study.

Elevation of prolactin levels by atypical antipsychotics

The D2 dopamine receptor occupancy of risperidone and its relationship to extrapyramidal symptoms: a PET study.

Separate brain regions code for salience vs. valence during reward prediction in humans

Negative symptoms have greater impact on functioning than positive symptoms in schizophrenia: analysis of CATIE data

Alterations of the brain reward system in antipsychotic naïve schizophrenia patients

The effect of paroxetine on 5-HT(2A) receptors in depression: an [(18)F]setoperone PET imaging study

Specific and generalized neuropsychological deficits: a comparison of patients with various first-episode psychosis presentations

Early response to antipsychotic drug therapy as a clinical marker of subsequent response in the treatment of schizophrenia

The amphetamine-induced sensitized state as a model of schizophrenia

An algorithm-based approach to first-episode schizophrenia: response rates over 3 prospective antipsychotic trials with a retrospective data analysis

Dissociation between in vivo occupancy and functional antagonism of dopamine D2 receptors: comparing aripiprazole to other antipsychotics in animal models

Dopaminergic function in cannabis users and its relationship to cannabis-induced psychotic symptoms.

Binding characteristics and sensitivity to endogenous dopamine of [11C]-(+)-PHNO, a new agonist radiotracer for imaging the high-affinity state of D2 receptors in vivo using positron emission tomography.

The neural correlates of intentional learning of verbal materials: a PET study in humans.