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List of works by Shitij Kapur

"Breakthrough" dopamine supersensitivity during ongoing antipsychotic treatment leads to treatment failure over time

scientific article

"Extended" Antipsychotic Dosing

scientific article published on 01 December 2005

"Extended" antipsychotic dosing in the maintenance treatment of schizophrenia: a double-blind, placebo-controlled trial

scientific article published on 07 September 2010

'Jumping to conclusions' and delusions in psychosis: relationship and response to treatment.

scientific article published on 25 September 2007

5-HT2 antagonism and EPS benefits: is there a causal connection?

scientific article published on March 1996

A PET study evaluating dopamine D2 receptor occupancy for long-acting injectable risperidone

scientific article published in March 2006

A PET study of dopamine D2 and serotonin 5-HT2 receptor occupancy in patients with schizophrenia treated with therapeutic doses of ziprasidone

scientific article published in May 2004

A comparison of two delivery modalities of a mobile phone-based assessment for serious mental illness: native smartphone application vs text-messaging only implementations.

scientific article published on 5 April 2013

A computational model of the functional role of the ventral-striatal D2 receptor in the expression of previously acquired behaviors

scientific article

A model of anticholinergic activity of atypical antipsychotic medications

scientific article published on 22 August 2006

A model of antipsychotic action in conditioned avoidance: a computational approach

scientific article published on June 2004

A neurobiological hypothesis for the classification of schizophrenia: type A (hyperdopaminergic) and type B (normodopaminergic).

scientific article published in July 2014

A positron emission tomography study of 5-hydroxytryptamine-1A receptors in Alzheimer disease

scientific article

A putative animal model of the "prodromal" state of schizophrenia

scientific article

A sensitizing regimen of amphetamine impairs visual attention in the 5-choice serial reaction time test: reversal by a D1 receptor agonist injected into the medial prefrontal cortex

scientific article published on 18 October 2006

A sensitizing regimen of amphetamine that disrupts attentional set-shifting does not disrupt working or long-term memory

scientific article

A simple method to measure baseline occupancy of neostriatal dopamine D2 receptors by dopamine in vivo in healthy subjects

scientific article

A systematic review of aripiprazole--dose, plasma concentration, receptor occupancy, and response: implications for therapeutic drug monitoring

scientific article published on June 2010

A voxel-by-voxel analysis of [18F]setoperone PET data shows no substantial serotonin 5-HT(2A) receptor changes in schizophrenia

scientific article

Aberrant Effective Connectivity in Schizophrenia Patients during Appetitive Conditioning

scientific article published on 17 January 2011

Actigraphic measurement of the effects of single-dose haloperidol and olanzapine on spontaneous motor activity in normal subjects.

scientific article

Activation of specific cortical regions by apomorphine: an [15O]H2O PET study in humans.

scientific article published in July 1994

Acute effects of single-dose aripiprazole and haloperidol on resting cerebral blood flow (rCBF) in the human brain

scientific article published on 25 March 2012

Adherence to treatment guidelines in clinical practice: study of antipsychotic treatment prior to clozapine initiation

scientific article published on 06 September 2012

Advantages and disadvantages of combination treatment with antipsychotics ECNP Consensus Meeting, March 2008, Nice.

scientific article published on 2 May 2009

Adverse subjective experience with antipsychotics and its relationship to striatal and extrastriatal D2 receptors: a PET study in schizophrenia

scientific article published in April 2007

Alterations in cortical and extrastriatal subcortical dopamine function in schizophrenia: systematic review and meta-analysis of imaging studies

scientific article published on June 2014

Alterations of the brain reward system in antipsychotic naïve schizophrenia patients

scientific article published on 13 March 2012

Amisulpride - dose, plasma concentration, occupancy and response: implications for therapeutic drug monitoring

scientific article published on July 2009

Amisulpride the 'atypical' atypical antipsychotic--comparison to haloperidol, risperidone and clozapine

scientific article

Amoxapine as an antipsychotic: comparative study versus haloperidol

scientific article

Amoxapine as an atypical antipsychotic: a comparative study vs risperidone

scientific article

Amoxapine in schizophrenia: a negative double-blind controlled trial

scientific article

Amoxapine shows an antipsychotic effect but worsens motor function in patients with Parkinson's disease and psychosis.

scientific article

Amoxapine shows atypical antipsychotic effects in patients with schizophrenia: results from a prospective open-label study

scientific article

Amphetamine pretreatment induces a change in both D2-Receptor density and apparent affinity: a [11C]raclopride positron emission tomography study in cats.

scientific article

Amphetamine-sensitized animals show a marked increase in dopamine D2 high receptors occupied by endogenous dopamine, even in the absence of acute challenges

scientific article published in December 2002

Amphetamine-sensitized animals show a sensorimotor gating and neurochemical abnormality similar to that of schizophrenia

scientific article published in November 2003

An algorithm-based approach to first-episode schizophrenia: response rates over 3 prospective antipsychotic trials with a retrospective data analysis

scientific article

An automated method for the extraction of regional data from PET images

scientific article published on 21 June 2006

Anesthetics inhibit high-affinity states of dopamine D2 and other G-linked receptors

scientific article published in October 2003

Antipsychotic dosing in preclinical models is often unrepresentative of the clinical condition: a suggested solution based on in vivo occupancy

scientific article published on 20 February 2003

Antipsychotic dosing: how much but also how often?

scientific article

Antipsychotic treatment resistance in schizophrenia associated with elevated glutamate levels but normal dopamine function.

scientific article published on 25 July 2013

Antipsychoticlike effects of amoxapine, without catalepsy, using the prepulse inhibition of the acoustic startle reflex test in rats

scientific article

Apathy in schizophrenia: clinical correlates and association with functional outcome

scientific article published in September 2003

Attribution style as a factor in psychosis and symptom resolution

scientific article published on 15 July 2008

Atypical antipsychotics: new directions and new challenges in the treatment of schizophrenia

scientific article

BL-1020, a novel antipsychotic candidate with GABA-enhancing effects: D2 receptor occupancy study in humans

scientific article published on 29 August 2009

Binding characteristics and sensitivity to endogenous dopamine of [11C]-(+)-PHNO, a new agonist radiotracer for imaging the high-affinity state of D2 receptors in vivo using positron emission tomography.

scientific article

Biomarkers for Psychiatry: The Journey from Fantasy to Fact, a Report of the 2013 CINP Think Tank

scientific article

Biomarkers of treatment outcome in schizophrenia: Defining a benchmark for clinical significance

scientific article published on 20 June 2015

Blockade of 5-HT2a receptors reduces haloperidol-induced attenuation of reward

scientific article published on 14 June 2006

Blockade of [11C](+)-PHNO binding in human subjects by the dopamine D3 receptor antagonist ABT-925.

scientific article published on 15 September 2009

Brain region binding of the D2/3 agonist [11C]-(+)-PHNO and the D2/3 antagonist [11C]raclopride in healthy humans

scientific article

Brain serotonin 5-HT(1A) receptor binding in schizophrenia measured by positron emission tomography and [11C]WAY-100635.

scientific article published in June 2002

CNVs conferring risk of autism or schizophrenia affect cognition in controls

scientific article (publication date: 18 December 2013)

Calculating occupancy when one does not have baseline: a comparison of different options

scientific article

Candidate-gene association analysis of response to risperidone in African-American and white patients with schizophrenia.

scientific article

Cannabidiol inhibits THC-elicited paranoid symptoms and hippocampal-dependent memory impairment

scientific article

Cerebral gray matter volume deficits in first episode psychosis

scientific article published in June 1998

Challenging the assumption that improvement in functional outcomes is delayed relative to improvement in symptoms in the treatment of schizophrenia

scientific article published on 15 January 2010

Changes in delusional dimensions and emotions over eight weeks of antipsychotic treatment in acute patients

scientific article published on 27 June 2015

Changes in delusions in the early phase of antipsychotic treatment - an experience sampling study

scientific article published on 24 December 2013

Clinical trials for negative symptoms--emerging directions and unresolved issues

scientific article published in November 2013

Clinically meaningful biomarkers for psychosis: a systematic and quantitative review

scientific article published on 27 May 2014

Clozapine and olanzapine exhibit an intrinsic anxiolytic property in two conditioned fear paradigms: contrast with haloperidol and chlordiazepoxide

scientific article published on October 2008

Clozapine can induce high dopamine D(2) receptor occupancy in vivo

scientific article published on 11 December 2001

Cognitive subtractions may not add up: the interaction between semantic processing and response mode

scientific article published on April 1997

Combining efficacy and completion rates with no data imputation: a composite approach with greater sensitivity for the statistical evaluation of active comparisons in antipsychotic trials

scientific article

Computerized cognitive remediation training for schizophrenia: an open label, multi-site, multinational methodology study.

scientific article published on 18 February 2012

Connectomic correlates of response to treatment in first-episode psychosis.

scientific article published on 21 December 2016

Continuous but not intermittent olanzapine infusion induces vacuous chewing movements in rats

scientific article published in February 2005

Contrasting effects of haloperidol and lithium on rodent brain structure: a magnetic resonance imaging study with postmortem confirmation

scientific article published on 15 January 2012

Contrasting loxapine to its isomer isoloxapine--the critical role of in vivo D2 blockade in determining atypicality

scientific article published in September 2005

Contributions of the mesial frontal cortex to the premovement potentials associated with intermittent hand movements in humans

scientific article published on 01 January 1996

Copy number variants and therapeutic response to antidepressant medication in major depressive disorder

scientific article published on 21 January 2014

Corrigendum to "Trajectories of response to treatment with atypical antipsychotic medication in patients with schizophrenia pooled from 6 double-blind, randomized clinical trials" [Shizophr. Res. 130 (2011) 11–19]

scholarly article published in Schizophrenia Research

D2 receptor blockade by risperidone correlates with attention deficits in late-life schizophrenia

scientific article published in December 2009

D2 receptor occupancy of olanzapine pamoate depot using positron emission tomography: an open-label study in patients with schizophrenia.

scientific article published on 18 April 2007

D2-receptor upregulation is dependent upon temporal course of D2-occupancy: a longitudinal [11C]-raclopride PET study in cats

scientific article published on 6 August 2008

Decreased binding of the D3 dopamine receptor-preferring ligand [11C]-(+)-PHNO in drug-naive Parkinson's disease

scientific article published on 19 January 2009

Delayed-onset hypothesis of antipsychotic action: a hypothesis tested and rejected

scientific article published in December 2003

Detecting improvements in acute psychotic symptoms using experience sampling methodology

scientific article published on 9 July 2013

Determinants of antipsychotic response in schizophrenia: implications for practice and future clinical trials

scientific article published on April 2014

Differential effects of aripiprazole on D(2), 5-HT(2), and 5-HT(1A) receptor occupancy in patients with schizophrenia: a triple tracer PET study.

scientific article

Differential effects of within-day continuous vs. transient dopamine D2 receptor occupancy in the development of vacuous chewing movements (VCMs) in rats

scientific article published on 2 July 2003

Direct activation of the ventral striatum in anticipation of aversive stimuli

scientific article

Disaster mental health in Asia and the Asian Journal of Psychiatry

scientific article published on 12 September 2008

Disruption of frontal θ coherence by Δ9-tetrahydrocannabinol is associated with positive psychotic symptoms

scientific article

Dissociation between in vivo occupancy and functional antagonism of dopamine D2 receptors: comparing aripiprazole to other antipsychotics in animal models

scientific article published on 30 November 2005

Do antipsychotics improve reasoning biases? A review

scientific article published on July 2010

Do loxapine plus cyproheptadine make an atypical antipsychotic? PET analysis of their dopamine D2 and serotonin2 receptor occupancy

scientific article published in July 1998

Does fast dissociation from the dopamine d(2) receptor explain the action of atypical antipsychotics?: A new hypothesis

scientific article

Does intravenous Δ9-tetrahydrocannabinol increase dopamine release? A SPET study

scientific article published on 17 September 2010

Dopamine D(2) receptor blockade by haloperidol. (3)H-raclopride reveals much higher occupancy than EEDQ.

scientific article published on November 2000

Dopamine D(2) receptor occupancy is a common mechanism underlying animal models of antipsychotics and their clinical effects

scientific article published in November 2001

Dopamine D(2) receptors and their role in atypical antipsychotic action: still necessary and may even be sufficient

scientific article

Dopamine D2 and D3 receptors in human putamen, caudate nucleus, and globus pallidus

scientific article

Dopamine D2 receptor occupancy predicts catalepsy and the suppression of conditioned avoidance response behavior in rats

scientific article published in July 2000

Dopamine D2 receptor radiotracers [(11)C](+)-PHNO and [(3)H]raclopride are indistinguishably inhibited by D2 agonists and antagonists ex vivo

scientific article published on 19 November 2007

Dopamine Synthesis Capacity in Patients With Treatment-Resistant Schizophrenia ⬇️

scientific article published on November 1, 2012

Dopamine specifically inhibits forebrain neural stem cell proliferation, suggesting a novel effect of antipsychotic drugs.

scientific article published in June 2005

Dopamine, prediction error and associative learning: a model-based account

scientific article

Dopamine-induced changes in neural network patterns supporting aversive conditioning

scientific article published on 2 December 2009

Dopaminergic activity in depressed smokers: a positron emission tomography study.

scientific article published on August 2009

Dopaminergic function in cannabis users and its relationship to cannabis-induced psychotic symptoms.

scientific article published on 29 June 2013

Drug-induced receptor occupancy: substantial differences in measurements made in vivo vs ex vivo

scientific article

Dynamic regulation of dopamine and serotonin responses to salient stimuli during chronic haloperidol treatment

scientific article

EMD 281014, a specific and potent 5HT2 antagonist in humans: a dose-finding PET study

scientific article published on September 2004

Early improvement on antipsychotic treatment as a predictor of subsequent response in schizophrenia: analyses from ziprasidone clinical studies

scientific article

Early onset of antipsychotic action in schizophrenia: evaluating the possibility of shorter acute efficacy trials

scientific article published in June 2010

Early onset of antipsychotic response in the treatment of acutely agitated patients with psychotic disorders

scientific article published on 20 May 2008

Early response to antipsychotic drug therapy as a clinical marker of subsequent response in the treatment of schizophrenia

scientific article

Early use of clozapine for poorly responding first-episode psychosis

scientific article published in August 2007

Effect of acute antipsychotic administration on dopamine synthesis in rodents and human subjects using 6-[18F]-L-m-tyrosine.

scientific article published in May 2004

Effect of antipsychotics on cortical inhibition using transcranial magnetic stimulation

scientific article published on 7 August 2003

Effect of chronic antipsychotic treatment on brain structure: a serial magnetic resonance imaging study with ex vivo and postmortem confirmation.

scientific article

Effect of chronic antipsychotic treatment on striatal phosphodiesterase 10A levels: a [¹¹C]MP-10 PET rodent imaging study with ex vivo confirmation.

scientific article

Effects of aging on 5-HT(2A) R binding: a HRRT PET study with and without partial volume corrections

scientific article published on 23 February 2011

Effects of antipsychotics on D3 receptors: a clinical PET study in first episode antipsychotic naive patients with schizophrenia using [11C]-(+)-PHNO.

scientific article published in September 2011

Effects of catecholamine depletion on D2 receptor binding, mood, and attentiveness in humans: a replication study

scientific article published in January 2003

Effects of chronic typical and atypical antipsychotic drug treatment on maternal behavior in rats

scientific article

Effects of novel antipsychotics, amisulpiride and aripiprazole, on maternal behavior in rats

scientific article published in September 2005

Effects of self-generated sad mood on regional cerebral activity: a PET study in normal subjects

scientific article published in January 1996

Effects of the dopamine stabilizer, OSU-6162, on brain stimulation reward and on quinpirole-induced changes in reward and locomotion

scientific article

Effects of typical and atypical antipsychotic drugs on maternal behavior in postpartum female rats

scientific article

Electroconvulsive shock increases tyrosine hydroxylase and neuropeptide Y gene expression in the locus coeruleus

scientific article published in April 1993

Elevation of prolactin levels by atypical antipsychotics

scientific article published in January 2002

Emerging drugs for schizophrenia

scientific article published on 01 September 2008

Equivalent occupancy of dopamine D1 and D2 receptors with clozapine: differentiation from other atypical antipsychotics

scientific article published in September 2004

Establishing test-retest reliability of an adapted [(18)F]fallypride imaging protocol in older people

scientific article published on 17 April 2013

Evaluation of N-desmethylclozapine as a potential antipsychotic--preclinical studies

scientific article

Evaluation of the motor initiation hypothesis of APD-induced conditioned avoidance decreases

scientific article

Evidence for impaired cortical inhibition in schizophrenia using transcranial magnetic stimulation

scientific article

Evidence for onset of antipsychotic effects within the first 24 hours of treatment

scientific article published in May 2005

Ex vivo [11C]-(+)-PHNO binding is unchanged in animal models displaying increased high-affinity states of the D2 receptor in vitro

scientific article published in November 2009

Exploring the neural correlates of delusions of reference

scientific article

First human evidence of d-amphetamine induced displacement of a D2/3 agonist radioligand: A [11C]-(+)-PHNO positron emission tomography study

scientific article published on 4 April 2007

From dopamine to salience to psychosis--linking biology, pharmacology and phenomenology of psychosis.

scientific article

Functional brain maps of retrieval mode and recovery of episodic information.

scientific article

Functional role of the prefrontal cortex in retrieval of memories: a PET study

scientific article

Genetic predictors of response to serotonergic and noradrenergic antidepressants in major depressive disorder: a genome-wide analysis of individual-level data and a meta-analysis

scientific article

Gestational methylazoxymethanol acetate treatment impairs select cognitive functions: parallels to schizophrenia

scientific article published on 11 October 2006

Gestational treatment with methylazoxymethanol (MAM) that disrupts hippocampal-dependent memory does not alter behavioural response to cocaine.

scientific article published on 23 May 2009

Going beyond "trial-and-error" in psychiatric treatments: OPTiMiSE-ing the treatment of first episode of schizophrenia

scientific article published in May 2015

Grand challenges in global mental health

scientific article

Half a century of antipsychotics and still a central role for dopamine D2 receptors

scientific article published on October 2003

Haloperidol and olanzapine mediate metabolic abnormalities through different molecular pathways.

scientific article published on 15 January 2013

Haloperidol modulates noradrenergic responses to aversive stimulation depending on treatment duration

scientific article

High-affinity states of human brain dopamine D2/3 receptors imaged by the agonist [11C]-(+)-PHNO.

scientific article published on 20 December 2005

How Antipsychotics Work: Linking Receptors to Response

How antipsychotics become anti-"psychotic"--from dopamine to salience to psychosis

scientific article published in August 2004

How antipsychotics impact the different dimensions of Schizophrenia: a test of competing hypotheses

scientific article published on 24 April 2014

How antipsychotics work-from receptors to reality

scientific article

How antipsychotics work: the patients' perspective

scientific article published in June 2005

How change comes: translating biological research into care

How psychotropic polypharmacy in schizophrenia begins: a longitudinal perspective

scientific article published on 15 December 2011

Imaging of brain structure and function: relevance to psychiatric disorders

Impaired subjective well-being in schizophrenia is associated with reduced anterior cingulate activity during reward processing.

scientific article

Improvement of brain reward abnormalities by antipsychotic monotherapy in schizophrenia

scientific article published on December 2012

In vivo characterization of the pharmacokinetics and pharmacological properties of [11C]-(+)-PHNO in rats using an intracerebral beta-sensitive system

scientific article published in August 2006

In vivo evidence for dopamine-mediated internalization of D2-receptors after amphetamine: differential findings with [3H]raclopride versus [3H]spiperone

scientific article published in February 2003

Increased Antipsychotic Sensitivity in Elderly Patients

Increased antipsychotic sensitivity in elderly patients: evidence and mechanisms

scientific article published on 16 December 2008

Increased dopamine D2 receptor binding after long-term treatment with antipsychotics in humans: a clinical PET study

scientific article

Increased dopamine D2(High) receptors in amphetamine-sensitized rats, measured by the agonist [(3)H](+)PHNO.

scientific article published in May 2007

Increased dopamine d(2) receptor occupancy and elevated prolactin level associated with addition of haloperidol to clozapine

scientific article

Increasing D2 affinity results in the loss of clozapine's atypical antipsychotic action

scientific article published on May 2002

Increasing Versus Maintaining the Dose of Olanzapine or Risperidone in Schizophrenia Patients Who Did Not Respond to a Modest Dosage: A Double-Blind Randomized Controlled Trial

scientific article published on October 2016

Individualized prediction of illness course at the first psychotic episode: a support vector machine MRI study

scientific article published on 7 November 2011

Initial depression severity and response to antidepressants v. placebo: patient-level data analysis from 34 randomised controlled trials

scientific article

Instrumentally Detected Changes in Motor Functioning in Patients with Low Levels of Antipsychotic Dopamine D2 Blockade

scientific article published on 01 January 2000

Integrating mobile-phone based assessment for psychosis into people's everyday lives and clinical care: a qualitative study.

scientific article

Inverse relationship between serotonin 5-HT(1A) receptor binding and anxiety: a [(11)C]WAY-100635 PET investigation in healthy volunteers

scientific article published in August 2001

Investigating schizophrenia in a "dish": possibilities, potential and limitations

scientific article published on October 2012

Is amoxapine an atypical antipsychotic? Positron-emission tomography investigation of its dopamine2 and serotonin2 occupancy

scientific article

Is desire for social relationships mediated by the serotonergic system in the prefrontal cortex? An [(18)F]setoperone PET study

scientific article published in March 2010

Issues and perspectives in designing clinical trials for negative symptoms in schizophrenia

scientific article

Jumping to conclusions, a lack of belief flexibility and delusional conviction in psychosis: a longitudinal investigation of the structure, frequency, and relatedness of reasoning biases

scientific article published on 12 September 2011

Ketamine has equal affinity for NMDA receptors and the high-affinity state of the dopamine D2 receptor

scientific article published in June 2001

Less is more: antipsychotic drug effects are greater with transient rather than continuous delivery

scientific article

Linking animal models of psychosis to computational models of dopamine function

scientific article published on 10 May 2006

Longitudinal in vivo maturational changes of metabolites in the prefrontal cortex of rats exposed to polyinosinic-polycytidylic acid in utero.

scientific article

Looking for a "biological test" to diagnose"schizophrenia": are we chasing red herrings?

scientific article

Loss of extra-striatal phosphodiesterase 10A expression in early premanifest Huntington's disease gene carriers

scientific article published on 15 July 2016

Loss of phosphodiesterase 10A expression is associated with progression and severity in Parkinson's disease

scientific article published on 25 July 2015

Mapping neural interactivity onto regional activity: an analysis of semantic processing and response mode interactions

scientific article published on April 1998

Mechanisms underlying psychosis and antipsychotic treatment response in schizophrenia: insights from PET and SPECT imaging.

scientific article published on January 2009

Meta-regression analysis of placebo response in antipsychotic trials, 1970-2010.

scientific article

Microglial activation in the rat brain following chronic antipsychotic treatment at clinically relevant doses

scientific article published on 17 August 2015

Microvascular abnormality in schizophrenia as shown by retinal imaging

scientific article published on December 2013

Mobile early detection and connected intervention to coproduce better care in severe mental illness.

scientific article

Modafinil combined with cognitive training is associated with improved learning in healthy volunteers--a randomised controlled trial

scientific article published on 16 January 2014

Modafinil combined with cognitive training: pharmacological augmentation of cognitive training in schizophrenia.

scientific article published on 31 March 2015

Modulation of cortical neuronal activity by a serotonergic agent: a PET study in humans

scientific article published in May 1994

Molecular imaging as a guide for the treatment of central nervous system disorders

scientific article published on September 2013

Monthly administration of long-acting injectable risperidone and striatal dopamine D2 receptor occupancy for the management of schizophrenia.

scientific article published on August 2008

NMDA receptor antagonists ketamine and PCP have direct effects on the dopamine D(2) and serotonin 5-HT(2)receptors-implications for models of schizophrenia

scientific article

Negative symptoms have greater impact on functioning than positive symptoms in schizophrenia: analysis of CATIE data

scientific article

Negative symptoms in schizophrenia – the remarkable impact of inclusion definitions in clinical trials and their consequences

scientific article published on 29 June 2013

Neuroanatomical Correlates of Human Reasoning

scientific article published on 01 May 1998

Neuromodulation of frontal and temporal cortex by intravenous d-fenfluramine: an [15O]H2O PET study in humans

scientific article published in March 1996

New and old antipsychotics: what ‘effectiveness’ trials tell us

New insights into schizophrenia from neuroimaging

Olanzapine: a systematic review and meta-regression of the relationships between dose, plasma concentration, receptor occupancy, and response

scientific article published on June 2013

Opposite effects of delta-9-tetrahydrocannabinol and cannabidiol on human brain function and psychopathology

scientific article

Oral D-amphetamine causes prolonged displacement of [11C]raclopride as measured by PET.

scientific article published in January 2004

Partial agonists in schizophrenia--why some work and others do not: insights from preclinical animal models

scientific article published on 19 November 2010

Pharmacogenetics in psychiatry: are we ready for widespread clinical use?

scientific article published on 27 August 2008

Pharmacogenetics of antidepressant response: A polygenic approach

scientific article published on 31 January 2017

Phosphodiesterase 10A PET Radioligand Development Program: From Pig to Human

article

Phosphodiesterase 10A in Schizophrenia: A PET Study Using [(11)C]IMA107.

scientific article

Polypharmacy: the good, the bad and the ugly

scientific article

Positron emission tomography quantification of [11C]-(+)-PHNO binding in the human brain.

scientific article published on 11 October 2006

Predicting a 'combined treatment outcome' in chronic schizophrenia: the role of demographics, symptomatology, functioning and subjective well-being

scientific article

Predicting brain occupancy from plasma levels using PET: superiority of combining pharmacokinetics with pharmacodynamics while modeling the relationship

scientific article published on 21 December 2011

Predicting clinical response in people at ultra-high risk of psychosis: a systematic and quantitative review

scientific article published on 18 March 2015

Psychosis as a state of aberrant salience: a framework linking biology, phenomenology, and pharmacology in schizophrenia

scientific article

Psychosis: from diagnosis to syndrome

scientific article published in January 2010

Quantification of l-stepholidine in rat brain and plasma by high performance liquid chromatography combined with fluorescence detection

scientific article published on 11 December 2006

Quantitative validation of an intracerebral beta-sensitive microprobe system to determine in vivo drug-induced receptor occupancy using [11C]raclopride in rats

scientific article published in May 2004

Quetiapine extended-release versus immediate-release formulation: a positron emission tomography study.

scientific article

Quetiapine: an effective antipsychotic in first-episode schizophrenia despite only transiently high dopamine-2 receptor blockade.

scientific article published on November 2002

Radiosynthesis and evaluation of [11C]-(+)-4-propyl-3,4,4a,5,6,10b-hexahydro-2H-naphtho[1,2-b][1,4]oxazin-9-ol as a potential radiotracer for in vivo imaging of the dopamine D2 high-affinity state with positron emission tomography.

scientific article published in June 2005

Rapid antipsychotic response with ziprasidone predicts subsequent acute manic/mixed episode remission

scientific article published on 21 August 2009

Re-examining the role of benzodiazepines in the treatment of schizophrenia: a systematic review

scientific article

Reduced cortical volume and elevated astrocyte density in rats chronically treated with antipsychotic drugs-linking magnetic resonance imaging findings to cellular pathology

scientific article published on 19 October 2013

Relation between cortical dopamine D(2) receptor occupancy and suppression of conditioned avoidance response in non-human primate

scientific article

Relationship between central and peripheral serotonin 5-HT2A receptors: a positron emission tomography study in healthy individuals

scientific article

Relationship between daily dose, plasma concentrations, dopamine receptor occupancy, and clinical response to quetiapine: a review

scientific article published on 25 January 2011

Relationship between dopamine D(2) occupancy, clinical response, and side effects: a double-blind PET study of first-episode schizophrenia

scientific article

Reply to: Lithium and the Expanding Brain

Response

Review: amisulpride is effective and safe for schizophrenia

scientific article

Role of dopamine D(2) receptors for antipsychotic activity

scientific article published on January 2012

Role of the dopaminergic system in depression

scientific article

Salience and psychosis: moving from theory to practise

scientific article

Schizophrenia

scholarly article about schizophrenia

Schizophrenia, amphetamine-induced sensitized state and acute amphetamine exposure all show a common alteration: increased dopamine D2 receptor dimerization

scientific journal article

Schizophrenia: more dopamine, more D2 receptors

scientific article

Sensitivity of older patients to antipsychotic motor side effects: a PET study examining potential mechanisms

scientific article published in March 2009

Sensitization to amphetamine, but not PCP, impairs attentional set shifting: reversal by a D1 receptor agonist injected into the medial prefrontal cortex

scientific article

Sensitization to amphetamine, but not phencyclidine, disrupts prepulse inhibition and latent inhibition

scientific article published on 26 April 2005

Separate brain regions code for salience vs. valence during reward prediction in humans

scientific article published in April 2007

Serotonin 5-HT1A receptor binding potential declines with age as measured by [11C]WAY-100635 and PET.

scientific article published on May 2001

Specific and generalized neuropsychological deficits: a comparison of patients with various first-episode psychosis presentations

scientific article published in December 2009

Stimulation of the subthalamic nucleus in Parkinson's disease does not produce striatal dopamine release

scientific article published in November 2003

Striatal vs extrastriatal dopamine D2 receptors in antipsychotic response--a double-blind PET study in schizophrenia

scientific article published in November 2006

Task-independent effect of time on rCBF.

scientific article published in May 1998

Temporal difference modeling of the blood-oxygen level dependent response during aversive conditioning in humans: effects of dopaminergic modulation

scientific article

Tetrabenazine augmentation in treatment-resistant schizophrenia: a 12-week, double-blind, placebo-controlled trial

scientific article

The "delayed onset" of antipsychotic action--an idea whose time has come and gone.

scientific article

The D2 dopamine receptor occupancy of risperidone and its relationship to extrapyramidal symptoms: a PET study.

scientific article

The D2 receptor occupancy profile of loxapine determined using PET.

scientific article published in December 1996

The Enduring Centrality of Dopamine in the Pathophysiology of Schizophrenia

scholarly article published 2014

The Pharmacology of Typical and Atypical Antipsychotics

scholarly article

The Relationship Between Risperidone Plasma Levels and Dopamine D (2) Occupancy

scientific article published on 01 February 1998

The Role of Neuroimaging in Development of and Treatment With Antipsychotics

article

The acute effects of synthetic intravenous Delta9-tetrahydrocannabinol on psychosis, mood and cognitive functioning

scientific article

The amphetamine-induced sensitized state as a model of schizophrenia

scientific article published on 28 August 2007

The antipsychotic potential of l-stepholidine--a naturally occurring dopamine receptor D1 agonist and D2 antagonist

scientific article

The antipsychotics olanzapine, risperidone, clozapine, and haloperidol are D2-selective ex vivo but not in vitro

scientific article

The different trajectories of antipsychotic response: antipsychotics versus placebo

scientific article published on 20 October 2010

The differential effects of atypical antipsychotics on prolactin elevation are explained by their differential blood-brain disposition: a pharmacological analysis in rats

scientific article published in September 2002

The dopamine D2 receptors in high-affinity state and D3 receptors in schizophrenia: a clinical [11C]-(+)-PHNO PET study

scientific article published on 5 November 2008

The dopamine hypothesis of schizophrenia: version III--the final common pathway

scientific article

The dopamine stabilizers (S)-(-)-(3-methanesulfonyl-phenyl)-1-propyl-piperidine [(-)-OSU6162] and 4-(3-methanesulfonylphenyl)-1-propyl-piperidine (ACR16) show high in vivo D2 receptor occupancy, antipsychotic-like efficacy, and low potential for mot

scientific article

The effect of antipsychotic treatment on Theory of Mind

scientific article published on 9 November 2006

The effect of antipsychotics on the high-affinity state of D2 and D3 receptors: a positron emission tomography study With [11C]-(+)-PHNO.

scientific article published on June 2009

The effect of paroxetine on 5-HT(2A) receptors in depression: an [(18)F]setoperone PET imaging study

scientific article

The effect of perinatal brain injury on dopaminergic function and hippocampal volume in adult life

scientific article published on 28 November 2017

The effects of a single dose of oxytocin on working memory in schizophrenia.

scientific article published on 08 January 2015

The effects of reality distortion syndrome on salient stimuli processing in patients with schizophrenia: an fMRI study

scientific article

The effects of single dose nefazodone and paroxetine upon 5-HT2A binding potential in humans using [18F]-setoperone PET.

scientific article published in June 1999

The evolution of antipsychotic switch and polypharmacy in natural practice--a longitudinal perspective

scientific article published on 31 May 2011

The feasibility and validity of ambulatory self-report of psychotic symptoms using a smartphone software application.

scientific article published on 17 October 2012

The formation of abnormal associations in schizophrenia: neural and behavioral evidence

scientific article published on 2 May 2007

The heterogeneity of antipsychotic response in the treatment of schizophrenia

scientific article

The link between dopamine function and apathy in cannabis users: an [18F]-DOPA PET imaging study.

scientific article published on 3 April 2014

The nature of dopamine dysfunction in schizophrenia and what this means for treatment

scientific article published on August 2012

The neural correlates of intentional learning of verbal materials: a PET study in humans.

scientific article

The neurobiology of schizophrenia: new leads and avenues for treatment.

scientific article published on 08 October 2010

The newer antipsychotics: underlying mechanisms and the new clinical realities

The optimization of treatment and management of schizophrenia in Europe (OPTiMiSE) trial: rationale for its methodology and a review of the effectiveness of switching antipsychotics

scientific article

The promise of biological markers for treatment response in first-episode psychosis: a systematic review

scientific article

The relationship between D 2 receptor occupancy and plasma levels on low dose oral haloperidol: a PET study

scientific article published on 01 May 1997

The relationship between antipsychotic D2 occupancy and change in frontal metabolism and working memory : A dual [(11)C]raclopride and [(18) F]FDG imaging study with aripiprazole

scientific article published on 28 December 2012

The relationship between dopamine D2 receptor occupancy and the vacuous chewing movement syndrome in rats

scientific article published in November 2002

The relationship between subjective well-being and dopamine D2 receptors in patients treated with a dopamine partial agonist and full antagonist antipsychotics

scientific article

The selective effect of antipsychotics on the different dimensions of the experience of psychosis in schizophrenia spectrum disorders

scientific article published on 07 September 2006

The use of healthy volunteers instead of patients to inform drug dosing studies: a [11C]raclopride PET study

scientific article published on 19 April 2011

Time course of the antipsychotic effect and the underlying behavioral mechanisms

scientific article

Trajectories of response to treatment with atypical antipsychotic medication in patients with schizophrenia pooled from 6 double-blind, randomized clinical trials

scientific article published on 13 April 2011

Translating genome-wide association findings into new therapeutics for psychiatry

scientific article

Treating impaired cognition in schizophrenia: the case for combining cognitive-enhancing drugs with cognitive remediation

scientific article published on 22 April 2013

UK Doubles Its "World-Leading" Research in Life Sciences and Medicine in Six Years: Testing the Claim?

scientific article published on 23 July 2015

Understanding pathophysiology is crucial in linking clinical staging to targeted therapeutics

scientific article published in October 2008

Use of random-sequence riboflavin as a marker of medication compliance in chronic schizophrenics

scientific article published on 01 December 1991

Variations of rest – activity rhythm and sleep – wake in schizophrenic patients versus healthy subjects: An actigraphic comparative study

Ventajas y desventajas del tratamiento de combinación con antipsicóticos. Reunión ECNP Consensus, marzo de 2008, Niza

What Kraepelin might say about schizophrenia: Just the facts

scientific article published on 01 May 2011

White matter integrity as a predictor of response to treatment in first episode psychosis

scientific article

Why has it taken so long for biological psychiatry to develop clinical tests and what to do about it?

scientific article published on 7 August 2012

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