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List of works by Roselyn J. Eisenberg

A protein-based smallpox vaccine protects mice from vaccinia and ectromelia virus challenges when given as a prime and single boost

scientific article

A protein-based smallpox vaccine protects non-human primates from a lethal monkeypox virus challenge

scientific article

Alpha-herpesvirus glycoprotein D interaction with sensory neurons triggers formation of varicosities that serve as virus exit sites

scientific article

An HSV-1 gD mutant virus as an entry-impaired live virus vaccine

scientific article published on 14 January 2008

Antibody against Extracellular Vaccinia Virus (EV) Protects Mice through Complement and Fc Receptors ⬇️

scientific article published on June 8, 2011

Antibody responses to vaccinia membrane proteins after smallpox vaccination

scientific article published on 4 June 2007

Antibody-Induced Conformational Changes in Herpes Simplex Virus Glycoprotein gD Reveal New Targets for Virus Neutralization ⬇️

scientific article published on November 30, 2011

Antigenic and mutational analyses of herpes simplex virus glycoprotein B reveal four functional regions

scientific article

Bimolecular complementation defines functional regions of Herpes simplex virus gB that are involved with gH/gL as a necessary step leading to cell fusion

scientific article

Bimolecular complementation reveals that glycoproteins gB and gH/gL of herpes simplex virus interact with each other during cell fusion

scholarly article

Blocking Immune Evasion as a Novel Approach for Prevention and Treatment of Herpes Simplex Virus Infection ⬇️

scientific article published on December 1, 2003

Capturing the Herpes Simplex Virus Core Fusion Complex (gB-gH/gL) in an Acidic Environment ⬇️

scientific article published on April 20, 2011

Cascade of Events Governing Cell-Cell Fusion Induced by Herpes Simplex Virus Glycoproteins gD, gH/gL, and gB ⬇️

scientific article published on September 22, 2010

Cellular localization of nectin-1 and glycoprotein D during herpes simplex virus infection

scientific article

Characterization of a heparan sulfate octasaccharide that binds to herpes simplex virus type 1 glycoprotein D.

scientific article

Characterization of chimpanzee/human monoclonal antibodies to vaccinia virus A33 glycoprotein and its variola virus homolog in vitro and in a vaccinia virus mouse protection model

scientific article

Chimpanzee/human mAbs to vaccinia virus B5 protein neutralize vaccinia and smallpox viruses and protect mice against vaccinia virus

scholarly article

Combinations of polyclonal or monoclonal antibodies to proteins of the outer membranes of the two infectious forms of vaccinia virus protect mice against a lethal respiratory challenge

scientific article

Comparative usage of herpesvirus entry mediator A and nectin-1 by laboratory strains and clinical isolates of herpes simplex virus

scientific article

Contribution of cysteine residues to the structure and function of herpes simplex virus gH/gL.

scientific article

Cross-Neutralizing and Protective Human Antibody Specificities to Poxvirus Infections

scientific article

Crystal structure of glycoprotein B from herpes simplex virus 1.

scientific article

Crystal structure of the conserved herpesvirus fusion regulator complex gH–gL

scientific article

Crystallization and preliminary diffraction studies of the ectodomain of the envelope glycoprotein D from herpes simplex virus 1 alone and in complex with the ectodomain of the human receptor HveA

scientific article (publication date: May 2002)

Disparity between levels of in vitro neutralization of vaccinia virus by antibody to the A27 protein and protection of mice against intranasal challenge

scientific article published on 4 June 2008

Displacement of the C terminus of herpes simplex virus gD is sufficient to expose the fusion-activating interfaces on gD.

scientific article published on 18 September 2013

Dissection of the antibody response against herpes simplex virus glycoproteins in naturally infected humans

scientific article published on 20 August 2014

Dominance and diversity in the primary human CD4 T cell response to replication-competent vaccinia virus

scientific article

Dual split protein-based fusion assay reveals that mutations to herpes simplex virus (HSV) glycoprotein gB alter the kinetics of cell-cell fusion induced by HSV entry glycoproteins

scientific article published on 14 August 2013

Dynamic organization of Herpesvirus glycoproteins on the viral envelope revealed by super-resolution microscopy

scientific article published on 02 December 2019

Effects of herpes simplex virus on structure and function of nectin-1/HveC.

scientific article

Effects of herpes simplex virus type 2 glycoprotein vaccines and CLDC adjuvant on genital herpes infection in the guinea pig ⬇️

scientific article published on January 14, 2011

Engineered disulfide bonds in herpes simplex virus type 1 gD separate receptor binding from fusion initiation and viral entry

scientific article published on 21 November 2007

Entry of herpes simplex virus type 1 into primary sensory neurons in vitro is mediated by Nectin-1/HveC

scientific journal article

Entry of herpesviruses into cells: the enigma variations

scientific article published on January 2013

Epitope mapping of herpes simplex virus type 2 gH/gL defines distinct antigenic sites, including some associated with biological function

scientific article

Epitope-mapping studies define two major neutralization sites on the vaccinia virus extracellular enveloped virus glycoprotein B5R.

scientific article

Function of herpes simplex virus type 1 gD mutants with different receptor-binding affinities in virus entry and fusion

scientific article

Functional fluorescent protein insertions in herpes simplex virus gB report on gB conformation before and after execution of membrane fusion.

scientific article

Fusion between perinuclear virions and the outer nuclear membrane requires the fusogenic activity of herpes simplex virus gB.

scientific article published on 16 September 2009

Global sensing of the antigenic structure of herpes simplex virus gD using high-throughput array-based SPR imaging

scientific article

Glycoprotein D receptor-dependent, low-pH-independent endocytic entry of herpes simplex virus type 1.

scientific article

HCMV GrAbs a Mechanism to Escape Neutralization ⬇️

scientific article published on September 15, 2011

Herpes simplex virus glycoprotein B associates with target membranes via its fusion loops

scientific article

Herpes simplex virus glycoprotein B binds to cell surfaces independently of heparan sulfate and blocks virus entry

scientific article

Herpes simplex virus glycoprotein D interferes with binding of herpesvirus entry mediator to its ligands through downregulation and direct competition

scientific article

Herpes simplex virus glycoproteins gB and gH function in fusion between the virion envelope and the outer nuclear membrane

scholarly article

Herpes simplex virus type 1 evades the effects of antibody and complement in vivo

scientific article

Herpes virus fusion and entry: a story with many characters.

scientific article

Immunogenicity of a highly attenuated MVA smallpox vaccine and protection against monkeypox

scientific article published on March 2004

In vivo role of nectin-1 in entry of herpes simplex virus type 1 (HSV-1) and HSV-2 through the vaginal mucosa

scientific article published on March 2004

Kinetic analysis of glycoprotein C of herpes simplex virus types 1 and 2 binding to heparin, heparan sulfate, and complement component C3b.

scientific article published in March 2002

Major neutralizing sites on vaccinia virus glycoprotein B5 are exposed differently on variola virus ortholog B6

scientific article

Mechanism of neutralization of herpes simplex virus by antibodies directed at the fusion domain of glycoprotein B. ⬇️

scientific article published on 18 December 2013

Mucosal administration of CpG oligodeoxynucleotide elicits strong CC and CXC chemokine responses in the vagina and serves as a potent Th1-tilting adjuvant for recombinant gD2 protein vaccination against genital herpes

scientific article

Mutational evidence of internal fusion loops in herpes simplex virus glycoprotein B

scientific article published on 21 February 2007

N-terminal mutants of herpes simplex virus type 2 gH are transported without gL but require gL for function

scientific article published on 7 March 2007

Nasal Immunization Confers High Avidity Neutralizing Antibody Response and Immunity to Primary and Recurrent Genital Herpes in Guinea Pigs

scientific article published on 26 December 2016

Nectin-1/HveC Mediates herpes simplex virus type 1 entry into primary human sensory neurons and fibroblasts

scientific article

Patient-Specific Neutralizing Antibody Responses to Herpes Simplex Virus Are Attributed to Epitopes on gD, gB, or Both and Can Be Type Specific

scientific article published on 24 June 2015

Physical and immunological characterization of a recombinant secreted form of the membrane protein encoded by the vaccinia virus L1R gene

scientific article

Potential nectin-1 binding site on herpes simplex virus glycoprotein d.

scientific article published on January 2005

Prophylactic Herpes Simplex Virus 2 (HSV-2) Vaccines Adjuvanted with Stable Emulsion and Toll-Like Receptor 9 Agonist Induce a Robust HSV-2-Specific Cell-Mediated Immune Response, Protect against Symptomatic Disease, and Reduce the Latent Viral Rese

scientific article published on 22 February 2017

Protective immunity to vaccinia virus induced by vaccination with multiple recombinant outer membrane proteins of intracellular and extracellular virions

scientific article published on October 2004

Rapid progression to simian AIDS can be accompanied by selection of CD4-independent gp120 variants with impaired ability to bind CD4.

scientific article

Recent insights into the structural characterization of herpes simplex virus fusion protein, gB ⬇️

Regulation of HSV glycoprotein induced cascade of events governing cell-cell fusion

scientific article published on 14 September 2016

Regulation of Herpes Simplex Virus gB-Induced Cell-Cell Fusion by Mutant Forms of gH/gL in the Absence of gD and Cellular Receptors ⬇️

scientific article published on February 26, 2013

Repertoire of epitopes recognized by serum IgG from humans vaccinated with herpes simplex virus 2 glycoprotein D

scientific article

Role of sulfatide in vaccinia virus infection.

scientific article published on July 2011

Spatiotemporal changes of the herpes simplex virus entry receptor nectin-1 in murine brain during postnatal development

scientific article published in June 2006

Specific association of glycoprotein B with lipid rafts during herpes simplex virus entry

scientific article

Stable association of herpes simplex virus with target membranes is triggered by low pH in the presence of the gD receptor, HVEM

scientific article

Structural Basis of Local, pH-Dependent Conformational Changes in Glycoprotein B from Herpes Simplex Virus Type 1 ⬇️

scientific article published on October 13, 2010

Structure of Herpes Simplex Virus Glycoprotein D Bound to the Human Receptor Nectin-1

scientific article

Structure of unliganded HSV gD reveals a mechanism for receptor-mediated activation of virus entry.

scientific article

Structure-based analysis of the herpes simplex virus glycoprotein D binding site present on herpesvirus entry mediator HveA (HVEM).

scientific article

Structure-based mutagenesis of herpes simplex virus glycoprotein D defines three critical regions at the gD-HveA/HVEM binding interface

scientific article

Structure-function analysis of herpes simplex virus type 1 gD and gH-gL: clues from gDgH chimeras

scientific article

Targeting of antigen to the herpesvirus entry mediator augments primary adaptive immune responses

scientific article published on 13 January 2008

The Fusion Loops of the Initial Prefusion Conformation of Herpes Simplex Virus 1 Fusion Protein Point Toward the Membrane ⬇️

scientific article

The Mature Virion of Ectromelia Virus, a Pathogenic Poxvirus, Is Capable of Intrahepatic Spread and Can Serve as a Target for Delayed Therapy ⬇️

scientific article published on April 17, 2013

The Membrane-Proximal Region (MPR) of Herpes Simplex Virus gB Regulates Association of the Fusion Loops with Lipid Membranes ⬇️

scientific article published on November 20, 2012

The Myristate Moiety and Amino Terminus of Vaccinia Virus L1 Constitute a Bipartite Functional Region Needed for Entry ⬇️

scientific article published on March 7, 2012

The Structure of Herpesvirus Fusion Glycoprotein B-Bilayer Complex Reveals the Protein-Membrane and Lateral Protein-Protein Interaction

scientific article

The herpes simplex virus receptor nectin-1 is down-regulated after trans-interaction with glycoprotein D.

scientific article published on 20 February 2008

The orthopoxvirus type I IFN binding protein is essential for virulence and an effective target for vaccination

scientific article published on 7 April 2008

The soluble ectodomain of herpes simplex virus gD contains a membrane-proximal pro-fusion domain and suffices to mediate virus entry

scientific article

Using a split luciferase assay (SLA) to measure the kinetics of cell-cell fusion mediated by herpes simplex virus glycoproteins

scientific article

Using antibodies and mutants to localize the presumptive gH/gL binding site on HSV gD

article

Vaccine-induced antibodies to herpes simplex virus glycoprotein D epitopes involved in virus entry and cell-to-cell spread correlate with protection against genital disease in guinea pigs.

scientific article

Vaccinia virus L1 binds to cell surfaces and blocks virus entry independently of glycosaminoglycans

scientific article

Vaccinia virus exhibits cell-type-dependent entry characteristics

scientific article

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