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List of works by Rafael de Cabo

"AcCoA"lade for energy and life span

scientific article published on April 2009

17α-Estradiol Attenuates Neuron Loss in Ovariectomized Dtg AβPP/PS1 Mice ⬇️

scientific article published on January 1, 2011

A blueberry-enriched diet provides cellular protection against oxidative stress and reduces a kainate-induced learning impairment in rats

scientific article published on 23 May 2007

A comparative study of matrix remodeling in chronic models for COPD; mechanistic insights into the role of TNF-α.

scientific article

A high-fat diet and NAD(+) activate Sirt1 to rescue premature aging in cockayne syndrome

scientific article (publication date: 4 November 2014)

A patent review of sirtuin activators: an update

scientific article published on 09 March 2012

A protein disulfide-thiol interchange activity of HeLa plasma membranes inhibited by the antitumor sulfonylurea N-(4-methylphenylsulfonyl)-N'-(4-chlorophenyl) urea (LY181984)

scientific article published on 01 April 1997

A rat epigenetic clock recapitulates phenotypic aging and co-localizes with heterochromatin

scientific article published on 12 November 2020

A regulatory role for microRNA 33* in controlling lipid metabolism gene expression.

scientific article published on April 2013

A roadmap to build a phenotypic metric of ageing: insights from the Baltimore Longitudinal Study of Aging

scientific article published on 27 February 2020

ARDD 2020: from aging mechanisms to interventions

scientific article published on 30 December 2020

Acetaminophen hepatotoxicity in mice: Effect of age, frailty and exposure type.

scientific article

Adaptations to oxidative stress induced by vitamin E deficiency in rat liver

scientific article published on 01 December 2006

Adipogenic signaling in rat white adipose tissue: modulation by aging and calorie restriction.

scientific article

Adverse Geriatric Outcomes Secondary to Polypharmacy in a Mouse Model: The Influence of Aging

scientific article published on 04 May 2015

Age and caloric restriction diets are confounding factors that modify the response to lipopolysaccharide by peritoneal macrophages in C57BL/6 mice

scientific article published in September 2004

Age-associated miRNA alterations in skeletal muscle from rhesus monkeys reversed by caloric restriction

scientific article published on September 2013

Age-associated vascular oxidative stress, Nrf2 dysfunction, and NF-{kappa}B activation in the nonhuman primate Macaca mulatta.

scientific article

Age-related changes in the liver sinusoidal endothelium: a mechanism for dyslipidemia

scientific article published on 05 September 2007

Age-related loss of responsiveness to 2,5-dimethoxy-4-iodoamphetamine in liver sinusoidal endothelial cells

scientific article published on 23 August 2013

Age-related pseudocapillarization of the liver sinusoidal endothelium impairs the hepatic clearance of acetaminophen in rats

scientific article

Aging biology and novel targets for drug discovery

scientific article

Aging, Drugs, and Drug Metabolism

scientific article published on 18 July 2011

Alterations in liver sinusoidal endothelium in a baboon model of type 1 diabetes

article

Alterations of ultrastructural and fission/fusion markers in hepatocyte mitochondria from mice following calorie restriction with different dietary fats.

scientific article published on 12 February 2013

An in vitro model of caloric restriction

scientific article published on 01 June 2003

An unSIRTain role in longevity ⬇️

scientific article published on 07 November 2011

Animal models of aging research: implications for human aging and age-related diseases

scientific article

Anti-oxidative and anti-inflammatory vasoprotective effects of caloric restriction in aging: role of circulating factors and SIRT1.

scientific article published on 21 June 2009

Are glycans the Holy Grail for biomarkers of aging?

scientific article published on 10 December 2013

Are sirtuins viable targets for improving healthspan and lifespan?

scientific article

Binding of manumycin A inhibits IkappaB kinase beta activity

scientific article

Bioenergetics of aging and calorie restriction.

scientific article

Caloric restriction improves health and survival of rhesus monkeys

scientific article

Caloric restriction modulates early events in insulin signaling in liver and skeletal muscle of rat.

scientific article published in June 2004

Caloric restriction modulates insulin receptor signaling in liver and skeletal muscle of rat.

scientific article published in March 2005

Caloric restriction reduces age-related pseudocapillarization of the hepatic sinusoid

scientific article published on 3 January 2007

Calorie Restriction, Aging and Longevity

Calorie restriction alters physical performance but not cognition in two models of altered neuroendocrine signaling

scientific article published on 15 January 2008

Calorie restriction in humans inhibits the PI3K/AKT pathway and induces a younger transcription profile

scientific article published on 05 June 2013

Calorie restriction induces mitochondrial biogenesis and bioenergetic efficiency

scientific article

Calorie restriction promotes mammalian cell survival by inducing the SIRT1 deacetylase

scientific article

Calorie restriction up-regulates the plasma membrane redox system in brain cells and suppresses oxidative stress during aging

scholarly article

Capsaicin inhibits plasma membrane NADH oxidase and growth of human and mouse melanoma lines

scientific article published on 01 October 1996

Cell survival from chemotherapy depends on NF-kappaB transcriptional up-regulation of coenzyme Q biosynthesis.

scientific article

Ceramide-dependent caspase 3 activation is prevented by coenzyme Q from plasma membrane in serum-deprived cells

scientific article

Chronic ingestion of 2-deoxy-D-glucose induces cardiac vacuolization and increases mortality in rats

scientific article

Circular RNAs in monkey muscle: age-dependent changes

scientific article

Cockayne syndrome group B protein prevents the accumulation of damaged mitochondria by promoting mitochondrial autophagy.

scientific article published on 2 April 2012

Comparison of rat liver and brain proteasomes for oxidative stress-induced inactivation: Influence of ageing and dietary restriction

scientific article published on January 2009

Conserved and differential effects of dietary energy intake on the hippocampal transcriptomes of females and males

scientific article

Cyclic AMP-plus ATP-dependent modulation of the NADH oxidase activity of porcine liver plasma membranes

scientific article published on 01 December 1994

Declining NAD(+) induces a pseudohypoxic state disrupting nuclear-mitochondrial communication during aging

scientific article

Deletion of the Mammalian INDY Homolog Mimics Aspects of Dietary Restriction and Protects against Adiposity and Insulin Resistance in Mice

scholarly article by Andreas L. Birkenfeld et al published October 2011 in Cell Metabolism

Deletion of the diabetes candidate gene Slc16a13 in mice attenuates diet-induced ectopic lipid accumulation and insulin resistance

scientific article published on 01 July 2021

Deletion of the mammalian INDY homolog mimics aspects of dietary restriction and protects against adiposity and insulin resistance in mice

scientific article

Determinants of serum-induced SIRT1 expression in older men: the CHAMP study

scientific article

Development of calorie restriction mimetics as a prolongevity strategy.

scientific article

Dietary Protein to Carbohydrate Ratio and Caloric Restriction: Comparing Metabolic Outcomes in Mice

scientific article

Dietary activators of Sirt1

scientific article

Dietary deprivation extends lifespan in Caenorhabditis elegans

scientific article published on 10 November 2006

Dietary fat and aging modulate apoptotic signaling in liver of calorie-restricted mice

scientific article

Dietary fat modifies mitochondrial and plasma membrane apoptotic signaling in skeletal muscle of calorie-restricted mice

scientific article

Dietary restriction: standing up for sirtuins

scientific article published on August 2010

Disruption of Nrf2 signaling impairs angiogenic capacity of endothelial cells: implications for microvascular aging

scientific article

Diverse roles of growth hormone and insulin-like growth factor-1 in mammalian aging: progress and controversies.

scientific article

Effect of caloric restriction on base-excision repair (BER) in the aging rat brain

scientific article

Effect of calorie restriction and refeeding on skin wound healing in the rat ⬇️

scientific article published on October 27, 2011

Effects of aging and calorie restriction on rat skeletal muscle glycogen synthase and glycogen phosphorylase.

scientific article published on 31 March 2009

Elucidating the mechanisms by which disulfiram protects against obesity and metabolic syndrome

scientific article published on 21 July 2020

Energy - A Hallmark of Physical Function

scientific article published on 13 August 2015

Evaluation of resveratrol, green tea extract, curcumin, oxaloacetic acid, and medium-chain triglyceride oil on life span of genetically heterogeneous mice

scientific article

FOXOs attenuate bone formation by suppressing Wnt signaling.

scientific article published on 15 July 2013

Factors that Impact on Interrater Reliability of the Mouse Clinical Frailty Index.

scientific article published on 2 April 2015

Fumarate is cardioprotective via activation of the Nrf2 antioxidant pathway.

scientific article published in March 2012

GH Receptor Deficiency in Ecuadorian Adults Is Associated With Obesity and Enhanced Insulin Sensitivity

scientific article published on 18 May 2015

Genetic deletion of Nrf2 promotes immortalization and decreases life span of murine embryonic fibroblasts

scientific article

Genome-wide identification of microRNAs regulating cholesterol and triglyceride homeostasis

scientific article published on 26 October 2015

Growth hormone receptor deficiency is associated with a major reduction in pro-aging signaling, cancer, and diabetes in humans

scientific article

Guest editorial

scientific article published on 01 June 2005

Health benefits of late-onset metformin treatment every other week in mice

scientific article published on 20 November 2017

Hepatic HuR modulates lipid homeostasis in response to high-fat diet

scientific article published on 16 June 2020

HuD regulates coding and noncoding RNA to induce APP→Aβ processing

scientific article

HuR and GRSF1 modulate the nuclear export and mitochondrial localization of the lncRNA RMRP.

scientific article published on 19 May 2016

Impact of Longevity Interventions on a Validated Mouse Clinical Frailty Index

scientific article

Impact of caloric restriction on health and survival in rhesus monkeys from the NIA study

scientific article

In vitro caloric restriction induces protective genes and functional rejuvenation in senescent SAMP8 astrocytes.

scientific article published on 25 February 2015

In vitro cellular adaptations of indicators of longevity in response to treatment with serum collected from humans on calorie restricted diets

scientific article

Inhibition of breast cancer metastasis by resveratrol-mediated inactivation of tumor-evoked regulatory B cells.

scientific article published on 16 September 2013

Intermittent fasting dissociates beneficial effects of dietary restriction on glucose metabolism and neuronal resistance to injury from calorie intake

scientific article

Interventions to Slow Aging in Humans: Are We Ready?

scientific article

JNK1 phosphorylates SIRT1 and promotes its enzymatic activity

scientific article

LKB1 and AMPK regulate synaptic remodeling in old age

scientific article published on 03 August 2014

Liver aging and pseudocapillarization in a Werner syndrome mouse model.

scientific article

Longitudinal analysis of calorie restriction on rat taste bud morphology and expression of sweet taste modulators

scientific article published on 28 September 2013

Longitudinal phenotypic aging metrics in the Baltimore Longitudinal Study of Aging

scientific article published in 2022

Loss of miR-451a enhances SPARC production during myogenesis

Macronutrients and caloric intake in health and longevity

scientific article published on 28 May 2015

Manipulation of caloric content but not diet composition, attenuates the deficit in learning and memory of senescence-accelerated mouse strain P8.

scientific article published on 2 February 2008

Maternal Exercise Improves Insulin Sensitivity in Mature Rat Offspring ⬇️

scientific article published on May 1, 2013

Measures of Healthspan as Indices of Aging in Mice-A Recommendation.

scientific article published on 22 August 2015

Measuring biological aging in humans: A quest

scientific article published on 12 December 2019

Mechanisms of vascular aging: new perspectives.

scientific article

Mechanisms underlying caloric restriction and lifespan regulation: implications for vascular aging.

scientific article published on March 2008

Membrane-bound CYB5R3 is a common effector of nutritional and oxidative stress response through FOXO3a and Nrf2.

scientific article

Metabolic remodelling of glucose, fatty acid and redox pathways in the heart of type 2 diabetic mice

scientific article published on 30 December 2018

Metformin improves healthspan and lifespan in mice

scientific article

Metformin-mediated increase in DICER1 regulates microRNA expression and cellular senescence

scientific article published on 17 March 2016

Metformin: A Hopeful Promise in Aging Research

scientific article published on March 2016

MicroRNA 33 regulates glucose metabolism.

scientific article published on 28 May 2013

MicroRNA-148a regulates LDL receptor and ABCA1 expression to control circulating lipoprotein levels

scientific article

Mitochondrial UCP4 mediates an adaptive shift in energy metabolism and increases the resistance of neurons to metabolic and oxidative stress

scientific journal article

Mitochondrial biogenesis and healthy aging

scientific article

Mitochondrial metabolic reprogramming induced by calorie restriction.

scientific article published on 15 October 2012

Mitochondrial permeabilization without caspase activation mediates the increase of basal apoptosis in cells lacking Nrf2.

scientific article published on 23 March 2016

Mitochondrial protection by resveratrol.

scientific article

Mitochondrial ultrastructure and markers of dynamics in hepatocytes from aged, calorie restricted mice fed with different dietary fats

scientific article

Mode of action of bullatacin, a potent antitumor acetogenin: inhibition of NADH oxidase activity of HeLa and HL-60, but not liver, plasma membranes

scientific article published in January 1995

Mouse liver plasma membrane redox system activity is altered by aging and modulated by calorie restriction.

scientific article published on June 2005

Muscle-Specific Myosin Heavy Chain Shifts in Response to a Long-Term High Fat/High Sugar Diet and Resveratrol Treatment in Nonhuman Primates

scientific article published on 2 March 2016

N-Acetyl cysteine does not prevent liver toxicity from chronic low-dose plus subacute high-dose paracetamol exposure in young or old mice

scientific article published on 28 January 2016

NQR1 controls lifespan by regulating the promotion of respiratory metabolism in yeast.

scientific article

NRF2, cancer and calorie restriction

scientific article

Negative regulation of STAT3 protein-mediated cellular respiration by SIRT1 protein

scientific article

Neuroprotection provided by dietary restriction in rats is further enhanced by reducing glucocortocoids.

scientific article

Novel RNA-binding activity of MYF5 enhances Ccnd1/Cyclin D1 mRNA translation during myogenesis

scientific article published on 26 January 2016

Novel RNA-binding activity of NQO1 promotes SERPINA1 mRNA translation

scientific article published on 8 August 2016

Nutrient-sensitive mitochondrial NAD+ levels dictate cell survival

scientific article

Nutrition and aging

scientific article

Of Greek heroes, wiggling worms, mighty mice, and old body builders.

scientific article published on 23 November 2011

Of mice and men: The benefits of caloric restriction, exercise, and mimetics ⬇️

scientific article published on December 20, 2011

Old age and the hepatic sinusoid

scientific article published on June 2008

Oxidative stress accumulates in adipose tissue during aging and inhibits adipogenesis.

scientific article

Perinatal diet influences health and survival in a mouse model of leukemia

scientific article published on 11 May 2020

Perinatal exercise improves glucose homeostasis in adult offspring

scientific article

Pharmacological Strategies to Retard Cardiovascular Aging ⬇️

scientific article published on May 2016

Pharmacological inhibition of PI3K reduces adiposity and metabolic syndrome in obese mice and rhesus monkeys.

scientific article

Preserved learning and memory following 5-fluorouracil and cyclophosphamide treatment in rats

scientific article

RAP1 protects from obesity through its extratelomeric role regulating gene expression

scientific article published on 20 June 2013

RNA-Binding Protein AUF1 Promotes Myogenesis by Regulating MEF2C Expression Levels

scientific article (publication date: 2 June 2014)

Rapamycin, but not resveratrol or simvastatin, extends life span of genetically heterogeneous mice

scientific article

Reconsidering the Role of Mitochondria in Aging

scientific article

Reduced expression of MYC increases longevity and enhances healthspan

scientific article

Regulation of SIRT6 protein levels by nutrient availability

scientific article published on 31 January 2008

Response of a protein disulfide isomerase-like activity of transitional endoplasmic reticulum to all-trans retinol

scientific article published on 01 January 1996

Restoration of energy homeostasis by SIRT6 extends healthy lifespan

scientific article published on 28 May 2021

Resveratrol confers endothelial protection via activation of the antioxidant transcription factor Nrf2.

scientific article

Resveratrol delays age-related deterioration and mimics transcriptional aspects of dietary restriction without extending life span

scientific article

Resveratrol improves adipose insulin signaling and reduces the inflammatory response in adipose tissue of rhesus monkeys on high-fat, high-sugar diet.

scientific article published on October 2013

Resveratrol improves health and survival of mice on a high-calorie diet

scientific article (publication date: 16 November 2006)

Resveratrol induces mitochondrial biogenesis in endothelial cells

scientific article published on 08 May 2009

Resveratrol prevents high fat/sucrose diet-induced central arterial wall inflammation and stiffening in nonhuman primates.

scientific article

Resveratrol prevents monocrotaline-induced pulmonary hypertension in rats.

scientific article published on 13 July 2009

Resveratrol prevents β-cell dedifferentiation in nonhuman primates given a high-fat/high-sugar diet.

scientific article published on 24 July 2013

Resveratrol supplementation: Where are we now and where should we go?

scientific article

SIRT1 but not its increased expression is essential for lifespan extension in caloric-restricted mice.

scientific article

SIRT1 is essential for normal cognitive function and synaptic plasticity

scientific article

SIRT1 is required for AMPK activation and the beneficial effects of resveratrol on mitochondrial function

scientific article

SIRT1 synchs satellite cell metabolism with stem cell fate.

scientific article

SRT1720 improves survival and healthspan of obese mice

scientific article

SRT2104 extends survival of male mice on a standard diet and preserves bone and muscle mass

scientific article

Sirtuin activation: a role for plasma membrane in the cell growth puzzle

scientific article

Sirtuin1 (Sirt1) promotes cortical bone formation by preventing β-catenin sequestration by FoxO transcription factors in osteoblast progenitors.

scientific article

Sirtuin1 Suppresses Osteoclastogenesis by Deacetylating FoxOs

scientific article

Spermidine to the rescue for an aging heart

scientific article

Survival transcriptome in the coenzyme Q10 deficiency syndrome is acquired by epigenetic modifications: a modelling study for human coenzyme Q10 deficiencies

scientific article published on 25 March 2013

The Aging Liver and the Effects of Long Term Caloric Restriction

The Evolution of Research on Ageing and Nutrition

scientific article published on 10 September 2013

The Neuromuscular Junction: Aging at the Crossroad between Nerves and Muscle

scientific article

The Roy Walford legacy: diet restriction from molecules to mice to monkeys to man and onto mimetics

scientific article published on 01 June 2004

The SIRT1 activator SRT1720 extends lifespan and improves health of mice fed a standard diet

scientific article

The SIRT1 deacetylase suppresses intestinal tumorigenesis and colon cancer growth

scientific article

The arcuate nucleus and neuropeptide Y contribute to the antitumorigenic effect of calorie restriction.

scientific article

The effect of ageing on isoniazid pharmacokinetics and hepatotoxicity in Fischer 344 rats.

scientific article

The effect of aging on acetaminophen pharmacokinetics, toxicity and Nrf2 in Fischer 344 rats

scientific article published on 17 July 2013

The effect of aging on mitochondrial and cytosolic hepatic intrinsic death pathway and apoptosis associated proteins in Fischer 344 rats.

scientific article

The effect of resveratrol on lifespan depends on both gender and dietary nutrient composition in Drosophila melanogaster ⬇️

scientific article published on November 16, 2011

The effects of age and lipopolysaccharide (LPS)-mediated peripheral inflammation on numbers of central catecholaminergic neurons.

scientific article

The impact of low-protein high-carbohydrate diets on aging and lifespan

scientific article published on 30 December 2015

The importance of plasma membrane coenzyme Q in aging and stress responses.

scientific article

The influence of dietary fat source on liver and skeletal muscle mitochondrial modifications and lifespan changes in calorie-restricted mice

scientific article

The influence of old age and poloxamer-407 on the hepatic disposition of diazepam in the isolated perfused rat liver

scientific article published on 19 September 2012

The mitochondrial-derived peptide MOTS-c promotes metabolic homeostasis and reduces obesity and insulin resistance

scientific journal article

The plasma membrane redox enzyme NQO1 sustains cellular energetics and protects human neuroblastoma cells against metabolic and proteotoxic stress ⬇️

scientific article published on April 13, 2011

The potential for dietary restriction to increase longevity in humans: extrapolation from monkey studies.

scientific article

The search for antiaging interventions: from elixirs to fasting regimens

scientific article

Toll-like receptors 2 and 4 modulate autonomic control of heart rate and energy metabolism

scientific article published on 18 October 2013

Translational strategies in aging and age-related disease

scientific article

Two-Year Trial of Human Caloric Restriction

scientific article published on 17 July 2015

Ubiquitin-mediated proteolysis of HuR by heat shock

scientific article

Ultrastructure of the liver microcirculation influences hepatic and systemic insulin activity and provides a mechanism for age-related insulin resistance

scientific article published on 20 April 2016

Up-regulation of plasma membrane-associated redox activities in neuronal cells lacking functional mitochondria.

scientific article published on 22 January 2007

Utilizing calorie restriction to evaluate the role of sirtuins in healthspan and lifespan of mice

scientific article published on 01 January 2013

Vascular oxidative stress in aging: a homeostatic failure due to dysregulation of NRF2-mediated antioxidant response

scientific article

Vasoprotective effects of resveratrol and SIRT1: attenuation of cigarette smoke-induced oxidative stress and proinflammatory phenotypic alterations

scientific article published on 18 April 2008

miR-27b inhibits LDLR and ABCA1 expression but does not influence plasma and hepatic lipid levels in mice

scientific article published on 29 October 2015

miR-519 suppresses tumor growth by reducing HuR levels

scientific article published on April 2010

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