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List of works by Ralf Bartenschlager

18 BILE ACIDS ENHANCE GENOTYPE 1 HEPATITIS C VIRUS REPLICATION

417 Subgenomic hepatitis C replicon deriving from a clinical isolate with virologic non-response to IFN-based therapy and IFN resistance in vitro

607 NEUTRALIZING HOST RESPONSES IN HEPATITIS C VIRUS INFECTION TARGET VIRAL ENTRY AT POST-BINDING STEPS AND MEMBRANE FUSION

article

A Combined Genetic-Proteomic Approach Identifies Residues within Dengue Virus NS4B Critical for Interaction with NS3 and Viral Replication

scientific article published on 29 April 2015

A Comprehensive Structure-Function Comparison of Hepatitis C Virus Strain JFH1 and J6 Polymerases Reveals a Key Residue Stimulating Replication in Cell Culture across Genotypes

scientific article

A Novel Cis-Acting RNA Structural Element Embedded in the Core Coding Region of the Hepatitis C Virus Genome Directs Internal Translation Initiation of the Overlapping Core+1 ORF

scientific article published on 22 September 2020

A Novel Inhibitor IDPP Interferes with Entry and Egress of HCV by Targeting Glycoprotein E1 in a Genotype-Specific Manner

scientific article published on 23 March 2017

A Proline-Tryptophan Turn in the Intrinsically Disordered Domain 2 of NS5A Protein Is Essential for Hepatitis C Virus RNA Replication

scientific article published on 17 June 2015

A Recurrent Neural Network for Particle Tracking in Microscopy Images Using Future Information, Track Hypotheses, and Multiple Detections

scientific article published on 13 January 2020

A Reverse Genetics System for Zika Virus Based on a Simple Molecular Cloning Strategy

article

A Slow Maturation Process Renders Hepatitis B Virus Infectious.

scientific article published on 15 June 2016

A Versatile Reporter System to Monitor Virus Infected Cells and Its Application to Dengue Virus and SARS-CoV-2

scientific article published on 30 November 2020

A concerted action of hepatitis C virus p7 and nonstructural protein 2 regulates core localization at the endoplasmic reticulum and virus assembly

scientific article

A conserved NS3 surface patch orchestrates NS2 protease stimulation, NS5A hyperphosphorylation and HCV genome replication

scientific article published on 16 March 2015

A major determinant of cyclophilin dependence and cyclosporine susceptibility of hepatitis C virus identified by a genetic approach

scientific article

A monocytic detour to replicate patient-derived hepatitis C virus in hepatoma cells and its use for phenotypic analyses

scientific article published on 10 March 2015

A novel function for a micro RNA: negative regulators can do positive for the hepatitis C virus

scientific article published in March 2006

A novel inhibitor of dengue virus replication that targets the capsid protein

scientific article published on 15 October 2012

A novel interaction between dengue virus nonstructural protein 1 and the NS4A-2K-4B precursor is required for viral RNA replication but not for formation of the membranous replication organelle

scientific article published on 09 May 2019

A plant-derived flavonoid inhibits entry of all HCV genotypes into human hepatocytes

scientific article

A replicon-based bioassay for the measurement of interferons in patients with chronic hepatitis C.

scientific article published in June 2003

A reporter cell line for rapid and sensitive evaluation of hepatitis C virus infectivity and replication

scientific article published on 3 May 2009

A sensor at the lipid-protein interface: lipid peroxidation controls hepatitis C virus replication

scientific article

Activation of Type I and III Interferon Response by Mitochondrial and Peroxisomal MAVS and Inhibition by Hepatitis C Virus

scientific article published on 20 November 2015

Adaptation of the hepatitis C virus to cell culture

scientific article

Alleviation of off-target effects from vector-encoded shRNAs via codelivered RNA decoys

scientific article published on 13 July 2015

Alternative approaches for efficient inhibition of hepatitis C virus RNA replication by small interfering RNAs

scientific article published on April 2004

Aminoterminal amphipathic α-helix AH1 of hepatitis C virus nonstructural protein 4B possesses a dual role in RNA replication and virus production

scientific article

An in vitro assay for hepatitis C virus NS3 serine proteinase.

scientific article published in May 1995

An orthogonal proteomic survey uncovers novel Zika virus host factors

scientific article published in Nature

Analysis of CD8+ T-cell-mediated inhibition of hepatitis C virus replication using a novel immunological model

scientific article

Analysis of Hepatitis C Virus Superinfection Exclusion by Using Novel Fluorochrome Gene-Tagged Viral Genomes

scientific article (publication date: May 2007)

Analysis of Hepatitis C Virus Superinfection Exclusion by Using Novel Fluorochrome Gene-Tagged Viral Genomes.

scientific article published in July 2007

Analysis of hepatitis C virus resistance to silibinin in vitro and in vivo points to a novel mechanism involving nonstructural protein 4B.

scientific article published on 7 February 2013

Antiviral effects of amantadine and iminosugar derivatives against hepatitis C virus

scientific article published in August 2007

Antiviral strategies. Preface

scientific article published on 01 January 2009

Apolipoprotein E Mediates Evasion From Hepatitis C Virus Neutralizing Antibodies

scientific article published on 21 September 2015

Apolipoprotein E likely contributes to a maturation step of infectious hepatitis C virus particles and interacts with viral envelope glycoproteins

scientific article

Application of the trak-C HCV core assay for monitoring antiviral activity in HCV replication systems

scientific article published on June 2004

Assembly of infectious hepatitis C virus particles

scientific article published on 14 December 2010

Automated Analysis of siRNA Screens of Virus Infected Cells Based on Immunofluorescence Microscopy

Biochemical and kinetic analyses of NS5B RNA-dependent RNA polymerase of the hepatitis C virus.

scientific article published on September 1998

Biochemical and morphological properties of hepatitis C virus particles and determination of their lipidome

scientific article

Biochemical and structural analysis of the NS5B RNA-dependent RNA polymerase of the hepatitis C virus.

scientific article

Biochemical properties of hepatitis C virus NS5B RNA-dependent RNA polymerase and identification of amino acid sequence motifs essential for enzymatic activity ⬇️

scientific article published on November 1, 1997

Broad neutralization of hepatitis C virus-resistant variants by Civacir hepatitis C immunoglobulin

scientific article

Candidate Targets for Hepatitis C Virus-Specific Antiviral Therapy ⬇️

scientific article published on January 1, 1997

Cardif is an adaptor protein in the RIG-I antiviral pathway and is targeted by hepatitis C virus

scientific article

Cell Culture Adaptation of Hepatitis C Virus and In Vivo Viability of an Adapted Variant

scientific article (publication date: December 2007)

Cell-free expression, purification, and membrane reconstitution for NMR studies of the nonstructural protein 4B from hepatitis C virus

scientific article published on 27 May 2016

Characterization of Determinants Important for Hepatitis C Virus p7 Function in Morphogenesis by Using trans-Complementation

scientific article (publication date: November 2009)

Characterization of cell lines carrying self-replicating hepatitis C virus RNAs

scientific article

Characterization of hepatitis C virus particle subpopulations reveals multiple usage of the scavenger receptor BI for entry steps.

scientific article

Characterization of the Early Steps of Hepatitis C Virus Infection by Using Luciferase Reporter Viruses

scientific article (publication date: June 2006)

Characterization of the hepatitis C virus E2 epitope defined by the broadly neutralizing monoclonal antibody AP33.

scientific article published in March 2006

Characterization of the mode of action of a potent dengue virus capsid inhibitor

scientific article

Chronic hepatitis C: Portrait of a silent epidemic and the etiologic agent

Chronic viral hepatitis and its association with liver cancer

scientific article

Clearance of persistent hepatitis C virus infection in humanized mice using a claudin-1-targeting monoclonal antibody

scientific article published on 23 March 2015

Comparative In Vitro Anti-Hepatitis C Virus Activities of a Selected Series of Polymerase, Protease, and Helicase Inhibitors

scientific article (publication date: September 2008)

Comparative analysis of the lambda-interferons IL-28A and IL-29 regarding their transcriptome and their antiviral properties against hepatitis C virus

scientific article

Complex formation between the NS3 serine-type proteinase of the hepatitis C virus and NS4A and its importance for polyprotein maturation

scientific article

Conserved RNA secondary structures and long-range interactions in hepatitis C viruses

scientific article published on 11 May 2015

Construction and characterization of infectious intragenotypic and intergenotypic hepatitis C virus chimeras

scientific article (publication date: 9 May 2006)

Control of temporal activation of hepatitis C virus-induced interferon response by domain 2 of nonstructural protein 5A.

scientific article

Coordination of Hepatitis C Virus Assembly by Distinct Regulatory Regions in Nonstructural Protein 5A

scientific article

Correction: A Conserved NS3 Surface Patch Orchestrates NS2 Protease Stimulation, NS5A Hyperphosphorylation and HCV Genome Replication

scientific article published on 8 January 2016

Correction: Essential Role of Cyclophilin A for Hepatitis C Virus Replication and Virus Production and Possible Link to Polyprotein Cleavage Kinetics

article

Correlative light and electron microscopy methods for the study of virus-cell interactions

scientific article published on 24 March 2016

Corrigendum: Conserved RNA secondary structures and long-range interactions in hepatitis C viruses

scientific article published on October 2016

Critical challenges and emerging opportunities in hepatitis C virus research in an era of potent antiviral therapy: Considerations for scientists and funding agencies

scientific article published on 22 February 2018

Cyclosporine A inhibits hepatitis C virus nonstructural protein 2 through cyclophilin A.

scientific article published on November 2009

DEB025 (Alisporivir) inhibits hepatitis C virus replication by preventing a cyclophilin A induced cis-trans isomerisation in domain II of NS5A

scientific article (publication date: 27 October 2010)

Daclatasvir-like inhibitors of NS5A block early biogenesis of hepatitis C virus-induced membranous replication factories, independent of RNA replication

scientific article

Deciphering the Origin and Evolution of Hepatitis B Viruses by Means of a Family of Non-enveloped Fish Viruses

scientific article published on 24 August 2017

Dengue Virus Inhibition of Autophagic Flux and Dependency of Viral Replication on Proteasomal Degradation of the Autophagy Receptor p62.

scientific article published on 27 May 2015

Dengue Virus Non-structural Protein 1 Modulates Infectious Particle Production via Interaction with the Structural Proteins

scientific article

Dengue Virus Perturbs Mitochondrial Morphodynamics to Dampen Innate Immune Responses

scientific article

Dengue virus- and hepatitis C virus-induced replication and assembly compartments: the enemy inside--caught in the web.

scientific article published on 12 March 2014

Deregulation of miR-92a expression is implicated in hepatocellular carcinoma development

scientific article

Detecting host factors involved in virus infection by observing the clustering of infected cells in siRNA screening images

scientific article published on September 2010

Detection of hepatitis C virus in paraffin-embedded liver biopsies of patients negative for viral RNA in serum

scientific article published on January 1999

Determinants of substrate specificity in the NS3 serine proteinase of the hepatitis C virus.

scientific article published on October 1997

Development of a high-throughput pyrosequencing assay for monitoring temporal evolution and resistance associated variant emergence in the Hepatitis C virus protease coding-region.

scientific article published on 22 July 2014

Discovery of Nanomolar Dengue and West Nile Virus Protease Inhibitors Containing a 4-Benzyloxyphenylglycine Residue

scientific article published on 12 November 2015

Discovery of highly divergent lineages of plant-associated astro-like viruses sheds light on the emergence of potyviruses

Discovery of highly divergent lineages of plant-associated astro-like viruses sheds light on the emergence of potyviruses

scholarly article by Chris Lauber et al published January 2019 in Virus Research

Dissecting the interferon-induced inhibition of hepatitis C virus replication by using a novel host cell line

scientific article

Divergent roles of autophagy in virus infection

scientific article published on 25 January 2013

Domain 3 of NS5A protein from the hepatitis C virus has intrinsic alpha-helical propensity and is a substrate of cyclophilin A.

scientific article

Dynamic oscillation of translation and stress granule formation mark the cellular response to virus infection

scientific article published on July 2012

E2 of hepatitis C virus inhibits apoptosis

scientific article published on December 2005

ER-shaping atlastin proteins act as central hubs to promote flavivirus replication and virion assembly

scientific article published on 21 October 2019

Editorial: An expanded view of viruses.

scientific article published in January 2017

Effects of NS2B-NS3 protease and furin inhibition on West Nile and Dengue virus replication

scientific article published on December 2017

Efficient hepatitis C virus cell culture system: what a difference the host cell makes

scientific article

Efficient rescue of hepatitis C virus RNA replication by trans-complementation with nonstructural protein 5A.

scientific article

Efficient trans-Encapsidation of Hepatitis C Virus RNAs into Infectious Virus-Like Particles

scientific article (publication date: July 2008)

Endoplasmic Reticulum: The Favorite Intracellular Niche for Viral Replication and Assembly

scientific article

Enhancement of genotype 1 hepatitis C virus replication by bile acids through FXR.

scientific article published on 3 December 2007

Enhancement of hepatitis C virus RNA replication by cell culture-adaptive mutations

scientific article

Erratum for Roth et al., "Flavivirus Infection Uncouples Translation Suppression from Cellular Stress Responses".

scientific article published on 18 April 2017

Erratum: Corrigendum: Production of infectious hepatitis C virus in tissue culture from a cloned viral genome

article

Erratum: Tuning a cellular lipid kinase activity adapts hepatitis C virus to replication in cell culture

scientific article published on 23 January 2017

Essential Role of Cyclophilin A for Hepatitis C Virus Replication and Virus Production and Possible Link to Polyprotein Cleavage Kinetics

scientific article

Essential Role of Domain III of Nonstructural Protein 5A for Hepatitis C Virus Infectious Particle Assembly

scientific article

Evidence for novel hepaciviruses in rodents

scientific article published in 2013

Evidence that hepatitis B virus replication in mouse cells is limited by the lack of a host cell dependency factor

scientific article published on 11 November 2015

Experimental models to study the immunobiology of hepatitis C virus

scientific article published on 09 December 2010

Exploitation of cellular pathways by Dengue virus

scientific article published on 27 July 2011

Expression of the P-protein of the human hepatitis B virus in a vaccinia virus system and detection of the nucleocapsid-associated P-gene product by radiolabelling at newly introduced phosphorylation sites ⬇️

scientific article published on January 25, 1992

Expression of the novel hepatitis C virus core+1/ARF protein in the context of JFH1-based replicons

scientific article

Factors that determine the antiviral efficacy of HCV-specific CD8(+) T cells ex vivo

scientific article

Faculty of 1000 evaluation for A diverse range of gene products are effectors of the type I interferon antiviral response

article

Faculty of 1000 evaluation for A pathogenic picornavirus acquires an envelope by hijacking cellular membranes

Faculty of 1000 evaluation for Antiviral RNA Interference in Mammalian Cells

Faculty of 1000 evaluation for Comparative RNAi screening reveals host factors involved in enterovirus infection of polarized endothelial monolayers

Faculty of 1000 evaluation for Completion of the entire hepatitis C virus life cycle in genetically humanized mice

Faculty of 1000 evaluation for Dephosphorylation of the RNA sensors RIG-I and MDA5 by the phosphatase PP1 is essential for innate immune signaling

Faculty of 1000 evaluation for Ebola Virus VP24 Targets a Unique NLS Binding Site on Karyopherin Alpha 5 to Selectively Compete with Nuclear Import of Phosphorylated STAT1

Faculty of 1000 evaluation for Experimental adaptation of an influenza H5 HA confers respiratory droplet transmission to a reassortant H5 HA/H1N1 virus in ferrets

article

Faculty of 1000 evaluation for Genetic screens in human cells using the CRISPR-Cas9 system

Faculty of 1000 evaluation for Genome-scale CRISPR-Cas9 knockout screening in human cells

Faculty of 1000 evaluation for Influenza Virus Adaptation PB2-627K Modulates Nucleocapsid Inhibition by the Pathogen Sensor RIG-I

Faculty of 1000 evaluation for Influenza virus M2 protein mediates ESCRT-independent membrane scission

Faculty of 1000 evaluation for Innate sensing of HIV-infected cells

article

Faculty of 1000 evaluation for KSHV-initiated notch activation leads to membrane-type-1 matrix metalloproteinase-dependent lymphatic endothelial-to-mesenchymal transition

Faculty of 1000 evaluation for Leukocyte-derived IFN-α/β and epithelial IFN-λ constitute a compartmentalized mucosal defense system that restricts enteric virus infections

Faculty of 1000 evaluation for Mapping a dynamic innate immunity protein interaction network regulating type I interferon production

article

Faculty of 1000 evaluation for Multi-layered stochasticity and paracrine signal propagation shape the type-I interferon response

Faculty of 1000 evaluation for Nucleic Acid-Sensing Toll-like Receptors Are Essential for the Control of Endogenous Retrovirus Viremia and ERV-Induced Tumors

Faculty of 1000 evaluation for Short-range exosomal transfer of viral RNA from infected cells to plasmacytoid dendritic cells triggers innate immunity

Faculty of 1000 evaluation for The RNA Sensor RIG-I Dually Functions as an Innate Sensor and Direct Antiviral Factor for Hepatitis B Virus

Faculty of 1000 evaluation for The membrane-bound transcription factor CREB3L1 is activated in response to virus infection to inhibit proliferation of virus-infected cells

Faculty of 1000 evaluation for Transfer of HBV Genomes Using Low Doses of Adenovirus Vectors Leads to Persistent Infection in Immune Competent Mice

Failure of innate and adaptive immune responses in controlling hepatitis C virus infection

scientific article published on 04 January 2012

Flaviviridae Replication Organelles: Oh, What a Tangled Web We Weave

scientific article

Flavivirus Infection Uncouples Translation Suppression from Cellular Stress Responses

scientific article (publication date: 10 January 2017)

From structure to function: new insights into hepatitis C virus RNA replication

scientific article

Functional expression, purification, characterization, and membrane reconstitution of non-structural protein 2 from hepatitis C virus

scientific article published on 28 August 2015

Functional properties of a monoclonal antibody inhibiting the hepatitis C virus RNA-dependent RNA polymerase

scientific article published on 18 October 2001

Generation of T-cell receptors targeting a genetically stable and immunodominant cytotoxic T-lymphocyte epitope within hepatitis C virus non-structural protein 3.

scientific article

Genetic Analysis of Sequences in the 3' Nontranslated Region of Hepatitis C Virus That Are Important for RNA Replication

scientific article

Geno2pheno[HCV] - A Web-based Interpretation System to Support Hepatitis C Treatment Decisions in the Era of Direct-Acting Antiviral Agents

scientific article

Genome packaging of reovirus is mediated by the scaffolding property of the microtubule network

scientific article

Genotypic resistance testing of HCV - is there a clinical need?

scientific article published on 4 August 2016

Glycine-zipper motifs in hepatitis C virus nonstructural protein 4B are required for the establishment of viral replication organelles

scientific article published on 22 November 2017

Going full circle: validation of P-body dispersion in hepatitis C virus-infected patients

scientific article published on 2 January 2015

HBV Bypasses the Innate Immune Response and Does not Protect HCV From Antiviral Activity of Interferon.

scientific article published on 31 January 2018

HCV modifies EGF signalling and upregulates production of CXCR2 ligands: role in inflammation and antiviral immune response

scientific article published on 26 April 2018

HCV proteins increase expression of heme oxygenase-1 (HO-1) and decrease expression of Bach1 in human hepatoma cells

scientific article published on 3 February 2006

Hepatitis B and C virus coinfection: a novel model system reveals the absence of direct viral interference

scientific article

Hepatitis B virus with antigenically altered hepatitis B surface antigen is selected by high-dose hepatitis B immune globulin after liver transplantation

scientific article published in January 1998

Hepatitis C Virus Activates a Neuregulin-Driven Circuit to Modify Surface Expression of Growth Factor Receptors of the ErbB Family

scientific article published on 17 February 2016

Hepatitis C Virus NS5A Protein Is a Substrate for the Peptidyl-prolyl cis/trans Isomerase Activity of Cyclophilins A and B

scientific article

Hepatitis C Virus Replicons Volume 3 and 4 ⬇️

scientific article published on November 16, 2012

Hepatitis C Virus p7 Protein Is Crucial for Assembly and Release of Infectious Virions

scientific article (publication date: July 2007)

Hepatitis C Virus-From Discovery to Cure: The 2016 Lasker-DeBakey Clinical Medical Research Award

scientific article published on 13 September 2016

Hepatitis C virus NS2/3 processing is required for NS3 stability and viral RNA replication

scientific article

Hepatitis C virus RNA replication and assembly: living on the fat of the land

scientific article

Hepatitis C virus RNA replication is resistant to tumour necrosis factor-alpha

scientific article published in May 2003

Hepatitis C virus and host cell lipids: an intimate connection

scientific article published on March 2011

Hepatitis C virus core triggers apoptosis in liver cells by inducing ER stress and ER calcium depletion

scientific article

Hepatitis C virus core+1/ARF protein decreases hepcidin transcription through an AP1 binding site.

scientific article published on 11 April 2013

Hepatitis C virus escape from the interferon regulatory factor 3 pathway by a passive and active evasion strategy

scientific article published on November 2007

Hepatitis C virus molecular clones and their replication capacity in vivo and in cell culture

scientific article

Hepatitis C virus molecular clones: from cDNA to infectious virus particles in cell culture

scientific article published on 30 June 2006

Hepatitis C virus replication cycle

scientific article published on June 2010

Hepatitis C virus replication depends on endosomal cholesterol homeostasis

scientific article published on 18 October 2017

Hepatitis C virus replicons: dinosaurs still in business?

scientific article

Hepatitis C virus replicons: potential role for drug development

scientific article

Hepatitis C virus-induced natural killer cell proliferation involves monocyte-derived cells and the OX40/OX40L axis

scientific article published on 31 October 2017

Hepatitis C virus-replicating hepatocytes induce fibrogenic activation of hepatic stellate cells.

scientific article published on July 2005

Hepatitis C: a mouse at the end of the tunnel

scientific article published on 24 September 2013

Hepatitis D virus replication is sensed by MDA5 and induces IFN-β/λ responses in hepatocytes.

scientific article published on 7 March 2018

Hepatitis viruses in the XXI century

Heterologous Src homology 4 domains support membrane anchoring and biological activity of HIV-1 Nef

scientific article

High density lipoprotein inhibits hepatitis C virus-neutralizing antibodies by stimulating cell entry via activation of the scavenger receptor BI.

scientific article published on 4 May 2006

High plasma level of nucleocapsid-free envelope glycoprotein-positive lipoproteins in hepatitis C patients

scientific article published on 25 April 2012

High-Throughput Screening Using Dengue Virus Reporter Genomes ⬇️

scientific article published on January 1, 2013

High-throughput RNA interference screens integrative analysis: Towards a comprehensive understanding of the virus-host interplay.

scientific article published on May 2013

Host factor prioritization for pan-viral genetic perturbation screens using random intercept models and network propagation

scientific article published on 10 February 2020

Host-directed therapies for bacterial and viral infections.

scientific article published on 22 September 2017

ID: 105

scholarly article by Silke Bender published in November 2015

ID: 219

scholarly article by Joschka Willemsen published in November 2015

Identification and characterization of amphiphysin II as a novel cellular interaction partner of the hepatitis C virus NS5A protein

scientific article

Identification of Determinants Involved in Initiation of Hepatitis C Virus RNA Synthesis by Using Intergenotypic Replicase Chimeras

scientific article

Identification of HNRNPK as regulator of hepatitis C virus particle production

scientific article

Identification of Interleukin1β as an Amplifier of Interferon alpha-induced Antiviral Responses

scientific article published on 01 October 2020

Identification of terfenadine as an inhibitor of human CD81-receptor HCV-E2 interaction: synthesis and structure optimization

scientific article

Identification of the Hepatitis C Virus RNA Replication Complex in Huh-7 Cells Harboring Subgenomic Replicons

scientific article

Identification of type I and type II interferon-induced effectors controlling hepatitis C virus replication.

scientific article published on 14 October 2012

Immune-mediated effects targeting hepatitis C virus in a syngeneic replicon cell transplantation mouse model.

scientific article published on 23 June 2017

In Vitro Replication Models

In vitro models for hepatitis C.

scientific article

In vitro studies on the activation of the hepatitis C virus NS3 proteinase by the NS4A cofactor.

scientific article published on July 1996

Inhibition of HCV replication by cyclophilin antagonists is linked to replication fitness and occurs by inhibition of membranous web formation

scientific article published on 31 January 2014

Inhibition of Hepatitis C virus by nucleic acid-based antiviral approaches

Inhibition of hepatitis C virus RNA translation by antisense bile acid conjugated phosphorothioate modified oligodeoxynucleotides (ODN).

scientific article published on 6 November 2012

Inhibition of hepatitis C virus gene expression by adenoviral vectors encoding antisense RNA in vitro and in vivo

scientific article published on 30 November 2010

Interferon type I gene expression in chronic hepatitis C.

scientific article

Interferon-alpha inhibits hepatitis C virus subgenomic RNA replication by an MxA-independent pathway

scientific article published in April 2001

Interferon-gamma inhibits replication of subgenomic and genomic hepatitis C virus RNAs

scientific article published in March 2002

Interferon-induced degradation of the persistent hepatitis B virus cccDNA form depends on ISG20

scientific article published on 09 May 2021

Interferon-inducible cholesterol-25-hydroxylase restricts hepatitis C virus replication through blockage of membranous web formation

scientific article

Interleukin-32: a new proinflammatory cytokine involved in hepatitis C virus-related liver inflammation and fibrosis

scientific article published on 14 May 2011

Investigation of NS3 Protease Resistance-Associated Variants and Phenotypes for the Prediction of Treatment Response to HCV Triple Therapy

scientific article published on 09 June 2016

Investigation of a role for lysine residues in non-structural proteins 2 and 2/3 of the hepatitis C virus for their degradation and virus assembly

scientific article

Kissing-loop interaction in the 3' end of the hepatitis C virus genome essential for RNA replication

scientific article (publication date: 2005)

Live Cell Analysis and Mathematical Modeling Identify Determinants of Attenuation of Dengue Virus 2'-O-Methylation Mutant

scientific article (publication date: December 2015)

Loss of viral fitness and cross-recognition by CD8+ T cells limit HCV escape from a protective HLA-B27–restricted human immune response

scientific article

Low oxygen tension enhances hepatitis C virus replication.

scientific article

MAP-kinase regulated cytosolic phospholipase A2 activity is essential for production of infectious hepatitis C virus particles

scientific article

Male offspring born to mildly ZIKV-infected mice are at risk of developing neurocognitive disorders in adulthood

scientific article published on 10 September 2018

Matrix conditions and KLF2-dependent induction of heme oxygenase-1 modulate inhibition of HCV replication by fluvastatin

scientific article

Maturation of secreted HCV particles by incorporation of secreted ApoE protects from antibodies by enhancing infectivity.

scientific article published on 21 April 2017

Mechanisms governing hepadnaviral nucleocapsid assembly.

scientific article

Membrane alterations induced by nonstructural proteins of human norovirus.

scientific article

Membrane association of the RNA-dependent RNA polymerase is essential for hepatitis C virus RNA replication

scientific article published on December 2004

Membrane undulation induced by NS4A of Dengue virus: a molecular dynamics simulation study

scientific article published on 22 August 2013

Membranous replication factories induced by plus-strand RNA viruses

scientific article

Modulation of hepatitis C virus NS5A hyperphosphorylation by nonstructural proteins NS3, NS4A, and NS4B

scientific article

Molecular aspects of Dengue virus replication

scientific article published on April 2008

Molecular mechanism of signal perception and integration by the innate immune sensor retinoic acid-inducible gene-I (RIG-I).

scientific article

Molecular mechanisms of hepatitis C virus (HCV) replication - implications for the development of antiviral drugs

scientific article published on 15 July 2011

Morphological and biochemical characterization of the membranous hepatitis C virus replication compartment

scientific article published on 24 July 2013

Mouse hepatic cells support assembly of infectious hepatitis C virus particles

scientific article published on 13 June 2011

Mouse-Specific Residues of Claudin-1 Limit Hepatitis C Virus Genotype 2a Infection in a Human Hepatocyte Cell Line

scientific article

Mutational analysis of hepatitis C virus nonstructural protein 5A: potential role of differential phosphorylation in RNA replication and identification of a genetically flexible domain.

scientific article published on March 2005

Mutations in Hepatitis C Virus RNAs Conferring Cell Culture Adaptation

scientific article (publication date: February 2001)

Mutations that alter use of hepatitis C virus cell entry factors mediate escape from neutralizing antibodies

scientific article published on 10 April 2012

Mutations that permit efficient replication of hepatitis C virus RNA in Huh-7 cells prevent productive replication in chimpanzees

scientific article

NS4B self-interaction through conserved C-terminal elements is required for the establishment of functional hepatitis C virus replication complexes

scientific article

NS5A Domain 1 and Polyprotein Cleavage Kinetics Are Critical for Induction of Double-Membrane Vesicles Associated with Hepatitis C Virus Replication

scientific article published on 7 July 2015

Neutralizing host responses in hepatitis C virus infection target viral entry at postbinding steps and membrane fusion.

scientific article published on 22 July 2008

New insights into structure and replication of the hepatitis C virus and clinical implications

scientific article published on 19 October 2010

New targets for antiviral therapy of chronic hepatitis C.

scientific article published on February 2012

Nonstructural 3/4A protease of hepatitis C virus activates epithelial growth factor-induced signal transduction by cleavage of the T-cell protein tyrosine phosphatase

scientific article published on June 2009

Nonstructural protein 3 of the hepatitis C virus encodes a serine-type proteinase required for cleavage at the NS3/4 and NS4/5 junctions

scientific article

Normalizing for individual cell population context in the analysis of high-content cellular screens

scientific article

Novel dengue virus NS2B/NS3 protease inhibitors

scientific article

Novel indole–flutimide heterocycles with activity against influenza PA endonuclease and hepatitis C virus

Novel insights into hepatitis C virus replication and persistence

scientific article (publication date: 2004)

Novel non-heteroarylpyrimidine (HAP) capsid assembly modifiers have a different mode of action from HAPs in vitro

scientific article published on 20 July 2018

Novel nucleoside analogues targeting HCV replication through an NS5A-dependent inhibition mechanism.

scientific article published on 28 February 2017

Nuclear localization of dengue virus nonstructural protein 5 does not strictly correlate with efficient viral RNA replication and inhibition of type I interferon signaling

scientific article published on 13 February 2013

O.067 Hepatitis C virus: Virology, immunology, natural history, treatment

scholarly article by Ralf Bartenschlager published in January 2006

O.137 HDL inhibits neutralisation by HCV antibodies via a ternary interaction with the scavenger receptor BI

O.171 HDL inhibits HCV neutralisation by CD81-NOB antibodies by stimulating cell entry through activation of the scavenger receptor BI

On the history of hepatitis C virus cell culture systems

scientific article

Optimization of Substrate-Analogue Furin Inhibitors

scientific article published on 23 October 2017

Oral immunization with HCV-NS3—transformed Salmonella: Induction of HCV-specific CTL in a transgenic mouse model ⬇️

scientific article published on November 1, 2001

Overall Structural Model of NS5A Protein from Hepatitis C Virus and Modulation by Mutations Confering Resistance of Virus Replication to Cyclosporin A.

scientific article published on 23 May 2017

P0676 : Clearance of persistent hepatitis c virus infection using a monoclonal antibody specific for tight junction protein claudin-1

Paradoxical role of antibodies in dengue virus infections: considerations for prophylactic vaccine development

scientific article

Peptide-Boronic Acid Inhibitors of Flaviviral Proteases: Medicinal Chemistry and Structural Biology

scientific article published on 14 December 2016

Perilipin discerns chronic from acute hepatocellular steatosis

scientific article published on 19 November 2013

Persistence of HCV in quiescent hepatic cells under conditions of an interferon-induced antiviral response

scientific article

Persistent and transient replication of full-length hepatitis C virus genomes in cell culture

scientific article

Persistent intracellular pathogens ⬇️

scientific article published on March 19, 2012

Phenylalanine and Phenylglycine Analogues as Arginine Mimetics in Dengue Protease Inhibitors

scientific article published on 14 September 2015

Phosphorylation-Dependent Feedback Inhibition of RIG-I by DAPK1 Identified by Kinome-wide siRNA Screening

scientific article published on 14 January 2017

Processing pathways of the hepatitis C virus proteins.

scientific article published on January 1996

Prodrug Activation by a Viral Protease: Evaluating Combretastatin Peptide Hybrids To Selectively Target Infected Cells

scientific article published on 18 July 2019

Production of Infectious Genotype 1b Virus Particles in Cell Culture and Impairment by Replication Enhancing Mutations

scientific article

Production of infectious hepatitis C virus in primary cultures of human adult hepatocytes

scientific article published on July 2010

Production of infectious hepatitis C virus in tissue culture from a cloned viral genome

scientific article (publication date: July 2005)

Production of infectious hepatitis C virus particles in three-dimensional cultures of the cell line carrying the genome-length dicistronic viral RNA of genotype 1b.

scientific article published on 6 May 2006

Promotion of hepatocellular carcinoma by hepatitis C virus

scientific article published on 24 October 2012

Proton-Detected Solid-State NMR of the Cell-Free Synthesized α-Helical Transmembrane Protein NS4B from Hepatitis C Virus

scientific article published on 18 December 2019

Quantitative Analysis of the Hepatitis C Virus Replication Complex

scientific article

RACK1 mediates rewiring of intracellular networks induced by hepatitis C virus infection

scientific article published on 16 September 2019

Reconstitution of the entire hepatitis C virus life cycle in nonhepatic cells.

scientific article

Reconstructing signaling pathways from RNAi data using probabilistic Boolean threshold networks

scientific article

Recruitment and activation of a lipid kinase by hepatitis C virus NS5A is essential for integrity of the membranous replication compartment

scientific article

Relation between viral fitness and immune escape within the hepatitis C virus protease

scientific article

Reovirus intermediate subviral particles constitute a strategy to infect intestinal epithelial cells by exploiting TGF-β dependent pro-survival signaling.

scientific article published on 8 June 2016

Replication of subgenomic hepatitis C virus RNAs in a hepatoma cell line

scientific article (publication date: 2 July 1999)

Replication of the hepatitis C virus

scientific article published on 01 April 2000

Replication of the hepatitis C virus in cell culture

scientific article published on October 2003

Replication vesicles are load- and choke-points in the hepatitis C virus lifecycle

scientific article

Revisiting dengue virus-host cell interaction: new insights into molecular and cellular virology

scientific article published on January 2014

Ribavirin Antagonizes the In Vitro Anti-Hepatitis C Virus Activity of 2'-C-Methylcytidine, the Active Component of Valopicitabine

scientific article

Robust RNAi enhancement via human Argonaute-2 overexpression from plasmids, viral vectors and cell lines

scientific article published on 17 September 2013

Role of RNA Structures in Genome Terminal Sequences of the Hepatitis C Virus for Replication and Assembly

scientific article

Role of annexin A2 in the production of infectious hepatitis C virus particles

scientific article published on 24 March 2010

Role of the Hepatitis C Virus Core+1 Open Reading Frame and Core cis-Acting RNA Elements in Viral RNA Translation and Replication

scientific article (publication date: December 2008)

SARS-CoV-2 infection induces a pro-inflammatory cytokine response through cGAS-STING and NF-κB

scientific article published on 12 January 2022

SARS-CoV-2 infection remodels the host protein thermal stability landscape

scientific article published on 01 February 2021

SARS-CoV-2 structure and replication characterized by in situ cryo-electron tomography

scientific article published on 18 November 2020

Scavenger receptor class B type I is a key host factor for hepatitis C virus infection required for an entry step closely linked to CD81.

scientific article published on December 2007

Secretion of Hepatitis C Virus Envelope Glycoproteins Depends on Assembly of Apolipoprotein B Positive Lipoproteins

scientific article (publication date: 2009)

Secretion of Hepatitis C Virus Replication Intermediates Reduces Activation of Toll-Like Receptor 3 in Hepatocytes

scientific article published on 10 March 2018

Selective stimulation of hepatitis C virus and pestivirus NS5B RNA polymerase activity by GTP.

scientific article published in April 1999

Semen inhibits Zika virus infection of cells and tissues from the anogenital region.

scientific article

Sequences in the 5' nontranslated region of hepatitis C virus required for RNA replication.

scientific article

Serum versus intrahepatic HCV RNA and liver histology

scientific article published in June 2002

Single-cell-based image analysis of high-throughput cell array screens for quantification of viral infection

scientific article published on April 2009

Soraphen A: A broad-spectrum antiviral natural product with potent anti-hepatitis C virus activity

scientific article published on 9 June 2015

Strategies to inhibit entry of HBV and HDV into hepatocytes.

scientific article published on 25 April 2014

Structural and Functional Characterization of Nonstructural Protein 2 for Its Role in Hepatitis C Virus Assembly

scientific article

Structural and Functional Properties of the Hepatitis C Virus p7 Viroporin

scientific article (publication date: August 2015)

Structural and Functional Studies of Nonstructural Protein 2 of the Hepatitis C Virus Reveal Its Key Role as Organizer of Virion Assembly

scientific article

Structure and function of the membrane anchor domain of hepatitis C virus nonstructural protein 5A.

scientific article published on 7 July 2004

Structures and distributions of SARS-CoV-2 spike proteins on intact virions

scientific article published on 17 August 2020

Subcellular localization and membrane topology of the Dengue virus type 2 Non-structural protein 4B.

scientific article published on 25 January 2006

Sustained delivery of siRNAs targeting viral infection by cell-degradable multilayered polyelectrolyte films

scientific article

Synthesis and biological evaluation of α-ketoamides as inhibitors of the Dengue virus protease with antiviral activity in cell-culture

scientific article published on 18 May 2011

Synthesis, Biological Evaluation, and Molecular Docking of Combretastatin and Colchicine Derivatives and their hCE1-Activated Prodrugs as Antiviral Agents

Synthesis, Biological Evaluation, and Molecular Docking of Combretastatin and Colchicine Derivatives and their hCE1-Activated Prodrugs as Antiviral Agents

scholarly article by Michael Richter et al published 25 January 2019 in ChemMedChem

TALEN/CRISPR-mediated engineering of a promoterless anti-viral RNAi hairpin into an endogenous miRNA locus

scientific article published on 09 September 2016

TCR-redirected human T cells inhibit hepatitis C virus replication: hepatotoxic potential is linked to antigen specificity and functional avidity

scientific article

TLR3 Activation by Zika Virus Stimulates Inflammatory Cytokine Production Which Dampens the Antiviral Response Induced by RIG-I-Like Receptors

scientific article published on 03 March 2021

Targeting of hepatitis C virus core protein to mitochondria through a novel C-terminal localization motif

scientific article published on August 2004

Targets for antiviral therapy of hepatitis C.

scientific article published on February 2014

The FDA-Approved Drug Cobicistat Synergizes with Remdesivir To Inhibit SARS-CoV-2 Replication <i>In Vitro</i> and Decreases Viral Titers and Disease Progression in Syrian Hamsters

scientific article published on 01 March 2022

The Hepatitis C Virus RNA 3'-Untranslated Region Strongly Enhances Translation Directed by the Internal Ribosome Entry Site

scientific article

The Level of CD81 Cell Surface Expression Is a Key Determinant for Productive Entry of Hepatitis C Virus into Host Cells

scientific article

The Role of Tissue Oxygen Tension in Dengue Virus Replication.

scientific article

The face of future hepatitis C antiviral drug development: recent biological and virologic advances and their translation to drug development and clinical practice

scientific article

The heme oxygenase 1 product biliverdin interferes with hepatitis C virus replication by increasing antiviral interferon response

scientific article

The hepatitis C virus RNA-dependent RNA polymerase membrane insertion sequence is a transmembrane segment

scientific article

The hepatitis C virus replicon system: from basic research to clinical application

scientific article

The interactomes of influenza virus NS1 and NS2 proteins identify new host factors and provide insights for ADAR1 playing a supportive role in virus replication

scientific journal article

The lipid droplet binding domain of hepatitis C virus core protein is a major determinant for efficient virus assembly

scientific article

The lipid droplet is an important organelle for hepatitis C virus production

scientific article (publication date: September 2007)

The lipid kinase phosphatidylinositol-4 kinase III alpha regulates the phosphorylation status of hepatitis C virus NS5A

scientific article published on 9 May 2013

The lysine methyltransferase SMYD3 interacts with hepatitis C virus NS5A and is a negative regulator of viral particle production

scientific article

The molecular and structural basis of advanced antiviral therapy for hepatitis C virus infection

scientific article published on 10 June 2013

The non-immunosuppressive cyclosporin DEBIO-025 is a potent inhibitor of hepatitis C virus replication in vitro

scientific article

The non-structural protein 4A of dengue virus is an integral membrane protein inducing membrane alterations in a 2K-regulated manner

scientific article published on 2 February 2007

The predominant species of nonstructural protein 4B in hepatitis C virus-replicating cells is not palmitoylated

scientific article

The quest for host targets to combat dengue virus infections

scientific article published on 17 September 2016

Thiazolidinone-peptide hybrids as dengue virus protease inhibitors with antiviral activity in cell culture

scientific article published on 22 October 2013

Three-dimensional architecture and biogenesis of membrane structures associated with hepatitis C virus replication

scientific article

Three-dimensional architecture of tick-borne encephalitis virus replication sites and trafficking of the replicated RNA.

scientific article

Tissue culture and animal models for hepatitis C virus

scientific article

Towards structural studies of self-assembled subviral particles: combining cell-free expression with 100 kHz MAS NMR.

scientific article published on 19 February 2018

Tuning a cellular lipid kinase activity adapts hepatitis C virus to replication in cell culture.

scientific article published on 19 December 2016

Type I and type II interferon responses in two human liver cell lines (Huh-7 and HuH6).

scientific article published on 28 December 2015

Ultrastructural Characterization of Zika Virus Replication Factories

scientific article (publication date: February 2017)

Unexpected host range of hepatitis C virus replicons.

scientific article

Viral Infection at High Magnification: 3D Electron Microscopy Methods to Analyze the Architecture of Infected Cells

scientific article

Viral and Cellular Determinants of Hepatitis C Virus RNA Replication in Cell Culture

scientific article (publication date: March 2003)

Viral immune modulators perturb the human molecular network by common and unique strategies

scientific article

Wheat germ cell-free expression: Two detergents with a low critical micelle concentration allow for production of soluble HCV membrane proteins

scientific article published on 12 October 2014

c-Src is required for complex formation between the hepatitis C virus-encoded proteins NS5A and NS5B: a prerequisite for replication

scientific article

euHCVdb: the European hepatitis C virus database

scientific article (publication date: 2007)

mRNAs biotinylated within the 5' cap and protected against decapping: new tools to capture RNA-protein complexes

scientific article published on 05 November 2018

miRNA-130a targets ATG2B and DICER1 to inhibit autophagy and trigger killing of chronic lymphocytic leukemia cells

scientific article

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