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List of works by Zena Werb

A bit of give and take: the relationship between the extracellular matrix and the developing chondrocyte

scientific article published on November 2003

A framework for advancing our understanding of cancer-associated fibroblasts

scientific article published on 24 January 2020

A functional overlap of plasminogen and MMPs regulates vascularization during placental development

scientific journal article

A molecular switch for the orientation of epithelial cell polarization

scientific article

A role for matrix metalloproteinases in regulating mammary stem cell function via the Wnt signaling pathway

scientific article published on 18 July 2013

A role for niches in hematopoietic cell development

scientific article

A whole-organism screen identifies new regulators of fat storage ⬇️

scientific article published on March 13, 2011

Active plasma kallikrein localizes to mast cells and regulates epithelial cell apoptosis, adipocyte differentiation, and stromal remodeling during mammary gland involution

scientific article published on 18 March 2009

Adaptive Immune Regulation of Mammary Postnatal Organogenesis

scientific article

Altered endochondral bone development in matrix metalloproteinase 13-deficient mice

scientific article published on December 2004

Amino-biphosphonate-mediated MMP-9 inhibition breaks the tumor-bone marrow axis responsible for myeloid-derived suppressor cell expansion and macrophage infiltration in tumor stroma

scientific article published on December 2007

Angiogenesis: vascular remodeling of the extracellular matrix involves metalloproteinases

scientific article

Animal Models of Corneal Injury

scientific article published in July 2015

Balancing the innate immune system in tumor development

scientific article

Blood‐spinal cord barrier after spinal cord injury: Relation to revascularization and wound healing ⬇️

scientific article published on October 15, 2003

CSN5 isopeptidase activity links COP9 signalosome activation to breast cancer progression

scientific article published on 1 January 2008

Cancer. Circulating tumor cells

scientific article published on September 2013

Candidate regulators of mammary branching morphogenesis identified by genome-wide transcript analysis

scientific article

Cell-polarity dynamics controls the mechanism of lumen formation in epithelial morphogenesis

scientific article published on April 2008

Cloning and characterization of two extracellular heparin-degrading endosulfatases in mice and humans

scientific article

Collective epithelial migration and cell rearrangements drive mammary branching morphogenesis

scientific article

Collective invasion in breast cancer requires a conserved basal epithelial program

scientific article

Comparative mechanisms of branching morphogenesis in diverse systems

scientific article published on October 2006

Complementary interplay between matrix metalloproteinase-9, vascular endothelial growth factor and osteoclast function drives endochondral bone formation

scientific article

Concepts of extracellular matrix remodelling in tumour progression and metastasis

scientific article published on 09 October 2020

Confocal Imaging of Myeloid Cells in the Corneal Stroma of Live Mice.

scientific article published in July 2015

Contribution of host MMP-2 and MMP-9 to promote tumor vascularization and invasion of malignant keratinocytes

scientific article

Cyclins E1 and E2 are required for endoreplication in placental trophoblast giant cells

scientific article

Cytokine-mediated deployment of SDF-1 induces revascularization through recruitment of CXCR4+ hemangiocytes

scientific article

Decreased allergic lung inflammatory cell egression and increased susceptibility to asphyxiation in MMP2-deficiency

scientific article

Deficiency in matrix metalloproteinase-2 results in long-term vascular instability and regression in the injured mouse spinal cord

scientific article published on 25 July 2016

Delineating CSF-1-dependent regulation of myeloid cell diversity in tumors

scientific article published on 2 March 2015

Development of the mammary gland requires DGAT1 expression in stromal and epithelial tissues

scientific article published on 26 May 2004

Developmental biology: vasculogenesis is a wreck without RECK.

scientific article

Differential temporal expression of matrix metalloproteinases after spinal cord injury: relationship to revascularization and wound healing

scientific article published on September 2003

Differentiated thyroid cancer cell invasion is regulated through epidermal growth factor receptor-dependent activation of matrix metalloproteinase (MMP)-2/gelatinase A.

scientific article published on December 2006

Discoidin domain receptor 2 mediates tumor cell cycle arrest induced by fibrillar collagen

scientific article

Diverse regulation of mammary epithelial growth and branching morphogenesis through noncanonical Wnt signaling

scientific article published on 7 March 2017

Dual Protective Mechanisms of Matrix Metalloproteinases 2 and 9 in Immune Defense against Streptococcus pneumoniae ⬇️

scientific article published on April 20, 2011

Dual targets for mouse mast cell protease-4 in mediating tissue damage in experimental bullous pemphigoid

scientific article

Dynamic, long-term in vivo imaging of tumor-stroma interactions in mouse models of breast cancer using spinning-disk confocal microscopy

scientific article

ECM microenvironment regulates collective migration and local dissemination in normal and malignant mammary epithelium ⬇️

scientific article published on August 23, 2012

Efficacy of a metalloproteinase inhibitor in spinal cord injured dogs

scientific article

Endothelial expression of constitutively active Notch4 elicits reversible arteriovenous malformations in adult mice

scientific article

Endovascular biopsy: Strategy for analyzing gene expression profiles of individual endothelial cells obtained from human vessels(✩).

scientific article published on August 2015

Epidermal development and wound healing in matrix metalloproteinase 13-deficient mice

scientific article published on February 2006

Epidermal growth factor receptor-deficient mice have delayed primary endochondral ossification because of defective osteoclast recruitment

scientific article published on 28 September 2004

Epithelial morphogenesis: Netrin comes to a sticky and terminal end.

scientific article

Ets2-dependent stromal regulation of mouse mammary tumors

scientific article published on December 2003

Evidence that transgenes encoding components of the Wnt signaling pathway preferentially induce mammary cancers from progenitor cells

scientific article

Extracellular matrix degradation and remodeling in development and disease

scientific article

Formation of cysts by alveolar type II cells in three-dimensional culture reveals a novel mechanism for epithelial morphogenesis

scientific article

G'rab'bing the microenvironment for invasion

scientific article

GATA-3 and the regulation of the mammary luminal cell fate

scientific article

GATA-3 links tumor differentiation and dissemination in a luminal breast cancer model

scientific article

GATA-3 maintains the differentiation of the luminal cell fate in the mammary gland

scientific article

GATA3 in development and cancer differentiation: cells GATA have it!

scientific article

Galectin-3 is a downstream regulator of matrix metalloproteinase-9 function during endochondral bone formation

scientific article

Gene trap disruption of the mouse heparan sulfate 6-O-endosulfatase gene, Sulf2

scientific article

Genetic mosaic analysis reveals FGF receptor 2 function in terminal end buds during mammary gland branching morphogenesis

scientific article published on 13 June 2008

HIF1alpha induces the recruitment of bone marrow-derived vascular modulatory cells to regulate tumor angiogenesis and invasion

scientific article published on March 2008

HSulf-2, an extracellular endoglucosamine-6-sulfatase, selectively mobilizes heparin-bound growth factors and chemokines: effects on VEGF, FGF-1, and SDF-1.

scientific article

Heparan sulfate sulfatase SULF2 regulates PDGFRα signaling and growth in human and mouse malignant glioma ⬇️

scientific article published on February 1, 2012

Hormonal and local control of mammary branching morphogenesis

scientific article

How proteases regulate bone morphogenesis

scientific article

Imaging tumor-stroma interactions during chemotherapy reveals contributions of the microenvironment to resistance

scientific article published in April 2012

Immune effector monocyte-neutrophil cooperation induced by the primary tumor prevents metastatic progression of breast cancer

scientific article published on 07 October 2019

In silico molecular comparisons of C. elegans and mammalian pharmacology identify distinct targets that regulate feeding

scientific article (publication date: November 2013)

Increased inflammation delays wound healing in mice deficient in collagenase-2 (MMP-8).

scientific article published on 28 March 2007

Inflammation and cancer

scientific article

Integrins engage mitochondrial function for signal transduction by a mechanism dependent on Rho GTPases

scientific article

Intravital imaging of stromal cell dynamics in tumors

scientific article

Intravital imaging reveals distinct responses of depleting dynamic tumor-associated macrophage and dendritic cell subpopulations

scientific article

Kynurenic acid is a nutritional cue that enables behavioral plasticity

scientific article

Lentiviral transduction of mammary stem cells for analysis of gene function during development and cancer

scientific article published on January 2008

Lgr5-expressing cells are sufficient and necessary for postnatal mammary gland organogenesis

scientific article published on 24 January 2013

Location, location, location: the cancer stem cell niche

scientific article published on December 2007

Low-dose irradiation promotes tissue revascularization through VEGF release from mast cells and MMP-9-mediated progenitor cell mobilization

scientific article

MMP-2 and MMP-9 synergize in promoting choroidal neovascularization

scientific article

MMP13 as a stromal mediator in controlling persistent angiogenesis in skin carcinoma

scientific article

MMP9 and SCF protect from apoptosis in acute kidney injury

scientific article published on April 2009

MULTI-seq: sample multiplexing for single-cell RNA sequencing using lipid-tagged indices

scientific article published on 17 June 2019

Macrophages contribute to the maintenance of stable regenerating neurites following peripheral nerve injury

scientific article published on September 2003

Mammary Gland Reprogramming: Metalloproteinases Couple Form with Function ⬇️

scientific article published on April 1, 2011

Mammary collective cell migration involves transient loss of epithelial features and individual cell migration within the epithelium ⬇️

scientific article published on February 17, 2012

Mammary ductal morphogenesis requires paracrine activation of stromal EGFR via ADAM17-dependent shedding of epithelial amphiregulin

scientific article

Mapping mammary gland architecture using multi-scale in situ analysis

scientific article

Marginating dendritic cells of the tumor microenvironment cross-present tumor antigens and stably engage tumor-specific T cells

scientific article published in March 2012

Mast cells contribute to the stromal microenvironment in mammary gland branching morphogenesis

scientific article published on 20 October 2009

Matrix Metalloproteinase-9 and Stromal Cell-Derived Factor-1 Act Synergistically to Support Migration of Blood-Borne Monocytes into the Injured Spinal Cord ⬇️

scientific article published on November 2, 2011

Matrix metalloproteinase 13 is induced in fibroblasts in polyomavirus middle T antigen-driven mammary carcinoma without influencing tumor progression

scientific article

Matrix metalloproteinase-2 facilitates wound healing events that promote functional recovery after spinal cord injury

scientific article published on September 2006

Matrix metalloproteinase-9 contributes to choroidal neovascularization

scientific article

Matrix metalloproteinase-9 deficiency phenocopies features of preeclampsia and intrauterine growth restriction

scientific article published on 17 June 2013

Matrix metalloproteinase-9 facilitates glial scar formation in the injured spinal cord

scientific article published on December 2008

Matrix metalloproteinase-9-dependent exposure of a cryptic migratory control site in collagen is required before retinal angiogenesis

scientific article published on October 2002

Matrix metalloproteinases 2 and 9 are dispensable for pancreatic islet formation and function in vivo

scientific article published on March 2005

Matrix metalloproteinases and neurotrauma: evolving roles in injury and reparative processes

scientific article published on April 2010

Matrix metalloproteinases contribute distinct roles in neuroendocrine prostate carcinogenesis, metastasis, and angiogenesis progression

scientific article

Matrix metalloproteinases in lung: multiple, multifarious, and multifaceted

scientific article published on January 2007

Matrix metalloproteinases in stem cell regulation and cancer

scientific article

Matrix metalloproteinases limit functional recovery after spinal cord injury by modulation of early vascular events.

scientific article published on September 2002

Matrix remodeling during endochondral ossification

scientific article published on February 2004

Measuring Matrix Metalloproteinase Activity in Macrophages and Polymorphonuclear Leukocytes ⬇️

scientific article published on April 1, 2011

Metalloproteases and adipogenesis: a weighty subject

scientific article published on May 2002

Metalloproteinases: a Functional Pathway for Myeloid Cells

scientific article published on April 2016

Mfge8 diminishes the severity of tissue fibrosis in mice by binding and targeting collagen for uptake by macrophages

scientific article

Mfge8 is critical for mammary gland remodeling during involution

scientific article

Mice deficient in Ext2 lack heparan sulfate and develop exostoses

scientific journal article

MicroRNAs Play a Big Role in Regulating Ovarian Cancer–Associated Fibroblasts and the Tumor Microenvironment ⬇️

scientific article published on December 1, 2012

Molecular determinants of lung development

scientific article published on April 2013

Monitoring of vital signs for long-term survival of mice under anesthesia

scientific article

Neutrophils: Critical components in experimental animal models of cancer

scientific article published on 11 March 2016

New functional roles for non-collagenous domains of basement membrane collagens

scientific article

New insights into saccular development and vascular formation in lung allografts under the renal capsule

scientific article published on March 2003

Overlapping and independent contributions of MMP2 and MMP9 to lung allergic inflammatory cell egression through decreased CC chemokines

scientific article published on April 2004

PDGFRbeta+ perivascular progenitor cells in tumours regulate pericyte differentiation and vascular survival

scientific article published on 21 August 2005

PIM1 kinase inhibition as a targeted therapy against triple-negative breast tumors with elevated MYC expression

scientific article published on 24 October 2016

Patterning mechanisms of branched organs

scientific article published on December 2008

Physiological levels of tumstatin, a fragment of collagen IV alpha3 chain, are generated by MMP-9 proteolysis and suppress angiogenesis via alphaV beta3 integrin

scientific article

Placental growth factor reconstitutes hematopoiesis by recruiting VEGFR1(+) stem cells from bone-marrow microenvironment

scientific article published on July 2002

Platelets induce neutrophil extracellular traps in transfusion-related acute lung injury

scientific article

Preparation of mice for long-term intravital imaging of the mammary gland

scientific article

Profiling human breast epithelial cells using single cell RNA sequencing identifies cell diversity.

scientific article published on 23 May 2018

Prognostic value of PAI1 in invasive breast cancer: evidence that tumor-specific factors are more important than genetic variation in regulating PAI1 expression

scientific article

Protective effects of matrix metalloproteinase-12 following corneal injury ⬇️

scientific article published on June 26, 2013

Proteomic identification of in vivo substrates for matrix metalloproteinases 2 and 9 reveals a mechanism for resolution of inflammation

scientific article published on November 2006

Quantitative proteomic analyses of mammary organoids reveals distinct signatures after exposure to environmental chemicals

scientific article published on 22 February 2016

RasGRP1 opposes proliferative EGFR-SOS1-Ras signals and restricts intestinal epithelial cell growth

scientific article

Real-time imaging of myeloid cells dynamics in ApcMin/+ intestinal tumors by spinning disk confocal microscopy

scientific article

Recruitment of stem and progenitor cells from the bone marrow niche requires MMP-9 mediated release of kit-ligand

scientific article

Regulation of mammary gland branching morphogenesis by the extracellular matrix and its remodeling enzymes

scientific article

Regulation of matrix biology by matrix metalloproteinases

scientific article published in October 2004

Remodelling the extracellular matrix in development and disease

scientific article

Roadblocks to translational advances on metastasis research

scientific article published on September 2013

Role of matrix metalloproteinase 13 in both endochondral and intramembranous ossification during skeletal regeneration

scientific journal article

Roles of the immune system in cancer: from tumor initiation to metastatic progression

scientific article published on 01 October 2018

Roles of the innate immune system in mammary gland remodeling during involution

scientific article published on March 2007

Signaling through the EGF receptor controls lung morphogenesis in part by regulating MT1-MMP-mediated activation of gelatinase A/MMP2.

scientific article published on February 2002

Single-cell analysis reveals a stem-cell program in human metastatic breast cancer cells

scientific article

Site-specific inductive and inhibitory activities of MMP-2 and MMP-3 orchestrate mammary gland branching morphogenesis.

scientific article published in September 2003

Sox10 directs neural stem cells toward the oligodendrocyte lineage by decreasing Suppressor of Fused expression

scientific article

Stage-specific action of matrix metalloproteinases influences progressive hereditary kidney disease

scientific article

Stromal effects on mammary gland development and breast cancer

scientific article

Stromal matrix metalloproteinase-9 regulates the vascular architecture in neuroblastoma by promoting pericyte recruitment

scientific article

Stromal regulation of vessel stability by MMP14 and TGFbeta

scientific article

Sulf-2, a proangiogenic heparan sulfate endosulfatase, is upregulated in breast cancer

scientific article

Synergy between a plasminogen cascade and MMP-9 in autoimmune disease

scientific article

Synthetic Tuning of Domain Stoichiometry in Nanobody-Enzyme Megamolecules

scientific article published on 10 December 2020

Systematic analysis of the achaete-scute complex-like gene signature in clinical cancer patients

scientific article

Targeting the cancer-associated fibroblasts as a treatment in triple-negative breast cancer

scientific article published on 14 October 2016

The Cleared Mammary Fat Pad Transplantation Assay for Mammary Epithelial Organogenesis

scientific article published on 02 December 2015

The Joy of a Career in Cell Biology ⬇️

scientific article published on November 15, 2010

The MAPK(ERK-1,2) pathway integrates distinct and antagonistic signals from TGFalpha and FGF7 in morphogenesis of mouse mammary epithelium

scientific article

The Role of Stroma in Tumor Development

scientific article (publication date: 2015)

The apical ectodermal ridge is a timer for generating distal limb progenitors

scientific article published on April 2008

The cancer stem cell niche: how essential is the niche in regulating stemness of tumor cells?

scientific article

The metalloprotease Kuzbanian (ADAM10) mediates the transactivation of EGF receptor by G protein-coupled receptors

scientific article

The plasminogen fibrinolytic pathway is required for hematopoietic regeneration

scientific article published on December 2007

The transcription factor ZNF217 is a prognostic biomarker and therapeutic target during breast cancer progression

scientific article

Tissue inhibitor of metalloproteinase 1 regulates resistance to infection

scientific article

Tissue type plasminogen activator regulates myeloid-cell dependent neoangiogenesis during tissue regeneration

scientific article

Transcriptional diversity and bioenergetic shift in human breast cancer metastasis revealed by single-cell RNA sequencing

scientific article published on 06 March 2020

Tube or not tube: remodeling epithelial tissues by branching morphogenesis

scientific article

Tumors as organs: complex tissues that interface with the entire organism

scientific article

Type I collagen is a genetic modifier of matrix metalloproteinase 2 in murine skeletal development

scientific journal article

Visualizing stromal cell dynamics in different tumor microenvironments by spinning disk confocal microscopy

scientific article

ZNF503/Zpo2 drives aggressive breast cancer progression by down-regulation of GATA3 expression

scientific article published on 3 March 2017

Zeppo1 is a novel metastasis promoter that represses E-cadherin expression and regulates p120-catenin isoform expression and localization

scientific journal article

beta4 integrin-dependent formation of polarized three-dimensional architecture confers resistance to apoptosis in normal and malignant mammary epithelium

scientific article published on September 2002

microRNA-mediated regulation of the tumor microenvironment

scientific article published on 26 August 2013

p114RhoGEF governs cell motility and lumen formation during tubulogenesis through a ROCK-myosin-II pathway

scientific article

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