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List of works by Hitoshi Okamura

2101 Circadian profiles of alpha7 and beta2 types of nicotinic acetyl-choline receptors in the rat suprachiasmatic nucleus

scientific article published in January 1997

3β-Hydroxysteroid dehydrogenase isoforms in human aldosterone-producing adenoma

scientific article published on 22 October 2014

Ablation of PDK1 in pancreatic beta cells induces diabetes as a result of loss of beta cell mass

scientific article published on 23 April 2006

Accelerating recovery from jet lag: prediction from a multi-oscillator model and its experimental confirmation in model animals

scientific article

Accurate determination of S-phase fraction in proliferative cells by dual fluorescence and peroxidase immunohistochemistry with 5-bromo-2'-deoxyuridine (BrdU) and Ki67 antibodies

scientific article published on 6 May 2011

Activation of AMPA receptors in the suprachiasmatic nucleus phase-shifts the mouse circadian clock in vivo and in vitro

scientific article (publication date: 3 June 2010)

Adrenergic regulation of clock gene expression in mouse liver

scientific article

Alterations of circadian expressions of clock genes in Dahl salt-sensitive rats fed a high-salt diet

scientific article published on 30 June 2003

Altered food-anticipatory activity rhythm in Cryptochrome-deficient mice

scientific article published on 28 March 2005

Angiotensin II triggers expression of the adrenal gland zona glomerulosa-specific 3β-hydroxysteroid dehydrogenase isoenzyme through de novo protein synthesis of the orphan nuclear receptors NGFIB and NURR1.

scientific article

Bimodal circadian secretion of melatonin from the pineal gland in a living CBA mouse

scientific article

Bmal1 regulates inflammatory responses in macrophages by modulating enhancer RNA transcription

scientific article published on August 2017

Brain expression of apurinic/apyrimidinic endonuclease (APE/Ref-1) multifunctional DNA repair enzyme gene in the mouse with special reference to the suprachiasmatic nucleus

scientific article published in August 2003

CK1δ/ε protein kinase primes the PER2 circadian phosphoswitch.

scientific article

CNOT1 regulates circadian behaviour through <i>Per2</i> mRNA decay in a deadenylation-dependent manner

scientific article published on 31 December 2021

Calcitonin receptors are ancient modulators for rhythms of preferential temperature in insects and body temperature in mammals

scientific article published on 12 February 2018

Carbachol Induces Phase-dependent Phase Shifts of Per1 Transcription Rhythms in Cultured Suprachiasmatic Nucleus Slices.

scientific article published in February 2017

Chronic hyperaldosteronism in cryptochrome-null mice induces high-salt- and blood pressure-independent kidney damage in mice.

scientific article

Chronic treatment with prednisolone represses the circadian oscillation of clock gene expression in mouse peripheral tissues

scientific article published on 3 November 2005

Circadian PER2 protein oscillations do not persist in cycloheximide-treated mouse embryonic fibroblasts in culture

scientific article

Circadian Profiling of Amino Acids in the SCN and Cerebral Cortex by Laser Capture Microdissection-Mass Spectrometry

scientific article published in October 2017

Circadian and light induced expression of Per1 and Per2 in the rat suprachiasmatic nucleus

scientific article published in January 1998

Circadian characteristics of mice depleted with GPR7.

scientific article published in December 2009

Circadian clock genes directly regulate expression of the Na(+)/H(+) exchanger NHE3 in the kidney

scientific journal article

Circadian clock regulates hepatic polyploidy by modulating Mkp1-Erk1/2 signaling pathway.

scientific article published on 21 December 2017

Circadian clock signals in the adrenal cortex

scientific article published on 19 August 2011

Circadian coordination of ATP release in the urothelium via connexin43 hemichannels

scientific article published on 31 January 2018

Circadian expression of 86- and 84-kDa heat shock proteins in the mouse suprachiasmatic nucleus

scientific article published on 01 April 2008

Circadian expression of clock genes in human peripheral leukocytes.

scientific article published on 22 January 2007

Circadian expression of the Na+/H+ exchanger NHE3 in the mouse renal medulla

scientific article

Circadian gene expression in the murine larynx.

scientific article

Circadian intraocular pressure rhythm is generated by clock genes

scientific article published on 01 September 2006

Circadian oscillation of a mammalian homologue of the Drosophila period gene ⬇️

scientific article published on October 2, 1997

Circadian regulation of intracellular G-protein signalling mediates intercellular synchrony and rhythmicity in the suprachiasmatic nucleus

scientific article

Circadian rhythm of aromatic L-amino acid decarboxylase in the rat suprachiasmatic nucleus: gene expression and decarboxylating activity in clock oscillating cells

scientific journal article

Circadian rhythms of micturition during jet lag.

scientific article published in January 2018

Clock genes and salt-sensitive hypertension: a new type of aldosterone-synthesizing enzyme controlled by the circadian clock and angiotensin II.

scientific article published on 21 July 2016

Clock genes in cell clocks: roles, actions, and mysteries

scientific article

Construction of a rhythm transfer system that mimics the cellular clock.

scientific article published on 14 September 2012

Control mechanism of the circadian clock for timing of cell division in vivo

scientific article published on 21 August 2003

Control of circadian phase by an artificial zinc finger transcription regulator

scientific article published on 8 September 2011

Corrigendum: Ecto-domain phosphorylation promotes functional recovery from spinal cord injury

scientific article published on July 2015

Decreased expression of 14-3-3 sigma is associated with advanced disease in human epithelial ovarian cancer: its correlation with aberrant DNA methylation

scientific article

Development of diurnal micturition pattern in mice after weaning

scientific article published on 8 October 2012

Does mPER2 protein oscillate without its coding mRNA cycling?: post-transcriptional regulation by cell clock

scientific article published on May 2006

Ecto-domain phosphorylation promotes functional recovery from spinal cord injury

scientific article

Effect of Daily Light on c-Fos Expression in the Suprachiasmatic Nucleus under Jet Lag Conditions.

scientific article

Excess S-adenosylmethionine inhibits methylation via catabolism to adenine

scientific article published on 05 April 2022

Expression of ubiquitin-related enzymes in the suprachiasmatic nucleus with special reference to ubiquitin carboxy-terminal hydrolase UchL1.

scientific article

FSP27 contributes to efficient energy storage in murine white adipocytes by promoting the formation of unilocular lipid droplets

scientific article published on August 2008

Fetal Leydig cells dedifferentiate and serve as adult Leydig stem cells

scientific article published on 05 December 2018

Functional D-box sequences reset the circadian clock and drive mRNA rhythms

Functional evolution of the photolyase/cryptochrome protein family: importance of the C terminus of mammalian CRY1 for circadian core oscillator performance.

scientific article

G-protein-coupled receptor signaling through Gpr176, Gz, and RGS16 tunes time in the center of the circadian clock [Review].

scientific article

Gm7325 is MyoD-dependently expressed in activated muscle satellite cells

scientific article published in January 2017

Gpr176 is a Gz-linked orphan G-protein-coupled receptor that sets the pace of circadian behaviour

scientific journal article

Gradients in the circadian expression of Per1 and Per2 genes in the rat suprachiasmatic nucleus.

scientific article published in April 2002

Hypertension due to loss of clock: novel insight from the molecular analysis of Cry1/Cry2-deleted mice

scientific article published on April 2011

Identification and functional characterisation of N-linked glycosylation of the orphan G protein-coupled receptor Gpr176

scientific article published on 10 March 2020

Imaging of ultraweak spontaneous photon emission from human body displaying diurnal rhythm

scientific article

Immunolocalization of murine type VI 3β-hydroxysteroid dehydrogenase in the adrenal gland, testis, skin, and placenta

scientific article published on 25 September 2013

Integration of molecular rhythms in the mammalian circadian system.

scientific article published on January 2003

Intrathecal cocaine delivery enables long-access self-administration with binge-like behavior in mice

scientific article published on 23 September 2010

Involvement of calcium/calmodulin‐dependent protein kinase II in the induction of mPer1 ⬇️

scientific article published on May 1, 2003

Involvement of urinary bladder Connexin43 and the circadian clock in coordination of diurnal micturition rhythm.

scientific article

Isoform-specific monoclonal antibodies against 3β-hydroxysteroid dehydrogenase/isomerase family provide markers for subclassification of human primary aldosteronism.

scientific article published in January 2013

Light activates the adrenal gland: timing of gene expression and glucocorticoid release

scientific article published in November 2005

Mammalian circadian clock system: Molecular mechanisms for pharmaceutical and medical sciences.

scientific article published on 08 July 2010

Mammalian clock gene Cryptochrome regulates arthritis via proinflammatory cytokine TNF-alpha.

scientific article published on 30 December 2009

Melatonin modulates the light-induced sympathoexcitation and vagal suppression with participation of the suprachiasmatic nucleus in mice

scientific article

Methylation deficiency disrupts biological rhythms from bacteria to humans

scientific article published on 06 May 2020

Mice genetically deficient in vasopressin V1a and V1b receptors are resistant to jet lag.

scientific article

Molecular clocks in mouse skin

scientific article published on 27 November 2008

Molecular machinery of the circadian clock in mammals

scientific article

Molecular signals of Mammalian circadian clock.

scientific article

Mouse Period1 (mPER1) acts as a circadian adaptor to entrain the oscillator to environmental light/dark cycles by regulating mPER2 protein

scientific journal article

Muscle-specific overexpression of heparin-binding epidermal growth factor-like growth factor increases peripheral glucose disposal and insulin sensitivity

scientific article

Non-coding cis-element of Period2 is essential for maintaining organismal circadian behaviour and body temperature rhythmicity

scientific article published on 12 June 2019

Nucleocytoplasmic shuttling and mCRY-dependent inhibition of ubiquitylation of the mPER2 clock protein

scientific article

Nucleocytoplasmic shuttling of clock proteins

scientific article

Opposing actions of neuropeptide Y and light on the expression of circadian clock genes in the mouse suprachiasmatic nuclei

scientific article published in January 2002

Physiology: brain comes to light

scientific article published on 01 March 2008

Publisher Correction: Methylation deficiency disrupts biological rhythms from bacteria to humans

scientific article published on 04 June 2020

Pulmonary phagocyte-derived NPY controls the pathology of severe influenza virus infection

scholarly article by Seiki Fujiwara et al published 19 November 2018 in Nature Microbiology

Quantification of circadian rhythms in single cells

scientific article

RETRACTED ARTICLE: A Clock mutation enhances light-phase responsiveness to cocaine in locomotor activity and self-administration with impulsive-like responding in mice

retracted scientific article published on 12 April 2016

RNA-methylation-dependent RNA processing controls the speed of the circadian clock

scientific journal article

Real-Time Recording of Circadian Per1 and Per2 Expression in the Suprachiasmatic Nucleus of Freely Moving Rats

scientific article published on 8 December 2015

Real-time imaging of the somite segmentation clock: revelation of unstable oscillators in the individual presomitic mesoderm cells

scientific article

Reduced alpha-adrenoceptor responsiveness and enhanced baroreflex sensitivity in Cry-deficient mice lacking a biological clock

scientific article published on 28 April 2005

Reply to comments to "Letter to the Editor: comment on Azmahani et al. steroidogenic enzymes, their related transcription factors and nuclear receptors in human sebaceous glands under normal and pathological conditions"

scientific article published on 09 October 2015

Responses to noxious stimuli in mice lacking α1d-adrenergic receptors ⬇️

scientific article published on October 6, 2003

Restoration of circadian behavioural rhythms in a period null Drosophila mutant (per01) by mammalian period homologues mPer1 and mPer2.

scientific article

Rev-erbalpha gene expression in the mouse brain with special emphasis on its circadian profiles in the suprachiasmatic nucleus

scientific article published in June 2002

Rhythmic expression of ROR beta mRNA in the mice suprachiasmatic nucleus

scientific article

Rhythmic nucleotide synthesis in the liver: temporal segregation of metabolites.

scientific article published on 20 April 2012

Role of angiotensin and the clock system in the circadian regulation of plasminogen activator inhibitor-1

scientific article published on 31 March 2009

Role of cyclic mPer2 expression in the mammalian cellular clock

scientific article published on March 2005

Role of hepatic STAT3 in brain-insulin action on hepatic glucose production

scientific article published in April 2006

S-adenosyl-l-homocysteine hydrolase links methionine metabolism to the circadian clock and chromatin remodeling

scientific article published on 16 December 2020

Salt-sensitive hypertension in circadian clock-deficient Cry-null mice involves dysregulated adrenal Hsd3b6.

scientific article published on 13 December 2009

Steroidogenic enzymes, their related transcription factors and nuclear receptors in human sebaceous glands under normal and pathological conditions

scientific article

Stimulus-selective induction of the orphan nuclear receptor NGFIB underlies different influences of angiotensin II and potassium on the human adrenal gland zona glomerulosa-specific 3β-HSD isoform gene expression in adrenocortical H295R cells.

scientific article

Suprachiasmatic nucleus cultures that maintain rhythmic properties in vitro

scientific article

Suprachiasmatic nucleus grafts restore circadian behavioral rhythms of genetically arrhythmic mice

scientific article published in April 2003

Synchronization and maintenance of timekeeping in suprachiasmatic circadian clock cells by neuropeptidergic signaling

scientific article published in March 2006

Synchronization of cellular clocks in the suprachiasmatic nucleus

scientific article

The dorsomedial hypothalamic nucleus is not necessary for food-anticipatory circadian rhythms of behavior, temperature or clock gene expression in mice.

scientific article

Transportin 1 in the mouse brain: appearance in regions of neurogenesis, cerebrospinal fluid production/sensing, and circadian clock

scientific article published on 01 June 2011

Two Ck1δ transcripts regulated by m6A methylation code for two antagonistic kinases in the control of the circadian clock.

scientific article

Two types of VIP neuronal components in rat suprachiasmatic nucleus

scientific article

V1a vasopressin receptors maintain normal blood pressure by regulating circulating blood volume and baroreflex sensitivity.

scholarly article

Vagal regulation of respiratory clocks in mice.

scientific article

Vasopressin Signal Inhibition in Aged Mice Decreases Mortality under Chronic Jet Lag

scientific article published on 18 July 2018

[113th Scientific Meeting of the Japanese Society of Internal Medicine: Presidential Lecture: Symposium: Sleep Disorders and Systemic Diseases: Introduction]

scientific article published on 01 September 2016

[Circadian clock and ubiquitin]

scientific article published on 01 August 2006

[Circadian clocks and hypertension]

scientific article published on 01 May 2012

[Circadian rhythm abnormality and hypertension]

scientific article published on 01 February 2012

[Explanatory diagrams of human circadian system].

scientific article

[Molecular mechanisms of biological clock: from molecular rhythms to physiological rhythms]

scientific article published on 01 January 2003

[Molecular mechanisms of circadian clock: how digestive organs tick?]

scientific article published on 01 October 2005

[Molecular oscillatory machinery of circadian rhythms]

scientific article published on 01 July 2012

[Vasopressin-mediated neuronal circuit in the suprachiasmatic nucleus and jet lag]

scientific article published on 01 October 2014

microRNA modulation of circadian-clock period and entrainment

scientific article

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