List of works by Laura J. van't Veer

2q36.3 is associated with prognosis for oestrogen receptor-negative breast cancer patients treated with chemotherapy

scientific article

70-Gene Signature as an Aid to Treatment Decisions in Early-Stage Breast Cancer

scientific article

A breast cancer gene signature for indolent disease

scientific article

A cell proliferation signature is a marker of extremely poor outcome in a subpopulation of breast cancer patients

scientific article

A common coding variant in CASP8 is associated with breast cancer risk

article

A comprehensive analysis of prognostic signatures reveals the high predictive capacity of the proliferation, immune response and RNA splicing modules in breast cancer ⬇️

scientific article

A gene-expression signature as a predictor of survival in breast cancer

scientific article (publication date: 19 December 2002)

A phase 1b study of the Akt-inhibitor MK-2206 in combination with weekly paclitaxel and trastuzumab in patients with advanced HER2-amplified solid tumor malignancies.

scientific article published on 13 February 2016

A protocol for building and evaluating predictors of disease state based on microarray data

scientific article

ATBF1 and NQO1 as candidate targets for allelic loss at chromosome arm 16q in breast cancer: absence of somatic ATBF1 mutations and no role for the C609T NQO1 polymorphism

scientific article

Abstract 3362: Factors driving industry participation in the collaborative I-SPY2 platform trial

scholarly article

Accuracy of the online prognostication tools PREDICT and Adjuvant! for early-stage breast cancer patients younger than 50 years.

scientific article published on 13 April 2017

Adaptive Randomization of Neratinib in Early Breast Cancer

scientific article published on July 2016

Adaptive Randomization of Veliparib-Carboplatin Treatment in Breast Cancer

scientific article published on July 2016

An Atlas of the Human Kinome Reveals the Mutational Landscape Underlying Dysregulated Phosphorylation Cascades in Cancer.

scientific article published on 26 February 2016

An information-theoretic analysis of genetics, gender and age in cancer patients

scientific article

Analysis of the MammaPrint breast cancer assay in a predominantly postmenopausal cohort

scientific article

Annexin A1 regulates TGF-beta signaling and promotes metastasis formation of basal-like breast cancer cells

scientific article

Are ATM mutations 7271T-->G and IVS10-6T-->G really high-risk breast cancer-susceptibility alleles?

scientific article published in February 2004

Assessment of Long-term Distant Recurrence-Free Survival Associated With Tamoxifen Therapy in Postmenopausal Patients With Luminal A or Luminal B Breast Cancer

scientific article published on 08 August 2019

Association of Event-Free and Distant Recurrence-Free Survival With Individual-Level Pathologic Complete Response in Neoadjuvant Treatment of Stages 2 and 3 Breast Cancer: Three-Year Follow-up Analysis for the I-SPY2 Adaptively Randomized Clinical T

scientific article published on 23 July 2020

Association of the germline TP53 R72P and MDM2 SNP309 variants with breast cancer survival in specific breast tumor subgroups.

scientific article

Associations of a Breast Cancer Polygenic Risk Score With Tumor Characteristics and Survival

scholarly article

Associations of breast cancer risk factors with tumor subtypes: a pooled analysis from the Breast Cancer Association Consortium studies

scientific article

Associations of common variants at 1p11.2 and 14q24.1 (RAD51L1) with breast cancer risk and heterogeneity by tumor subtype: findings from the Breast Cancer Association Consortium

scientific article published on 18 August 2011

Bilateral prophylactic mastectomy reduces breast cancer risk in BRCA1 and BRCA2 mutation carriers: the PROSE Study Group

scientific article published on 23 February 2004

Biological functions of the genes in the mammaprint breast cancer profile reflect the hallmarks of cancer.

scientific article published on 28 November 2010

Body mass index and breast cancer survival: a Mendelian randomization analysis

scientific article published in December 2017

Breast Cancer Screening in the Precision Medicine Era: Risk-Based Screening in a Population-Based Trial.

scientific article

Breast Cancer Survival and Tumor Characteristics in Premenopausal Women Carrying theCHEK2*1100delCGermline Mutation

scientific article published on 20 January 2006

Breast Cancer Survival of BRCA1/BRCA2 Mutation Carriers in a Hospital-Based Cohort of Young Women.

scientific article published on August 2017

Breast cancer risk and 6q22.33: combined results from Breast Cancer Association Consortium and Consortium of Investigators on Modifiers of BRCA1/2

scientific article

CHEK2*1100delC heterozygosity in women with breast cancer associated with early death, breast cancer-specific death, and increased risk of a second breast cancer

scientific article

Calibration and discriminatory accuracy of prognosis calculation for breast cancer with the online Adjuvant! program: a hospital-based retrospective cohort study.

scientific article

Clinical application of the 70-gene profile: the MINDACT trial

scientific article

Clinical utility of the 70-gene MammaPrint profile in a Japanese population.

scientific article published on 27 January 2010

Co-expression modules identified from published immune signatures reveal five distinct immune subtypes in breast cancer

scientific article

Combined effects of single nucleotide polymorphisms TP53 R72P and MDM2 SNP309, and p53 expression on survival of breast cancer patients

scientific article

Comparison of gene expression profiles predicting progression in breast cancer patients treated with tamoxifen

scientific article

Complex landscapes of somatic rearrangement in human breast cancer genomes

scientific article

Comprehensive transcriptomic analysis of cell lines as models of primary tumors across 22 tumor types

scientific article published on 08 August 2019

Concordance among gene-expression-based predictors for breast cancer

scientific article

Confirmation of 5p12 as a susceptibility locus for progesterone-receptor-positive, lower grade breast cancer

scientific article

Controlling technical variation amongst 6693 patient microarrays of the randomized MINDACT trial

scientific article published on 27 July 2020

Converting a breast cancer microarray signature into a high-throughput diagnostic test.

scientific article

Correction: Cost-Effectiveness Of Treatment Strategies for BRAF-Mutated Metastatic Melanoma

scientific article published on 20 April 2015

Corrigendum: Frequent somatic transfer of mitochondrial DNA into the nuclear genome of human cancer cells

scientific article published on May 2016

Cost-effectiveness analysis of the 70-gene signature compared with clinical assessment in breast cancer based on a randomised controlled trial

scientific article published on 11 August 2020

Cost-effectiveness of treatment strategies for BRAF-mutated metastatic melanoma

scientific article

Cross-validated Cox regression on microarray gene expression data

scientific article

Current Landscape of Breast Cancer Imaging and Potential Quantitative Imaging Markers of Response in ER-Positive Breast Cancers Treated with Neoadjuvant Therapy

scientific article published on 09 June 2020

DNA repair deficiency biomarkers and the 70-gene ultra-high risk signature as predictors of veliparib/carboplatin response in the I-SPY 2 breast cancer trial

scientific article published on 25 August 2017

Detection of circulating breast tumor cells by differential expression of marker genes

scientific article published on 01 June 2002

Discordant assessment of tumor biomarkers by histopathological and molecular assays in the EORTC randomized controlled 10041/BIG 03-04 MINDACT trial breast cancer : Intratumoral heterogeneity and DCIS or normal tissue components are unlikely to be t

scientific article published on 28 January 2016

Do MDM2 SNP309 and TP53 R72P interact in breast cancer susceptibility? A large pooled series from the breast cancer association consortium

scientific article

Do rectal cancer patients with PIK3CA mutations benefit from preoperative radiotherapy with regard to local recurrences?

scientific article

E-cadherin breast tumor expression, risk factors and survival: Pooled analysis of 5,933 cases from 12 studies in the Breast Cancer Association Consortium.

scientific article published on 26 April 2018

Effect of Pembrolizumab Plus Neoadjuvant Chemotherapy on Pathologic Complete Response in Women With Early-Stage Breast Cancer: An Analysis of the Ongoing Phase 2 Adaptively Randomized I-SPY2 Trial

scientific article published on 13 February 2020

Equivalence of MammaPrint array types in clinical trials and diagnostics

scientific article

Erratum to: Modeling precision treatment of breast cancer

scientific article published on 12 May 2015

Erratum: Corrigendum: A common coding variant in CASP8 is associated with breast cancer risk

scholarly article published in Nature Genetics

Evaluation of National Comprehensive Cancer Network guideline-based Tool for Risk Assessment for breast and ovarian Cancer (N-TRAC): A patient-reported survey for genetic high-risk assessment for breast and ovarian cancers in women

scientific article published on 21 January 2019

Evaluation of the Dutch BRCA1/2 clinical genetic center referral criteria in an unselected early breast cancer population

scientific article

Evidence that breast cancer risk at the 2q35 locus is mediated through IGFBP5 regulation

scientific article

Expanded genomic profiling of circulating tumor cells in metastatic breast cancer patients to assess biomarker status and biology over time

scientific article published on 8 January 2018

Expression of insulin-like growth factor system components in colorectal tissue and its relation with serum IGF levels

scientific article published on 17 September 2008

Expression profiling of circulating tumor cells in metastatic breast cancer

scientific article

Expression profiling predicts outcome in breast cancer

scientific article

Family history, genetic testing, and clinical risk prediction: pooled analysis of CHEK2 1100delC in 1,828 bilateral breast cancers and 7,030 controls

scientific article published on January 2009

Fine-mapping identifies two additional breast cancer susceptibility loci at 9q31.2.

scientific article published on 4 February 2015

Fine-scale mapping of the FGFR2 breast cancer risk locus: putative functional variants differentially bind FOXA1 and E2F1.

scientific article

Five polymorphisms and breast cancer risk: results from the Breast Cancer Association Consortium

scientific article

Functional mechanisms underlying pleiotropic risk alleles at the 19p13.1 breast-ovarian cancer susceptibility locus

scientific article published on 7 September 2016

Ganitumab and metformin plus standard neoadjuvant therapy in stage 2/3 breast cancer

scientific article published on 05 October 2021

Gene Expression Signature to Improve Prognosis Prediction of Stage II and III Colorectal Cancer

article

Gene co-expression modules as clinically relevant hallmarks of breast cancer diversity

scientific article

Gene expression profiles from formalin fixed paraffin embedded breast cancer tissue are largely comparable to fresh frozen matched tissue

scientific article (publication date: 11 February 2011)

Gene expression profiling predicts clinical outcome of breast cancer

scientific article (publication date: 31 January 2002)

Gene expression profiling to identify the histogenetic origin of metastatic adenocarcinomas of unknown primary

scientific article published on 01 September 2008

Gene signature evaluation as a prognostic tool: challenges in the design of the MINDACT trial

scientific article published on October 2006

Genetic variants in TGFβ-1 and PAI-1 as possible risk factors for cardiovascular disease after radiotherapy for breast cancer.

scientific article

Genetic variation at CYP3A is associated with age at menarche and breast cancer risk: a case-control study

scientific article

Genetic variation in mitotic regulatory pathway genes is associated with breast tumor grade

scientific article

Genome-wide association studies identify four ER negative-specific breast cancer risk loci

scientific article published in April 2013

Glutamine sensitivity analysis identifies the xCT antiporter as a common triple-negative breast tumor therapeutic target

scientific article published on 03 October 2013

Heterogeneous drug penetrance of veliparib and carboplatin measured in triple negative breast tumors

scientific article published on 11 September 2017

High-throughput automated scoring of Ki67 in breast cancer tissue microarrays from the Breast Cancer Association Consortium

scientific article published on 06 April 2016

Identification and characterization of novel associations in the CASP8/ALS2CR12 region on chromosome 2 with breast cancer risk

scientific article

Impact of Age at Primary Breast Cancer on Contralateral Breast Cancer Risk in BRCA1/2 Mutation Carriers

scientific article published on 23 December 2015

Impact of mammographic screening on the detection of good and poor prognosis breast cancers

scientific article published on 04 September 2011

Individualization of therapy using Mammaprint: from development to the MINDACT Trial

scientific article

Insulin-like growth factor (IGF)-system mRNA quantities in normal and tumor breast tissue of women with sporadic and familial breast cancer risk

scientific article published in April 2004

Intratumor Heterogeneity of the Estrogen Receptor and the Long-term Risk of Fatal Breast Cancer.

scientific article published on 19 January 2018

Landscape of somatic mutations in 560 breast cancer whole-genome sequences

scientific article

Large-scale genotyping identifies 41 new loci associated with breast cancer risk

scientific article

Laura van 't Veer, PhD: bringing tumor gene profiles into the clinic. Interview

scientific article published in August 2004

Lobular histology and response to neoadjuvant chemotherapy in invasive breast cancer.

scientific article published on 8 September 2012

Locoregional Breast Cancer Recurrence in the European Organisation for Research and Treatment of Cancer 10041/BIG 03-04 MINDACT Trial: Analysis of Risk Factors Including the 70-Gene Signature

scholarly article

Low penetrance breast cancer susceptibility loci are associated with specific breast tumor subtypes: findings from the Breast Cancer Association Consortium

scientific article

Lycopene supplementation elevates circulating insulin-like growth factor binding protein-1 and -2 concentrations in persons at greater risk of colorectal cancer

scientific article published on 01 November 2007

MK-2206 and Standard Neoadjuvant Chemotherapy Improves Response in Patients With Human Epidermal Growth Factor Receptor 2-Positive and/or Hormone Receptor-Negative Breast Cancers in the I-SPY 2 Trial

scientific article published on 07 February 2019

MammaPrint 70-gene profile quantifies the likelihood of recurrence for early breast cancer

scientific article published in March 2009

MammaPrint and BluePrint Molecular Diagnostics Using Targeted RNA Next-Generation Sequencing Technology

scientific article published on 04 June 2019

MammaPrint molecular diagnostics on formalin-fixed, paraffin-embedded tissue

scientific article published on 28 December 2013

Mammosphere-derived gene set predicts outcome in patients with ER-positive breast cancer

scientific article published on July 2009

Mapping phospho-catalytic dependencies of therapy-resistant tumours reveals actionable vulnerabilities

scientific article published on 03 June 2019

Mechanism of action biomarkers predicting response to AKT inhibition in the I-SPY 2 breast cancer trial

scientific article published on 02 October 2020

Metastatic potential of T1 breast cancer can be predicted by the 70-gene MammaPrint signature

scientific article published on 22 January 2010

MicroRNA related polymorphisms and breast cancer risk

scientific article

Missense variants in ATM in 26,101 breast cancer cases and 29,842 controls

scientific article

Mobile DNA in cancer. Extensive transduction of nonrepetitive DNA mediated by L1 retrotransposition in cancer genomes

scientific article

Molecular Portraits and 70-Gene Prognosis Signature Are Preserved throughout the Metastatic Process of Breast Cancer

article

Molecular classification of breast carcinomas by comparative genomic hybridization: a specific somatic genetic profile for BRCA1 tumors

scientific article published on 01 December 2002

Multi-gene panel testing for hereditary cancer predisposition in unsolved high-risk breast and ovarian cancer patients

scientific article

Multiplatform analysis of 12 cancer types reveals molecular classification within and across tissues of origin

scientific article

New Horizons in Advocacy Engaged Physical Sciences and Oncology Research.

scientific article published on 15 March 2018

No clinical utility of KRAS variant rs61764370 for ovarian or breast cancer.

scientific article published in May 2015

No effect of red clover-derived isoflavone intervention on the insulin-like growth factor system in women at increased risk of colorectal cancer

scientific article published on October 2008

PIK3CA Mutations Predict Local Recurrences in Rectal Cancer Patients

scientific article published on 10 November 2009

PKA-induced phosphorylation of ERα at serine 305 and high PAK1 levels is associated with sensitivity to tamoxifen in ER-positive breast cancer

scientific article

PRoBE the cloud toolkit: finding the best biomarkers of drug response within a breast cancer clinical trial

scientific article

Pathologic complete response predicts recurrence-free survival more effectively by cancer subset: results from the I-SPY 1 TRIAL--CALGB 150007/150012, ACRIN 6657.

scientific article

Performance characteristics of the MammaPrint®breast cancer diagnostic gene signature

article

Physical activity and the risk of breast cancer in BRCA1/2 mutation carriers

scientific article published on 13 August 2009

Potential for bias in studies on efficacy of prophylactic surgery for BRCA1 and BRCA2 mutation

scientific article

Prediction and clinical utility of a contralateral breast cancer risk model

scientific article published on 17 December 2019

Prediction of contralateral breast cancer: external validation of risk calculators in 20 international cohorts

scientific article published on 11 April 2020

Presence of ATM protein and residual kinase activity correlates with the phenotype in ataxia-telangiectasia: a genotype-phenotype study

scientific article published on 25 January 2012

Prognostic Impact of Breast-Conserving Therapy Versus Mastectomy of BRCA1/2 Mutation Carriers Compared With Noncarriers in a Consecutive Series of Young Breast Cancer Patients

scientific article published on 01 August 2019

Prognostic Value of MammaPrint® in Invasive Lobular Breast Cancer

scientific article published on 11 December 2016

Publisher Correction: Evidence that breast cancer risk at the 2q35 locus is mediated through IGFBP5 regulation.

scientific article published on 10 April 2018

Recent advances in metastasis research

scientific article published on February 2008

Regulatory aspects of genetic research with residual human tissue: effective and efficient data coding

scientific article

Reliable and effective diagnostics are keys to accelerating personalized cancer medicine and transforming cancer care: a policy statement from the american association for cancer research

scientific article published on 09 September 2014

Road map to metastasis

scientific article published on 01 August 2003

Robust interlaboratory reproducibility of a gene expression signature measurement consistent with the needs of a new generation of diagnostic tools

scientific article

Robustness, scalability, and integration of a wound-response gene expression signature in predicting breast cancer survival

scientific article

Serial expression analysis of breast tumors during neoadjuvant chemotherapy reveals changes in cell cycle and immune pathways associated with recurrence and response

scientific article published on 29 May 2015

Somatic mutations reveal asymmetric cellular dynamics in the early human embryo

scientific article

Specific genomic aberrations in primary colorectal cancer are associated with liver metastases

scientific article

Standard Anthracycline Based Versus Docetaxel-Capecitabine in Early High Clinical and/or Genomic Risk Breast Cancer in the EORTC 10041/BIG 3-04 MINDACT Phase III Trial

scientific article published on 21 February 2020

Synchronous Detection of Circulating Tumor Cells in Blood and Disseminated Tumor Cells in Bone Marrow Predicts Adverse Outcome in Early Breast Cancer

scientific article published on 29 May 2019

TP53 germline mutation testing in 180 families suspected of Li-Fraumeni syndrome: mutation detection rate and relative frequency of cancers in different familial phenotypes

scientific article published on 01 June 2010

Tamoxifen therapy benefit for patients with 70-gene signature high and low risk

scientific article

Targetable mechanisms driving immunoevasion of persistent senescent cells link chemotherapy-resistant cancer to aging

scientific article published on 11 June 2019

Ten-year follow-up of the observational RASTER study, prospective evaluation of the 70-gene signature in ER-positive, HER2-negative, node-negative, early breast cancer

scholarly article

The 70-gene prognosis-signature predicts disease outcome in breast cancer patients with 1–3 positive lymph nodes in an independent validation study

article

The 70-gene signature as a response predictor for neoadjuvant chemotherapy in breast cancer

scientific article published on 13 February 2009

The Athena Breast Health Network: developing a rapid learning system in breast cancer prevention, screening, treatment, and care.

scientific article published on 26 July 2013

The BRCA1ness signature is associated significantly with response to PARP inhibitor treatment versus control in the I-SPY 2 randomized neoadjuvant setting.

scientific article published on 25 August 2017

The MINDACT trial: the first prospective clinical validation of a genomic tool

scientific article (publication date: December 2007)

The Neoadjuvant Model Is Still the Future for Drug Development in Breast Cancer

scientific article published on 24 February 2015

The San Francisco Cancer Initiative: A Community Effort To Reduce The Population Burden Of Cancer

scientific article published in January 2018

The insulin-like growth factor system in cancer prevention: potential of dietary intervention strategies.

scientific article

The predictive value of the 70-gene signature for adjuvant chemotherapy in early breast cancer.

scientific article

The role of genetic breast cancer susceptibility variants as prognostic factors

scientific article

The single-nucleotide polymorphism 309 in the MDM2 gene contributes to the Li-Fraumeni syndrome and related phenotypes

scientific article published on 27 September 2006

Tumor Drug Penetration Measurements Could Be the Neglected Piece of the Personalized Cancer Treatment Puzzle

scientific article published on 06 October 2018

Use of 70-gene signature to predict prognosis of patients with node-negative breast cancer: a prospective community-based feasibility study (RASTER).

scientific article published on 26 November 2007

Use of Molecular Tools to Identify Patients With Indolent Breast Cancers With Ultralow Risk Over 2 Decades.

scientific article published on 29 June 2017

Validation and clinical utility of a 70-gene prognostic signature for women with node-negative breast cancer

scientific article

Worse breast cancer prognosis of BRCA1/BRCA2 mutation carriers: what's the evidence? A systematic review with meta-analysis

scientific article

Paulina is supported by:

About Paulina

Help