Search filters

List of works by René Bernards

70-Gene Signature as an Aid to Treatment Decisions in Early-Stage Breast Cancer

scientific article

A CRISPR screen identifies CDK7 as a therapeutic target in hepatocellular carcinoma.

scientific article published on 5 March 2018

A Missing Link in Genotype-Directed Cancer Therapy ⬇️

scientific article published on October 26, 2012

A RNA interference screen identifies the protein phosphatase 2A subunit PR55gamma as a stress-sensitive inhibitor of c-SRC

scientific article

A Vulnerability of a Subset of Colon Cancers with Potential Clinical Utility

scientific article published in April 2016

A causal role for the human tumor antigen preferentially expressed antigen of melanoma in cancer

scientific article published on November 2006

A cell proliferation signature is a marker of extremely poor outcome in a subpopulation of breast cancer patients

scientific article

A chromatin modifier genetic screen identifies SIRT2 as a modulator of response to targeted therapies through the regulation of MEK kinase activity

scientific article published on 27 January 2014

A combined oncogenic pathway signature of BRAF, KRAS and PI3KCA mutation improves colorectal cancer classification and cetuximab treatment prediction

scientific article published on 14 July 2012

A diagnostic gene profile for molecular subtyping of breast cancer associated with treatment response

scientific article

A functional approach to questions about life, death, and phosphorylation

scientific article published in June 2005

A functional genetic approach identifies the PI3K pathway as a major determinant of trastuzumab resistance in breast cancer

scientific article

A functional genetic screen identifies TFE3 as a gene that confers resistance to the anti-proliferative effects of the retinoblastoma protein and transforming growth factor-beta.

scientific article published on 31 May 2006

A functional genetic screen identifies retinoic acid signaling as a target of histone deacetylase inhibitors

scholarly article

A functional screen identifies hDRIL1 as an oncogene that rescues RAS-induced senescence

scientific article

A functionally distinct member of the DP family of E2F subunits

scientific article published on 01 May 2006

A gene signature for late distant metastasis in breast cancer identifies a potential mechanism of late recurrences

scientific article published on 17 July 2013

A gene-expression signature as a predictor of survival in breast cancer

scientific article (publication date: 19 December 2002)

A genetic screen identifies PITX1 as a suppressor of RAS activity and tumorigenicity

scientific article

A genomic and functional inventory of deubiquitinating enzymes

scientific article

A large scale shRNA barcode screen identifies the circadian clock component ARNTL as putative regulator of the p53 tumor suppressor pathway

scientific article

A large-scale RNAi screen in human cells identifies new components of the p53 pathway

scientific article

A powerful drug combination strategy targeting glutamine addiction for the treatment of human liver cancer

scientific article published on 05 October 2020

A price to pay for tumor regression

scientific article published on 21 April 2015

A progression puzzle

scientific article

A regression model for estimating DNA copy number applied to capture sequencing data

scientific article

A robust genomic signature for the detection of colorectal cancer patients with microsatellite instability phenotype and high mutation frequency

scientific article

A senescence rescue screen identifies BCL6 as an inhibitor of anti-proliferative p19(ARF)-p53 signaling

scientific article

A system for stable expression of short interfering RNAs in mammalian cells

scientific article (publication date: 19 April 2002)

ARID1A mutation sensitizes most ovarian clear cell carcinomas to BET inhibitors

scientific article published on 15 May 2018

Adenovirus: transformation and oncogenicity

scientific article published on December 1984

Allelic expression imbalance of PIK3CA mutations is frequent in breast cancer and prognostically significant

scientific article published on 08 June 2022

Amino-terminal domains of c-myc and N-myc proteins mediate binding to the retinoblastoma gene product

scientific article published on August 1991

An evaluation of the efficacy of topical application of salicylic acid for the treatment of familial cylindromatosis

scientific article

An in vivo functional genetic screen reveals a role for the TRK-T3 oncogene in tumor progression

scientific article published in June 2004

An integrated genomic approach identifies that the PI3K/AKT/FOXO pathway is involved in breast cancer tumor initiation

scientific article published on 22 November 2015

An integrative genomic and proteomic analysis of PIK3CA, PTEN, and AKT mutations in breast cancer

scientific article published on August 2008

An shRNA barcode screen provides insight into cancer cell vulnerability to MDM2 inhibitors

scientific article published on 13 February 2006

An α-E-catenin (CTNNA1) mutation in hereditary diffuse gastric cancer.

scientific article published in March 2013

Analysis of the MammaPrint breast cancer assay in a predominantly postmenopausal cohort

scientific article

Anti-cancer therapy: senescence is the new black

scientific article published on 18 April 2018

Assessment of PD-L1 expression across breast cancer molecular subtypes, in relation to mutation rate, BRCA1-like status, tumor-infiltrating immune cells and survival

scientific article published on 11 September 2018

B-myb rescues ras-induced premature senescence, which requires its transactivation domain

scientific article published on September 2001

BRCA1-like signature in triple negative breast cancer: Molecular and clinical characterization reveals subgroups with therapeutic potential

scientific article

Biological functions of the genes in the mammaprint breast cancer profile reflect the hallmarks of cancer.

scientific article published on 28 November 2010

CDK-independent activation of estrogen receptor by cyclin D1

scientific article

CDK-independent activities of D type cyclins

scientific article

CDK12 inhibition mediates DNA damage and is synergistic with sorafenib treatment in hepatocellular carcinoma

scientific article published on 13 September 2019

CRISPR knockout screening outperforms shRNA and CRISPRi in identifying essential genes.

scientific article published on 25 April 2016

Cancer of the esophagus and gastric cardia: recent advances

scientific article published on January 2004

Cancer: Entangled pathways

scientific article published in September 2008

Candidate biomarkers of response to an experimental cancer drug identified through a large-scale RNA interference genetic screen

scientific article published in September 2009

Cell cycle regulation by the retinoblastoma family of growth inhibitory proteins

scientific article published on June 1996

Chairperson's Introduction

Colorectal cancer intrinsic subtypes predict chemotherapy benefit, deficient mismatch repair and epithelial-to-mesenchymal transition

scientific article

Communication between the extracellular environment, cytoplasmic signalling cascades and the nuclear cell-cycle machinery

scientific article published on June 1997

Constitutive E2F1 overexpression delays endochondral bone formation by inhibiting chondrocyte differentiation

scientific article

Convergence of mitogenic and DNA damage signaling in the G1 phase of the cell cycle

scientific article

Converting a breast cancer microarray signature into a high-throughput diagnostic test.

scientific article

Correction for Bernards et al., Structure and Expression of the Murine Retinoblastoma Gene and Characterization of its Encoded Protein, PNAS 1989 86:6474-6478

scholarly article

Crystal structure of murine/human Ubc9 provides insight into the variability of the ubiquitin-conjugating system

scientific article

Cues for migration

scientific article published in Nature

Cycling in Switzerland

scientific article

DNA-Guided Precision Medicine for Cancer: A Case of Irrational Exuberance?

article published in 2016

Deoxycytidine kinase is overexpressed in poor outcome breast cancer and determines responsiveness to nucleoside analogs

scientific article published on 5 April 2011

E2F transcriptional repressor complexes are critical downstream targets of p19(ARF)/p53-induced proliferative arrest

scientific article published on July 2002

E2F-7: a distinctive E2F family member with an unusual organization of DNA-binding domains

scientific article

E2F: a nodal point in cell cycle regulation ⬇️

scientific article published on December 9, 1997

ERBB2 Mutations Characterize a Subgroup of Muscle-invasive Bladder Cancers with Excellent Response to Neoadjuvant Chemotherapy

scientific article published on 27 January 2015

Elongation factor ELOF1 drives transcription-coupled repair and prevents genome instability

scientific article published on 09 June 2021

Enabling personalized cancer medicine through analysis of gene-expression patterns

scientific article published on April 2008

Equivalence of MammaPrint array types in clinical trials and diagnostics

scientific article

Erratum: Ras signalling linked to the cell-cycle machinery by the retinoblastoma protein

scientific article published in Nature

Escape from premature senescence is not sufficient for oncogenic transformation by Ras.

scientific article

Estrogen receptor splice variants as a potential source of false-positive estrogen receptor status in breast cancer diagnostics

scientific article published on 04 August 2013

Estrogen receptor variants in ER-positive basal-type breast cancers responding to therapy like ER-negative breast cancers

scientific article published on 18 April 2019

Exploring liver cancer biology through functional genetic screens

scientific article published in 2021

Exploring the uses of RNAi--gene knockdown and the Nobel Prize

scientific article published in December 2006

Expression of class I major histocompatibility antigens switched off by highly oncogenic adenovirus 12 in transformed rat cells

scientific article

Expression profiling predicts outcome in breast cancer

scientific article

FGFR1 Is a Potential Prognostic Biomarker and Therapeutic Target in Head and Neck Squamous Cell Carcinoma

scientific article published on 02 March 2016

Feedback and redundancy in receptor tyrosine kinase signaling: relevance to cancer therapies

scientific article

Fighting Drug Resistance through the Targeting of Drug-Tolerant Persister Cells

scientific article published in 2021

Finding biomarkers of resistance to targeted cancer therapies

Finding effective cancer therapies through loss of function genetic screens

scientific article published on 20 December 2013

Functional Subtyping of Breast Cancer

Functional analysis of Burkitt's lymphoma mutant c-Myc proteins

scientific article

Functional annotation of deubiquitinating enzymes using RNA interference

scientific article

Functional identification of LRF as an oncogene that bypasses RASV12-induced senescence via upregulation of CYCLIN E.

scientific article

Functional interaction between a novel protein phosphatase 2A regulatory subunit, PR59, and the retinoblastoma-related p107 protein

scientific article

Gene expression profiling in follicular lymphoma to assess clinical aggressiveness and to guide the choice of treatment

scientific article published on 2 September 2004

Gene expression profiling predicts clinical outcome of breast cancer

scientific article (publication date: 31 January 2002)

Genetic and functional studies implicate synaptic overgrowth and ring gland cAMP/PKA signaling defects in the Drosophila melanogaster neurofibromatosis-1 growth deficiency

scientific article

Genome-wide loss-of-function screen reveals an important role for the proteasome in HDAC inhibitor-induced apoptosis

scientific article

High incidence of thymic epithelial tumors in E2F2 transgenic mice

scientific article published on 18 December 2003

Human immunodeficiency virus type 1 escapes from RNA interference-mediated inhibition

scientific article published on March 2004

Hurdles on the road to personalized medicine

scientific article published on 30 August 2014

Identification of F-box only protein 7 as a negative regulator of NF-kappaB signalling.

scientific article

Identification of recurrent FGFR3 fusion genes in lung cancer through kinome-centred RNA sequencing

scientific article

Inhibition of the PI3K pathway: hope we can believe in?

scientific article published on 16 April 2010

Integration of genomic, transcriptomic and proteomic data identifies two biologically distinct subtypes of invasive lobular breast cancer

scientific article

Interleukin-1R-associated kinase 2 is a novel modulator of the transforming growth factor beta signaling cascade

scientific article

Intrinsic resistance to MEK inhibition in KRAS mutant lung and colon cancer through transcriptional induction of ERBB3.

scientific article

Intrinsic resistance to PIM kinase inhibition in AML through p38α-mediated feedback activation of mTOR signaling

scientific article published on 05 June 2016

Involvement of MINK, a Ste20 family kinase, in Ras oncogene-induced growth arrest in human ovarian surface epithelial cells

scientific article published in December 2005

It's Diagnostics, Stupid

Long-term impact of the 70-gene signature on breast cancer outcome

scientific article published on 21 January 2014

Loss of ARID1A Activates ANXA1, which Serves as a Predictive Biomarker for Trastuzumab Resistance.

scientific article

Loss of p53 induces cell proliferation via Ras-independent activation of the Raf/Mek/Erk signaling pathway

scientific article

Loss of the cylindromatosis tumour suppressor inhibits apoptosis by activating NF-kappaB

scientific article (publication date: 14 August 2003)

Loss-of-function genetic screens as a tool to improve the diagnosis and treatment of cancer

scientific article published on 21 September 2009

MAP3K1 and MAP2K4 mutations are associated with sensitivity to MEK inhibitors in multiple cancer models.

scientific article published on 24 May 2018

MED12 controls the response to multiple cancer drugs through regulation of TGF-β receptor signaling

scientific article

Mapping phospho-catalytic dependencies of therapy-resistant tumours reveals actionable vulnerabilities

scientific article published on 03 June 2019

Mastermind-Like 3 Controls Proliferation and Differentiation in Neuroblastoma

scientific article published on 19 January 2016

Minimizing the risk of reporting false positives in large-scale RNAi screens

article

Miz1 and HectH9 regulate the stability of the checkpoint protein, TopBP1

scientific article

Molecular Landscape of Acquired Resistance to Targeted Therapy Combinations in BRAF-Mutant Colorectal Cancer

scientific article published on 16 June 2016

Molecular basis of the anti-cancer effects of histone deacetylase inhibitors

scientific article published on 12 August 2008

Multiple low dose therapy as an effective strategy to treat EGFR inhibitor-resistant NSCLC tumours

scientific article published on 22 June 2020

NF-κB drives acquired resistance to a novel mutant-selective EGFR inhibitor

scientific article published on 29 April 2015

NF1 is a tumor suppressor in neuroblastoma that determines retinoic acid response and disease outcome

scientific article

Next generation sequencing of triple negative breast cancer to find predictors for chemotherapy response

scientific article

Opportunities and challenges provided by crosstalk between signalling pathways in cancer

scientific article published on 18 May 2015

PIK3CA mutations are associated with decreased benefit to neoadjuvant human epidermal growth factor receptor 2-targeted therapies in breast cancer

scientific article published on 05 January 2015

PIK3CA mutations are associated with reduced pathological complete response rates in primary HER2-positive breast cancer: pooled analysis of 967 patients from five prospective trials investigating lapatinib and trastuzumab.

scientific article

PR130 is a modulator of the Wnt-signaling cascade that counters repression of the antagonist Naked cuticle

scientific article

PR72, a novel regulator of Wnt signaling required for Naked cuticle function

scientific article

PRAME expression and clinical outcome of breast cancer

scientific article published on 22 July 2008

PTPN11 Is a Central Node in Intrinsic and Acquired Resistance to Targeted Cancer Drugs

scientific article published on 9 September 2015

Performance characteristics of the MammaPrint®breast cancer diagnostic gene signature

article

Phosphatidylinositol 3-kinase hyperactivation results in lapatinib resistance that is reversed by the mTOR/phosphatidylinositol 3-kinase inhibitor NVP-BEZ235.

scientific article published on November 2008

Plasminogen activator inhibitor-1 is a critical downstream target of p53 in the induction of replicative senescence

scientific article

Protein phosphatase 2A regulatory subunits and cancer.

scientific article published on 03 June 2008

RAF suppression synergizes with MEK inhibition in KRAS mutant cancer cells

scientific article

RNAi Delivers Insights into Liver Cancer

scientific article published in November 2008

Radical Sabbaticals

scientific article published on 01 November 2015

Rapid dephosphorylation of p107 following UV irradiation.

scientific article published on January 1999

Ras signalling linked to the cell-cycle machinery by the retinoblastoma protein

scientific article

Re-evaluating cell-cycle regulation by E2Fs

scientific article published in December 2006

Reaction to American Society of Clinical Oncology 2007 Update of Recommendations for the Use of Tumor Markers in Breast Cancer

article published in 2008

Reduced NF1 expression confers resistance to EGFR inhibition in lung cancer

scientific article

Regulation of monoubiquitinated PCNA by DUB autocleavage

scientific journal article

Reply to Eliezer M. Van Allen, Levi A. Garraway and Jonathan E. Rosenberg's Letter to the Editor re: Floris H. Groenendijk, Jeroen de Jong, Elisabeth E. Fransen van de Putte, et al. ERBB2 Mutations Characterize a Subgroup of Muscle-invasive Bladder C

article published in 2015

Reversal of senescence in mouse fibroblasts through lentiviral suppression of p53.

scientific article published on 27 January 2003

Reversible and adaptive resistance to BRAF(V600E) inhibition in melanoma

scientific article

SHP2 is required for growth of KRAS-mutant non-small-cell lung cancer in vivo.

scientific article

SMARCE1 suppresses EGFR expression and controls responses to MET and ALK inhibitors in lung cancer

scientific article

Stable suppression of tumorigenicity by virus-mediated RNA interference

scientific article published in September 2002

Suppression of the p53-dependent replicative senescence response by lysophosphatidic acid signaling

scientific article

Systematic discovery of mutation-specific synthetic lethals by mining pan-cancer human primary tumor data.

scientific article

TBX-3, the gene mutated in Ulnar-Mammary Syndrome, is a negative regulator of p19ARF and inhibits senescence

scientific article

TGF-β: an emerging player in drug resistance

scientific article published on 12 August 2013

TSPYL5 suppresses p53 levels and function by physical interaction with USP7

scientific article

Taming the dragon: genomic biomarkers to individualize the treatment of cancer.

scientific article published on March 2011

Targeting the RB-E2F pathway in breast cancer

scientific article

Targeting the epigenome for treatment of cancer

scientific article published on 5 December 2011

The KLF4 tumour suppressor is a transcriptional repressor of p53 that acts as a context-dependent oncogene

scientific article

The NuRD complex cooperates with DNMTs to maintain silencing of key colorectal tumor suppressor genes

scientific article published on 27 May 2013

The cocaine- and amphetamine-regulated transcript mediates ligand-independent activation of ERα, and is an independent prognostic factor in node-negative breast cancer.

scientific article

The consensus molecular subtypes of colorectal cancer

scientific article

The corepressor CTBP2 is a coactivator of retinoic acid receptor/retinoid X receptor in retinoic acid signaling

scientific article

The deubiquitinating enzyme USP1 regulates the Fanconi anemia pathway

scientific article (publication date: 4 February 2005)

The deubiquitinating enzyme USP26 is a regulator of androgen receptor signaling

scientific article

The histone demethylase Jarid1b (Kdm5b) is a novel component of the Rb pathway and associates with E2f-target genes in MEFs during senescence

scientific article

The human tumor antigen PRAME is a dominant repressor of retinoic acid receptor signaling

scientific article

The translation initiation factor 3f (eIF3f) exhibits a deubiquitinase activity regulating Notch activation

scientific article

The ubiquitin-specific protease USP28 is required for MYC stability

scientific article

Transforming growth factor-beta requires its target plasminogen activator inhibitor-1 for cytostatic activity

scientific article

Treatment Individualization in Colorectal Cancer

scientific article

Tumorigenicity of cells transformed by adenovirus type 12 by evasion of T-cell immunity

scientific article published in Nature

Twenty-second annual Pezcoller Symposium: RNA biology and cancer

scientific article published in December 2010

Two E2F sites control growth-regulated and cell cycle-regulated transcription of the Htf9-a/RanBP1 gene through functionally distinct mechanisms.

scientific article published on April 1999

UNC45A confers resistance to histone deacetylase inhibitors and retinoic acid

scientific article published on 20 October 2009

USP15 stabilizes TGF-β receptor I and promotes oncogenesis through the activation of TGF-β signaling in glioblastoma

scientific article

USP9X downregulation renders breast cancer cells resistant to tamoxifen

scientific article

Understanding resistance to targeted cancer drugs through loss of function genetic screens

scientific article published on October 2012

Unlikely Suspects Identified in Neuroblastoma Conspiracy

Unresponsiveness of colon cancer to BRAF(V600E) inhibition through feedback activation of EGFR.

scientific article

Using functional genetics to understand breast cancer biology

scientific article

Vorinostat combined with bexarotene for treatment of cutaneous T-cell lymphoma: in vitro and phase I clinical evidence supporting augmentation of retinoic acid receptor/retinoid X receptor activation by histone deacetylase inhibition

scientific article

Wip-ing out cancer

scientific article

With great power comes great vulnerability

scientific article published on 09 October 2018

ZNF423 is critically required for retinoic acid-induced differentiation and is a marker of neuroblastoma outcome

scientific article

c-Myc/Max heterodimers bind cooperatively to the E-box sequences located in the first intron of the rat ornithine decarboxylase (ODC) gene

scientific article published on April 1997

mUBC9, a novel adenovirus E1A-interacting protein that complements a yeast cell cycle defect

scientific article

phospho-ERK is a response biomarker to a combination of sorafenib and MEK inhibition in liver cancer

shRNA libraries and their use in cancer genetics

scientific article published in September 2006

Paulina is supported by:

About Paulina

Help