List of works - Geert Kops

A phospho/methyl switch at histone H3 regulates TFIID association with mitotic chromosomes.

scientific article

A role for Aurora C in the chromosomal passenger complex during human preimplantation embryo development

scientific article published on 14 April 2011

AFX-like Forkhead transcription factors mediate cell-cycle regulation by Ras and PKB through p27kip1

scientific article

Altered gene expression in drug-resistant human breast cancer cells.

scientific article published in December 1997

Attachment issues: kinetochore transformations and spindle checkpoint silencing.

scientific article published on 2 March 2016

Aurora B potentiates Mps1 activation to ensure rapid checkpoint establishment at the onset of mitosis. ⬇️

scientific article published on January 2011

CELL DIVISION CYCLE. Competition between MPS1 and microtubules at kinetochores regulates spindle checkpoint signaling.

scientific article published on 11 June 2015

Cell cycle and death control: long live Forkheads

scientific journal article

Cell cycle inhibition by FoxO forkhead transcription factors involves downregulation of cyclin D.

scientific article published on November 2002

Cell division: SACing the anaphase problem.

scientific article published in March 2014

Centromere-associated protein-E is essential for the mammalian mitotic checkpoint to prevent aneuploidy due to single chromosome loss

scientific article

Chromosomal copy number heterogeneity predicts survival rates across cancers

scientific article published on 27 May 2021

Chromosomal instability by mutations in the novel minor spliceosome component CENATAC

scientific article published on 19 May 2021

Collateral Genome Instability by DNA Damage in Mitosis

scientific article published on 01 November 2014

Connecting up and clearing out: how kinetochore attachment silences the spindle assembly checkpoint.

scientific article published on 11 July 2012

Control of cell cycle exit and entry by protein kinase B-regulated forkhead transcription factors

scientific article

Crystal structure of a PP2A B56-BubR1 complex and its implications for PP2A substrate recruitment and localization

scientific article published on 28 June 2016

Cyclin B1 scaffolds MAD1 at the kinetochore corona to activate the mitotic checkpoint

scientific article published on 23 March 2020

Degree and site of chromosomal instability define its oncogenic potential

scientific article published on 20 March 2020

Difference Makers: Chromosomal Instability versus Aneuploidy in Cancer.

scientific article published on 24 September 2016

Direct control of the Forkhead transcription factor AFX by protein kinase B

scientific article

Dynamic Kinetochore Size Regulation Promotes Microtubule Capture And Chromosome Biorientation In Mitosis

Dynamic kinetochore size regulation promotes microtubule capture and chromosome biorientation in mitosis

scientific article published on 18 June 2018

Elevating the frequency of chromosome mis-segregation as a strategy to kill tumor cells.

scientific article published on 23 October 2009

Evolutionary dynamics of the kinetochore network in eukaryotes as revealed by comparative genomics.

scientific article published on 22 June 2017

Finding the middle ground: how kinetochores power chromosome congression.

scientific article

Forkhead transcription factor FOXO3a protects quiescent cells from oxidative stress

scientific article (publication date: 19 September 2002)

Forkhead transcription factors: new insights into protein kinase B (c-akt) signaling.

scientific article

Human chromosome-specific aneuploidy is influenced by DNA-dependent centromeric features

scientific article published on 21 November 2019

Inhibition of nuclear import by protein kinase B (Akt) regulates the subcellular distribution and activity of the forkhead transcription factor AFX.

scientific article

Inhibition of the spindle assembly checkpoint kinase TTK enhances the efficacy of docetaxel in a triple-negative breast cancer model

scientific article published on 7 July 2015

Interactions between N-terminal modules in MPS1 enable spindle checkpoint silencing

Joined at the hip: kinetochores, microtubules, and spindle assembly checkpoint signaling

scientific article published on 11 September 2014

Kinetochore Malfunction in Human Pathologies

scientific article published on January 2017

Kinetochore-microtubule attachment is sufficient to satisfy the human spindle assembly checkpoint

scientific article

Leader of the SAC: molecular mechanisms of Mps1/TTK regulation in mitosis

scientific article published on 01 August 2018

Lethality to human cancer cells through massive chromosome loss by inhibition of the mitotic checkpoint.

scientific article

Live imaging of cell division in 3D stem-cell organoid cultures

article

Molecular causes for BUBR1 dysfunction in the human cancer predisposition syndrome mosaic variegated aneuploidy.

scientific article published on June 2010

Mps1 phosphorylates Borealin to control Aurora B activity and chromosome alignment

scientific article

Negative feedback at kinetochores underlies a responsive spindle checkpoint signal.

scientific article

On the road to cancer: aneuploidy and the mitotic checkpoint

scientific article (publication date: October 2005)

Ongoing chromosomal instability and karyotype evolution in human colorectal cancer organoids

scientific article published on 29 April 2019

Phylogenomics-guided discovery of a novel conserved cassette of short linear motifs in BubR1 essential for the spindle checkpoint

Phylogenomics-guided discovery of a novel conserved cassette of short linear motifs in BubR1 essential for the spindle checkpoint.

scientific article published on December 2016

Preventing aneuploidy: the contribution of mitotic checkpoint proteins.

scientific article published on 22 April 2008

Reconstructing single-cell karyotype alterations in colorectal cancer identifies punctuated and gradual diversification patterns

scientific article published on 01 July 2021

Regulation of sterol carrier protein gene expression by the forkhead transcription factor FOXO3a

scientific article (publication date: 2004)

Release of Mps1 from kinetochores is crucial for timely anaphase onset.

scientific article published on 11 October 2010

Sequential cancer mutations in cultured human intestinal stem cells.

scientific article published on 29 April 2015

Spindle checkpoint silencing at kinetochores with submaximal microtubule occupancy

scientific article published on 17 June 2019

Studying Kinetochore Kinases.

scientific article published in January 2016

Survivin is required for a sustained spindle checkpoint arrest in response to lack of tension

scientific article

Targeting the mitotic checkpoint to kill tumor cells

scientific article published on 17 December 2010

The forkhead transcription factor FoxO regulates transcription of p27Kip1 and Bim in response to IL-2

scientific article (publication date: 15 May 2002)

The vertebrate mitotic checkpoint protein BUBR1 is an unusual pseudokinase.

scientific article published in June 2012

Towards elucidating the stability, dynamics and architecture of the nucleosome remodeling and deacetylase complex by using quantitative interaction proteomics

scientific article

Unique Phylogenetic Distributions of the Ska and Dam1 Complexes Support Functional Analogy and Suggest Multiple Parallel Displacements of Ska by Dam1.

scientific article published on 4 May 2017

Virus-delivered small RNA silencing sustains strength in amyotrophic lateral sclerosis

scientific article

Widespread Recurrent Patterns of Rapid Repeat Evolution in the Kinetochore Scaffold KNL1.

scientific article published on 8 August 2015

ZW10 links mitotic checkpoint signaling to the structural kinetochore.

scientific article

List of works by Geert Kops

A phospho/methyl switch at histone H3 regulates TFIID association with mitotic chromosomes.

A role for Aurora C in the chromosomal passenger complex during human preimplantation embryo development

AFX-like Forkhead transcription factors mediate cell-cycle regulation by Ras and PKB through p27kip1

Altered gene expression in drug-resistant human breast cancer cells.

Attachment issues: kinetochore transformations and spindle checkpoint silencing.

Aurora B potentiates Mps1 activation to ensure rapid checkpoint establishment at the onset of mitosis. ⬇️

CELL DIVISION CYCLE. Competition between MPS1 and microtubules at kinetochores regulates spindle checkpoint signaling.

Cell cycle and death control: long live Forkheads

Cell cycle inhibition by FoxO forkhead transcription factors involves downregulation of cyclin D.

Cell division: SACing the anaphase problem.

Centromere-associated protein-E is essential for the mammalian mitotic checkpoint to prevent aneuploidy due to single chromosome loss

Chromosomal copy number heterogeneity predicts survival rates across cancers

Chromosomal instability by mutations in the novel minor spliceosome component CENATAC

Collateral Genome Instability by DNA Damage in Mitosis

Connecting up and clearing out: how kinetochore attachment silences the spindle assembly checkpoint.

Control of cell cycle exit and entry by protein kinase B-regulated forkhead transcription factors

Crystal structure of a PP2A B56-BubR1 complex and its implications for PP2A substrate recruitment and localization

Cyclin B1 scaffolds MAD1 at the kinetochore corona to activate the mitotic checkpoint

Degree and site of chromosomal instability define its oncogenic potential

Difference Makers: Chromosomal Instability versus Aneuploidy in Cancer.

Direct control of the Forkhead transcription factor AFX by protein kinase B

Dynamic Kinetochore Size Regulation Promotes Microtubule Capture And Chromosome Biorientation In Mitosis

Dynamic kinetochore size regulation promotes microtubule capture and chromosome biorientation in mitosis

Elevating the frequency of chromosome mis-segregation as a strategy to kill tumor cells.

Evolutionary dynamics of the kinetochore network in eukaryotes as revealed by comparative genomics.

Finding the middle ground: how kinetochores power chromosome congression.

Forkhead transcription factor FOXO3a protects quiescent cells from oxidative stress

Forkhead transcription factors: new insights into protein kinase B (c-akt) signaling.

Human chromosome-specific aneuploidy is influenced by DNA-dependent centromeric features

Inhibition of nuclear import by protein kinase B (Akt) regulates the subcellular distribution and activity of the forkhead transcription factor AFX.

Inhibition of the spindle assembly checkpoint kinase TTK enhances the efficacy of docetaxel in a triple-negative breast cancer model

Interactions between N-terminal modules in MPS1 enable spindle checkpoint silencing

Joined at the hip: kinetochores, microtubules, and spindle assembly checkpoint signaling

Kinetochore Malfunction in Human Pathologies

Kinetochore-microtubule attachment is sufficient to satisfy the human spindle assembly checkpoint

Leader of the SAC: molecular mechanisms of Mps1/TTK regulation in mitosis

Lethality to human cancer cells through massive chromosome loss by inhibition of the mitotic checkpoint.

Live imaging of cell division in 3D stem-cell organoid cultures

Molecular causes for BUBR1 dysfunction in the human cancer predisposition syndrome mosaic variegated aneuploidy.

Mps1 phosphorylates Borealin to control Aurora B activity and chromosome alignment

Negative feedback at kinetochores underlies a responsive spindle checkpoint signal.

On the road to cancer: aneuploidy and the mitotic checkpoint

Ongoing chromosomal instability and karyotype evolution in human colorectal cancer organoids

Phylogenomics-guided discovery of a novel conserved cassette of short linear motifs in BubR1 essential for the spindle checkpoint

Phylogenomics-guided discovery of a novel conserved cassette of short linear motifs in BubR1 essential for the spindle checkpoint.

Preventing aneuploidy: the contribution of mitotic checkpoint proteins.

Reconstructing single-cell karyotype alterations in colorectal cancer identifies punctuated and gradual diversification patterns

Regulation of sterol carrier protein gene expression by the forkhead transcription factor FOXO3a

Release of Mps1 from kinetochores is crucial for timely anaphase onset.

Sequential cancer mutations in cultured human intestinal stem cells.

Spindle checkpoint silencing at kinetochores with submaximal microtubule occupancy

Studying Kinetochore Kinases.

Survivin is required for a sustained spindle checkpoint arrest in response to lack of tension

Targeting the mitotic checkpoint to kill tumor cells

The forkhead transcription factor FoxO regulates transcription of p27Kip1 and Bim in response to IL-2

The vertebrate mitotic checkpoint protein BUBR1 is an unusual pseudokinase.

Towards elucidating the stability, dynamics and architecture of the nucleosome remodeling and deacetylase complex by using quantitative interaction proteomics

Unique Phylogenetic Distributions of the Ska and Dam1 Complexes Support Functional Analogy and Suggest Multiple Parallel Displacements of Ska by Dam1.

Virus-delivered small RNA silencing sustains strength in amyotrophic lateral sclerosis

Widespread Recurrent Patterns of Rapid Repeat Evolution in the Kinetochore Scaffold KNL1.

ZW10 links mitotic checkpoint signaling to the structural kinetochore.