List of works by Jukka-Pekka Mecklin

3'-UTR poly(T/U) repeat of EWSR1 is altered in microsatellite unstable colorectal cancer with nearly perfect sensitivity.

scientific article published in May 2015

A comparative pan-genome perspective of niche-adaptable cell-surface protein phenotypes in Lactobacillus rhamnosus.

scientific article

A novel functionally deficient MYH variant in individuals with colorectal adenomatous polyposis.

scientific article published in October 2005

A prospective randomized controlled multicenter trial comparing antibiotic therapy with appendectomy in the treatment of uncomplicated acute appendicitis (APPAC trial).

scientific article

ARLTS1 germline variants and the risk for breast, prostate, and colorectal cancer

scientific article

Allelic Imbalance at rs6983267 Suggests Selection of the Risk Allele in Somatic Colorectal Tumor Evolution

scientific article published on 01 January 2008

Altered Expression of MLH1, MSH2, and MSH6 in Predisposition to Hereditary Nonpolyposis Colorectal Cancer

scientific article published in October 2003

Antibiotic Therapy vs Appendectomy for Treatment of Uncomplicated Acute Appendicitis: The APPAC Randomized Clinical Trial

scientific article published on June 2015

Appendiceal neoplasm risk associated with complicated acute appendicitis-a population based study

scientific article published on 22 September 2018

Association analyses identify 31 new risk loci for colorectal cancer susceptibility

scientific article published on 14 May 2019

Associations of Pathogenic Variants in MLH1, MSH2, and MSH6 With Risk of Colorectal Adenomas and Tumors and With Somatic Mutations in Patients With Lynch Syndrome

scientific article published on 08 January 2020

BMPR1A mutations in hereditary nonpolyposis colorectal cancer without mismatch repair deficiency.

scientific article

BRAF mutation in sporadic colorectal cancer and Lynch syndrome.

scientific article published on 21 August 2013

Background Mutation Frequency in Microsatellite-Unstable Colorectal Cancer

scientific article published on 01 June 2007

Biallelic inactivation of fumarate hydratase (FH) occurs in nonsyndromic uterine leiomyomas but is rare in other tumors

scientific article

Body Weight, Physical Activity, and Risk of Cancer in Lynch Syndrome

scientific article

Breast carcinoma and Lynch syndrome: molecular analysis of tumors arising in mutation carriers, non-carriers, and sporadic cases

scientific article

CTCF/cohesin-binding sites are frequently mutated in cancer

scientific article published on 8 June 2015

Cancer Risk in Hereditary Nonpolyposis Colorectal Cancer Syndrome: Later Age of Onset

Cancer costs and outcomes for common cancer sites in the Finnish population between 2009-2014.

scientific article published on 16 February 2018

Cancer costs and outcomes in the Finnish population 2004-2014.

scientific article published on 11 July 2017

Cancer incidence and survival in Lynch syndrome patients receiving colonoscopic and gynaecological surveillance: first report from the prospective Lynch syndrome database

scientific article published on 9 December 2015

Cancer occurrence during follow-up of the CAPP2 study -aspirin use for up to four years significantly reduces Lynch syndrome cancers for up to several years after completion of therapy.

scientific article published on 25 May 2010

Cancer prevention with aspirin in hereditary colorectal cancer (Lynch syndrome), 10-year follow-up and registry-based 20-year data in the CAPP2 study: a double-blind, randomised, placebo-controlled trial

scientific article published on 01 June 2020

Cancer risk and survival in path_MMR carriers by gene and gender up to 75 years of age: a report from the Prospective Lynch Syndrome Database

scientific article published on 28 July 2017

Cancer risk in hereditary nonpolyposis colorectal cancer syndrome: later age of onset.

scientific article published in August 2005

Cancer risks by gene, age, and gender in 6350 carriers of pathogenic mismatch repair variants: findings from the Prospective Lynch Syndrome Database

scientific article published on 24 July 2019

Candidate driver genes in microsatellite-unstable colorectal cancer

scientific article published on 3 August 2011

Carbonic anhydrase IX is highly expressed in hereditary nonpolyposis colorectal cancer

scientific article published on 01 September 2007

Carcinoma of the Stomach and Its Heredity in Young Patients ⬇️

scientific article published on 01 April 1988

Causes of death of mutation carriers in Finnish Lynch syndrome families

scientific article published on 01 September 2012

Clinical and laboratory findings in the diagnosis of right lower quadrant abdominal pain: outcome analysis of the APPAC trial

scientific article

Colorectal cancer incidence in path_MLH1 carriers subjected to different follow-up protocols: a Prospective Lynch Syndrome Database report

scientific article published on 10 October 2017

Colorectal pretumor progression before and after loss of DNA mismatch repair

scientific article

Colorectal surveillance in Lynch syndrome families.

scientific article published on June 2013

Combination of microsatellite instability and BRAF mutation status for subtyping colorectal cancer

scientific article

Combined prognostic value of CD274 (PD-L1)/PDCDI (PD-1) expression and immune cell infiltration in colorectal cancer as per mismatch repair status

scientific article published on 05 February 2019

Common variation near CDKN1A, POLD3 and SHROOM2 influences colorectal cancer risk

scientific article

Comparison of lifestyle, hormonal and medical factors in women with sporadic and Lynch syndrome-associated endometrial cancer: A retrospective case-case study.

scientific article

Compliance and Satisfaction with Long-Term Surveillance in Finnish HNPCC Families.

scientific article published on January 2006

Comprehensive Evaluation of Protein Coding Mononucleotide Microsatellites in Microsatellite-Unstable Colorectal Cancer

scientific article published on 13 June 2017

Comprehensive characterization of HNPCC-related colorectal cancers reveals striking molecular features in families with no germline mismatch repair gene mutations.

scientific article

Comprehensive evaluation of coding region point mutations in microsatellite‐unstable colorectal cancer

scientific article published on 14 August 2018

Contribution of allelic imbalance to colorectal cancer

scientific article published in Nature Communications

Converging endometrial and ovarian tumorigenesis in Lynch syndrome: Shared origin of synchronous carcinomas

scientific article published on 30 April 2018

Correction: Cancer risks by gene, age, and gender in 6350 carriers of pathogenic mismatch repair variants: findings from the Prospective Lynch Syndrome Database

scientific article published on 20 July 2020

DNA hypermethylation appears early and shows increased frequency with dysplasia in Lynch syndrome-associated colorectal adenomas and carcinomas

scientific article published on 22 July 2015

DNA methylation changes and somatic mutations as tumorigenic events in Lynch syndrome-associated adenomas retaining mismatch repair protein expression.

scientific article published on 18 December 2018

Descriptive study on subjective experience of genetic testing with respect to relationship, family planning and psychosocial wellbeing among women with lynch syndrome

scientific article

Development of Colorectal Tumors in Colonoscopic Surveillance in Lynch Syndrome

article

Distinct Mutational Profile of Lynch Syndrome Colorectal Cancers Diagnosed under Regular Colonoscopy Surveillance

scientific article

Distinct molecular profiles in Lynch syndrome-associated and sporadic ovarian carcinomas

scientific article published on 21 June 2013

Does breast carcinoma belong to the Lynch syndrome tumor spectrum? - Somatic mutational profiles vs. ovarian and colorectal carcinomas

scientific article published on 07 April 2020

EPHB2 germline variants in patients with colorectal cancer or hyperplastic polyposis

scientific article

EXO1 variants occur commonly in normal population: evidence against a role in hereditary nonpolyposis colorectal cancer

scientific article (publication date: 2003)

Early-onset renal cell carcinoma as a novel extraparaganglial component of SDHB-associated heritable paraganglioma

scientific article

Effect of aspirin or resistant starch on colorectal neoplasia in the Lynch syndrome

scientific article

Eleven candidate susceptibility genes for common familial colorectal cancer

scientific article

Endometrial cancer risk factors among Lynch syndrome women: a retrospective cohort study

scientific article published on 23 June 2016

Epidemiological, clinical and molecular characterization of Lynch-like syndrome: A population-based study

scientific article published on 07 January 2019

Epigenetic analysis of sporadic and Lynch-associated ovarian cancers reveals histology-specific patterns of DNA methylation

scientific article

Evaluation of a fast-track protocol for patients undergoing colorectal surgery

scientific article published on 02 April 2014

Exome and immune cell score analyses reveal great variation within synchronous primary colorectal cancers

scientific article published on 21 March 2019

Exome sequencing in diagnostic evaluation of colorectal cancer predisposition in young patients

scientific article published on 2 April 2013

Exome sequencing reveals frequent inactivating mutations in ARID1A, ARID1B, ARID2 and ARID4A in microsatellite unstable colorectal cancer

scientific article published on 13 January 2014

Exome-wide somatic mutation characterization of small bowel adenocarcinoma.

scientific article published on 9 March 2018

Explaining the familial colorectal cancer risk associated with mismatch repair (MMR)-deficient and MMR-stable tumors

scientific article published on January 2007

Features of gastric cancer in hereditary non-polyposis colorectal cancer syndrome

scientific article published on 01 October 1997

Five-Year Follow-up of Antibiotic Therapy for Uncomplicated Acute Appendicitis in the APPAC Randomized Clinical Trial

scientific article published on 01 September 2018

Gene-expression profiling predicts recurrence in Dukes' C colorectal cancer

scientific article published in September 2005

Genetic and Epigenetic Characteristics of Inflammatory Bowel Disease–Associated Colorectal Cancer

scientific article

Genome-wide allelotyping of 104 Finnish colorectal cancers reveals an excess of allelic imbalance in chromosome 20q in familial cases

scientific article published in April 2003

Genome-wide association study and meta-analysis in Northern European populations replicate multiple colorectal cancer risk loci

scientific article published on 28 September 2017

Genotype and phenotype in hereditary nonpolyposis colon cancer: a study of families with different vs. shared predisposing mutations

scientific article published on January 1, 2001

Germline mutation of RPS20, encoding a ribosomal protein, causes predisposition to hereditary nonpolyposis colorectal carcinoma without DNA mismatch repair deficiency

scientific article

High frequency of TTK mutations in microsatellite-unstable colorectal cancer and evaluation of their effect on spindle assembly checkpoint.

scientific article

High immune cell score predicts improved survival in pancreatic cancer

scientific article published on 22 January 2018

History of the International Collaborative Group on Hereditary Non Polyposis Colorectal Cancer.

scientific article published in January 2003

Identification of 33 candidate oncogenes by screening for base-specific mutations.

scientific article

Identification of candidate oncogenes in human colorectal cancers with microsatellite instability

scientific article

Immune Contexture of MMR-Proficient Primary Colorectal Cancer and Matched Liver and Lung Metastases

scientific article

Immunophenotype based on inflammatory cells, PD-1/PD-L1 signalling pathway and M2 macrophages predicts survival in gastric cancer

scientific article published on 18 September 2020

Immunoprofiles and DNA Methylation of Inflammatory Marker Genes in Ulcerative Colitis-Associated Colorectal Tumorigenesis

scientific article

Immunoscore in mismatch repair-proficient and -deficient colon cancer.

scientific article published on 19 July 2017

Impact of Age and Comorbidity on Multimodal Management and Survival from Colorectal Cancer: A Population-Based Study

scientific article

Incidence of Hereditary Nonpolyposis Colorectal Cancer and the Feasibility of Molecular Screening for the Disease

article

Incidence of and survival after subsequent cancers in carriers of pathogenic MMR variants with previous cancer: a report from the prospective Lynch syndrome database

scientific article published on 3 June 2016

Incident colorectal cancer in Lynch syndrome is usually not preceded by compromised quality of colonoscopy

scientific article published on 12 December 2019

Is preoperative distinction between complicated and uncomplicated acute appendicitis feasible without imaging?

scientific article

Ischaemic colitis--a clinical study of seven patients with special emphasis on diagnostic problems

scientific article published on January 1, 1991

Lack of association between screening interval and cancer stage in Lynch syndrome may be accounted for by over-diagnosis; a prospective Lynch syndrome database report

scientific article published on 28 February 2019

Large genomic rearrangements and germline epimutations in Lynch syndrome

scientific article published on 01 May 2009

Little evidence for involvement of MLH3 in colorectal cancer predisposition

scientific article

Long-term effect of aspirin on cancer risk in carriers of hereditary colorectal cancer: an analysis from the CAPP2 randomised controlled trial

scientific article published on 27 October 2011

Long-term effect of resistant starch on cancer risk in carriers of hereditary colorectal cancer: an analysis from the CAPP2 randomised controlled trial

article

Loss of the wild type MLH1 gene is a feature of hereditary nonpolyposis colorectal cancer

article

Low-level microsatellite instability in most colorectal carcinomas

scientific article published on 01 February 2002

Low-penetrance susceptibility variants in familial colorectal cancer

scientific article

Mendelian randomisation implicates hyperlipidaemia as a risk factor for colorectal cancer

scientific article

MicroRNAs Associated With Biological Pathways of Left- and Right-sided Colorectal Cancer

scientific article published on 01 July 2020

Molecular Analysis of Endometrial Tumorigenesis: Importance of Complex Hyperplasia Regardless of Atypia

article

Molecular Basis of Mismatch Repair Protein Deficiency in Tumors from Lynch Suspected Cases with Negative Germline Test Results

scientific article published on 09 July 2020

Molecular changes preceding endometrial and ovarian cancer: a study of consecutive endometrial specimens from Lynch syndrome surveillance.

scientific article published on 27 March 2018

Mutations in Exon 1 highlight the role of MED12 in uterine leiomyomas

scientific article (publication date: September 2014)

Mutations in the circadian gene CLOCK in colorectal cancer

scientific article

Mutations in two short noncoding mononucleotide repeats in most microsatellite-unstable colorectal cancers

scientific article published on June 2005

NOD23020insC Alone Is Not Sufficient for Colorectal Cancer Predisposition

scientific article published on 01 October 2004

No Difference in Colorectal Cancer Incidence or Stage at Detection by Colonoscopy Among 3 Countries With Different Lynch Syndrome Surveillance Policies

scientific article published on 29 July 2018

No Difference in Penetrance between Truncating and Missense/Aberrant Splicing Pathogenic Variants in and : A Prospective Lynch Syndrome Database Study

scientific article

No evidence for association of NOD2 R702W and G908R with colorectal cancer

scientific article published on July 2007

Numbers of mutations to different types of colorectal cancer

scientific article

Obesity, Aspirin, and Risk of Colorectal Cancer in Carriers of Hereditary Colorectal Cancer: A Prospective Investigation in the CAPP2 Study

scientific article published on 17 August 2015

PolyA deletions in hereditary nonpolyposis colorectal cancer: mutations before a gatekeeper

scientific article published on April 2002

Preferential amplification ofAURKA 91A (Ile31) in familial colorectal cancers

article

Prevalence of adenomas and hyperplastic polyps in mismatch repair mutation carriers among CAPP2 participants: report by the colorectal adenoma/carcinoma prevention programme 2.

scientific article published on July 2008

Pro-inflammatory fatty acid profile and colorectal cancer risk: A Mendelian randomisation analysis

scientific article

Prognostic Value of Immune Environment Analysis in Small Bowel Adenocarcinomas with Verified Mutational Landscape and Predisposing Conditions

scientific article published on 23 July 2020

Prognostic impact of CD73 expression and its relationship to PD-L1 in patients with radically treated pancreatic cancer

scientific article published on 16 July 2020

Proportion and phenotype of MYH-associated colorectal neoplasia in a population-based series of Finnish colorectal cancer patients

scientific article published on September 2003

Psychosocial consequences of predictive genetic testing for Lynch syndrome and associations to surveillance behaviour in a 7-year follow-up study

scientific article published in December 2013

Quality of Life and Patient Satisfaction at 7-Year Follow-up of Antibiotic Therapy vs Appendectomy for Uncomplicated Acute Appendicitis: A Secondary Analysis of a Randomized Clinical Trial

scientific article published on 19 February 2020

Quantitative Analysis of γ-H2AX and p53 Nuclear Expression Levels in Ovarian and Fallopian Tube Epithelium from Risk-reducing Salpingo-Oophorectomies in BRCA1 and BRCA2 Mutation Carriers

scientific article published on 01 May 2014

Recent advances in Lynch syndrome

scientific article published on 08 August 2020

Recessively inherited right atrial isomerism caused by mutations in growth/differentiation factor 1 (GDF1)

article published in 2010

Recommendations to improve identification of hereditary and familial colorectal cancer in Europe.

scientific article published on 18 September 2009

Recurrent groin hernia surgery after primary open inguinal procedures: a reappraisal of the open preperitoneal (Ugahary) technique

scientific article published on 12 November 2018

Reliability and Validity Study of the Finnish Adaptation of Scoliosis Research Society Questionnaire Version SRS-30.

scientific article published on 25 January 2017

Reply

scientific article published on 22 November 2014

Retrotransposon insertions can initiate colorectal cancer and are associated with poor survival

scientific article published on 06 September 2019

Revised guidelines for the clinical management of Lynch syndrome (HNPCC): recommendations by a group of European experts

scientific article published on 13 February 2013

Risk factors and possibilities of prevention of bowel cancer

scientific article published on January 2016

Risk-Reducing Gynecological Surgery in Lynch Syndrome: Results of an International Survey from the Prospective Lynch Syndrome Database

scientific article published on 18 July 2020

Risk-reducing hysterectomy and bilateral salpingo-oophorectomy in female heterozygotes of pathogenic mismatch repair variants: a Prospective Lynch Syndrome Database report

scientific article published on 01 December 2020

SMAD genes in juvenile polyposis

article

SMAD4 as a Prognostic Marker in Colorectal Cancer

scientific article published on 01 April 2005

SMAD4 levels and response to 5-fluorouracil in colorectal cancer

scientific article

Sharing genetic risk with next generation: mutation-positive parents' communication with their offspring in Lynch Syndrome

scientific article published on 01 March 2011

Somatic MED12 mutations in prostate cancer and uterine leiomyomas promote tumorigenesis through distinct mechanisms.

scientific article published on 18 September 2015

Somatic MED12 mutations in uterine leiomyosarcoma and colorectal cancer.

scientific article

Somatic mutations and germline sequence variants in patients with familial colorectal cancer.

scientific article

Spinopelvic Changes Based on the Simplified SRS-Schwab Adult Spinal Deformity Classification: Relationships with Disability and Health-related Quality of Life in Adult Patients with Prolonged Degenerative Spinal Disorders

scientific article

Stromal hyaluronan accumulation is associated with low immune response and poor prognosis in pancreatic cancer

scientific article

Subtotal Colectomy for Colon Cancer Reduces the Need for Subsequent Surgery in Lynch Syndrome

scientific article

Surveillance for endometrial cancer in hereditary nonpolyposis colorectal cancer syndrome

scientific article published on 01 February 2007

Surveillance in Lynch syndrome

scientific article

Survival by colon cancer stage and screening interval in Lynch syndrome: a prospective Lynch syndrome database report

scientific article published on 14 October 2019

Systematic search for enhancer elements and somatic allelic imbalance at seven low-penetrance colorectal cancer predisposition loci.

scientific article

Systematic search for rare variants in Finnish early-onset colorectal cancer patients

scientific article published on 31 December 2014

Ten Years After Mutation Testing for Lynch Syndrome: Cancer Incidence and Outcome in Mutation-Positive and Mutation-Negative Family Members

scientific article published on 31 August 2009

The "unnatural" history of colorectal cancer in Lynch syndrome: lessons from colonoscopy surveillance

scientific article published on 19 July 2020

The Accuracy of The Computed Tomography Diagnosis of Acute Appendicitis: Does The Experience of The Radiologist Matter?

scientific article published in September 2017

The Role of Chromosomal Instability and Epigenetics in Colorectal Cancers Lacking β-Catenin/TCF Regulated Transcription

scientific article published on 7 March 2016

The common colorectal cancer predisposition SNP rs6983267 at chromosome 8q24 confers potential to enhanced Wnt signaling.

scientific article published on 28 June 2009

The genetics of HNPCC: application to diagnosis and screening

scientific article

The impact of upper GI endoscopy referral volume on the diagnosis of gastroesophageal reflux disease and its complications: a 1-year cross-sectional study in a referral area with 260,000 inhabitants

scientific article published on 01 October 2002

The risk of extra-colonic, extra-endometrial cancer in the Lynch syndrome.

scientific article published on July 2008

The shared frameshift mutation landscape of microsatellite-unstable cancers suggests immunoediting during tumor evolution

scientific article published on 21 September 2020

Unregulated smooth-muscle myosin in human intestinal neoplasia

scientific article

Uptake of genetic testing by the children of Lynch syndrome variant carriers across three generations.

scientific article published on 23 August 2017

Uptake of hysterectomy and bilateral salpingo-oophorectomy in carriers of pathogenic mismatch repair variants: a Prospective Lynch Syndrome Database report

scientific article

Uroepithelial and kidney carcinoma in Lynch syndrome

scientific article published on 01 September 2012

Variation at 2q35 (PNKD and TMBIM1) influences colorectal cancer risk and identifies a pleiotropic effect with inflammatory bowel disease

scientific article published on 22 March 2016

Video-assisted surgery: suggestions for failure prevention in laparoscopic cholecystectomy

scientific article

WNT2 activation through proximal germline deletion predisposes to small intestinal neuroendocrine tumors and intestinal adenocarcinomas

[Diagnosis and treatment of Lynch syndrome]

[Rectal cancer]

scientific article published on 01 January 2002

p53 Codon 72 and MDM2 SNP309 Polymorphisms and Age of Colorectal Cancer Onset in Lynch Syndrome

scientific article published on 01 October 2005

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