List of works - Oliver Brüstle

A 3D human neural cell culture system for modeling Alzheimer's disease

scientific article published on 11 June 2015

A Single-Cell Model for Synaptic Transmission and Plasticity in Human iPSC-Derived Neurons

scientific article published on 01 May 2019

A novel human high-risk ependymoma stem cell model reveals the differentiation-inducing potential of the histone deacetylase inhibitor Vorinostat

scientific article

A reporter cell system for the triggering receptor expressed on myeloid cells 2 reveals differential effects of disease-associated variants on receptor signaling and activation by antibodies against the stalk region

scientific article published on 14 December 2020

A reproducible and versatile system for the dynamic expansion of human pluripotent stem cells in suspension

scientific article

A rosette-type, self-renewing human ES cell-derived neural stem cell with potential for in vitro instruction and synaptic integration

scholarly article

A stably self-renewing adult blood-derived induced neural stem cell exhibiting patternability and epigenetic rejuvenation

scientific article published in Nature Communications

APP processing in human pluripotent stem cell-derived neurons is resistant to NSAID-based γ-secretase modulation.

scientific article published on 5 December 2013

Adult germ line stem cells as a source of functional neurons and glia

scientific article

Altered Levels of Proteins and Phosphoproteins, in the Absence of Early Causative Transcriptional Changes, Shape the Molecular Pathogenesis in the Brain of Young Presymptomatic Ki91 SCA3/MJD Mouse.

scientific article published on 14 June 2019

An Autaptic Culture System for Standardized Analyses of iPSC-Derived Human Neurons

scientific article published on 01 May 2019

Anticancer effects of niclosamide in human glioblastoma.

scientific article

Arylsulfatase A Overexpressing Human iPSC-derived Neural Cells Reduce CNS Sulfatide Storage in a Mouse Model of Metachromatic Leukodystrophy

scientific article published on 10 June 2015

Auto-attraction of neural precursors and their neuronal progeny impairs neuronal migration

scientific article

Automated large-scale culture and medium-throughput chemical screen for modulators of proliferation and viability of human induced pluripotent stem cell-derived neuroepithelial-like stem cells.

scientific article

Automated maintenance of embryonic stem cell cultures

scientific article published in January 2007

Automated selection and harvesting of pluripotent stem cell colonies

scientific article published on March 2012

Axonal regeneration. Systemic administration of epothilone B promotes axon regeneration after spinal cord injury

scientific article

Bivalent histone modifications in stem cells poise miRNA loci for CpG island hypermethylation in human cancer

scientific article

Blood-derived integration-free iPS cell line UKBi011-A from a diagnosed male Alzheimer's disease patient with APOE ɛ4/ɛ4 genotype

scientific article published on 23 April 2018

Bone morphogenetic protein-mediated modulation of lineage diversification during neural differentiation of embryonic stem cells

scientific article published on 11 January 2007

Breakdown of the potentiality principle and its impact on global stem cell research

scientific article published on 01 August 2007

CD44 and hyaluronan promote invasive growth of B35 neuroblastoma cells into the brain

scientific article

Cancer genes hypermethylated in human embryonic stem cells

scientific article

Capture of neuroepithelial-like stem cells from pluripotent stem cells provides a versatile system for in vitro production of human neurons

scientific article

Cell fusion enhances mesendodermal differentiation of human induced pluripotent stem cells

scientific article

Clinical translation of stem cells in neurodegenerative disorders.

scientific article

Co-existence of intact stemness and priming of neural differentiation programs in mES cells lacking Trim71.

scientific article published on 9 June 2015

Copy number variation and selection during reprogramming to pluripotency

scientific article published on March 2011

Correct setup of the substantia nigra requires Reelin-mediated fast, laterally-directed migration of dopaminergic neurons

scientific article published on 28 January 2019

Correction: MicroRNA-Based Promotion of Human Neuronal Differentiation and Subtype Specification

scientific article published on 12 September 2013

Creating Patient-Specific Neural Cells for the In Vitro Study of Brain Disorders

scientific article

DNA methylation alterations in iPSC- and hESC-derived neurons: potential implications for neurological disease modeling.

scientific article published on 29 January 2018

Deep-learning-based multi-class segmentation for automated, non-invasive routine assessment of human pluripotent stem cell culture status

scientific article published on 11 December 2020

Derivation and maintenance of murine trophoblast stem cells under defined conditions

scientific article published on 30 January 2014

Developmental neuroscience: Miniature human brains

scientific article published on 28 August 2013

Direct conversion of fibroblasts into stably expandable neural stem cells

scientific article

Dissecting Alzheimer's disease pathogenesis in human 2D and 3D models

scientific article published on 14 October 2020

Drug repositioning of antiretroviral ritonavir for combinatorial therapy in glioblastoma

scientific article published on 19 October 2020

ES cell-derived glial precursors contribute to remyelination in acutely demyelinated spinal cord lesions

scientific article published in July 2005

Electrophysiological evaluation of engrafted stem cell-derived neurons

scientific article published in January 2007

Embryonic stem cell-based modeling of tau pathology in human neurons.

scientific article published on 13 March 2013

Emerging concepts in neural stem cell research: autologous repair and cell-based disease modelling

scientific article published on September 2009

Energy Metabolism Disturbances in Cell Models of PARK2 CNV Carriers with ADHD

scientific article published on 18 December 2020

Engineering cell-permeant FLP recombinase for tightly controlled inducible and reversible overexpression in embryonic stem cells

scientific article published on May 2010

Engineering embryonic stem cell derived glia for adenosine delivery

scientific article published in November 2004

Establishment of a versatile seminoma model indicates cellular plasticity of germ cell tumor cells.

scientific article

Evolving principles underlying neural lineage conversion and their relevance for biomedical translation

scientific article published on 30 August 2019

Excitation-induced ataxin-3 aggregation in neurons from patients with Machado-Joseph disease

scientific article published on 23 November 2011

Expression studies in gliomas and glial cells do not support a tumor suppressor role for LGI1.

scientific article published on 2 March 2006

Fifty ways to make a neuron: shifts in stem cell hierarchy and their implications for neuropathology and CNS repair

scientific article

Functional Subclone Profiling for Prediction of Treatment-Induced Intratumor Population Shifts and Discovery of Rational Drug Combinations in Human Glioblastoma

scientific article

Functional analysis of embryonic stem cell-derived glial cells after integration into hippocampal slice cultures.

scientific article

Functional integration of embryonic stem cell-derived neurons in hippocampal slice cultures.

scientific article published in August 2003

Functional integration of embryonic stem cell-derived neurons in vivo.

scientific article published in June 2004

Functional network integration of embryonic stem cell-derived astrocytes in hippocampal slice cultures.

scientific article

Functional neuronal cells generated by human parthenogenetic stem cells

scientific article

Functional properties of ES cell-derived neurons engrafted into the hippocampus of adult normal and chronically epileptic rats

scientific article published on January 2005

Generation and potential biomedical applications of embryonic stem cell-derived glial precursors

scientific article published on 26 October 2007

Generation of purified oligodendrocyte progenitors from embryonic stem cells

scientific article

Genome Editing in Neuroepithelial Stem Cells to Generate Human Neurons with High Adenosine-Releasing Capacity.

scientific article

Glycoconjugates reveal diversity of human neural stem cells (hNSCs) derived from human induced pluripotent stem cells (hiPSCs).

scientific article

High density bioprocessing of human pluripotent stem cells by metabolic control and in silico modeling

scientific article published on 04 March 2021

High-purity lineage selection of embryonic stem cell-derived neurons.

scientific article published on February 2005

High-resolution DNA analysis of human embryonic stem cell lines reveals culture-induced copy number changes and loss of heterozygosity

article

Human embryonic stem cell-derived neurons establish region-specific, long-range projections in the adult brain.

scientific article published on 21 July 2011

Human induced pluripotent stem cell-derived cortical neurons integrate in stroke-injured cortex and improve functional recovery

scientific article published on 21 October 2013

Human induced pluripotent stem cells improve recovery in stroke-injured aged rats.

scientific article

Human-induced pluripotent stem cells form functional neurons and improve recovery after grafting in stroke-damaged brain

scientific article

Hypomorphic mutations in POLR3A are a frequent cause of sporadic and recessive spastic ataxia

scientific article published on 27 April 2017

Impact of Zika Virus Infection on Human Neural Stem Cell MicroRNA Signatures

scientific article published on 27 October 2020

Impedimetric real-time monitoring of neural pluripotent stem cell differentiation process on microelectrode arrays

scientific article published on 20 June 2016

In Vitro Recapitulation of Developmental Transitions in Human Neural Stem Cells

scientific article published on 24 August 2019

In vitro segregation and isolation of human pluripotent stem cell-derived neural crest cells

scientific article published on 13 October 2017

Induced pluripotent stem cell-based modeling of mutant LRRK2-associated Parkinson's disease

scientific article published on 01 February 2019

Induced pluripotent stem cell-based modeling of neurodegenerative diseases: a focus on autophagy.

scientific article published on 07 June 2017

Induction of pluripotency in adult unipotent germline stem cells

scientific article published in July 2009

Inhibition of notch signaling in human embryonic stem cell-derived neural stem cells delays G1/S phase transition and accelerates neuronal differentiation in vitro and in vivo.

scientific article published on May 2010

Integrated platform for production and purification of human pluripotent stem cell-derived neural precursors.

scientific article published on April 2014

Laser-assisted photoablation of human pluripotent stem cells from differentiating cultures

scientific article

Laser-assisted selection and passaging of human pluripotent stem cell colonies

scientific article

Leveling Waddington: the emergence of direct programming and the loss of cell fate hierarchies.

scientific article published on 13 March 2013

Licensing of myeloid cells promotes central nervous system autoimmunity and is controlled by peroxisome proliferator-activated receptor γ.

scientific article published on 24 March 2012

Lineage conversion of murine extraembryonic trophoblast stem cells to pluripotent stem cells.

scientific article

Lineage selection of functional and cryopreservable human embryonic stem cell-derived neurons

scientific article published on 17 April 2008

Long-term expansion of human induced pluripotent stem cells in a microcarrier-based dynamic system

Merging fields: stem cells in neurogenesis, transplantation, and disease modeling

scientific article published on April 2006

MicroRNA-based promotion of human neuronal differentiation and subtype specification

scientific article

MicroRNAs Engage in Complex Circuits Regulating Adult Neurogenesis

Migration and differentiation of myogenic precursors following transplantation into the developing rat brain

scientific article published on January 2003

Mitochondrial DNA copy number is associated with psychosis severity and anti-psychotic treatment

scientific article published in Scientific Reports

Multiparametric rapid screening of neuronal process pathology for drug target identification in HSP patient-specific neurons

scientific article published on 03 July 2019

Neural Cell Adhesion Molecule Polysialylation Enhances the Sensitivity of Embryonic Stem Cell-Derived Neural Precursors to Migration Guidance Cues

scientific article published on 06 September 2007

Neural commitment of human pluripotent stem cells under defined conditions recapitulates neural development and generates patient-specific neural cells.

scientific article

Neural conversion of human embryonic stem cell colonies in the presence of fibroblast growth factor-2.

scientific article published in November 2006

Non-genetic modulation of Notch activity by artificial delivery of Notch intracellular domain into neural stem cells

scientific article published on September 2012

Notch/Hes signaling and miR-9 engage in complex feedback interactions controlling neural progenitor cell proliferation and differentiation

scientific article published on 12 May 2017

Nucleofection of human embryonic stem cells

scientific article published in January 2008

Nucleofection of human embryonic stem cells.

scientific article published on August 2005

Optogenetics reveal delayed afferent synaptogenesis on grafted human-induced pluripotent stem cell-derived neural progenitors

scientific article published in December 2014

Phosphorylation of the amyloid β-peptide at Ser26 stabilizes oligomeric assembly and increases neurotoxicity.

scientific article published on 22 February 2016

Plastin 3 is upregulated in iPSC-derived motoneurons from asymptomatic SMN1-deleted individuals.

scientific article published on 16 November 2015

Pluripotent stem cell-derived radial glia-like cells as stable intermediate for efficient generation of human oligodendrocytes

scientific article

Presenilin-1 L166P mutant human pluripotent stem cell-derived neurons exhibit partial loss of γ-secretase activity in endogenous amyloid-β generation.

scientific article published on 14 April 2012

Protocol for the Standardized Generation of Forward Programmed Cryopreservable Excitatory and Inhibitory Forebrain Neurons

scientific article published on 03 June 2020

Publisher Correction: Mitochondrial DNA copy number is associated with psychosis severity and anti-psychotic treatment

scientific article published on 05 November 2019

Pumilio-2 Function in the Mouse Nervous System ⬇️

scientific article published on October 7, 2011

Rapid establishment of the European Bank for induced Pluripotent Stem Cells (EBiSC) - the Hot Start experience

scientific article

Reciprocal Regulation between Bifunctional miR-9/9(∗) and its Transcriptional Modulator Notch in Human Neural Stem Cell Self-Renewal and Differentiation.

scientific article published on 13 July 2016

Regulation of oligodendrocyte precursor maintenance by chondroitin sulphate glycosaminoglycans

scientific article published on 10 October 2015

Regulation of stem cell therapies under attack in Europe: for whom the bell tolls

scientific article published on 3 May 2013

Repurposing HAMI3379 to Block GPR17 and Promote Rodent and Human Oligodendrocyte Differentiation.

scientific article published on 18 April 2018

Residual tumor cells are unique cellular targets in glioblastoma

scientific article published on August 2010

Retinoic acid induction of ES-cell-derived neurons: the radial glia connection

scientific article

Robust Generation of Cardiomyocytes from Human iPS Cells Requires Precise Modulation of BMP and WNT Signaling

scientific article

Self-organization of neural tissue architectures from pluripotent stem cells.

scientific article published on 07 May 2014

Signals from embryonic fibroblasts induce adult intestinal epithelial cells to form nestin-positive cells with proliferation and multilineage differentiation capacity in vitro.

scientific article

Sirt1 contributes critically to the redox-dependent fate of neural progenitors.

scientific article published on 16 March 2008

Site-specific recombination in human embryonic stem cells induced by cell-permeant Cre recombinase

scientific article published in June 2006

Small molecules enable highly efficient neuronal conversion of human fibroblasts

scientific article

Spatial and temporal control of cell aggregation efficiently directs human pluripotent stem cells towards neural commitment.

scientific article

Specific Inhibition of β-Secretase Processing of the Alzheimer Disease Amyloid Precursor Protein

scientific article

Stage-specific conditional mutagenesis in mouse embryonic stem cell-derived neural cells and postmitotic neurons by direct delivery of biologically active Cre recombinase

scientific article published on 7 September 2006

Stem cell engineering using transducible Cre recombinase

scientific article published in January 2007

Store-operated calcium entry modulates neuronal network activity in a model of chronic epilepsy.

scientific article published on 30 August 2011

Suppression of kindled seizures by paracrine adenosine release from stem cell-derived brain implants

scientific article

Suppression of kindling epileptogenesis by adenosine releasing stem cell-derived brain implants.

scientific article

Synaptic inputs from stroke-injured brain to grafted human stem cell-derived neurons activated by sensory stimuli.

scientific article

TDP-43 loss of function inhibits endosomal trafficking and alters trophic signaling in neurons

scientific article published on 12 September 2016

Targeting the cytosolic innate immune receptors RIG-I and MDA5 effectively counteracts cancer cell heterogeneity in glioblastoma

scientific article published on June 2013

Tau EGFP embryonic stem cells: An efficient tool for neuronal lineage selection and transplantation

scientific article published on 01 September 2002

Temporally restricted substrate interactions direct fate and specification of neural precursors derived from embryonic stem cells

scholarly article

The StemCellFactory: A Modular System Integration for Automated Generation and Expansion of Human Induced Pluripotent Stem Cells

scientific article published on 09 November 2020

The death receptor CD95 activates adult neural stem cells for working memory formation and brain repair

scientific article published in August 2009

The function of the mammalian Pumilio gene, Pum1, in early embryonic development of mice

The nomenclature system should be sustainable, but also practical

scientific article published in June 2011

The role of microRNAs in human neural stem cells, neuronal differentiation and subtype specification

scientific article

Tracking of human cells in mice.

scientific article

Transcription Factor-Based Fate Specification and Forward Programming for Neural Regeneration

scientific article published on 20 May 2020

Transcription factor-based modulation of neural stem cell differentiation using direct protein transduction

scientific article

Transduction of human embryonic stem cells by ecotropic retroviral vectors.

scientific article published on 22 September 2006

Transplantation of human umbilical cord blood-derived adherent progenitors into the developing rodent brain

scientific article published on 01 August 2005

Tripotential differentiation of adherently expandable neural stem (NS) cells

scientific article

Upregulation of miR-370 and miR-543 is associated with reduced expression of heat shock protein 40 in spinocerebellar ataxia type 3

scientific article published in PLoS ONE

VPA response in SMA is suppressed by the fatty acid translocase CD36 ⬇️

scientific article published on October 16, 2012

Whole-brain 3D mapping of human neural transplant innervation.

scientific article

p66(ShcA) adaptor molecule accelerates ES cell neural induction

scientific article

List of works by Oliver Brüstle

A 3D human neural cell culture system for modeling Alzheimer's disease

A Single-Cell Model for Synaptic Transmission and Plasticity in Human iPSC-Derived Neurons

A novel human high-risk ependymoma stem cell model reveals the differentiation-inducing potential of the histone deacetylase inhibitor Vorinostat

A reporter cell system for the triggering receptor expressed on myeloid cells 2 reveals differential effects of disease-associated variants on receptor signaling and activation by antibodies against the stalk region

A reproducible and versatile system for the dynamic expansion of human pluripotent stem cells in suspension

A rosette-type, self-renewing human ES cell-derived neural stem cell with potential for in vitro instruction and synaptic integration

A stably self-renewing adult blood-derived induced neural stem cell exhibiting patternability and epigenetic rejuvenation

APP processing in human pluripotent stem cell-derived neurons is resistant to NSAID-based γ-secretase modulation.

Adult germ line stem cells as a source of functional neurons and glia

Altered Levels of Proteins and Phosphoproteins, in the Absence of Early Causative Transcriptional Changes, Shape the Molecular Pathogenesis in the Brain of Young Presymptomatic Ki91 SCA3/MJD Mouse.

An Autaptic Culture System for Standardized Analyses of iPSC-Derived Human Neurons

Anticancer effects of niclosamide in human glioblastoma.

Arylsulfatase A Overexpressing Human iPSC-derived Neural Cells Reduce CNS Sulfatide Storage in a Mouse Model of Metachromatic Leukodystrophy

Auto-attraction of neural precursors and their neuronal progeny impairs neuronal migration

Automated large-scale culture and medium-throughput chemical screen for modulators of proliferation and viability of human induced pluripotent stem cell-derived neuroepithelial-like stem cells.

Automated maintenance of embryonic stem cell cultures

Automated selection and harvesting of pluripotent stem cell colonies

Axonal regeneration. Systemic administration of epothilone B promotes axon regeneration after spinal cord injury

Bivalent histone modifications in stem cells poise miRNA loci for CpG island hypermethylation in human cancer

Blood-derived integration-free iPS cell line UKBi011-A from a diagnosed male Alzheimer's disease patient with APOE ɛ4/ɛ4 genotype

Bone morphogenetic protein-mediated modulation of lineage diversification during neural differentiation of embryonic stem cells

Breakdown of the potentiality principle and its impact on global stem cell research

CD44 and hyaluronan promote invasive growth of B35 neuroblastoma cells into the brain

Cancer genes hypermethylated in human embryonic stem cells

Capture of neuroepithelial-like stem cells from pluripotent stem cells provides a versatile system for in vitro production of human neurons

Cell fusion enhances mesendodermal differentiation of human induced pluripotent stem cells

Clinical translation of stem cells in neurodegenerative disorders.

Co-existence of intact stemness and priming of neural differentiation programs in mES cells lacking Trim71.

Copy number variation and selection during reprogramming to pluripotency

Correct setup of the substantia nigra requires Reelin-mediated fast, laterally-directed migration of dopaminergic neurons

Correction: MicroRNA-Based Promotion of Human Neuronal Differentiation and Subtype Specification

Creating Patient-Specific Neural Cells for the In Vitro Study of Brain Disorders

DNA methylation alterations in iPSC- and hESC-derived neurons: potential implications for neurological disease modeling.

Deep-learning-based multi-class segmentation for automated, non-invasive routine assessment of human pluripotent stem cell culture status

Derivation and maintenance of murine trophoblast stem cells under defined conditions

Developmental neuroscience: Miniature human brains

Direct conversion of fibroblasts into stably expandable neural stem cells

Dissecting Alzheimer's disease pathogenesis in human 2D and 3D models

Drug repositioning of antiretroviral ritonavir for combinatorial therapy in glioblastoma

ES cell-derived glial precursors contribute to remyelination in acutely demyelinated spinal cord lesions

Electrophysiological evaluation of engrafted stem cell-derived neurons

Embryonic stem cell-based modeling of tau pathology in human neurons.

Emerging concepts in neural stem cell research: autologous repair and cell-based disease modelling

Energy Metabolism Disturbances in Cell Models of PARK2 CNV Carriers with ADHD

Engineering cell-permeant FLP recombinase for tightly controlled inducible and reversible overexpression in embryonic stem cells

Engineering embryonic stem cell derived glia for adenosine delivery

Establishment of a versatile seminoma model indicates cellular plasticity of germ cell tumor cells.

Evolving principles underlying neural lineage conversion and their relevance for biomedical translation

Excitation-induced ataxin-3 aggregation in neurons from patients with Machado-Joseph disease

Expression studies in gliomas and glial cells do not support a tumor suppressor role for LGI1.

Fifty ways to make a neuron: shifts in stem cell hierarchy and their implications for neuropathology and CNS repair

Functional Subclone Profiling for Prediction of Treatment-Induced Intratumor Population Shifts and Discovery of Rational Drug Combinations in Human Glioblastoma

Functional analysis of embryonic stem cell-derived glial cells after integration into hippocampal slice cultures.

Functional integration of embryonic stem cell-derived neurons in hippocampal slice cultures.

Functional integration of embryonic stem cell-derived neurons in vivo.

Functional network integration of embryonic stem cell-derived astrocytes in hippocampal slice cultures.

Functional neuronal cells generated by human parthenogenetic stem cells

Functional properties of ES cell-derived neurons engrafted into the hippocampus of adult normal and chronically epileptic rats

Generation and potential biomedical applications of embryonic stem cell-derived glial precursors

Generation of purified oligodendrocyte progenitors from embryonic stem cells

Genome Editing in Neuroepithelial Stem Cells to Generate Human Neurons with High Adenosine-Releasing Capacity.

Glycoconjugates reveal diversity of human neural stem cells (hNSCs) derived from human induced pluripotent stem cells (hiPSCs).

High density bioprocessing of human pluripotent stem cells by metabolic control and in silico modeling

High-purity lineage selection of embryonic stem cell-derived neurons.

High-resolution DNA analysis of human embryonic stem cell lines reveals culture-induced copy number changes and loss of heterozygosity

Human embryonic stem cell-derived neurons establish region-specific, long-range projections in the adult brain.

Human induced pluripotent stem cell-derived cortical neurons integrate in stroke-injured cortex and improve functional recovery

Human induced pluripotent stem cells improve recovery in stroke-injured aged rats.

Human-induced pluripotent stem cells form functional neurons and improve recovery after grafting in stroke-damaged brain

Hypomorphic mutations in POLR3A are a frequent cause of sporadic and recessive spastic ataxia

Impact of Zika Virus Infection on Human Neural Stem Cell MicroRNA Signatures

Impedimetric real-time monitoring of neural pluripotent stem cell differentiation process on microelectrode arrays

In Vitro Recapitulation of Developmental Transitions in Human Neural Stem Cells

In vitro segregation and isolation of human pluripotent stem cell-derived neural crest cells

Induced pluripotent stem cell-based modeling of mutant LRRK2-associated Parkinson's disease

Induced pluripotent stem cell-based modeling of neurodegenerative diseases: a focus on autophagy.

Induction of pluripotency in adult unipotent germline stem cells

Inhibition of notch signaling in human embryonic stem cell-derived neural stem cells delays G1/S phase transition and accelerates neuronal differentiation in vitro and in vivo.

Integrated platform for production and purification of human pluripotent stem cell-derived neural precursors.