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List of works by Munir Pirmohamed

17q21 variant increases the risk of exacerbations in asthmatic children despite inhaled corticosteroids use

scientific article published on 09 July 2018

3 The pharmacology of the cytochrome P450 enzyme system

scholarly article by Neil R. Kitteringham et al published June 1998 in Bailliere's clinical anaesthesiology

A Framework for Multi-Omic Prediction of Treatment Response to Biologic Therapy for Psoriasis

scientific article published on 17 July 2018

A Randomized Controlled Trial of Extended Brief Intervention for Alcohol-Dependent Patients in an Acute Hospital Setting

A Review of the Important Role of CYP2D6 in Pharmacogenomics

scientific article published on 30 October 2020

A Systematic Review of Economic Evaluations of Pharmacogenetic Testing for Prevention of Adverse Drug Reactions.

scientific article published on 16 March 2016

A common missense variant of LILRB5 is associated with statin intolerance and myalgia.

scientific article

A comparison of HMGB1 concentrations between cerebrospinal fluid and blood in patients with neurological disease.

scientific article

A comprehensive functional and clinical analysis of ABCC2 and its impact on treatment response to carbamazepine

article

A genome-wide association study and biological pathway analysis of epilepsy prognosis in a prospective cohort of newly treated epilepsy

scientific journal article

A mechanistic investigation of the predisposing factors for idiosyncratic drug reactions

doctoral thesis

A method for the rapid depletion of albumin and immunoglobulin from human plasma.

scientific article

A multi-factorial analysis of response to warfarin in a UK prospective cohort

scientific article

A multi-system approach assessing the interaction of anticonvulsants with P-gp

scientific article

A pilot randomised controlled trial to assess the utility of an e-learning package that trains users in adverse drug reaction causality

scientific article published on 29 May 2015

A proposal for an individualized pharmacogenetics-based warfarin initiation dose regimen for patients commencing anticoagulation therapy

scientific article published on 28 September 2011

A prospective cohort study examining the effectiveness of baclofen in the maintenance of abstinence in alcohol use disorder patients attending a joint liver and alcohol treatment clinic

scientific article published on 15 May 2017

A randomised controlled trial of extended brief intervention for alcohol dependent patients in an acute hospital setting (ADPAC).

scientific article

A randomized trial of genotype-guided dosing of warfarin

scientific article published on 19 November 2013

A reference set of clinically relevant adverse drug-drug interactions

scientific article published on 4 March 2022

A review of a priori regression models for warfarin maintenance dose prediction

scientific article

A role for the pregnane X receptor in flucloxacillin-induced liver injury.

scientific article published in May 2010

A systematic review of cost-effectiveness analyses of pharmacogenetic-guided dosing in treatment with coumarin derivatives

scientific article published on July 2010

A “Bundle of Care” to Improve Anticoagulation Control in Patients Receiving Warfarin in Uganda and South Africa: Protocol for an Implementation Study

scientific article published in 2023

ABCB1 genotype and PGP expression, function and therapeutic drug response: a critical review and recommendations for future research.

scientific article published on 12 September 2006

ABCB1 single nucleotide polymorphisms (1236C>T, 2677G>T, and 3435C>T) do not affect transport activity of human P-glycoprotein

scientific article published in June 2013

Abs No: HLA-A*31:01 positive hypersensitive patient

scientific article

Acceptance of biomarker-based tests for application in clinical practice: criteria and obstacles

scientific article published on October 27, 2010

Achieving the World Health Organization's vision for clinical pharmacology

scientific article published on 14 October 2015

Activation of T cells by carbamazepine and carbamazepine metabolites

scientific article

Activation of T-cells from allergic patients and volunteers by p-phenylenediamine and Bandrowski's base

scientific article published on 4 October 2007

Activation of carbamazepine-responsive T-cell clones with metabolically inert halogenated derivatives

scientific article

Active transport of imatinib into and out of cells: implications for drug resistance

scientific article

Adherence and variability in warfarin dose requirements: assessment in a prospective cohort

scientific article

Adipogenic gene variants in patients with HIV-associated lipodystrophy

article

Adrenal responses to a low-dose short synacthen test in children with asthma

article

Adrenal responses to a low-dose short synacthen test in children with asthma.

scientific article

Adrenal suppression with inhaled corticosteroids: the seed and the soil - Authors' reply

scientific article published on 01 June 2018

Advances in the Pharmacogenomics of Adverse Drug Reactions.

scientific article

Adverse Drug Reactions

article

Adverse drug reactions and off-label and unlicensed medicines in children: a nested case-control study of inpatients in a pediatric hospital

scientific article

Adverse drug reactions and off-label and unlicensed medicines in children: a prospective cohort study of unplanned admissions to a paediatric hospital

scientific article

Adverse drug reactions and pharmacogenomics: recent advances

Adverse drug reactions as a cause of admission to an acute medical assessment unit: a pilot study

scientific article published on 01 October 2000

Adverse drug reactions as cause of admission to hospital: Authors' reply

scientific article published in August 2004

Adverse drug reactions as cause of admission to hospital: prospective analysis of 18 820 patients

scientific article (publication date: 3 July 2004)

Adverse drug reactions causing admission to a paediatric hospital

scientific article

Adverse drug reactions causing admission to a paediatric hospital: a pilot study

scientific article published on 25 August 2010

Adverse drug reactions in hospital in-patients: a pilot study

scientific article

Adverse drug reactions in hospital in-patients: a prospective analysis of 3695 patient-episodes

scientific article

Adverse drug reactions in hospitals: a narrative review

scientific article published on January 2007

Adverse drug reactions: back to the future

scientific article

Alcohol abuse and the burden on the NHS--time for action

article

Altered adipokine response in murine 3T3-F442A adipocytes treated with protease inhibitors and nucleoside reverse transcriptase inhibitors.

scientific article

Aminoglycoside-induced nephrotoxicity in children

scientific article published on 15 November 2016

An assessment of the impact of pharmacogenomics on health disparities: a systematic literature review

scientific article

An integrative in silico system for predicting dysregulated genes in the human epileptic focus: Application to SLC transporters.

scientific article published on 16 July 2016

An investigation of the formation of cytotoxic, genotoxic, protein-reactive and stable metabolites from naphthalene by human liver microsomes

scientific article published on 01 November 1993

An investigation of the formation of cytotoxic, protein-reactive and stable metabolites from carbamazepine in vitro

scientific article published on 01 April 1992

Anticipating, investigating and managing the adverse effects of drugs.

scientific article

Anticonvulsant Agents

article

Antigen exposure required for T cell activation

scientific article

Antigenicity and immunogenicity of sulphamethoxazole: demonstration of metabolism-dependent haptenation and T-cell proliferation in vivo

scientific article

Antiprotozoal drugs

Antiprotozoal drugs

Antiprotozoal drugs

Antiprotozoal drugs

Application of in Vitro T Cell Assay Using Human Leukocyte Antigen-Typed Healthy Donors for the Assessment of Drug Immunogenicity.

scientific article published on 13 February 2018

Are chemically reactive metabolites responsible for adverse reactions to drugs?

scientific article

Aspirin resistance: effect of clinical, biochemical and genetic factors

scientific article published on 02 February 2011

Assessment of adipokine expression and mitochondrial toxicity in HIV patients with lipoatrophy on stavudine- and zidovudine-containing regimens

scientific article

Association analysis of drug metabolizing enzyme gene polymorphisms in HIV-positive patients with co-trimoxazole hypersensitivity

article

Association of ABCC10 polymorphisms with nevirapine plasma concentrations in the German Competence Network for HIV/AIDS

scientific article published on January 2012

Association of human leukocyte antigen alleles and nevirapine hypersensitivity in a Malawian HIV-infected population

scientific article published on 29 January 2013

Attitudes and knowledge of hospital pharmacists to adverse drug reaction reporting

scientific article

Author's reply to Backman and Bakhai

scientific article

Authors' reply to Zermansky and Khatib

scientific article published in the British Medical Journal

Best evidence and the clinical decision making process

scientific article published in May 2002

Beyond registration--measuring the public-health potential of new treatments for malaria in Africa

scientific article

Bioactivation and bioinactivation of drugs and drug metabolites: Relevance to adverse drug reactions

Bioactivation of clozapine by murine cardiac tissue in vivo and in vitro

scientific article

Biomarkers of adverse drug reactions.

scientific article published in January 2017

Brief interventions in dependent drinkers: a comparative prospective analysis in two hospitals

scientific article

CKM Glu83Gly Is Associated With Blunted Creatine Kinase Variation, but Not With Myalgia

scientific article published on August 2017

CORRIGENDUM: Implementing Pharmacogenomics in Europe: Design and Implementation Strategy of the Ubiquitous Pharmacogenomics Consortium

scientific article published on 01 July 2017

CSF/plasma HIV-1 RNA discordance even at low levels is associated with up-regulation of host inflammatory mediators in CSF

scientific article published on 28 April 2016

CYP2B6 c.983T>C polymorphism is associated with nevirapine hypersensitivity in Malawian and Ugandan HIV populations

scientific article published on 20 August 2014

CYP2B6*18 is associated with nevirpine hypersensitivity independently of HLA-C*04:01 in a Malawian HIV population.

scientific article

CYP2B6*6 is an independent determinant of inferior response to fludarabine plus cyclophosphamide in chronic lymphocytic leukemia.

scientific article published on 15 October 2013

CYP2C19*17 gain-of-function polymorphism is associated with peptic ulcer disease.

scientific article published on 26 October 2012

Calprotectin and lactoferrin faecal levels in patients with Clostridium difficile infection (CDI): a prospective cohort study

scientific article

Carbamazepine is not a substrate for P-glycoprotein

scientific article

Carbamazepine-hypersensitivity: assessment of clinical and in vitro chemical cross-reactivity with phenytoin and oxcarbazepine.

scientific article

Carbamazepine-induced acute liver failure as part of the DRESS syndrome.

scientific article

Cardiovascular pharmacogenomics: expectations and practical benefits

scientific article published on 09 December 2013

Cardiovascular side effects of cancer therapies: a position statement from the Heart Failure Association of the European Society of Cardiology

scientific article published on January 2011

Causality Patterns for Detecting Adverse Drug Reactions From Social Media: Text Mining Approach (Preprint)

scholarly article published 15 June 2017

Causality Patterns for Detecting Adverse Drug Reactions From Social Media: Text Mining Approach.

scientific article published on 9 May 2018

Cellular Uptake of the Atypical Antipsychotic Clozapine Is a Carrier-Mediated Process

scientific article published on 10 July 2018

Cellular disposition of sulphamethoxazole and its metabolites: implications for hypersensitivity

scientific article published in March 1999

Challenges and approaches for the development of safer immunomodulatory biologics

scientific article published on April 2013

Chapter 37 Idiosyncratic drug reactions

Chapter 5. Drug Transporters at the Blood–Brain Barrier

Characterisation and carriage ratio of Clostridium difficile strains isolated from a community-dwelling elderly population in the United Kingdom

scientific article

Characterisation of flucloxacillin and 5-hydroxymethyl flucloxacillin haptenated HSA in vitro and in vivo.

scientific article published on June 2009

Characterisation of the toxic metabolite(s) of naphthalene

article

Characterization of Clozapine-Responsive Human T Cells

scientific article published on 28 September 2020

Characterization of amoxicillin and clavulanic-acid-responsive CD4+ And CD8+ T-cells in patients with co-amoxiclav-induced liver injury

scientific article

Characterization of amoxicillin- and clavulanic acid-specific T cells in patients with amoxicillin-clavulanate-induced liver injury.

scientific article published on 23 July 2015

Characterization of drug-specific T cells in lamotrigine hypersensitivity

scientific article published on June 2003

Characterization of drug-specific lymphocyte responses in a patient with drug-induced liver injury

article

Characterization of p-phenylenediamine-albumin binding sites and T-cell responses to hapten-modified protein

scientific article published on 27 August 2009

Characterization of sulfamethoxazole and sulfamethoxazole metabolite-specific T-cell responses in animals and humans

scientific article published on 3 April 2003

Characterization of the T-cell response in a patient with phenindione hypersensitivity

scientific article (publication date: June 2005)

Characterization of the antigen specificity of T-cell clones from piperacillin-hypersensitive patients with cystic fibrosis

scientific article

Characterization of the metabolites of carbamazepine in patient urine by liquid chromatography/mass spectrometry

scientific article published on 01 March 1997

Childhood asthma exacerbations and the Arg16 β2-receptor polymorphism: A meta-analysis stratified by treatment

scientific article published on 07 January 2016

Clinical Pharmacogenetics Implementation Consortium (CPIC) Guideline for Pharmacogenetics-Guided Warfarin Dosing: 2017 Update

scientific article published on 15 February 2017

Clinical Pharmacogenetics Implementation Consortium Guideline for HLA Genotype and Use of Carbamazepine and Oxcarbazepine: 2017 Update.

scientific article published on 2 February 2018

Clinical Pharmacogenetics Implementation Consortium Guidelines for CYP2C9 and VKORC1 genotypes and warfarin dosing

scientific article

Clinical Pharmacogenetics Implementation Consortium Guidelines for HLA-B Genotype and Abacavir Dosing: 2014 update

scientific article

Clinical Pharmacogenetics Implementation Consortium guidelines for HLA-B genotype and carbamazepine dosing.

scientific article

Clinical coding of prospectively identified paediatric adverse drug reactions--a retrospective review of patient records.

scientific article

Clinical factors and ABCB1 polymorphisms in prediction of antiepileptic drug response: a prospective cohort study

scientific article

Clinical management of HIV-associated lipodystrophy

scientific article published on August 2009

Clinical pharmacogenetics implementation consortium guidelines for HLA-B genotype and abacavir dosing

scientific article

Clinical pharmacology: special safety considerations in drug development and pharmacovigilance

scientific article published on January 2004

Clinical practice. Antibiotic allergy

scientific article

Clozapine-induced agranulocytosis is associated with rare HLA-DQB1 and HLA-B alleles

scientific article

Collecting and sharing information about harms

scientific article published in July 2004

Commentary: changing aetiology of peptic ulcers - author's reply

Common ABCB1 polymorphisms are not associated with multidrug resistance in epilepsy using a gene-wide tagging approach

article

Communication regarding adverse drug reactions between secondary and primary care: a postal questionnaire survey of general practitioners

scientific article published on 01 April 1999

Comparative effectiveness of dabigatran, rivaroxaban, apixaban, and warfarin in the management of patients with nonvalvular atrial fibrillation.

scientific article published on 25 April 2013

Comparison of the metabolism and toxicity of dapsone in rat, mouse and man

article

Copy number variation in exportin-4 (XPO4) gene and its association with histological severity of non-alcoholic fatty liver disease.

scientific article

Correction: Folate Augmentation of Treatment – Evaluation for Depression (FolATED): protocol of a randomised controlled trial.

scientific article published on 7 April 2009

Correction: The Effect of Inhibitory Signals on the Priming of Drug Hapten-Specific T Cells That Express Distinct Vβ Receptors.

scientific article published on 2 February 2018

Cost effectiveness analysis of HLA-B*58:01 genotyping prior to initiation of allopurinol for gout

scientific article published in October 2017

Cost-effectiveness analysis of HLA B*5701 genotyping in preventing abacavir hypersensitivity

scientific article

Cost-effectiveness of pharmacogenetic-guided dosing of warfarin in the United Kingdom and Sweden

scientific article

Cost-effectiveness of pharmacogenetics in anticoagulation: international differences in healthcare systems and costs

scientific article published on September 2012

Cost-effectiveness of pharmacogenetics-guided warfarin therapy vs. alternative anticoagulation in atrial fibrillation.

scientific article published on 23 September 2013

Cost-effectiveness of screening forHLA-A*31:01prior to initiation of carbamazepine in epilepsy

article published in 2015

Covalent binding of the nitroso metabolite of sulfamethoxazole leads to toxicity and major histocompatibility complex-restricted antigen presentation

scientific article published in September 2002

Current assessment of risk-benefit by regulators: is it time to introduce decision analyses?

scientific article published in August 2007

Cytochrome P450 enzyme polymorphisms and adverse drug reactions

scientific article published on October 2003

Cytochrome P450 testing for prescribing antipsychotics in adults with schizophrenia: systematic review and meta-analyses

scientific article published on 28 September 2010

Dabigatran etexilate versus warfarin in management of non-valvular atrial fibrillation in UK context: quantitative benefit-harm and economic analyses

scientific article

Defining drug response for stratified medicine

scientific article published on 3 November 2016

Deletion of exon 3 in the growth hormone receptor gene in adults with growth hormone deficiency: comparison of symptomatic and asymptomatic patients

scientific article

Detection of Drug-Induced Acute Kidney Injury in Humans Using Urinary KIM-1, miR-21, -200c, and -423

scientific article published on 27 April 2016

Detection of Primary T Cell Responses to Drugs and Chemicals in HLA-Typed Volunteers: Implications for the Prediction of Drug Immunogenicity.

scientific article published on 16 September 2016

Detection of an autoantibody directed against human liver microsomal protein in a patient with carbamazepine hypersensitivity

scientific article

Development and inter-rater reliability of the Liverpool adverse drug reaction causality assessment tool

scientific article

Development of ELISAs for diagnosis of acute typhoid fever in Nigerian children.

scientific article

Development of interferon beta-neutralising antibodies in multiple sclerosis--a systematic review and meta-analysis

scientific article published on 14 August 2015

Development of predictive genetic tests for improving the safety of new medicines: the utilization of routinely collected electronic health records

scientific article published on 14 November 2013

Development of the Liverpool Adverse Drug Reaction Avoidability Assessment Tool

scientific article

Development, validation and application of a novel HPLC-MS/MS method for the quantification of atorvastatin, bisoprolol and clopidogrel in a large cardiovascular patient cohort

scholarly article by Richard Myles Turner et al published 10 September 2018 in Journal of Pharmaceutical and Biomedical Analysis

Dexamethasone and haemorrhage risk in paediatric tonsillectomy: a systematic review and meta-analysis.

scientific article

Direct and metabolism-dependent toxicity of sulphasalazine and its principal metabolites towards human erythrocytes and leucocytes

scientific article published in September 1991

Direct evidence for the formation of diastereoisomeric benzylpenicilloyl haptens from benzylpenicillin and benzylpenicillenic acid in patients

scientific article

Direct oral anticoagulants versus warfarin: is new always better than the old?

scientific article published on 7 February 2018

Discordant CSF/plasma HIV-1 RNA in patients with unexplained low-level viraemia.

scientific article published on 18 May 2016

Disposition of amodiaquine and related antimalarial agents in human neutrophils: implications for drug design

scientific article published on February 1997

Drug Induced Hypersensitivity and the HLA Complex.

scientific article published on 23 December 2010

Drug hypersensitivity reactions in patients with HIV disease

scientific article published on May 2007

Drug metabolism

Drug metabolism and drug toxicity

article

Drug presentation to T cells

scientific article

Drug therapy for alcohol dependence in primary care in the UK: A Clinical Practice Research Datalink study.

scientific article

Drug-drug interactions and adverse drug reactions: separating the wheat from the chaff

Drug-grapefruit juice interactions

scholarly article

Drug-induced hypersensitivity reactions and pharmacogenomics: past, present and future

scientific article

Drugs and the retina

scientific article published on May 2004

Dual glutathione-S-transferase-θ1 and -μ1 gene deletions determine imatinib failure in chronic myeloid leukemia

scientific article published on 4 September 2014

Early deaths during tuberculosis treatment are associated with depressed innate responses, bacterial infection, and tuberculosis progression

scientific article published in August 2011

Efavirenz and Metabolites in Cerebrospinal Fluid: Relationship with CYP2B6 c.516G→T Genotype and Perturbed Blood-Brain Barrier Due to Tuberculous Meningitis.

scientific article

Effect of CYP4F2, VKORC1, and CYP2C9 in Influencing Coumarin Dose: A Single-Patient Data Meta-Analysis in More Than 15,000 Individuals

scientific article published on 17 February 2019

Effect of Genetic Variability in the CYP4F2, CYP4F11, and CYP4F12 Genes on Liver mRNA Levels and Warfarin Response.

scientific article published on 31 May 2017

Effect of atazanavir and ritonavir on the differentiation and adipokine secretion of human subcutaneous and omental preadipocytes.

scientific article published in July 2008

Effect of topiramate on acid-base balance: extent, mechanism and effects

scientific article

Effective dasatinib uptake may occur without human organic cation transporter 1 (hOCT1): implications for the treatment of imatinib-resistant chronic myeloid leukemia

scientific article

Effects of CYP4F2 genetic polymorphisms and haplotypes on clinical outcomes in patients initiated on warfarin therapy

scientific article published in October 2009

Effects of genetic variation at the CYP2C19/CYP2C9 locus on pharmacokinetics of chlorcycloguanil in adult Gambians

scientific article published on September 2009

Electronic health records for biological sample collection: feasibility study of statin-induced myopathy using the Clinical Practice Research Datalink.

scientific article published on May 2014

Emergence and global spread of epidemic healthcare-associated Clostridium difficile

scientific article published on 9 December 2012

Emergency re-admissions to hospital due to adverse drug reactions within 1 year of the index admission

scientific article

Enhancing communication about paediatric medicines: lessons from a qualitative study of parents' experiences of their child's suspected adverse drug reaction

scientific article

Enzyme-induction dependent bioactivation of troglitazone and troglitazone quinone in vivo.

scientific article published in August 2001

Epidemiology of alcohol dependence in UK primary care: Results from a large observational study using the Clinical Practice Research Datalink

scientific article

Establishment of an HLA-typed cohort of 1000 healthy blood donors and use of a dendritic cell priming assay to prime naive T cells to structurally divergent drugs

scientific article

Evaluation of laboratory tests for cirrhosis and for alcohol use, in the context of alcoholic cirrhosis

scientific article

Evidence to Support Inclusion of Pharmacogenetic Biomarkers in Randomised Controlled Trials

scientific article published on 01 September 2019

Exon sequencing and high resolution haplotype analysis of ABC transporter genes implicated in drug resistance

scientific article

Expanding role of pharmacogenomics in the management of cardiovascular disorders

scientific article published on June 2013

Explanation for HLA-B*57:01-linked immune-mediated abacavir-induced hypersensitivity.

scientific article

Exploring the genomic basis of pharmacoresistance in epilepsy: an integrative analysis of large-scale gene expression profiling studies on brain tissue from epilepsy surgery

scientific article

Expression of cytochrome P4502E1 in human liver: assessment by mRNA, genotype and phenotype

scientific article published on October 1998

Expression of the uptake drug transporter hOCT1 is an important clinical determinant of the response to imatinib in chronic myeloid leukemia

scientific article

Folate Augmentation of Treatment--Evaluation for Depression (FolATED): randomised trial and economic evaluation.

scientific article published on July 2014

Folate augmentation of treatment - evaluation for depression (FolATED): protocol of a randomised controlled trial

scientific article

Functional validity, role, and implications of heavy alcohol consumption genetic loci

scientific article published on 15 January 2020

GATM gene variants and statin myopathy risk

scientific article published in Nature

General pharmacology

scholarly article published 2012

General practice nurses' knowledge of alcohol use and misuse: a questionnaire survey

scientific article

Generation and characterization of antigen-specific CD4+, CD8+, and CD4+CD8+ T-cell clones from patients with carbamazepine hypersensitivity.

scientific article published on 22 February 2007

Genetic Predisposition to Anticonvulsant Hypersensitivity

scientific article published on 13 September 2019

Genetic analysis of microsomal epoxide hydrolase in patients with carbamazepine hypersensitivity

article

Genetic and environmental factors determining clinical outcomes and cost of warfarin therapy: a prospective study

scientific article published in October 2009

Genetic and nongenetic factors that may predispose individuals to allergic drug reactions

scientific article published on 01 August 2018

Genetic factors in the predisposition to drug-induced hypersensitivity reactions

scientific article

Genetic polymorphism of cytochrome P4502E1 and risk of alcoholic liver disease in Caucasians

Genetic regulation of gene expression in the epileptic human hippocampus

scientific article

Genetic variants of ABCC10, a novel tenofovir transporter, are associated with kidney tubular dysfunction

scientific article

Genetics and the Potential for Predictive Tests in Adverse Drug Reactions ⬇️

scientific article published on May 3, 2012

Genetics of epilepsy: epilepsy research foundation workshop report

scientific article published in June 2007

Genetics of immune-mediated adverse drug reactions: a comprehensive and clinical review

scientific article published on June 2015

Genome-Based Infection Tracking Reveals Dynamics of Clostridium difficile Transmission and Disease Recurrence

scientific article published on 18 December 2015

Genome-wide association study of nevirapine hypersensitivity in a malawian HIV-infected population

scientific article

Genome-wide association study of nevirapine hypersensitivity in a sub-Saharan African HIV-infected population

scientific article

Genome-wide association study of serious blistering skin rash caused by drugs ⬇️

scientific article published on January 11, 2011

Genome-wide association study of warfarin maintenance dose in a Brazilian sample

scientific article

Genomics of Adverse Drug Reactions

scientific article published on 09 December 2016

Genotype-guided dosing of coumarin derivatives: the European pharmacogenetics of anticoagulant therapy (EU-PACT) trial design

scientific article published in October 2009

Genotype-guided dosing of vitamin K antagonists

scientific article published on May 2014

Genotype-guided versus standard vitamin K antagonist dosing algorithms in patients initiating anticoagulation. A systematic review and meta-analysis

scientific article published on 9 July 2015

Glucuronidation of dihydroartemisinin in vivo and by human liver microsomes and expressed UDP-glucuronosyltransferases

scientific article published in September 2002

Glutathione S‐transferase mu genotype (GSTM1*0) in Alzheimer's patients with tacrine transaminitis ⬇️

scientific article published on April 1, 1995

HIV and Drug Hypersensitivity

article

HIV and drug allergy.

scientific article

HIV-associated lipodystrophy: a review of underlying mechanisms and therapeutic options

scientific article published on 18 June 2008

HLA Restriction of Carbamazepine-Specific T-Cell Clones from an HLA-A*31:01-Positive Hypersensitive Patient

article by Maike Lichtenfels et al published 31 January 2014 in Chemical Research in Toxicology

HLA genotype and carbamazepine-induced cutaneous adverse drug reactions: a systematic review

scientific article

HLA-A 31:01 is not associated with the development of methotrexate pneumonitis in the UK population: results from a genome-wide association study.

scientific article

HLA-A*3101 and carbamazepine-induced hypersensitivity reactions in Europeans

scientific article

HLA-B locus in Caucasian patients with carbamazepine hypersensitivity

scientific article

HLA-B*38:02:01predicts carbimazole/methimazole-induced agranulocytosis

scholarly article by C-L Cheung et al published 12 January 2016 in Clinical Pharmacology & Therapeutics

HLA-B*5701 genotype is a major determinant of drug-induced liver injury due to flucloxacillin

scientific article

HLA-DQ allele-restricted activation of nitroso sulfamethoxazole-specific CD4-positive T lymphocytes from patients with cystic fibrosis

scientific article published in August 2015

HLA-DQ restricted activation of nitroso-sulfamethoxazole-specific CD4+ T-lymphocytes

scientific article

HLA-allelotype associations with nevirapine-induced hypersensitivity reactions and hepatotoxicity: a systematic review of the literature and meta-analysis.

scientific article

Haemolytic anaemia associated with indinavir

scientific article

Haplotype structure of CYP2B6 and association with plasma efavirenz concentrations in a Chilean HIV cohort

scientific article

Heart Failure in Practice.: B S P Chin, M K Davies, and G Y H Lip. (Pp 76; 14.95.) Royal Society of Medicine Press, 2002. ISBN 1-85315-487-3

Hemolytic anemia in two patients with glioblastoma multiforme: A possible interaction between vorinostat and dapsone

scientific article published on 27 February 2014

Hepatitis B vaccine and neurotoxicity

scientific article

Hepatocellular response to chemical stress in CD-1 mice: induction of early genes and gamma-glutamylcysteine synthetase

scientific article published in August 2000

Herbal medicines

scientific article published in September 2003

Herbal medicines and acute medical emergency admissions to hospital

scientific article published on 10 November 2006

How can we improve our understanding of cardiovascular safety liabilities to develop safer medicines?

scientific article

How do NHS general hospitals in England deal with patients with alcohol-related problems? A questionnaire survey

scientific article

How important is aspirin adherence when evaluating effectiveness of low-dose aspirin?

scientific article published on 3 October 2017

Human leucocyte antigen class II genotype in susceptibility and resistance to co-amoxiclav-induced liver injury

scientific article published on August 2010

Human leukocyte antigen (HLA)-B*57:01-restricted activation of drug-specific T cells provides the immunological basis for flucloxacillin-induced liver injury.

scientific article

Hydralazine-induced lupus: yet another autoantibody!

scientific article published on 01 April 1996

Hypersensitivity reactions to HIV therapy

scientific article

Hypersensitivity reactions to carbamazepine: characterization of the specificity, phenotype, and cytokine profile of drug-specific T cell clones

scientific article published in March 2003

Identification of Organ-Enriched Protein Biomarkers of Acute Liver Injury by Targeted Quantitative Proteomics of Blood in Acetaminophen- and Carbon-Tetrachloride-Treated Mouse Models and Acetaminophen Overdose Patients

scientific article published on 30 August 2016

Identification of susceptible HLA class II co-amoxiclav genotypes based on the analysis of drug-specific T-cells from patients with liver injury

scientific article

Identifying Drug–Drug Interactions in Spontaneous Reports Utilizing Signal Detection and Biological Plausibility Aspects

scientific article published in 2024

Identifying cisplatin-induced kidney damage in paediatric oncology patients

scientific article published on 18 August 2017

Identifying new antiepileptic drugs through genomics-based drug repurposing

scientific article published on 4 January 2017

Identifying the biological pathways underlying human focal epilepsy: from complexity to coherence to centrality

scientific article published on 4 May 2015

Idiosyncratic drug reactions. Metabolic bioactivation as a pathogenic mechanism

scientific article published on September 1996

Idiosyncratic drug reactions: a mechanistic evaluation of risk factors

scientific article

Idiosyncratic reactions to antidepressants: A review of the possible mechanisms and predisposing factors ⬇️

scientific article published on January 1, 1992

Immunogenicity to biologics: mechanisms, prediction and reduction

scientific article

Immunoglobulin G1 and immunoglobulin G4 antibodies in multiple sclerosis patients treated with IFNβ interact with the endogenous cytokine and activate complement

scientific article published on 22 May 2013

Immunological principles of T-cell-mediated adverse drug reactions in skin

scientific article

Immunological principles of adverse drug reactions: the initiation and propagation of immune responses elicited by drug treatment

scientific article

Immunomodulatory interventions for focal epilepsy syndromes

scientific article (published 2013-06-27)

Immunopharmacology of hypersensitivity reactions to drugs

scientific article

Impact of the CYP4F2 p.V433M polymorphism on coumarin dose requirement: systematic review and meta-analysis

scientific article

Implementing Pharmacogenomics in Europe: Design and Implementation Strategy of the Ubiquitous Pharmacogenomics Consortium.

scientific article published on 27 December 2016

Important questions in Allergy: 1--drug allergy/hypersensitivity

scientific article published on May 2008

Improved glycaemia correlates with liver fat reduction in obese, type 2 diabetes, patients given glucagon-like peptide-1 (GLP-1) receptor agonists

scientific article

In Vitro Priming of Naı̈ve T-cells with p-Phenylenediamine and Bandrowski's Base.

scientific article published on 10 September 2015

In silico analysis of HLA associations with drug-induced liver injury: use of a HLA-genotyped DNA archive from healthy volunteers

scientific article

In vivo and in vitro efficacy of amodiaquine against Plasmodium falciparum in an area of continued use of 4-aminoquinolines in East Africa

scientific article published in June 2009

Incidence, characteristics and risk factors of adverse drug reactions in hospitalized children - a prospective observational cohort study of 6,601 admissions

scientific article

Induction of P-glycoprotein in lymphocytes by carbamazepine and rifampicin: the role of nuclear hormone response elements

scientific article

Influence of CYP2C9 and VKORC1 on patient response to warfarin: a systematic review and meta-analysis

scientific article

Institutional profile: the Wolfson Centre for Personalised Medicine, University of Liverpool, Liverpool, UK.

scientific article published in June 2013

Integration of genetic, clinical, and INR data to refine warfarin dosing

scientific article

Interaction of metoprolol and fluoxetine

scientific article published in The Lancet

Interindividual and interspecies variation in hepatic microsomal epoxide hydrolase activity: studies with cis-stilbene oxide, carbamazepine 10, 11-epoxide and naphthalene

scientific article published on 01 September 1996

Interpreting adverse drug reaction (ADR) reports as hospital patient safety incidents

scientific article

Intracellular glutathione in the peripheral blood cells of HIV-infected patients: failure to show a deficiency

article

Investigating the prevalence, predictors, and prognosis of suboptimal statin use early after a non-ST elevation acute coronary syndrome

scientific article

Investigation into the multidimensional genetic basis of drug-induced Stevens-Johnson syndrome and toxic epidermal necrolysis

scientific article

Investigation of inter-individual variability of the one-carbon folate pathway: a bioinformatic and genetic review.

scientific article published on 07 July 2009

Investigation of mechanisms in toxic epidermal necrolysis induced by carbamazepine

scientific article published on 01 May 1994

Investigation of toxic metabolites during drug development

scientific article

Is the interleukin 8 promoter polymorphism rs4073/-251T >A associated with Clostridium difficile infection?

scientific article

Kinetic parameters of lymphocyte microsomal epoxide hydrolase in carbamazepine hypersensitive patients

scientific article published on 01 October 1995

LC determination of carbamazepine in murine brain

scientific article published in November 2001

Lack of association between schizophrenia and theCYPZD6 gene polymorphisms

article

Lack of interaction between sulphasalazine and cimetidine in patients with rheumatoid arthritis

scientific article published in March 1993

Lamotrigine is a substrate for OCT1 in brain endothelial cells

scientific article published on 29 December 2011

Length of Variable Numbers of Tandem Repeats in the Carboxyl Ester Lipase (CEL) Gene May Confer Susceptibility to Alcoholic Liver Cirrhosis but Not Alcoholic Chronic Pancreatitis

scientific article

Letter to the Editor: Response to Costa et al

scientific article published on 12 April 2018

Letter: are idiopathic (non-NSAID, non-Helicobacter pylori) ulcers really increasing? Authors’ reply

Lipodystrophy in patients with HIV-1 infection: effect of stopping protease inhibitors on TNF-alpha and TNF-receptor levels, and on metabolic parameters

scientific article published in December 2004

Lymphocyte microsomal epoxide hydrolase in patients on carbamazepine therapy

scientific article

Management of allergy to penicillins and other beta-lactams.

scientific article published in February 2015

Mass Spectrometric Characterization of Circulating Covalent Protein Adducts Derived from Epoxide Metabolites of Carbamazepine in Patients

scientific article

Mass spectrometric characterization of circulating and functional antigens derived from piperacillin in patients with cystic fibrosis

scientific article

Measurement of CD4+ and CD8+ T-lymphocyte cytokine secretion and gene expression changes in p-phenylenediamine allergic patients and tolerant individuals

scientific article published in January 2010

Mechanism of clozapine-induced agranulocytosis : current status of research and implications for drug development

scientific article published in February 1997

Mechanism-based urinary biomarkers to identify the potential for aminoglycoside-induced nephrotoxicity in premature neonates: a proof-of-concept study ⬇️

scientific article

Mechanisms of Adverse Drug Reactions

Mechanisms of Adverse Drug Reactions

Mechanisms of drug hypersensitivity in HIV-infected patients: the role of the immune system.

scientific article

Metabolic acidosis with topiramate and zonisamide: an assessment of its severity and predictors.

scientific article

Metabolic activation in drug allergies.

scientific article

Metabolism of Lamotrigine to a Reactive Arene Oxide Intermediate

scientific article published on 01 November 2000

Metabolism-dependent neutrophil cytotoxicity of amodiaquine: A comparison with pyronaridine and related antimalarial drugs.

scientific article published on December 1998

Misoprostol-induced fever and genetic polymorphisms in drug transporters SLCO1B1 and ABCC4 in women of Latin American and European ancestry

scientific article

Modulation of LAT1 (SLC7A5) transporter activity and stability by membrane cholesterol.

scientific article

Molecular and genetic association of interleukin-6 in tacrine-induced hepatotoxicity.

scientific article

Molecular isoforms of high-mobility group box 1 are mechanistic biomarkers for epilepsy

scientific article

Monitoring drug treatment

scientific article published in November 2003

Monitoring of long-term toxicities of HIV treatments ⬇️

scientific article published on November 21, 2003

Monocyte unresponsiveness and impaired IL1β, TNFα and IL7 production are associated with a poor outcome in Malawian adults with pulmonary tuberculosis

scientific article published on 13 November 2015

N-acetyltransferase 2 (NAT2) genotype as a risk factor for development of drug-induced liver injury relating to antituberculosis drug treatment in a mixed-ethnicity patient group

article

Neutrophil cytotoxicity of the chemically reactive metabolite(s) of clozapine: possible role in agranulocytosis ⬇️

scientific article published on December 1, 1997

New Approaches to Investigate Drug-Induced Hypersensitivity

scientific article published on 2 November 2016

New genetic findings lead the way to a better understanding of fundamental mechanisms of drug hypersensitivity

scientific article

New uses for old drugs

scientific article published on 26 June 2018

Nilotinib concentration in cell lines and primary CD34(+) chronic myeloid leukemia cells is not mediated by active uptake or efflux by major drug transporters.

scientific article

No association between tacrine transaminitis and the glutathione transferase theta genotype in patients with Alzheimer's disease.

scientific article published in August 1998

Nonmedical prescriber experiences of training and competence to report adverse drug reactions in the UK

scientific article published on 11 September 2018

Nucleic acid based therapies: developing frontier for precision medicine

scientific article published on 23 January 2018

Nurses' confidence in caring for patients with alcohol-related problems

scientific article published on 01 November 1997

Off-label and unlicensed medicine use and adverse drug reactions in children: a narrative review of the literature

scientific article published on 22 July 2011

Open letter on access to the BIA 10-2474 clinical trial data

scientific article published on 7 December 2016

Oral anticoagulation: a critique of recent advances and controversies

scientific article

Paediatric pharmacogenomics: an overview

scientific article

Paediatric use of mycophenolate mofetil

scientific article published on January 2013

Parsing interindividual drug variability: an emerging role for systems pharmacology

scientific article

Patients benefit from genetics-guided coumarin anticoagulant therapy

scientific article

Personalized medicine approaches in epilepsy

scientific article

Personalized medicine: decades away?

scientific article

Personalized pharmacogenomics: predicting efficacy and adverse drug reactions

scientific article published on 29 May 2014

Pharmacodynamic and pharmacokinetic study of oral Curcuma extract in patients with colorectal cancer.

scientific article published in July 2001

Pharmacogenetic Markers of Drug Efficacy and Toxicity

scientific article published on 03 June 2015

Pharmacogenetic testing prior to carbamazepine treatment of epilepsy: patients' and physicians' preferences for testing and service delivery

scientific article

Pharmacogenetic tests: the need for a level playing field

scientific article published on 01 January 2013

Pharmacogenetic warfarin dose refinements remain significantly influenced by genetic factors after one week of therapy

scientific article published on 21 December 2011

Pharmacogenetics and Pharmacogenomics

Pharmacogenetics and pharmacogenomics

scientific article

Pharmacogenetics for the prescriber

Pharmacogenetics for the prescriber

Pharmacogenetics in clinical practice: considerations for testing

scientific article

Pharmacogenetics in reproductive and perinatal medicine

scientific article published on January 2010

Pharmacogenetics in the treatment of chronic lymphocytic leukemia: what does the future hold?

scientific article

Pharmacogenetics of Adverse Drug Reactions

Pharmacogenetics of Adverse Drug Reactions

Pharmacogenetics of Adverse Drug Reactions

scientific article published on 01 January 2018

Pharmacogenetics of HIV therapy

scientific article

Pharmacogenetics of antiepileptic drug-induced hypersensitivity

scientific article published on April 2014

Pharmacogenetics of idiosyncratic adverse drug reactions

scientific article published on January 2010

Pharmacogenetics of warfarin in a paediatric population: time in therapeutic range, initial and stable dosing and adverse effects.

scientific article

Pharmacogenetics of warfarin: current status and future challenges

scientific article published on 19 September 2006

Pharmacogenetics: past, present and future ⬇️

scientific article published on August 22, 2011

Pharmacogenomics for Primary Care: An Overview

scientific article published on 12 November 2020

Pharmacogenomics in neurology: current state and future steps

scientific article

Pharmacogenomics in the UK National Health Service: opportunities and challenges

scientific article published on 29 October 2020

Pharmacogenomics: Current State-of-the-Art

scientific article

Pharmacogenomics: the importance of accurate phenotypes

scientific article published in April 2010

Pharmacologic markers and predictors of responses to imatinib therapy in patients with chronic myeloid leukemia

scientific article published on April 2008

Pharmacotherapy for alcohol dependence: A stratified approach

scientific article published on 16 May 2015

Pharmacovigilance in developing countries

scientific article published on September 2007

Pharmacovigilance of drug allergy and hypersensitivity using the ENDA-DAHD database and the GALEN platform. The Galenda project.

scientific article published in February 2009

Phase I clinical trial of oral curcumin: biomarkers of systemic activity and compliance

scientific article published in October 2004

Phenotype standardization for immune-mediated drug-induced skin injury.

scientific article published on 11 May 2011

Phenotype standardization for statin-induced myotoxicity

scientific article

Phenotype standardization of angioedema in the head and neck region caused by agents acting on the angiotensin system.

scientific article

Physiological, pharmacological and toxicological considerations of drug-induced structural cardiac injury

scientific article

Polymorphism in gene for microsomal epoxide hydrolase and lung disease

scientific article published in The Lancet

Polymorphisms in the TNF-alpha and TNF-receptor genes in patients with coronary artery disease

article

Population pharmacokinetic and pharmacogenetic analysis of nevirapine in hypersensitive and tolerant HIV-infected patients from Malawi

scientific article published on 11 November 2013

Population pharmacokinetic and pharmacogenetic analysis of nevirapine in hypersensitive and tolerant HIV-infected patients from Malawi

article

Possible interaction between warfarin and cranberry juice

scientific article

Pragmatic randomised trials using routine electronic health records: putting them to the test

scientific article

Predictive genetic testing for drug-induced liver injury: considerations of clinical utility

scientific article published on August 2012

Predictors and outcomes of increases in creatine phosphokinase concentrations or rhabdomyolysis risk during statin treatment

scientific article

Prescribing in liver disease

Prescribing in liver disease

Prescribing in liver disease

Progress in pharmacogenetics: consortiums and new strategies

scientific article

Promiscuous T-cell responses to drugs and drug-haptens

article

Quality of life in patients with venous thromboembolism and atrial fibrillation treated with coumarin anticoagulants

scientific article published on 25 April 2015

Quantification of urinary mevalonic acid as a biomarker of HMG-CoA reductase activity by a novel translational LC–MS/MS method

article published in 2014

Quantifying the metabolic activation of nevirapine in patients by integrated applications of NMR and mass spectrometries

scientific article published in January 2010

RXRγ gene variants are associated with HIV lipodystrophy

scientific article published in August 2013

Randomised Evaluations of Accepted Choices in Treatment (REACT) trials: large-scale pragmatic trials within databases of routinely collected electronic healthcare records.

scientific article

Randomized controlled trial: lisinopril reduces proteinuria, ammonia, and renal polypeptide tubular catabolism in patients with chronic allograft nephropathy

scientific article published on January 2010

Rationale and design of the multiethnic Pharmacogenomics in Childhood Asthma consortium

scientific article published on 22 June 2017

Recognition of sulfamethoxazole and its reactive metabolites by drug-specific CD4+ T cells from allergic individuals

scientific article published in June 2000

Reference intervals for urinary renal injury biomarkers KIM-1 and NGAL in healthy children

scientific article

Relationship between the C3435T and G2677T(A) polymorphisms in the ABCB1 gene and P-glycoprotein expression in human liver

scientific article

Release of intracellular calcium primes chronic myeloid leukaemia cells for tyrosine kinase inhibitor-induced apoptosis.

scientific article

Relevance of induction of human drug-metabolizing enzymes: pharmacological and toxicological implications

scientific article

Renal function monitoring in heart failure - what is the optimal frequency? A narrative review

scientific article published on 13 September 2017

Reported paediatric adverse drug reactions in the UK 2000-2009

scientific article

Reporting of adverse drug reactions by nurses

scientific article published in The Lancet

Reporting of adverse drug reactions: practice in the UK

scientific article published on 01 March 1998

Reporting of drug induced depression and fatal and non-fatal suicidal behaviour in the UK from 1998 to 2011.

scientific article

Repurposing Statins for Renal Protection: Is It a Class Effect?

scientific article published on 15 November 2017

Research Directions in Genetic Predispositions to Stevens-Johnson Syndrome / Toxic Epidermal Necrolysis.

scientific article published on 6 November 2017

Response 2 to pharmacogenetic screening to prevent carbamazepine-induced toxic epidermal necrolysis and Stevens-Johnson syndrome: a critical appraisal

article

Response to “HLA Allelic Variants and Carbamazepine-Induced Hypersensitivity”

Review article: cellular and molecular mechanisms of NSAID-induced peptic ulcers

scientific article published on 03 July 2009

Risk modeling strategies for pharmacogenetic studies

scientific article published on March 2011

Risperidone-induced photosensitivity ⬇️

scientific article published on April 1, 1998

Role of Drug Disposition in Drug Hypersensitivity: A Chemical, Molecular, and Clinical Perspective

article by B. Kevin Park et al published September 1998 in Chemical Research in Toxicology

SJS/TEN 2017: Building Multidisciplinary Networks to Drive Science and Translation

scientific article published in January 2018

SLCO1B1 genetic variant associated with statin-induced myopathy: a proof-of-concept study using the clinical practice research datalink

scientific article

ST13 polymorphisms and their effect on exacerbations in steroid-treated asthmatic children and young adults.

scientific article published on June 2015

Safety assessment of peroxide antimalarials: clinical and chemical perspectives

scientific article published on December 1998

Serious carbamazepine-induced hypersensitivity reactions associated with the HSP70 gene cluster

scientific article

Serum mannose-binding lectin concentration, but not genotype, is associated with Clostridium difficile infection recurrence: a prospective cohort study

scientific article

Shared Genetic Risk Factors Across Carbamazepine-Induced Hypersensitivity Reactions

scientific article published on 03 July 2019

Short-term exercise training improves body composition and hyperlipidaemia in HIV-positive individuals with lipodystrophy

scientific article

Simultaneous determination of nilotinib, imatinib and its main metabolite (CGP-74588) in human plasma by ultra-violet high performance liquid chromatography

scientific article published on 9 December 2009

Skewing of the TCR V repertoire in SMX-NO specific T cell responses

scientific article

Slow acetylator phenotype and genotype in HIV-positive patients with sulphamethoxazole hypersensitivity ⬇️

scientific article published on February 2003

Social media and pharmacovigilance: A review of the opportunities and challenges

scientific article

Specialist nurse reporting of adverse drug reactions

scientific article published on 01 February 2000

Spontaneous hemothorax following anticoagulation with low-molecular-weight heparin

scientific article published on 18 August 2009

Statin-Related Myotoxicity: A Comprehensive Review of Pharmacokinetic, Pharmacogenomic and Muscle Components

scientific article published on 20 December 2019

Statins inhibit aminoglycoside accumulation and cytotoxicity to renal proximal tubule cells

scientific article published on February 2010

Statins, immunomodulation, and infections: a complex and unresolved relationship.

scientific article

Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis Standard Reporting and Evaluation Guidelines: Results of a National Institutes of Health Working Group.

scientific article published on 15 March 2017

Stroke Pharmacogenetics

Sulfamethoxazole and its metabolite nitroso sulfamethoxazole stimulate dendritic cell costimulatory signaling

scientific article

Susceptibility to amoxicillin-clavulanate-induced liver injury is influenced by multiple HLA class I and II alleles

scientific article

Susceptibility to corticosteroid-induced adrenal suppression: a genome-wide association study.

scientific article

Synthesis and reactions of nitroso sulphamethoxazole with biological nucleophiles: Implications for immune mediated toxicity

article

Systematic review: Baclofen dosing protocols for alcohol use disorders used in observational studies.

scientific article published on 19 September 2017

Systemic illness with skin eruption, fever and positive lymphocyte transformation test in a patient on irbesartan.

scientific article

T-cells from HLA-B*57:01+ human subjects are activated with abacavir through two independent pathways and induce cell death by multiple mechanisms

scientific article published on 12 April 2013

TNF, LTA, HSPA1L and HLA-DR gene polymorphisms in HIV-positive patients with hypersensitivity to cotrimoxazole.

scientific article published in April 2009

TNF-alpha promoter region gene polymorphisms in HIV-positive patients with lipodystrophy

scientific article

TNFalpha promoter region gene polymorphisms in carbamazepine-hypersensitive patients.

scientific article

TPMT, COMT and ACYP2 genetic variants in paediatric cancer patients with cisplatin-induced ototoxicity.

scientific article published on 25 April 2017

Tacrine-induced liver damage: an analysis of 19 candidate genes

scientific article

Telmisartan and Insulin Resistance in HIV (TAILoR): protocol for a dose-ranging phase II randomised open-labelled trial of telmisartan as a strategy for the reduction of insulin resistance in HIV-positive individuals on combination antiretroviral th

scientific article

Telmisartan reverses antiretroviral-induced adipocyte toxicity and insulin resistance in vitro.

scientific article published on 21 February 2018

Telmisartan to reduce insulin resistance in HIV-positive individuals on combination antiretroviral therapy: the TAILoR dose-ranging Phase II RCT

The B-cell lymphoma 2 (BCL2)-inhibitors, ABT-737 and ABT-263, are substrates for P-glycoprotein.

scientific article published on 13 April 2011

The Effect of Inhibitory Signals on the Priming of Drug Hapten-Specific T Cells That Express Distinct Vβ Receptors

scientific article

The HLA-A*31:01 allele: influence on carbamazepine treatment

scientific article published on 31 January 2017

The International Serious Adverse Events Consortium (iSAEC) phenotype standardization project for drug-induced torsades de pointes

scientific article published on 02 July 2012

The Role of Active Metabolites in Drug Toxicity

article

The accumulation and metabolism of zidovudine in 3T3-F442A pre-adipocytes

scientific article published on 10 December 2009

The applications of pharmacogenetics to prescribing: what is currently practicable?

scientific article published on October 2009

The association between polymorphisms in RLIP76 and drug response in epilepsy

scientific article

The burden of alcohol misuse on an inner-city general hospital

scientific article published on May 2000

The clinical effectiveness and cost-effectiveness of testing for cytochrome P450 polymorphisms in patients with schizophrenia treated with antipsychotics: a systematic review and economic evaluation

scientific article published on January 2010

The clinical significance of ABCC3 as an imatinib transporter in chronic myeloid leukaemia

scientific article published on 20 January 2014

The d3/fl-GH receptor gene polymorphism does not influence quality of life and body composition in GH-deficient adults receiving GH replacement therapy

scientific article published on 15 July 2009

The danger hypothesis--potential role in idiosyncratic drug reactions

scientific article

The effect of enzyme induction on the cytochrome P450-mediated bioactivation of carbamazepine by mouse liver microsomes

scientific article published on December 15, 1992

The effect of fluconazole and ketoconazole on the metabolism of sulphamethoxazole

scientific article published on September 1996

The effect of genetic polymorphisms in CYP2C9 on sulphamethoxazole N-hydroxylation.

scientific article published on February 1999

The future prospects of pharmacogenetics in oral anticoagulation therapy

scientific article

The hOCT1 SNPs M420del and M408V alter imatinib uptake and M420del modifies clinical outcome in imatinib-treated chronic myeloid leukemia

scientific article published on 5 December 2012

The metabolic formation of reactive intermediates from clozapine, a drug associated with agranulocytosis in man

scientific article published on 01 December 1995

The molecular genetics of chemotherapy-induced peripheral neuropathy: A systematic review and meta-analysis.

scientific article published on 25 September 2017

The opportunities and challenges of pragmatic point-of-care randomised trials using routinely collected electronic records: evaluations of two exemplar trials

scientific article

The pharmacogenomics of HIV therapy.

scientific article

The phenotype standardization project: improving pharmacogenetic studies of serious adverse drug reactions.

scientific article published on June 2011

The population pharmacokinetics of R- and S-warfarin: effect of genetic and clinical factors

scientific article published on January 2012

The prescribable drugs with efficacy in experimental epilepsies (PDE3) database for drug repurposing research in epilepsy.

scientific article published on 17 January 2018

The quality of information on monitoring for haematological adverse drug reactions.

scientific article

The relationship between the disposition and immunogenicity of sulfamethoxazole in the rat

scientific article published on 01 August 1997

The relative contribution of NSAIDs and Helicobacter pylori to the aetiology of endoscopically-diagnosed peptic ulcer disease: observations from a tertiary referral hospital in the UK between 2005 and 2010.

scientific article

The role of Clostridium difficile in the paediatric and neonatal gut - a narrative review

scientific article

The role of cytochrome P450 enzymes in hepatic and extrahepatic human drug toxicity

scientific article published on January 1995

The role of metabolic activation in drug-induced hepatotoxicity

scientific article

The role of polymorphism in manganese superoxide dismutase in susceptibility to alcoholic liver disease

scientific article published on 01 June 2003

The role of polymorphisms of glutathione S-transferases GSTM1, M3, P1, T1 and A1 in susceptibility to alcoholic liver disease

scientific article published in November 2004

The top 100 drug interactions. A Guide to Patient Management. 2003 Edition.

scientific article published in February 2004

The use of opioids and laxatives, and incidence of constipation, in patients requiring neck-of-femur (NOF) surgery: a pilot study

scientific article published in October 2008

Therapeutics 1995

scientific article published on 01 November 1995

Thiopurine monitoring in children with inflammatory bowel disease: a systematic review

scientific article

Through a glass darkly: economics and personalised medicine

scientific article published on November 2014

Time to onset of bisphosphonate-related osteonecrosis of the jaws: a multicentre retrospective cohort study.

scientific article published on 31 December 2016

Towards better models and mechanistic biomarkers for drug-induced gastrointestinal injury

scientific article published on 26 January 2017

Transport of gabapentin by LAT1 (SLC7A5).

scientific article published on 6 April 2013

Trastuzumab uptake in HER2-positive breast cancer patients: a systematic review and meta-analysis of observational studies

scientific article published on 03 August 2018

Treatment of paracetamol overdose: room for improvement?

scientific article published on 28 November 2013

Trimethoprim stimulates T-cells through metabolism-dependent and -independent pathways

scientific article published on 3 May 2011

Urinary Biomarkers of Aminoglycoside-Induced Nephrotoxicity in Cystic Fibrosis: Kidney Injury Molecule-1 and Neutrophil Gelatinase-Associated Lipocalin.

scientific article published on 23 March 2018

Validation of a multigenic model to predict seizure control in newly treated epilepsy.

scientific article published on 16 September 2014

Variability of antibiotic prescribing in patients with chronic obstructive pulmonary disease exacerbations: a cohort study

scientific article

Variation in warfarin prescribing and dosing in the UK: a national survey of anticoagulation clinics

scientific article

Warfarin pharmacogenetics: a single VKORC1 polymorphism is predictive of dose across 3 racial groups

scientific article

Warfarin pharmacogenetics: economic considerations

scientific article published in January 2007

Warfarin: The End or the End of One Size Fits All Therapy?

scientific article published on 28 June 2018

Warfarin: almost 60 years old and still causing problems

scientific article

What can we learn from parents about enhancing participation in pharmacovigilance?

scientific article published on April 2013

Which drugs cause preventable admissions to hospital? A systematic review

scientific article

Whole-blood cultures from renal-transplant patients stimulated ex vivo show that the effects of cyclosporine on lymphocyte proliferation are related to P-glycoprotein expression

scientific article

Zoonotic Transfer of Clostridium difficile Harboring Antimicrobial Resistance between Farm Animals and Humans.

scientific article

hOCT 1 and resistance to imatinib

scientific article published in August 2005

β-Lactam antibiotics form distinct haptenic structures on albumin and activate drug-specific T-lymphocyte responses in multiallergic patients with cystic fibrosis

scientific article published on 23 May 2013

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