List of works - Christopher A. Lipinski

A crowdsourcing evaluation of the NIH chemical probes

scientific article (publication date: July 2009)

Analysis and hit filtering of a very large library of compounds screened against Mycobacterium tuberculosis

scientific article

Badapple: promiscuity patterns from noisy evidence

scientific article

Bioisosteric design of conformationally restricted pyridyltriazole histamine H2-receptor antagonists ⬇️

scientific article published on January 1, 1983

Bioisosteric prototype design of biaryl imidazolyl and triazolyl competitive histamine H2-receptor antagonists

scientific article published on November 1986

Chemical Tools for Indications Discovery

Chris Lipinski discusses life and chemistry after the Rule of Five

scientific article published in January 2003

Computational prediction and validation of an expert's evaluation of chemical probes

scientific article

Drug-like properties and the causes of poor solubility and poor permeability

scientific article

Erratum: A crowdsourcing evaluation of the NIH chemical probes

article

High throughput sonication: evaluation for compound solubilization

scientific article published in September 2005

Hydantoin bioisosteres. In vivo active spiro hydroxy acetic acid aldose reductase inhibitors

scientific article published on June 1992

Lead- and drug-like compounds: the rule-of-five revolution

scientific article published on December 2004

MLR-1023 is a potent and selective allosteric activator of Lyn kinase in vitro that improves glucose tolerance in vivo.

scientific article

Medicinal chemistry of aldose reductase inhibitors

scientific article published on April 1988

Navigating chemical space for biology and medicine

scientific article

Parallel worlds of public and commercial bioactive chemistry data

scientific article

Pseudosymmetry and bioisosterism in biaryl pyridyl competitive histamine H2-receptor antagonists

scientific article published on November 1985

Quantitative structure-activity relationships among macrolide antibacterial agents: in vitro and in vivo potency against Pasteurella multocida.

scientific article published in April 1997

Rule of five in 2015 and beyond: Target and ligand structural limitations, ligand chemistry structure and drug discovery project decisions

scientific article

Single-mode compound retrieval for QSAR, QSPR data sets, and batch mode exact structure searching

scientific article

Small molecules with antiviral activity against the Ebola virus

scientific article

Synthesis and antitubercular activity of 7-(R)- and 7-(S)-methyl-2-nitro-6-(S)-(4-(trifluoromethoxy)benzyloxy)-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazines, analogues of PA-824.

scientific article published on 7 March 2008

The Lyn kinase activator MLR-1023 is a novel insulin receptor potentiator that elicits a rapid-onset and durable improvement in glucose homeostasis in animal models of type 2 diabetes.

scientific article

The anti-intellectual effects of intellectual property

scientific article published on 7 July 2006

The rule of five should not impede anti-parasitic drug development

scientific article

Thermodynamic Proxies to Compensate for Biases in Drug Discovery Methods

scientific article published on 27 August 2015

List of works by Christopher A. Lipinski

A crowdsourcing evaluation of the NIH chemical probes

Analysis and hit filtering of a very large library of compounds screened against Mycobacterium tuberculosis

Badapple: promiscuity patterns from noisy evidence

Bioisosteric design of conformationally restricted pyridyltriazole histamine H2-receptor antagonists ⬇️

Bioisosteric prototype design of biaryl imidazolyl and triazolyl competitive histamine H2-receptor antagonists

Chemical Tools for Indications Discovery

Chris Lipinski discusses life and chemistry after the Rule of Five

Computational prediction and validation of an expert's evaluation of chemical probes

Drug-like properties and the causes of poor solubility and poor permeability

Erratum: A crowdsourcing evaluation of the NIH chemical probes

High throughput sonication: evaluation for compound solubilization

Hydantoin bioisosteres. In vivo active spiro hydroxy acetic acid aldose reductase inhibitors

Lead- and drug-like compounds: the rule-of-five revolution

MLR-1023 is a potent and selective allosteric activator of Lyn kinase in vitro that improves glucose tolerance in vivo.

Medicinal chemistry of aldose reductase inhibitors

Navigating chemical space for biology and medicine

Parallel worlds of public and commercial bioactive chemistry data

Pseudosymmetry and bioisosterism in biaryl pyridyl competitive histamine H2-receptor antagonists

Quantitative structure-activity relationships among macrolide antibacterial agents: in vitro and in vivo potency against Pasteurella multocida.

Rule of five in 2015 and beyond: Target and ligand structural limitations, ligand chemistry structure and drug discovery project decisions

Single-mode compound retrieval for QSAR, QSPR data sets, and batch mode exact structure searching

Small molecules with antiviral activity against the Ebola virus

Synthesis and antitubercular activity of 7-(R)- and 7-(S)-methyl-2-nitro-6-(S)-(4-(trifluoromethoxy)benzyloxy)-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazines, analogues of PA-824.

The Lyn kinase activator MLR-1023 is a novel insulin receptor potentiator that elicits a rapid-onset and durable improvement in glucose homeostasis in animal models of type 2 diabetes.

The anti-intellectual effects of intellectual property

The rule of five should not impede anti-parasitic drug development

Thermodynamic Proxies to Compensate for Biases in Drug Discovery Methods