Search filters

List of works by Martin Klingenspor

2-O-β-D-Glucopyranosyl-carboxyatractyligenin from Coffea L. inhibits adenine nucleotide translocase in isolated mitochondria but is quantitatively degraded during coffee roasting

scientific article published on 2 May 2013

3-Iodothyronamine: a novel hormone controlling the balance between glucose and lipid utilisation

scientific article published on 3 October 2007

A broad phenotypic screen identifies novel phenotypes driven by a single mutant allele in Huntington's disease CAG knock-in mice

scientific article

A functional nexus between photoperiod acclimation, torpor expression and somatic fatty acid composition in a heterothermic mammal.

scientific article

A humanized version of Foxp2 affects cortico-basal ganglia circuits in mice

scientific article (publication date: 29 May 2009)

A novel N-ethyl-N-nitrosourea-induced mutation in phospholipase Cγ2 causes inflammatory arthritis, metabolic defects, and male infertility in vitro in a murine model

article

A novel SP1/SP3 dependent intronic enhancer governing transcription of the UCP3 gene in brown adipocytes

scientific article

A novel missense mutation in the mouse growth hormone gene causes semidominant dwarfism, hyperghrelinemia, and obesity

scientific article

A paternal methyl donor-rich diet altered cognitive and neural functions in offspring mice.

scientific article

A review of standardized metabolic phenotyping of animal models

scientific article published on 09 September 2014

A role for brain-derived neurotrophic factor in B cell development

scientific article published on 9 April 2005

Absence of UCP3 in brown adipose tissue does not impair nonshivering thermogenesis

scientific article published in January 2004

Adaptive thermogenesis and thermal conductance in wild-type and UCP1-KO mice

scientific article

Adipose Mitochondrial Respiratory Capacity in Obesity is Impaired Independently of Glycemic Status of Tissue Donors

scientific article published on 26 March 2019

Aminoglycosides, but not PTC124 (Ataluren), rescue nonsense mutations in the leptin receptor and in luciferase reporter genes

scientific article

An ancient look at UCP1.

scientific article published on 18 March 2008

An intronic single base exchange leads to a brown adipose tissue-specific loss of Ucp3 expression and an altered body mass trajectory

scientific article

Analysis of mammalian gene function through broad-based phenotypic screens across a consortium of mouse clinics

scientific article

Behavioural mechanisms affecting energy regulation in mice prone or resistant to diet- induced obesity

scientific article published on 16 December 2009

Boosting mitochondrial biogenesis in white adipocytes: A route towards improved insulin sensitivity?

scientific article published on 10 July 2013

Brown adipose tissue specific lack of uncoupling protein 3 is associated with impaired cold tolerance and reduced transcript levels of metabolic genes

scientific article published on 7 November 2007

Brown fat develops a brite future

scientific article published on 22 December 2012

Browning attenuates murine white adipose tissue expansion during postnatal development

scientific article published on 30 January 2013

CIN85 regulates dopamine receptor endocytosis and governs behaviour in mice

scientific article

Characterization of the melanocortin-4-receptor nonsense mutation W16X in vitro and in vivo

scientific article published on 4 October 2011

Chicken ovalbumin upstream promoter transcription factor II regulates uncoupling protein 3 gene transcription in Phodopus sungorus

scientific article

Cold-induced recruitment of brown adipose tissue thermogenesis.

scientific article

Comparative gene array analysis of progenitor cells from human paired deep neck and subcutaneous adipose tissue

scientific article published on 4 August 2014

Comparison of particle-exposure triggered pulmonary and systemic inflammation in mice fed with three different diets

scientific article

Contrasting adrenergic effects on lipoprotein lipase gene expression in the brown adipose tissue of intact mice and in cultured brown adipocytes from mice

article

Control of adipogenesis by oxylipins, GPCRs and PPARs

scientific article published on 26 December 2016

Cyclooxygenase-2 controls energy homeostasis in mice by de novo recruitment of brown adipocytes

scientific article

Cytochrome c oxidase subunit 4 isoform 2-knockout mice show reduced enzyme activity, airway hyporeactivity, and lung pathology

scientific article

Defective lipolysis and altered energy metabolism in mice lacking adipose triglyceride lipase

scientific article

Depression of transcription and translation during daily torpor in the Djungarian hamster (Phodopus sungorus).

scientific article

Development of a capillary isoelectric focusing immunoassay to measure DJ-1 isoforms in biological samples

scientific article published on 17 September 2013

Diet-induced and mono-genetic obesity alter volatile organic compound signature in mice

scientific article published on 10 February 2016

Diet-induced obesity causes metabolic impairment independent of alterations in gut barrier integrity

scientific article published on 20 March 2015

Diet-induced obesity in ad libitum-fed mice: food texture overrides the effect of macronutrient composition

scientific article

Dietary fat and gut microbiota interactions determine diet-induced obesity in mice

scientific article

Distinct signatures of host-microbial meta-metabolome and gut microbiome in two C57BL/6 strains under high-fat diet

scientific article

Disturbed gut microbiota and bile homeostasis in Giardia-infected mice contributes to metabolic dysregulation and growth impairment

scientific article published on 01 October 2020

Dll1 haploinsufficiency in adult mice leads to a complex phenotype affecting metabolic and immunological processes

scientific journal article

Does enamelin have pleiotropic effects on organs other than the teeth? Lessons from a phenotyping screen of two enamelin-mutant mouse lines

scientific journal article

EBI2 is a negative modulator of brown adipose tissue energy expenditure in mice and human brown adipocytes

scientific article published on 29 March 2022

Effect of unilateral surgical denervation of brown adipose tissue on uncoupling protein mRNA level and cytochrom-c-oxidase activity in the Djungarian hamster

scientific article published on 01 January 1994

Effects of diet-matrix on volatile organic compounds in breath in diet-induced obese mice

article

Evidence for Nr4a1 as a cold-induced effector of brown fat thermogenesis

scientific article published on 11 October 2005

Expanding the body mass range: associations between BMR and tissue morphology in wild type and mutant dwarf mice (David mice).

scientific article published on 29 September 2006

FTO deficiency induces UCP-1 expression and mitochondrial uncoupling in adipocytes

scientific article published on 10 June 2013

Fibroblast growth factor 8b induces uncoupling protein 1 expression in epididymal white preadipocytes.

scientific article

Functional characterisation of UCP1 in the common carp: uncoupling activity in liver mitochondria and cold-induced expression in the brain

scientific article published on 19 June 2007

Functional characterization of UCP1 in mammalian HEK293 cells excludes mitochondrial uncoupling artefacts and reveals no contribution to basal proton leak

scientific article

Functional compensation among HMGN variants modulates the DNase I hypersensitive sites at enhancers

scientific article published on 8 July 2015

Functional inactivation of the genome-wide association study obesity gene neuronal growth regulator 1 in mice causes a body mass phenotype

scientific journal article

Gene set of nuclear-encoded mitochondrial regulators is enriched for common inherited variation in obesity

scientific article

Gene-gene interaction between APOA5 and USF1: two candidate genes for the metabolic syndrome

scientific article

Generation and Standardized, Systemic Phenotypic Analysis of Pou3f3L423P Mutant Mice

scientific article

Generation of mice lacking DUF1220 protein domains: effects on fecundity and hyperactivity

scientific article

Glucocorticoid hormone stimulates mitochondrial biogenesis specifically in skeletal muscle

scientific article

Glucose Tolerance Tests for Systematic Screening of Glucose Homeostasis in Mice

High energy digestion efficiency and altered lipid metabolism contribute to obesity in BFMI mice.

scientific article published on 23 April 2009

High fat diet accelerates pathogenesis of murine Crohn's disease-like ileitis independently of obesity

scientific article

High-fat diet induced isoform changes of the Parkinson's disease protein DJ-1.

scientific article published on 28 March 2014

Impact of dietary ω3 polyunsaturated fatty acid supplementation on brown and brite adipocyte function.

scientific article published on 17 January 2018

Inflammation and mitochondrial fatty acid beta-oxidation link obesity to early tumor promotion

scientific article

Innovations in phenotyping of mouse models in the German Mouse Clinic

scientific article

Intrinsic differences in BRITE adipogenesis of primary adipocytes from two different mouse strains

scientific article published on 19 June 2014

Introducing the German Mouse Clinic: open access platform for standardized phenotyping

scientific article

Inverse relationship between body mass index and mitochondrial oxidative phosphorylation capacity in human subcutaneous adipocytes

scientific article published on 16 June 2015

Large-scale phenotyping of an accurate genetic mouse model of JNCL identifies novel early pathology outside the central nervous system

scientific article

Leveraging cross-species transcription factor binding site patterns: from diabetes risk loci to disease mechanisms

scientific article published on January 2014

Limited OXPHOS capacity in white adipocytes is a hallmark of obesity in laboratory mice irrespective of the glucose tolerance status

scientific article

Limited mitochondrial capacity of visceral versus subcutaneous white adipocytes in male C57BL/6N mice

scientific article published on 30 December 2014

Localization of profilin-1 (Pfn1) and a related sequence (Pfn1-rs) to mouse chromosomes 11 and 15 respectively

scientific article published in July 1997

Localization of ubiquitin gene family members to mouse chromosomes 5, 11, and 18.

scientific article

Long-Acting PASylated Leptin Ameliorates Obesity by Promoting Satiety and Preventing Hypometabolism in Leptin-Deficient Lep(ob/ob) Mice

scientific article published on 22 October 2015

Long-term proteasomal inhibition in transgenic mice by UBB(+1) expression results in dysfunction of central respiration control reminiscent of brainstem neuropathology in Alzheimer patients

scientific article

Loss of the actin remodeler Eps8 causes intestinal defects and improved metabolic status in mice

scientific article (publication date: 2 March 2010)

Marsupial uncoupling protein 1 sheds light on the evolution of mammalian nonshivering thermogenesis.

scientific article

Meaningful respirometric measurements of UCP1-mediated thermogenesis

scientific article published on 13 December 2016

Meis1: effects on motor phenotypes and the sensorimotor system in mice

scientific article published on 23 June 2017

Metabolic phenotyping of the Crohn's disease-like IBD etiopathology in the TNF(ΔARE/WT) mouse model

article

Metformin causes a futile intestinal-hepatic cycle which increases energy expenditure and slows down development of a type 2 diabetes-like state

scientific article published on 5 May 2017

Microphthalmia, parkinsonism, and enhanced nociception in Pitx3 ( 416insG ) mice

scientific article published on 22 December 2009

Mildly compromised tetrahydrobiopterin cofactor biosynthesis due to Pts variants leads to unusual body fat distribution and abdominal obesity in mice

scientific article published in February 2016

Mitochondrial DNA variants in obesity

scientific article

Mitochondrial dysfunction and decrease in body weight of a transgenic knock-in mouse model for TDP-43.

scientific article

Mitochondrial function controls intestinal epithelial stemness and proliferation

scientific article published on 27 October 2016

Mitochondrial proton conductance in skeletal muscle of a cold-exposed marsupial, Antechinus flavipes, is unlikely to be involved in adaptive nonshivering thermogenesis but displays increased sensitivity toward carbon-centered radicals

scientific article published on September 2009

Modification of the fatty acid composition of an obesogenic diet improves the maternal and placental metabolic environment in obese pregnant mice

scientific article

Molecular evolution of UCP1 and the evolutionary history of mammalian non-shivering thermogenesis

scientific article

Mouse Genetics and Metabolic Mouse Phenotyping

article

Mouse models for the central melanocortin system.

scientific article published on 06 March 2009

Mouse phenotyping

scientific article

Mutation screen in the GWAS derived obesity gene SH2B1 including functional analyses of detected variants

scientific article

Neurobeachin, a regulator of synaptic protein targeting, is associated with body fat mass and feeding behavior in mice and body-mass index in humans

scientific article

Neuronal distribution of melanin-concentrating hormone, cocaine- and amphetamine-regulated transcript and orexin B in the brain of the Djungarian hamster (Phodopus sungorus).

scientific article published in March 2005

Neuronal expression of glucosylceramide synthase in central nervous system regulates body weight and energy homeostasis.

scientific article

No Effect of Dietary Fish oil Supplementation on the Recruitment of Brown and Brite Adipocytes in Mice or Humans Under Thermoneutral Conditions

scientific article published on 04 December 2020

Non-adrenergic control of lipolysis and thermogenesis in adipose tissues.

scientific article

Novel missense mutation of uromodulin in mice causes renal dysfunction with alterations in urea handling, energy, and bone metabolism

scientific article published on 19 August 2009

Nuclear receptor cofactor receptor interacting protein 140 controls hepatic triglyceride metabolism during wasting in mice

scientific article

Online breath gas analysis in unrestrained mice by hs-PTR-MS.

scientific article

PASylation of Murine Leptin Leads to Extended Plasma Half-Life and Enhanced in Vivo Efficacy

PC1/3 and PC2 gene expression and post-translational endoproteolytic pro-opiomelanocortin processing is regulated by photoperiod in the seasonal Siberian hamster (Phodopus sungorus).

scientific article

Peri-conceptional obesogenic exposure induces sex-specific programming of disease susceptibilities in adult mouse offspring.

scientific article

Photoperiod-dependent regulation of carboxypeptidase E affects the selective processing of neuropeptides in the seasonal Siberian hamster (Phodopus sungorus).

scientific article published in February 2013

Photoperiodic regulation of insulin receptor mRNA and intracellular insulin signaling in the arcuate nucleus of the Siberian hamster, Phodopus sungorus

scientific article published on 6 April 2006

Photoperiodic regulation of leptin resistance in the seasonally breeding Siberian hamster (Phodopus sungorus).

scientific article

Photoperiodic regulation of leptin sensitivity in the Siberian hamster, Phodopus sungorus, is reflected in arcuate nucleus SOCS-3 (suppressor of cytokine signaling) gene expression

scientific article published on 26 November 2003

Photoperiodic regulation of satiety mediating neuropeptides in the brainstem of the seasonal Siberian hamster (Phodopus sungorus).

scientific article

Phylogenetic differences of mammalian basal metabolic rate are not explained by mitochondrial basal proton leak.

scientific article published in June 2011

Pleiotropic functions for transcription factor zscan10.

scientific article

Power matters in closing the phenotyping gap.

scientific article

Proteome differences between brown and white fat mitochondria reveal specialized metabolic functions

scientific journal article

Proteomic and Metabolite Profiling Reveals Profound Structural and Metabolic Reorganization of Adipocyte Mitochondria in Obesity

scientific article published on 07 February 2020

Proximate causes for diet-induced obesity in laboratory mice: a case study

scientific article published on February 2017

Rapamycin extends murine lifespan but has limited effects on aging

scientific article

Rapid single step subcloning procedure by combined action of type II and type IIs endonucleases with ligase

scientific article published on 26 November 2007

Raw coffee based dietary supplements contain carboxyatractyligenin derivatives inhibiting mitochondrial adenine-nucleotide-translocase

scientific article

Reduced mitochondrial mass and function add to age-related susceptibility toward diet-induced fatty liver in C57BL/6J mice

scientific article

Requirement of the RNA-editing enzyme ADAR2 for normal physiology in mice

scientific article

Rescue of melanocortin 4 receptor (MC4R) nonsense mutations by aminoglycoside-mediated read-through

scientific article

Restless legs syndrome-associated intronic common variant in Meis1 alters enhancer function in the developing telencephalon

scientific journal article

SMC6 is an essential gene in mice, but a hypomorphic mutant in the ATPase domain has a mild phenotype with a range of subtle abnormalities

scientific article published on 18 March 2013

Seasonal leptin resistance is associated with impaired signalling via JAK2-STAT3 but not ERK, possibly mediated by reduced hypothalamic GRB2 protein

scientific article published on 24 December 2011

Seasonal regulation of cocaine- and amphetamine-regulated transcript in the arcuate nucleus of Djungarian hamster (Phodopus sungorus).

scientific article published on 18 April 2008

Seasonal thermogenic acclimation of diurnally and nocturnally active desert spiny mice

scientific article published on January 2000

Secretin Links Brown Fat to Food Intake: New Perspectives for Targeting Energy Balance in Humans

scientific article published on 01 June 2019

Secretin activates brown fat and induces satiation

scientific article published in 2021

Serum Response Factor (SRF) Ablation Interferes with Acute Stress-Associated Immediate and Long-Term Coping Mechanisms

scientific article published on 2 December 2016

Short photoperiod reduces leptin gene expression in white and brown adipose tissue of Djungarian hamsters

article

Standardized, systemic phenotypic analysis of Umod(C93F) and Umod(A227T) mutant mice

scientific article

Structural features and bioavailability of four flavonoids and their implications for lifespan-extending and antioxidant actions in C. elegans.

scientific article

Submucosal enteric neurons of the cavine distal colon are sensitive to hypoosmolar stimuli

scientific article published on 03 September 2020

Substrate fluxes in brown adipocytes upon adrenergic stimulation and uncoupling protein 1 ablation

Susceptibility to diet-induced obesity at thermoneutral conditions is independent of UCP1

scientific article published in 2022

Systemic first-line phenotyping

scientific article published on January 2009

Taking control over intracellular fatty acid levels is essential for the analysis of thermogenic function in cultured primary brown and brite/beige adipocytes

scientific article published on 18 August 2014

Teneurin-2 (TENM2) deficiency induces UCP1 expression in differentiating human fat cells

scientific article

Test systems to study the structure and function of uncoupling protein 1: a critical overview.

scientific article

The First Scube3 Mutant Mouse Line with Pleiotropic Phenotypic Alterations.

scientific article

The German Mouse Clinic: a platform for systemic phenotype analysis of mouse models.

scientific article

The brown and brite adipocyte marker Cox7a1 is not required for non-shivering thermogenesis in mice

scientific article

The development of diet-induced obesity and associated metabolic impairments in Dj-1 deficient mice

scientific article published on 2 October 2014

The effects of fasting and cold exposure on metabolic rate and mitochondrial proton leak in liver and skeletal muscle of an amphibian, the cane toad Bufo marinus.

scientific article published in June 2008

The gut hormone secretin triggers a gut-brown fat-brain axis in the control of food intake

scientific article published on 09 April 2020

The hepatic phosphatidylcholine transporter ABCB4 as modulator of glucose homeostasis

scientific article

The molecular and biochemical basis of nonshivering thermogenesis in an African endemic mammal, Elephantulus myurus

scientific article

The role of the IGF-I system for vitellogenesis in maturing female sterlet, Acipenser ruthenus Linnaeus, 1758.

scientific article published in September 2006

The suppressor of cytokine signalling 3, SOCS3, may be one critical modulator of seasonal body weight changes in the Siberian hamster, Phodopus sungorus

scientific article published in February 2006

Tissue-specific expression and cold-induced mRNA levels of uncoupling proteins in the Djungarian hamster

scientific article published in March 2001

Toxicity modelling of Plk1-targeted therapies in genetically engineered mice and cultured primary mammalian cells

scientific article

Treatment of diet-induced lipodystrophic C57BL/6J mice with long-acting PASylated leptin normalises insulin sensitivity and hepatic steatosis by promoting lipid utilisation

scientific article published on 7 June 2016

Two new Loci for body-weight regulation identified in a joint analysis of genome-wide association studies for early-onset extreme obesity in French and german study groups

scientific journal article

Uncoupling protein 1 and the capacity for nonshivering thermogenesis are components of the glucose homeostatic system

scientific article published on 12 November 2019

Uncoupling protein 1 expression and high-fat diets

scientific article

Uncoupling protein 1 in fish uncovers an ancient evolutionary history of mammalian nonshivering thermogenesis

scientific article published on 10 May 2005

Viable Ednra Y129F mice feature human mandibulofacial dysostosis with alopecia (MFDA) syndrome due to the homologue mutation

scientific article

Wheel running affects seasonal acclimatization of physiological and morphological traits in the Djungarian hamster (Phodopus sungorus).

scientific article published on 27 June 2007

eIF6 coordinates insulin sensitivity and lipid metabolism by coupling translation to transcription

scientific journal article

Paulina is supported by:

About Paulina

Help