List of works - Roger Y. Tsien

A Structural Basis for the Assembly and Functions of a Viral Polymer that Inactivates Multiple Tumor Suppressors

scientific article

A drug-controllable tag for visualizing newly synthesized proteins in cells and whole animals

scholarly article

A guide to choosing fluorescent proteins

scientific article

A monomeric red fluorescent protein

scientific article (publication date: 11 June 2002)

A new form of cerebellar long-term potentiation is postsynaptic and depends on nitric oxide but not cAMP.

scientific article

Activatable cell penetrating peptides linked to nanoparticles as dual probes for in vivo fluorescence and MR imaging of proteases

scientific article

All-optical histology using ultrashort laser pulses.

scientific article

Aptamers switch on fluorescence of triphenylmethane dyes

scientific article

Autofluorescent Proteins with Excitation in the Optical Window for Intravital Imaging in Mammals

scientific article

Bcl-2-mediated alterations in endoplasmic reticulum Ca2+ analyzed with an improved genetically encoded fluorescent sensor

scholarly article

Ca2+ indicators based on computationally redesigned calmodulin-peptide pairs

scientific article published in May 2006

Characterization of engineered channelrhodopsin variants with improved properties and kinetics

scientific article

Creating new fluorescent probes for cell biology.

scientific article

Detection and monitoring of localized matrix metalloproteinase upregulation in a murine model of asthma

scientific article published on 07 February 2014

Detection of Subclinical Arthritis in Mice by a Thrombin Receptor-Derived Imaging Agent.

scientific article published on 22 November 2017

Dual targeting of integrin αvβ3 and matrix metalloproteinase-2 for optical imaging of tumors and chemotherapeutic delivery

scientific article

Early detection of squamous cell carcinoma in carcinogen induced oral cancer rodent model by ratiometric activatable cell penetrating peptides ⬇️

scientific article published on 27 June 2017

Early detection of thrombin activity in neuroinflammatory disease

scientific article

Erratum: Creating new fluorescent probes for cell biology

scholarly article published in Nature Reviews Molecular Cell Biology

Exploration of new chromophore structures leads to the identification of improved blue fluorescent proteins

scientific article published on 20 April 2007

Fast 18F Labeling of a Near-Infrared Fluorophore Enables Positron Emission Tomography and Optical Imaging of Sentinel Lymph Nodes ⬇️

scientific article published on October 20, 2010

Fluorescent and photo-oxidizing TimeSTAMP tags track protein fates in light and electron microscopy

scientific article

Fluorescent ligand for human progesterone receptor imaging in live cells

scientific article published on 29 April 2013

Fluorescent peptides highlight peripheral nerves during surgery in mice

scientific article

Fluorescently labeled peptide increases identification of degenerated facial nerve branches during surgery and improves functional outcome

scientific article

Gelatinase activity imaged by activatable cell-penetrating peptides in cell-based and in vivo models of stroke

scientific article published on 17 December 2015

Genetically targeted chromophore-assisted light inactivation

scientific article

Golgi twins in late mitosis revealed by genetically encoded tags for live cell imaging and correlated electron microscopy

scientific article

Hairpin structure of a biarsenical-tetracysteine motif determined by NMR spectroscopy

scientific article published on April 2009

Identification of High-Risk Plaques by MRI and Fluorescence Imaging in a Rabbit Model of Atherothrombosis

scientific article published on 8 October 2015

Improved facial nerve identification with novel fluorescently labeled probe

scientific article

Improved monomeric red, orange and yellow fluorescent proteins derived from Discosoma sp. red fluorescent protein

scientific article (publication date: December 2004)

Improving FRET dynamic range with bright green and red fluorescent proteins

scientific article

In vivo characterization of activatable cell penetrating peptides for targeting protease activity in cancer

scientific article

In vivo fluorescence imaging of atherosclerotic plaques with activatable cell-penetrating peptides targeting thrombin activity

scientific article published on 26 April 2012

In vivo quantitative proteomics of somatosensory cortical synapses shows which protein levels are modulated by sensory deprivation

scientific article published on 4 February 2013

Isoform-specific PKA dynamics revealed by dye-triggered aggregation and DAKAP1alpha-mediated localization in living cells

scientific article published in September 2007

Laminin targeting of a peripheral nerve-highlighting peptide enables degenerated nerve visualization

scientific article (publication date: 20 October 2016)

Mammalian cell-based optimization of the biarsenical-binding tetracysteine motif for improved fluorescence and affinity

scientific article published on 11 September 2005

Mammalian expression of infrared fluorescent proteins engineered from a bacterial phytochrome

scientific article

Monitoring Integrated Activity of Individual Neurons Using FRET-Based Voltage-Sensitive Dyes

scientific article published on January 2015

Multicolor Electron Microscopy for Simultaneous Visualization of Multiple Molecular Species

scientific article published on 31 October 2016

Multicolor and electron microscopic imaging of connexin trafficking

scientific article

Nerve-targeted probes for fluorescence-guided intraoperative imaging

Neuroligin trafficking deficiencies arising from mutations in the alpha/beta-hydrolase fold protein family

scientific article

New biarsenical ligands and tetracysteine motifs for protein labeling in vitro and in vivo: synthesis and biological applications

scientific article published in May 2002

Novel chromophores and buried charges control color in mFruits

scientific article published in August 2006

Optically monitoring voltage in neurons by photo-induced electron transfer through molecular wires

scientific article published on 24 January 2012

Parallel in vivo and in vitro selection using phage display identifies protease-dependent tumor-targeting peptides

scientific article

Ratiometric activatable cell-penetrating peptides label pancreatic cancer, enabling fluorescence-guided surgery, which reduces metastases and recurrence in orthotopic mouse models

scientific article

Ratiometric activatable cell-penetrating peptides provide rapid in vivo readout of thrombin activation

scientific article

Real-time in vivo molecular detection of primary tumors and metastases with ratiometric activatable cell-penetrating peptides

scientific article

Reversing cerebellar long-term depression.

scientific article

Simultaneous visualization of protumorigenic Src and MT1-MMP activities with fluorescence resonance energy transfer.

scientific article published on 2 March 2010

Surgery with molecular fluorescence imaging using activatable cell-penetrating peptides decreases residual cancer and improves survival

scientific article

Systemic in vivo distribution of activatable cell penetrating peptides is superior to that of cell penetrating peptides

scientific article

Systems analysis of PKA-mediated phosphorylation gradients in live cardiac myocytes

scholarly article

Tetracysteine genetic tags complexed with biarsenical ligands as a tool for investigating gap junction structure and dynamics

scientific article published in July 2003

Thrombin activity associated with neuronal damage during acute focal ischemia

scientific article

Tumor Detection at 3 Tesla with an Activatable Cell Penetrating Peptide Dendrimer (ACPPD-Gd), a T1 Magnetic Resonance (MR) Molecular Imaging Agent

scientific article

Tumor imaging by means of proteolytic activation of cell-penetrating peptides

scientific article

List of works by Roger Y. Tsien

A Structural Basis for the Assembly and Functions of a Viral Polymer that Inactivates Multiple Tumor Suppressors

A drug-controllable tag for visualizing newly synthesized proteins in cells and whole animals

A guide to choosing fluorescent proteins

A monomeric red fluorescent protein

A new form of cerebellar long-term potentiation is postsynaptic and depends on nitric oxide but not cAMP.

Activatable cell penetrating peptides linked to nanoparticles as dual probes for in vivo fluorescence and MR imaging of proteases

All-optical histology using ultrashort laser pulses.

Aptamers switch on fluorescence of triphenylmethane dyes

Autofluorescent Proteins with Excitation in the Optical Window for Intravital Imaging in Mammals

Bcl-2-mediated alterations in endoplasmic reticulum Ca2+ analyzed with an improved genetically encoded fluorescent sensor

Ca2+ indicators based on computationally redesigned calmodulin-peptide pairs

Characterization of engineered channelrhodopsin variants with improved properties and kinetics

Creating new fluorescent probes for cell biology.

Detection and monitoring of localized matrix metalloproteinase upregulation in a murine model of asthma

Detection of Subclinical Arthritis in Mice by a Thrombin Receptor-Derived Imaging Agent.

Dual targeting of integrin αvβ3 and matrix metalloproteinase-2 for optical imaging of tumors and chemotherapeutic delivery

Early detection of squamous cell carcinoma in carcinogen induced oral cancer rodent model by ratiometric activatable cell penetrating peptides ⬇️

Early detection of thrombin activity in neuroinflammatory disease

Erratum: Creating new fluorescent probes for cell biology

Exploration of new chromophore structures leads to the identification of improved blue fluorescent proteins

Fast 18F Labeling of a Near-Infrared Fluorophore Enables Positron Emission Tomography and Optical Imaging of Sentinel Lymph Nodes ⬇️

Fluorescent and photo-oxidizing TimeSTAMP tags track protein fates in light and electron microscopy

Fluorescent ligand for human progesterone receptor imaging in live cells

Fluorescent peptides highlight peripheral nerves during surgery in mice

Fluorescently labeled peptide increases identification of degenerated facial nerve branches during surgery and improves functional outcome

Gelatinase activity imaged by activatable cell-penetrating peptides in cell-based and in vivo models of stroke

Genetically targeted chromophore-assisted light inactivation

Golgi twins in late mitosis revealed by genetically encoded tags for live cell imaging and correlated electron microscopy

Hairpin structure of a biarsenical-tetracysteine motif determined by NMR spectroscopy

Identification of High-Risk Plaques by MRI and Fluorescence Imaging in a Rabbit Model of Atherothrombosis

Improved facial nerve identification with novel fluorescently labeled probe

Improved monomeric red, orange and yellow fluorescent proteins derived from Discosoma sp. red fluorescent protein

Improving FRET dynamic range with bright green and red fluorescent proteins

In vivo characterization of activatable cell penetrating peptides for targeting protease activity in cancer

In vivo fluorescence imaging of atherosclerotic plaques with activatable cell-penetrating peptides targeting thrombin activity

In vivo quantitative proteomics of somatosensory cortical synapses shows which protein levels are modulated by sensory deprivation

Isoform-specific PKA dynamics revealed by dye-triggered aggregation and DAKAP1alpha-mediated localization in living cells

Laminin targeting of a peripheral nerve-highlighting peptide enables degenerated nerve visualization

Mammalian cell-based optimization of the biarsenical-binding tetracysteine motif for improved fluorescence and affinity

Mammalian expression of infrared fluorescent proteins engineered from a bacterial phytochrome

Monitoring Integrated Activity of Individual Neurons Using FRET-Based Voltage-Sensitive Dyes

Multicolor Electron Microscopy for Simultaneous Visualization of Multiple Molecular Species

Multicolor and electron microscopic imaging of connexin trafficking

Nerve-targeted probes for fluorescence-guided intraoperative imaging

Neuroligin trafficking deficiencies arising from mutations in the alpha/beta-hydrolase fold protein family

New biarsenical ligands and tetracysteine motifs for protein labeling in vitro and in vivo: synthesis and biological applications

Novel chromophores and buried charges control color in mFruits

Optically monitoring voltage in neurons by photo-induced electron transfer through molecular wires

Parallel in vivo and in vitro selection using phage display identifies protease-dependent tumor-targeting peptides

Ratiometric activatable cell-penetrating peptides label pancreatic cancer, enabling fluorescence-guided surgery, which reduces metastases and recurrence in orthotopic mouse models

Ratiometric activatable cell-penetrating peptides provide rapid in vivo readout of thrombin activation

Real-time in vivo molecular detection of primary tumors and metastases with ratiometric activatable cell-penetrating peptides

Reversing cerebellar long-term depression.

Simultaneous visualization of protumorigenic Src and MT1-MMP activities with fluorescence resonance energy transfer.

Surgery with molecular fluorescence imaging using activatable cell-penetrating peptides decreases residual cancer and improves survival

Systemic in vivo distribution of activatable cell penetrating peptides is superior to that of cell penetrating peptides

Systems analysis of PKA-mediated phosphorylation gradients in live cardiac myocytes

Tetracysteine genetic tags complexed with biarsenical ligands as a tool for investigating gap junction structure and dynamics

Thrombin activity associated with neuronal damage during acute focal ischemia

Tumor Detection at 3 Tesla with an Activatable Cell Penetrating Peptide Dendrimer (ACPPD-Gd), a T1 Magnetic Resonance (MR) Molecular Imaging Agent

Tumor imaging by means of proteolytic activation of cell-penetrating peptides