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List of works by Wendy Barclay

A common TMPRSS2 variant has a protective effect against severe COVID-19

scientific article published on 10 January 2022

A complicated message: Identification of a novel PB1-related protein translated from influenza A virus segment 2 mRNA.

scientific article published on 03 June 2009

A conserved basic loop in hepatitis C virus p7 protein is required for amantadine-sensitive ion channel activity in mammalian cells but is dispensable for localization to mitochondria

scientific article published on February 2004

A phase I clinical trial of a PER.C6 cell grown influenza H7 virus vaccine

scientific article

A reverse genetics approach for recovery of recombinant influenza B viruses entirely from cDNA.

scientific article published on November 2002

A single amino acid in the HA of pH1N1 2009 influenza virus affects cell tropism in human airway epithelium, but not transmission in ferrets

scientific article

ACE2: The Only Thing That Matters?

scientific article published on 10 June 2020

ANP32 Proteins Are Essential for Influenza Virus Replication in Human Cells

scientific article published on 13 August 2019

Accumulation of human-adapting mutations during circulation of A(H1N1)pdm09 influenza virus in humans in the United Kingdom.

scientific article

Adjuvant-free immunization with hemagglutinin-Fc fusion proteins as an approach to influenza vaccines

scientific article published on 29 December 2010

Alterations in receptor binding properties of recent human influenza H3N2 viruses are associated with reduced natural killer cell lysis of infected cells.

scientific article published on August 2007

Amino acid substitution D222N from fatal influenza infection affects receptor-binding properties of the influenza A(H1N1)pdm09 virus

scientific article published on 4 June 2015

An engineered avian-origin influenza A virus for pancreatic ductal adenocarcinoma virotherapy

scientific article published on 14 July 2016

An influenza reassortant with polymerase of pH1N1 and NS gene of H3N2 influenza A virus is attenuated in vivo

scientific article

Antibody prevalence for SARS-CoV-2 following the peak of the pandemic in England: REACT2 study in 100,000 adults

scientific article

Antigenic mapping of an H9N2 avian influenza virus reveals two discrete antigenic sites and a novel mechanism of immune escape

scientific article

Antiviral Screening of Multiple Compounds against Ebola Virus

scientific article published on 27 October 2016

Antiviral therapies against Ebola and other emerging viral diseases using existing medicines that block virus entry

scientific article published on 29 January 2015

Assays to Measure the Activity of Influenza Virus Polymerase

scientific article published on 01 January 2018

Assessing a novel, lab-free, point-of-care test for SARS-CoV-2 (CovidNudge): a diagnostic accuracy study

scientific article published on 17 September 2020

Attenuating mutations in the influenza virus genome which may increase the safety of vaccine production

Avian ANP32B does not support influenza A virus polymerase and influenza A virus relies exclusively on ANP32A in chicken cells.: Supplementary Information

Avian Influenza virus glycoproteins restrict virus replication and spread through human airway epithelium at temperatures of the proximal airways

scientific article

Baloxavir treatment of ferrets infected with influenza A(H1N1)pdm09 virus reduces onward transmission

scientific article published on 15 April 2020

Can defective interfering RNAs affect the live attenuated influenza vaccine? - Authors' reply

scientific article

Cellular immune correlates of protection against symptomatic pandemic influenza.

scientific article

Changes in in vitro susceptibility of influenza A H3N2 viruses to a neuraminidase inhibitor drug during evolution in the human host

scientific article published on 17 March 2004

Characterising viable virus from air exhaled by H1N1 influenza-infected ferrets reveals the importance of haemagglutinin stability for airborne infectivity

scientific article published on 25 February 2020

Characterization of recombinant influenza B viruses with key neuraminidase inhibitor resistance mutations.

scientific article published on 21 January 2005

Clinical and laboratory evaluation of SARS-CoV-2 lateral flow assays for use in a national COVID-19 seroprevalence survey

scientific article published on 12 August 2020

Computational and molecular analysis of conserved influenza A virus RNA secondary structures involved in infectious virion production

scientific article published on 11 July 2016

Contact transmission of influenza virus between ferrets imposes a looser bottleneck than respiratory droplet transmission allowing propagation of antiviral resistance

scientific article

Determining the Mutation Bias of Favipiravir in Influenza Using Next-generation Sequencing

scholarly article by Daniel Goldhill et al published 31 October 2018 in Journal of Virology

Determining the Mutation Bias of Favipiravir in Influenza Using Next-generation Sequencing

Development of a reverse genetics system enabling the rescue of recombinant avian influenza virus A/Turkey/England/50-92/91 (H5N1).

scientific article published on March 2007

Effect of a Russian-backbone live-attenuated influenza vaccine with an updated pandemic H1N1 strain on shedding and immunogenicity among children in The Gambia: an open-label, observational, phase 4 study

scientific article published on 21 June 2019

Elucidating the Interactions between Influenza Virus Polymerase and Host Factor ANP32A

scientific article published on 17 January 2020

Entry of the bat influenza H17N10 virus into mammalian cells is enabled by the MHC class II HLA-DR receptor

scientific article published on 29 July 2019

Evaluating the fitness of PA/I38T-substituted influenza A viruses with reduced baloxavir susceptibility in a competitive mixtures ferret model

scientific article published on 06 May 2021

Evidence for avian and human host cell factors that affect the activity of influenza virus polymerase

scientific article published on 14 July 2010

Fatal cases of influenza a in childhood

scientific article

Ferret airway epithelial cell cultures support efficient replication of influenza B virus but not mumps virus

scientific article

Ferrets as Models for Influenza Virus Transmission Studies and Pandemic Risk Assessments.

scientific article

Generation of candidate human influenza vaccine strains in cell culture - rehearsing the European response to an H7N1 pandemic threat

scientific article

Genomic screening of 16 UK native bat species through conservationist networks uncovers coronaviruses with zoonotic potential

scientific article published in 2023

Glycomic characterization of respiratory tract tissues of ferrets: implications for its use in influenza virus infection studies

scientific article

HIV-1 infection of macrophages is dependent on evasion of innate immune cellular activation

scientific article

High and increasing prevalence of SARS-CoV-2 swab positivity in England during end September beginning October 2020: REACT-1 round 5 updated report

scientific article

High prevalence of SARS-CoV-2 swab positivity and increasing R number in England during October 2020: REACT-1 round 6 interim report

High prevalence of SARS-CoV-2 swab positivity in England during September 2020: interim report of round 5 of REACT-1 study

scientific article

Host ANP32A mediates the assembly of the influenza virus replicase

scientific article published on 18 November 2020

Host Cell Factors That Interact with Influenza Virus Ribonucleoproteins

scientific article published on 28 September 2020

Host Determinants of Influenza RNA Synthesis

scientific article published on 05 July 2019

Host and viral determinants of influenza A virus species specificity

scientific article published on 01 January 2019

Human MX2 is an interferon-induced post-entry inhibitor of HIV-1 infection

scientific article

Identification of novel expressed sequences, up-regulated in the leucocytes of chronic fatigue syndrome patients

article

Immune Escape Variants of H9N2 Influenza Viruses Containing Deletions at the Hemagglutinin Receptor Binding Site Retain Fitness In Vivo and Display Enhanced Zoonotic Characteristics

scientific article

Immune responses in pigs vaccinated with adjuvanted and non-adjuvanted A(H1N1)pdm/09 influenza vaccines used in human immunization programmes

scientific article published on 9 March 2012

Increasing SARS-CoV-2 antibody prevalence in England at the start of the second wave: REACT-2 Round 4 cross-sectional study in 160,000 adults

scientific article

Infection of human airway epithelium by human and avian strains of influenza a virus.

scientific article

Inflammasome activation in multiple sclerosis and experimental autoimmune encephalomyelitis (EAE).

scientific article published on 20 December 2016

Influence of PB2 host-range determinants on the intranuclear mobility of the influenza A virus polymerase

scientific article

Influenza A virus PB1-F2 protein prolongs viral shedding in chickens lengthening the transmission window

scientific article published on 23 August 2016

Influenza Virus with Increased pH of Hemagglutinin Activation Has Improved Replication in Cell Culture but at the Cost of Infectivity in Human Airway Epithelium

scientific article published on 13 August 2019

Influenza pandemics

scientific article published on January 2011

Influenza: a world of discoveries, outbreaks and controversy

scientific article published on 23 May 2017

Internal genes of a highly pathogenic H5N1 influenza virus determine high viral replication in myeloid cells and severe outcome of infection in mice.

scientific article published on 4 January 2018

Investigation of influenza virus polymerase activity in pig cells

scientific article published on 17 October 2012

Knowns and unknowns of influenza B viruses

scientific article published on 18 December 2015

Lack of transmission of a human influenza virus with avian receptor specificity between ferrets is not due to decreased virus shedding but rather a lower infectivity in vivo

scientific article published on 20 April 2011

Low dose influenza virus challenge in the ferret leads to increased virus shedding and greater sensitivity to oseltamivir.

scientific article

M1-like monocytes are a major immunological determinant of severity in previously healthy adults with life-threatening influenza

scientific article published on 06 April 2017

Molecular characterization of Iranian wheat stripe virus shows its taxonomic position as a distinct species in the genus Tenuivirus.

scientific article

Molecular studies of influenza B virus in the reverse genetics era.

scientific article published on 06 October 2010

Mouse Models of Influenza Infection with Circulating Strains to Test Seasonal Vaccine Efficacy

scientific article published on 31 January 2018

Mutations in H5N1 influenza virus hemagglutinin that confer binding to human tracheal airway epithelium.

scientific article

Mutations in haemagglutinin that affect receptor binding and pH stability increase replication of a PR8 influenza virus with H5 HA in the upper respiratory tract of ferrets and may contribute to transmissibility

scientific article

Mutations that adapt SARS-CoV-2 to mink or ferret do not increase fitness in the human airway

scientific article published on 19 January 2022

NB protein does not affect influenza B virus replication in vitro and is not required for replication in or transmission between ferrets

scientific article published on 24 December 2015

NS1 proteins of avian influenza A viruses can act as antagonists of the human alpha/beta interferon response.

scientific article published on 20 December 2006

Obesity and susceptibility to severe outcomes following respiratory viral infection

scientific article

One-way trip: influenza virus' adaptation to gallinaceous poultry may limit its pandemic potential.

scientific article

P251 The induction of early, dynamic airway mucosal and systemic immune responses following recent SARS-CoV-2 household exposure

scholarly article

Pandemic H1N1 2009 influenza virus with the H275Y oseltamivir resistance neuraminidase mutation shows a small compromise in enzyme activity and viral fitness

scientific article

Pandemic risks from bird flu.

scientific article published in January 2004

Passage of influenza A/H3N2 viruses in human airway cells removes artefactual variants associated with neuraminidase-mediated binding

scientific article published on 08 November 2019

Pause on avian flu transmission research

scientific article published on January 2012

Predominance of heterosubtypic IFN-γ-only-secreting effector memory T cells in pandemic H1N1 naive adults

scientific article

Pregnancy-related immune suppression leads to altered influenza vaccine recall responses

scientific article published on 27 August 2019

Preliminary genomic characterisation of an emergent SARS-CoV-2 lineage in the UK defined by a novel set of spike mutations. ⬇️

Scientific report published 18 December 2020

Probing the receptor interactions of an H5 avian influenza virus using a baculovirus expression system and functionalised poly(acrylic acid) ligands

scientific article published on 02 April 2007

Publisher Correction: Host and viral determinants of influenza A virus species specificity

scientific article published on 01 January 2019

Quantifying mechanistic traits of influenza viral dynamics using in vitro data

scientific article published on 03 October 2020

REACT-1 round 10 report: Level prevalence of SARS-CoV-2 swab-positivity in England during third national lockdown in March 2021

scientific article

REACT-1 round 13 interim report: acceleration of SARS-CoV-2 Delta epidemic in the community in England during late June and early July 2021

scientific article

REACT-1 round 6 updated report: high prevalence of SARS-CoV-2 swab positivity with reduced rate of growth in England at the start of November 2020

scientific article

REACT-1 round 7 interim report: fall in prevalence of swab-positivity in England during national lockdown

scientific article

REACT-1 round 7 updated report: regional heterogeneity in changes in prevalence of SARS-CoV-2 infection during the second national COVID-19 lockdown in England

scientific article

REACT-1 round 8 final report: high average prevalence with regional heterogeneity of trends in SARS-CoV-2 infection in the community in England during January 2021

scientific article

REACT-1 round 8 interim report: SARS-CoV-2 prevalence during the initial stages of the third national lockdown in England

scientific article

REACT-1 round 9 final report: Continued but slowing decline of prevalence of SARS-CoV-2 during national lockdown in England in February 2021

scientific article

REACT-1 round 9 interim report: downward trend of SARS-CoV-2 in England in February 2021 but still at high prevalence

scientific article

RIG-I detects viral genomic RNA during negative-strand RNA virus infection

scientific article

RNAi-based small molecule repositioning reveals clinically approved urea-based kinase inhibitors as broadly active antivirals

scientific article published on 18 March 2019

Rapid generation of a well-matched vaccine seed from a modern influenza A virus primary isolate without recourse to eggs.

scientific article

Receptor binding profiles of avian influenza virus hemagglutinin subtypes on human cells as a predictor of pandemic potential

scientific article

Receptor for bat influenza virus uncovers potential risk to humans

scientific article published on 01 March 2019

Reduced incorporation of the influenza B virus BM2 protein in virus particles decreases infectivity

scientific article published on May 2004

Regulation of influenza A virus mRNA splicing by CLK1

scientific article published on 06 June 2019

Restrictions to the adaptation of influenza a virus h5 hemagglutinin to the human host.

scientific article published on January 2004

Resurgence of SARS-CoV-2 in England: detection by community antigen surveillance

scientific article

Resurgence of SARS-CoV-2: Detection by community viral surveillance

scientific article

SARS-CoV-2 one year on: evidence for ongoing viral adaptation

article by Thomas P. Peacock et al published 15 April 2021 in Journal of General Virology

Safety, tolerability and viral kinetics during SARS-CoV-2 human challenge in young adults

scientific article published on 31 March 2022

Site-directed M2 proton channel inhibitors enable synergistic combination therapy for rimantadine-resistant pandemic influenza

scientific article published on 11 August 2020

Species difference in ANP32A underlies influenza A virus polymerase host restriction

scientific article

Species specific differences in use of ANP32 proteins by influenza A virus

scientific article published on 4 June 2019

Structure of an avian influenza A virus NS1 protein effector domain

scientific article

Suitability of PER.C6 cells to generate epidemic and pandemic influenza vaccine strains by reverse genetics.

scientific article

Swine ANP32A supports avian influenza virus polymerase

scientific article published on 08 April 2020

The 1918 Influenza Pandemic: one hundred years of progress, but where now?

scientific article published on 22 June 2018

The Emergence of H7N7 Highly Pathogenic Avian Influenza Virus from Low Pathogenicity Avian Influenza Virus Using an in ovo Embryo Culture Model

scientific article published on 21 August 2020

The Functional Study of the N-Terminal Region of Influenza B Virus Nucleoprotein

scientific article published on 14 September 2015

The MHC class-II HLA-DR receptor mediates bat influenza A-like H17N10 virus entry into mammalian cells

The Origins of SARS-CoV-2: A Critical Review

scholarly article

The SARS-CoV-2 variant, Omicron, shows rapid replication in human primary nasal epithelial cultures and efficiently uses the endosomal route of entry

preprint

The cellular localization of avian influenza virus PB1-F2 protein alters the magnitude of IFN2 promoter and NFκB-dependent promoter antagonism in chicken cells

scientific article published on 23 January 2019

The dynamics of humoral immune responses following SARS-CoV-2 infection and the potential for reinfection

scientific article published on 20 May 2020

The effect of the PB2 mutation 627K on highly pathogenic H5N1 avian influenza virus is dependent on the virus lineage.

scientific article published on 10 July 2013

The furin cleavage site in the SARS-CoV-2 spike protein is required for transmission in ferrets

scholarly article by Thomas P. Peacock published in April 2021

The mechanism of resistance to favipiravir in influenza

article published in the Proceedings of the National Academy of Sciences of the United States of America

The short stalk length of highly pathogenic avian influenza H5N1 virus neuraminidase limits transmission of pandemic H1N1 virus in ferrets

scientific article

Transcriptional reprogramming from innate immune functions to a pro-thrombotic signature by monocytes in COVID-19

scientific article published in 2022

Transfer of the amino-terminal nuclear envelope targeting domain of human MX2 converts MX1 into an HIV-1 resistance factor

scientific article

Transient dynamics of SARS-CoV-2 as England exited national lockdown

scientific article

Transmission of a 2009 H1N1 pandemic influenza virus occurs before fever is detected, in the ferret model

scientific article published in 2012

Transmission studies resume for avian flu.

scientific article

Twin peaks: The Omicron SARS-CoV-2 BA.1 and BA.2 epidemics in England

scientific article published on 24 May 2022

Ultrastructure of Cell Trafficking Pathways and Coronavirus: How to Recognise the Wolf Amongst the Sheep

scientific article published on 12 September 2020

Unravelling the mysteries of influenza

scientific article published on 01 December 2002

Unstable polymerase-nucleoprotein interaction is not responsible for avian influenza virus polymerase restriction in human cells

scientific article

Urgent challenges in implementing live attenuated influenza vaccine

scientific article published on 2 August 2017

Usability and acceptability of home-based self-testing for SARS-CoV-2 antibodies for population surveillance

scientific article published on 12 August 2020

Vaccine uptake and SARS-CoV-2 antibody prevalence among 207,337 adults during May 2021 in England: REACT-2 study

scientific article

Variability in H9N2 haemagglutinin receptor-binding preference and the pH of fusion

scientific article

Variation in the ability of human influenza A viruses to induce and inhibit the IFN-beta pathway.

scientific article published on 27 December 2005

Viral determinants of influenza A virus host range

scientific article published on 28 February 2014

Viral factors in influenza pandemic risk assessment.

scientific article

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