List of works by Eva-Maria Mandelkow

'Prion-like' propagation of mouse and human tau aggregates in an inducible mouse model of tauopathy

scientific article published on 13 February 2010

A combinatorial native MS and LC-MS/MS approach reveals high intrinsic phosphorylation of human tau but minimal levels of other key modifications

scientific article published on 26 October 2020

A mechanistic model of tau amyloid aggregation based on direct observation of oligomers

scientific article published on 30 April 2015

A nucleated assembly mechanism of Alzheimer paired helical filaments

scientific article

A zebrafish model of tauopathy allows in vivo imaging of neuronal cell death and drug evaluation

scientific article

Abnormal Alzheimer-like phosphorylation of tau-protein by cyclin-dependent kinases cdk2 and cdk5

scientific article published on 01 December 1993

Accurate balance of the polarity kinase MARK2/Par-1 is required for proper cortical neuronal migration.

scientific article published in May 2008

Adenosine A1 receptor antagonist rolofylline alleviates axonopathy caused by human Tau ΔK280

scientific article published on 26 September 2016

Age-dependent neuroinflammation and cognitive decline in a novel Ala152Thr-Tau transgenic mouse model of PSP and AD.

scientific article

Alzheimer-like paired helical filaments and antiparallel dimers formed from microtubule-associated protein tau in vitro ⬇️

scientific article published on August 1, 1992

Amyloid-β oligomers induce synaptic damage via Tau-dependent microtubule severing by TTLL6 and spastin

scientific article

Analysis of in vivo turnover of tau in a mouse model of tauopathy

scientific article published on 26 October 2015

Antagonistic effects of doublecortin and MARK2/Par-1 in the developing cerebral cortex.

scientific article published in November 2008

Anthraquinones inhibit tau aggregation and dissolve Alzheimer's paired helical filaments in vitro and in cells

scientific article

Anti-aggregant tau mutant promotes neurogenesis

scientific article published on 4 December 2017

Assembly of tau protein into Alzheimer paired helical filaments depends on a local sequence motif ((306)VQIVYK(311)) forming beta structure

scientific article published on May 2000

Assessment of the In Vivo Relationship Between Cerebral Hypometabolism, Tau Deposition, TSPO Expression, and Synaptic Density in a Tauopathy Mouse Model: a Multi-tracer PET Study

scientific article published on 21 March 2022

Atypical, non-standard functions of the microtubule associated Tau protein

scientific article published on 29 November 2017

Autophagic degradation of tau in primary neurons and its enhancement by trehalose.

scientific article published on 14 December 2011

Axodendritic sorting and pathological missorting of Tau are isoform-specific and determined by axon initial segment architecture

scientific article published on 23 May 2017

Aβ Oligomers Cause Localized Ca2+Elevation, Missorting of Endogenous Tau into Dendrites, Tau Phosphorylation, and Destruction of Microtubules and Spines ⬇️

scientific article published on September 8, 2010

Biochemistry and cell biology of tau protein in neurofibrillary degeneration

scientific article published on July 2012

Carboxy terminus heat shock protein 70 interacting protein reduces tau-associated degenerative changes

scientific article

Cascade of tau toxicity in inducible hippocampal brain slices and prevention by aggregation inhibitors

scientific article published on 15 November 2012

Cdk5 inhibits anterograde axonal transport of neurofilaments but not that of tau by inhibition of mitogen-activated protein kinase activity

scientific article

Cell cycle-dependent phosphorylation and microtubule binding of tau protein stably transfected into Chinese hamster ovary cells.

scientific article published on October 1995

Cleavage of Tau by calpain in Alzheimer's disease: the quest for the toxic 17 kD fragment ⬇️

scientific article published on October 18, 2010

Clogging of axons by tau, inhibition of axonal traffic and starvation of synapses

scientific article published in December 2003

Cloning and sequencing of a cDNA encoding rat brain mitogen-activated protein (MAP) kinase activator.

scientific article

Cognitive defects are reversible in inducible mice expressing pro-aggregant full-length human Tau.

scientific article published on 25 April 2012

Conformations of kinesin: solution vs. crystal structures and interactions with microtubules

scientific article published on 01 January 1998

Conformations of microtubule-associated protein Tau mapped by fluorescence resonance energy transfer

scientific article published on 01 January 2012

Cryo-electron microscopy of unstained frozen-hydrated microtubules

scientific article published on January 1986

Crystallization of a macromolecular ring assembly of tubulin liganded with the anti-mitotic drug podophyllotoxin

scientific article published on 01 December 1999

Dephosphorylation of tau protein and Alzheimer paired helical filaments by calcmeurin and phosphatase-2A

scholarly article by G. Drewes published in December 1993

Development of tau aggregation inhibitors for Alzheimer's disease

scientific article

Domain structure and antiparallel dimers of microtubule-associated protein 2 (MAP2)

scientific article published on January 1, 1992

Domains of Neuronal Microtubule-associated Proteins and Flexural Rigidity of Microtubules ⬇️

scientific article published on September 8, 1997

Domains of tau protein and interactions with microtubules

scientific article published on 01 August 1994

Domains of tau protein, differential phosphorylation, and dynamic instability of microtubules

scientific article published on December 1995

Dynamics of microtubules from erythrocyte marginal bands

scientific article published on March 1993

Dynamics of the microtubule oscillator: role of nucleotides and tubulin-MAP interactions ⬇️

scientific article published on February 1, 1988

Emerging modes of PINK1 signaling: another task for MARK2

scientific article

Evidence for a role of the rare p.A152T variant in MAPT in increasing the risk for FTD-spectrum and Alzheimer's diseases

scientific article

Extracellular low-n oligomers of tau cause selective synaptotoxicity without affecting cell viability

scientific article

Extracellular monomeric tau protein is sufficient to initiate the spread of tau protein pathology

scientific article published on 14 November 2013

FRET-based Tau seeding assay does not represent prion-like templated assembly of Tau filaments

scientific article published on 16 July 2020

Fluorimetric studies on the influence of metal ions and chelators on the interaction between myosin and ATP

scientific article published on 01 July 1973

Functional networks are impaired by elevated tau-protein but reversible in a regulatable Alzheimer's disease mouse model

scholarly article by Claudia Green et al published 27 March 2019 in Molecular Neurodegeneration

Glutamatergic nervous system degeneration in a C. elegans TauA152T tauopathy model involves pathways of excitotoxicity and Ca2+ dysregulation

scientific article published on 09 June 2018

Glycogen synthase kinase (GSK) 3beta directly phosphorylates Serine 212 in the regulatory loop and inhibits microtubule affinity-regulating kinase (MARK) 2.

scientific article published on 18 April 2008

Glycogen synthase kinase-3 and the Alzheimer-like state of microtubule-associated protein tau.

scientific article published in December 1992

Guidelines for the use and interpretation of assays for monitoring autophagy

scientific article

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

scientific article

Human Tau isoforms assemble into ribbon-like fibrils that display polymorphic structure and stability

scientific article

Hyperphosphorylation and aggregation of tau in experimental autoimmune encephalomyelitis

scientific article published on 19 October 2004

Image reconstruction of tubulin hoops ⬇️

scientific article published on 01 January 1981

In vivo microdialysis reveals age-dependent decrease of brain interstitial fluid tau levels in P301S human tau transgenic mice

scientific article

Indirubins inhibit glycogen synthase kinase-3 beta and CDK5/p25, two protein kinases involved in abnormal tau phosphorylation in Alzheimer's disease. A property common to most cyclin-dependent kinase inhibitors?

scientific article published in January 2001

Inducible expression of Tau repeat domain in cell models of tauopathy: aggregation is toxic to cells but can be reversed by inhibitor drugs

scientific article

Inhibition of APP trafficking by tau protein does not increase the generation of amyloid-beta peptides

scientific article

Inhibition of cyclin-dependent kinases, GSK-3beta and CK1 by hymenialdisine, a marine sponge constituent

scientific article

Inhibition of tau aggregation in a novel Caenorhabditis elegans model of tauopathy mitigates proteotoxicity

scientific article published on 18 May 2012

Inhibition of tau aggregation in cell models of tauopathy

scientific article published on December 2007

Interaction between kinesin, microtubules, and microtubule-associated protein 2.

scientific article published in January 1989

Interaction of Epothilone B (Patupilone) with Microtubules as Detected by Two-Dimensional Solid-State NMR Spectroscopy

scholarly article by Ashutosh Kumar et al published 31 August 2010 in Angewandte Chemie International Edition

Interaction of monomeric and dimeric kinesin with microtubules

scientific article published on 01 February 1998

Interactions of MAP/microtubule affinity regulating kinases with the adaptor complex AP-2 of clathrin-coated vesicles.

scientific article published in August 2009

Interplay of pathogenic forms of human tau with different autophagic pathways

scientific article

Isoforms of tau protein from mammalian brain and avian erythrocytes: structure, self-assembly, and elasticity

scientific article published in October 1990

Junctions between microtubule walls ⬇️

scientific article published on March 25, 1979

Kinesin motors and disease

scientific article

Linking amyloid-β and tau: amyloid-β induced synaptic dysfunction via local wreckage of the neuronal cytoskeleton

scientific article

MAPs, MARKs and microtubule dynamics.

scientific article published in August 1998

MARK, a novel family of protein kinases that phosphorylate microtubule-associated proteins and trigger microtubule disruption

scientific article

MARK/PAR1 kinase is a regulator of microtubule-dependent transport in axons

scientific article published on 4 October 2004

MARKK, a Ste20-like kinase, activates the polarity-inducing kinase MARK/PAR-1 ⬇️

scientific article published on October 1, 2003

MMP-9 and MMP-2 Contribute to Neuronal Cell Death in iPSC Models of Frontotemporal Dementia with MAPT Mutations

scientific article published on September 2016

Making the brain glow: in vivo bioluminescence imaging to study neurodegeneration

scientific article

Microtubular structure and tubulin polymerization

scientific article published on February 1990

Microtubular structure and tubulin polymerization

scientific article

Microtubule affinity regulating kinase activity in living neurons was examined by a genetically encoded fluorescence resonance energy transfer/fluorescence lifetime imaging-based biosensor: inhibitors with therapeutic potential

scientific article

Microtubule affinity-regulating kinase 2 (MARK2) turns on phosphatase and tensin homolog (PTEN)-induced kinase 1 (PINK1) at Thr-313, a mutation site in Parkinson disease: effects on mitochondrial transport

scientific article

Microtubule assembly and disassembly studied by synchrotron X-ray scattering and cryoelectron microscopy

scientific article published on 01 January 1986

Microtubule dynamics and microtubule caps: a time-resolved cryo-electron microscopy study

scientific article published on September 1991

Microtubule oscillations

scientific article published on January 1, 1992

Microtubule oscillations. Role of nucleation and microtubule number concentration

scientific article published in March 1990

Microtubule structure studied by quick freezing: cryo-electron microscopy and freeze fracture

scientific article published on March 1986

Microtubule-Affinity Regulating Kinase (MARK) Is Tightly Associated with Neurofibrillary Tangles in Alzheimer Brain: A Fluorescence Resonance Energy Transfer Study

scientific article published on 01 November 2000

Microtubule-associated protein tau, paired helical filaments, and phosphorylation.

scientific article

Microtubule-associated protein/microtubule affinity-regulating kinase (p110mark). A novel protein kinase that regulates tau-microtubule interactions and dynamic instability by phosphorylation at the Alzheimer-specific site serine 262

scientific article

Microtubules and microtubule-associated proteins

scientific article

Missorting of tau in neurons causes degeneration of synapses that can be rescued by the kinase MARK2/Par-1.

scientific article published on March 2007

Mitogen activated protein (MAP) kinase transforms tau protein into an Alzheimer-like state

scientific article published on June 1992

Molecular imaging reveals epileptogenic Ca2+-channel promoter activation in hippocampi of living mice

scientific article published on 3 June 2014

Mutations of tau protein in frontotemporal dementia promote aggregation of paired helical filaments by enhancing local beta-structure

scientific article published in Journal of Biological Chemistry

N'-benzylidene-benzohydrazides as novel and selective tau-PHF ligands

scientific article published in January 2011

N-phenylamine derivatives as aggregation inhibitors in cell models of tauopathy

scientific article published on September 2007

Neuronal activity regulates extracellular tau in vivo

scientific article published on 17 February 2014

Novel antibody against low-n oligomers of tau protein promotes clearance of tau in cells via lysosomes

scientific article published on 28 October 2020

Novel diffusion barrier for axonal retention of Tau in neurons and its failure in neurodegeneration

scientific article published on 18 October 2011

Oligomer formation of tau protein hyperphosphorylated in cells

scientific article

On the rigidity of the cytoskeleton: are MAPs crosslinkers or spacers of microtubules?

scientific article published in July 2000

On the structure of microtubules, tau, and paired helical filaments

scientific article

On the surface lattice of microtubules: helix starts, protofilament number, seam, and handedness

scientific article published on March 1986

Oxidation of cysteine-322 in the repeat domain of microtubule-associated protein tau controls the in vitro assembly of paired helical filaments ⬇️

scientific article published on August 29, 1995

PAK5 kinase is an inhibitor of MARK/Par-1, which leads to stable microtubules and dynamic actin

scientific article

Paullones are potent inhibitors of glycogen synthase kinase-3beta and cyclin-dependent kinase 5/p25.

scientific article

Phenylthiazolyl-hydrazide and its derivatives are potent inhibitors of tau aggregation and toxicity in vitro and in cells

scientific article published on 8 August 2007

Phosphorylation of MAP2c and MAP4 by MARK kinases leads to the destabilization of microtubules in cells

scientific article

Phosphorylation of Ser262 strongly reduces binding of tau to microtubules: distinction between PHF-like immunoreactivity and microtubule binding.

scientific article published in July 1993

Phosphorylation of microtubule-associated protein tau: identification of the site for Ca2(+)-calmodulin dependent kinase and relationship with tau phosphorylation in Alzheimer tangles.

scientific article published on November 1990

Phosphorylation of microtubule-associated proteins MAP2 and MAP4 by the protein kinase p110mark. Phosphorylation sites and regulation of microtubule dynamics

scientific article

Phosphorylation of microtubule-associated proteins MAP2a,b and MAP2c at Ser136 by proline-directed kinases in vivo and in vitro

scientific article published on June 1, 1994

Phosphorylation of tau protein by recombinant GSK-3beta: pronounced phosphorylation at select Ser/Thr-Pro motifs but no phosphorylation at Ser262 in the repeat domain

scientific article published on 01 July 1999

Phosphorylation that detaches tau protein from microtubules (Ser262, Ser214) also protects it against aggregation into Alzheimer paired helical filaments

scientific article (publication date: 23 March 1999)

Phosphorylation-dependent epitopes of neurofilament antibodies on tau protein and relationship with Alzheimer tau ⬇️

scientific article published on June 15, 1992

Presynaptic Pathophysiology Encoded in Different Domains of Tau - Hyper-Versus Hypoexcitability?

scientific article published on 01 January 2019

Prevention of tau increase in cerebrospinal fluid of APP transgenic mice suggests downstream effect of BACE1 inhibition

scientific article published on 14 October 2016

Preventive methylene blue treatment preserves cognition in mice expressing full-length pro-aggregant human Tau.

scientific article

Pro-aggregant Tau impairs mossy fiber plasticity due to structural changes and Ca(++) dysregulation

scientific article

Proline-directed pseudo-phosphorylation at AT8 and PHF1 epitopes induces a compaction of the paperclip folding of Tau and generates a pathological (MC-1) conformation

scientific article published on 25 August 2008

Protein kinase MARK/PAR-1 is required for neurite outgrowth and establishment of neuronal polarity

scientific article

Proteolytic processing of tau.

scientific article published on August 2010

Quantification of amyloid precursor protein and tau for the study of axonal traffic pathways.

scientific article published in March 2007

Quick-frozen microtubules studied by cryoelectron microscopy and image processing

scientific article published on 01 January 1986

RNA stimulates aggregation of microtubule-associated protein tau into Alzheimer-like paired helical filaments

scientific article

Rapid assembly of Alzheimer-like paired helical filaments from microtubule-associated protein tau monitored by fluorescence in solution

scientific article

Reconstructions of tubulin protofilaments: different appearances of the same structure

scientific article

Regulatable transgenic mouse models of Alzheimer disease: onset, reversibility and spreading of Tau pathology

scientific article published on 22 April 2013

Reversibility of Tau-related cognitive defects in a regulatable FTD mouse model

scientific article published on 6 August 2011

Reversible Cation-Selective Attachment and Self-Assembly of Human Tau on Supported Brain Lipid Membranes

scientific article published on 17 April 2018

Rhodanine-based tau aggregation inhibitors in cell models of tauopathy

scientific article published on January 2007

S/P and T/P phosphorylation is critical for tau neurotoxicity in Drosophila.

scientific article published in May 2007

Screening for inhibitors of tau polymerization

scientific article published in April 2005

Sequential phosphorylation of Tau by glycogen synthase kinase-3beta and protein kinase A at Thr212 and Ser214 generates the Alzheimer-specific epitope of antibody AT100 and requires a paired-helical-filament-like conformation

scientific article

Single-molecule investigation of the interference between kinesin, tau and MAP2c

scientific article published on September 2002

Spatial patterns from oscillating microtubules

scientific article

Specific tau phosphorylation sites correlate with severity of neuronal cytopathology in Alzheimer's disease.

scientific article published in January 2002

Spectroscopic approaches to the conformation of tau protein in solution and in paired helical filaments

scientific article published on January 2006

Spred1 and TESK1--two new interaction partners of the kinase MARKK/TAO1 that link the microtubule and actin cytoskeleton

scientific article

Stages and conformations of the Tau repeat domain during aggregation and its effect on neuronal toxicity

scientific article published on 13 May 2014

Stages of tubulin assembly and disassembly studied by time-resolved synchrotron X-ray scattering.

scientific article published in February 1983

Stepwise proteolysis liberates tau fragments that nucleate the Alzheimer-like aggregation of full-length tau in a neuronal cell model

scholarly article

Structural principles of tau and the paired helical filaments of Alzheimer's disease

scientific article published on January 2007

Structural variations in the catalytic and ubiquitin-associated domains of microtubule-associated protein/microtubule affinity regulating kinase (MARK) 1 and MARK2.

scientific article published on 27 June 2006

Structure and elasticity of microtubule-associated protein tau

scientific article published in Nature

Structure and regulation of MARK, a kinase involved in abnormal phosphorylation of Tau protein

scientific article

Structure of tau protein and assembly into paired helical filaments

scientific article

Structure of the catalytic and ubiquitin-associated domains of the protein kinase MARK/Par-1.

scientific article published on February 2006

Structure of tubulin rings studied by X-ray scattering using synchrotron radiation

scientific article published on 01 June 1983

Structure, microtubule interactions, and paired helical filament aggregation by tau mutants of frontotemporal dementias

scientific article published in 2000

Structure, microtubule interactions, and phosphorylation of tau protein

scientific article published on January 1996

Structure, stability, and aggregation of paired helical filaments from tau protein and FTDP-17 mutants probed by tryptophan scanning mutagenesis

scientific article published on 26 August 2002

Suppressing Tau Aggregation and Toxicity by an Anti-Aggregant Tau Fragment

scientific article published on 08 September 2018

Surface-decoration of microtubules by human tau

scientific journal article

Swimming against the tide: mobility of the microtubule-associated protein tau in neurons

article

Synchrotron X-ray studies of biopolymers: self-assembly and oscillations of microtubules

scientific article published on 01 January 1989

Synergy and antagonism of macroautophagy and chaperone-mediated autophagy in a cell model of pathological tau aggregation

scientific article published on January 2010

Tau aggregation is driven by a transition from random coil to beta sheet structure

scientific article

Tau as a marker for Alzheimer's disease

scientific article published on December 1993

Tau blocks traffic of organelles, neurofilaments, and APP vesicles in neurons and enhances oxidative stress

scientific article published on 18 March 2002

Tau domains, phosphorylation, and interactions with microtubules.

scientific article

Tau fragmentation, aggregation and clearance: the dual role of lysosomal processing

scientific article

Tau in Alzheimer's disease.

scientific article published in November 1998

Tau missorting and spastin-induced microtubule disruption in neurodegeneration: Alzheimer Disease and Hereditary Spastic Paraplegia

scientific article

Tau mutant A152T, a risk factor for FTD/PSP, induces neuronal dysfunction and reduced lifespan independently of aggregation in a C. elegans Tauopathy model

scientific article

Tau neurotoxicity and rescue in animal models of human Tauopathies

scientific article published on 29 September 2015

Tau protein and Alzheimer's disease

scientific article

Tau protein and tau aggregation inhibitors

scientific article published on 10 February 2010

Tau protein becomes long and stiff upon phosphorylation: correlation between paracrystalline structure and degree of phosphorylation

scientific article published on October 1989

Tau regulates the attachment/detachment but not the speed of motors in microtubule-dependent transport of single vesicles and organelles

scientific article published on 01 July 1999

Tau's role in the developing brain: implications for intellectual disability

scientific article published on 21 December 2011

Tau-induced defects in synaptic plasticity, learning, and memory are reversible in transgenic mice after switching off the toxic Tau mutant.

scientific article published in February 2011

Tau/MAPT disease-associated variant A152T alters tau function and toxicity via impaired retrograde axonal transport

scientific article published on 01 May 2019

Tau: From research to clinical development

scientific article published on 3 May 2016

The 'jaws' model of tau-microtubule interaction examined in CHO cells

scientific article published on 01 March 1997

The Alzheimer-like phosphorylation of tau protein reduces microtubule binding and involves Ser-Pro and Thr-Pro motifs ⬇️

scientific article published on July 28, 1992

The Tau/A152T mutation, a risk factor for frontotemporal-spectrum disorders, leads to NR2B receptor-mediated excitotoxicity

scientific article published on March 2016

The beta-propensity of Tau determines aggregation and synaptic loss in inducible mouse models of tauopathy

scientific article published in Journal of Biological Chemistry

The core of tau-paired helical filaments studied by scanning transmission electron microscopy and limited proteolysis

scientific article published in May 2006

The crystal structure of dimeric kinesin and implications for microtubule-dependent motility

scientific article

The endogenous and cell cycle-dependent phosphorylation of tau protein in living cells: implications for Alzheimer's disease

scientific article

The juvenile microtubule-associated protein MAP2c is a rod-like molecule that forms antiparallel dimers ⬇️

scientific article published on May 25, 1992

The microtubule lattice--dynamic instability of concepts

scientific article published on 01 July 1995

The natively unfolded character of tau and its aggregation to Alzheimer-like paired helical filaments.

scientific article published on 11 September 2008

The potential for beta-structure in the repeat domain of tau protein determines aggregation, synaptic decay, neuronal loss, and coassembly with endogenous Tau in inducible mouse models of tauopathy.

scientific article

The release and trans-synaptic transmission of Tau via exosomes

scientific article

The switch of tau protein to an Alzheimer-like state includes the phosphorylation of two serine-proline motifs upstream of the microtubule binding region ⬇️

scientific article published on April 1, 1992

The tau of MARK: a polarized view of the cytoskeleton

scientific article published on 24 June 2009

Time course of Tau toxicity and pharmacologic prevention in a cell model of Tauopathy

scientific article published on 3 May 2017

Tracking Tau in Neurons: How to Grow, Fix, and Stain Primary Neurons for the Investigation of Tau in All Developmental Stages

scientific article

Tracking Tau in Neurons: How to Transfect and Track Exogenous Tau into Primary Neurons

scientific article

Tubulin hoops

scientific article published in February 1977

Tubulin oligomers and microtubule assembly studied by time-resolved X-ray scattering: separation of prenucleation and nucleation events

scientific article published on 01 February 1987

Tubulin oligomers and microtubule oscillations. Antagonistic role of microtubule stabilizers and destabilizers

scientific article published on 01 December 1988

Unstained microtubules studied by cryo-electron microscopy. Substructure, supertwist and disassembly

scientific article published on January 1985

What is the evidence that tau pathology spreads through prion-like propagation?

scientific article published on 19 December 2017

X-ray kinetic studies of microtubule assembly using synchrotron radiation

scientific article published on 01 October 1980

X-ray structure and microtubule interaction of the motor domain of Neurospora crassa NcKin3, a kinesin with unusual processivity

scientific article

X-ray structure of motor and neck domains from rat brain kinesin

scientific article

Paulina is supported by:

About Paulina

Help