List of works - Eckhard Mandelkow

"Lest we forget you--methylene blue...".

scientific article published on 12 February 2011

A combinatorial native MS and LC-MS/MS approach reveals high intrinsic phosphorylation of human tau but minimal levels of other key modifications

scientific article published on 26 October 2020

A mechanistic model of tau amyloid aggregation based on direct observation of oligomers

scientific article published on 30 April 2015

Acetylation mimic of lysine 280 exacerbates human Tau neurotoxicity in vivo

scientific article published on 4 March 2016

Adenosine A1 receptor antagonist rolofylline alleviates axonopathy caused by human Tau ΔK280

scientific article published on 26 September 2016

Alternative conformations of the Tau repeat domain in complex with an engineered binding protein

scientific article published on 25 June 2014

Alzheimer Disease in 2020 ⬇️

scientific article published on November 1, 2012

Amyloid-β oligomers induce synaptic damage via Tau-dependent microtubule severing by TTLL6 and spastin

scientific article

Anthraquinones inhibit tau aggregation and dissolve Alzheimer's paired helical filaments in vitro and in cells

scientific article

Anti-aggregant tau mutant promotes neurogenesis

scientific article published on 4 December 2017

Assessment of the In Vivo Relationship Between Cerebral Hypometabolism, Tau Deposition, TSPO Expression, and Synaptic Density in a Tauopathy Mouse Model: a Multi-tracer PET Study

scientific article published on 21 March 2022

Atypical, non-standard functions of the microtubule associated Tau protein

scientific article published on 29 November 2017

Automatic assignment of the intrinsically disordered protein Tau with 441-residues

scientific article published in September 2010

Axodendritic sorting and pathological missorting of Tau are isoform-specific and determined by axon initial segment architecture

scientific article published on 23 May 2017

Aβ Oligomers Cause Localized Ca2+Elevation, Missorting of Endogenous Tau into Dendrites, Tau Phosphorylation, and Destruction of Microtubules and Spines ⬇️

scientific article published on September 8, 2010

Backbone assignment for minimal protein amounts of low structural homogeneity in the absence of deuteration

scientific article published on 01 March 2016

Biochemistry and Cell Biology of Tau Protein in Neurofibrillary Degeneration ⬇️

scientific article published on July 1, 2012

Caenorhabditis elegans models of tauopathy

scientific article published in December 2017

Cascade of tau toxicity in inducible hippocampal brain slices and prevention by aggregation inhibitors ⬇️

scientific article published on November 15, 2012

Characterization of Alzheimer's-like paired helical filaments from the core domain of tau protein using solid-state NMR spectroscopy

scientific article

Cleavage of Tau by calpain in Alzheimer's disease: the quest for the toxic 17 kD fragment ⬇️

scientific article published on October 18, 2010

Competing interactions stabilize pro- and anti-aggregant conformations of human Tau.

scientific article published on 15 April 2011

Conformational changes specific for pseudophosphorylation at serine 262 selectively impair binding of tau to microtubules

scientific article published in October 2009

Curcumin-derived pyrazoles and isoxazoles: Swiss army knives or blunt tools for Alzheimer's disease?

scientific article published in January 2008

Deciphering Alzheimer disease

scientific article published on January 2012

Degradation of tau protein by autophagy and proteasomal pathways ⬇️

scientific article published on August 1, 2012

Development of tau aggregation inhibitors for Alzheimer's disease

scientific article

Domain conformation of tau protein studied by solution small-angle X-ray scattering

scientific article published on 5 September 2008

Dynamics and cooperativity of microtubule decoration by the motor protein kinesin11Edited by W. Baumeister

article

Evidence for a role of the rare p.A152T variant in MAPT in increasing the risk for FTD-spectrum and Alzheimer's diseases

scientific article

Extracellular low-n oligomers of tau cause selective synaptotoxicity without affecting cell viability

scientific article

Extracellular monomeric tau protein is sufficient to initiate the spread of tau protein pathology

scientific article published on 14 November 2013

FLEXITau: Quantifying Post-translational Modifications of Tau Protein in Vitro and in Human Disease

scientific article published on 15 February 2016

Folding of the Tau Protein on Microtubules

scientific article

Gaining Insights into Specific Drug Formulation Additives for Solubilizing a Potential Anti-Alzheimer Disease Drug B4A1.

scientific article published on 10 May 2017

Generalizing the Concept of Specific Compound Formulation Additives towards Non-Fluorescent Drugs: A Solubilization Study on Potential Anti-Alzheimer-Active Small-Molecule Compounds

scientific article

Global hairpin folding of tau in solution

scientific article published in February 2006

Glycogen synthase kinase (GSK) 3beta directly phosphorylates Serine 212 in the regulatory loop and inhibits microtubule affinity-regulating kinase (MARK) 2.

scientific article published on 18 April 2008

Highly populated turn conformations in natively unfolded tau protein identified from residual dipolar couplings and molecular simulation

scientific article published on 27 March 2007

Hsp90-Tau complex reveals molecular basis for specificity in chaperone action

scientific article

Human Tau isoforms assemble into ribbon-like fibrils that display polymorphic structure and stability

scientific article

Human cyclophilin 40 unravels neurotoxic amyloids

scientific article

Identification of Small Molecule Inhibitors of Tau Aggregation by Targeting Monomeric Tau As a Potential Therapeutic Approach for Tauopathies

scientific article (publication date: 19 October 2015)

Imbalance of Hsp70 family variants fosters tau accumulation

scientific article published on 27 December 2012

Inducible expression of Tau repeat domain in cell models of tauopathy: aggregation is toxic to cells but can be reversed by inhibitor drugs

scientific article

Inhibition of APP trafficking by tau protein does not increase the generation of amyloid-beta peptides

scientific article

Inhibition of Tau Filament Formation by Conformational Modulation ⬇️

scientific article published on February 5, 2013

Inhibition of Tau Protein Aggregation by Rhodanine-based Compounds Solubilized Via Specific Formulation Additives to Improve Bioavailability and Cell Viability

scientific article published on February 2017

Inhibition of tau aggregation in a novel Caenorhabditis elegans model of tauopathy mitigates proteotoxicity

scientific article published on 18 May 2012

Inhibition of tau aggregation in cell models of tauopathy

scientific article published on December 2007

Interaction of Tau Protein with Model Lipid Membranes Induces Tau Structural Compaction and Membrane Disruption ⬇️

scientific article published on March 14, 2012

Interplay of pathogenic forms of human tau with different autophagic pathways

scientific article

Intrinsic fluorescent detection of tau conformation and aggregation

scientific article published in January 2005

Investigating Fibrillar Aggregates of Tau Protein by Atomic Force Microscopy

Kinesin motors and disease

scientific article

Liquid-liquid phase separation of the microtubule-binding repeats of the Alzheimer-related protein Tau.

scientific article

Lost after translation: missorting of Tau protein and consequences for Alzheimer disease

scientific article published on 12 September 2014

Low-power solid-state NMR experiments for resonance assignment under fast magic-angle spinning

MARKK, a Ste20-like kinase, activates the polarity-inducing kinase MARK/PAR-1 ⬇️

scientific article published on October 1, 2003

Mechanistic Basis of Phenothiazine‐Driven Inhibition of Tau Aggregation ⬇️

scientific article published on February 11, 2013

Microscopic evidence for a minus-end-directed power stroke in the kinesin motor ncd.

scientific article

Microtubule affinity regulating kinase activity in living neurons was examined by a genetically encoded fluorescence resonance energy transfer/fluorescence lifetime imaging-based biosensor: inhibitors with therapeutic potential

scientific article

Microtubule-associated protein/microtubule affinity-regulating kinase (p110mark). A novel protein kinase that regulates tau-microtubule interactions and dynamic instability by phosphorylation at the Alzheimer-specific site serine 262

scientific article

Modulation of kinesin binding by the C-termini of tubulin

scientific article

N'-benzylidene-benzohydrazides as novel and selective tau-PHF ligands

scientific article published in January 2011

Novel diffusion barrier for axonal retention of Tau in neurons and its failure in neurodegeneration ⬇️

scientific article published on October 18, 2011

Nucleotide-induced conformations in the neck region of dimeric kinesin

scientific article

Oligomer formation of tau protein hyperphosphorylated in cells

scientific article

On the structure of microtubules, tau, and paired helical filaments

scientific article

PAK5 kinase is an inhibitor of MARK/Par-1, which leads to stable microtubules and dynamic actin

scientific article

Pathological missorting of endogenous MAPT/Tau in neurons caused by failure of protein degradation systems

scientific article published on 13 September 2018

Phenylthiazolyl-hydrazide and its derivatives are potent inhibitors of tau aggregation and toxicity in vitro and in cells

scientific article published on 8 August 2007

Phosphorylation of human Tau protein by microtubule affinity-regulating kinase 2.

scientific article published on 22 November 2013

Predictive atomic resolution descriptions of intrinsically disordered hTau40 and α-synuclein in solution from NMR and small angle scattering

scientific article published on 19 December 2013

Preventive methylene blue treatment preserves cognition in mice expressing full-length pro-aggregant human Tau.

scientific article

Pro-aggregant Tau impairs mossy fiber plasticity due to structural changes and Ca(++) dysregulation

scientific article

Progress and Developments in Tau Aggregation Inhibitors for Alzheimer Disease ⬇️

scientific article published on March 13, 2013

Proline-directed pseudo-phosphorylation at AT8 and PHF1 epitopes induces a compaction of the paperclip folding of Tau and generates a pathological (MC-1) conformation

scientific article published on 25 August 2008

Proteasomal degradation of the intrinsically disordered protein tau at single-residue resolution

scientific article published on 22 July 2020

Protein kinase MARK/PAR-1 is required for neurite outgrowth and establishment of neuronal polarity

scientific article

Proteolytic processing of tau.

scientific article published on August 2010

Purification of recombinant tau protein and preparation of Alzheimer-paired helical filaments in vitro.

scientific article published in January 2005

Remodeling of the conformational ensemble of the repeat domain of tau by an aggregation enhancer

scientific article published on 3 March 2016

Reversibility of Tau-related cognitive defects in a regulatable FTD mouse model

scientific article published on 6 August 2011

Rhodanine-based tau aggregation inhibitors in cell models of tauopathy

scientific article published on January 2007

Screening for inhibitors of tau polymerization

scientific article published in April 2005

Screening for inhibitors of tau protein aggregation into Alzheimer paired helical filaments: a ligand based approach results in successful scaffold hopping

scientific article

Selection and Characterization of Tau Binding ᴅ-Enantiomeric Peptides with Potential for Therapy of Alzheimer Disease

scientific article

Single-molecule investigation of the interference between kinesin, tau and MAP2c

scientific article published on September 2002

Sites of tau important for aggregation populate {beta}-structure and bind to microtubules and polyanions

scientific article published on 26 April 2005

Stages and conformations of the Tau repeat domain during aggregation and its effect on neuronal toxicity

scientific article published on 13 May 2014

Structural Impact of Proline-Directed Pseudophosphorylation at AT8, AT100, and PHF1 Epitopes on 441-Residue Tau ⬇️

scientific article published on September 15, 2011

Structural Impact of Tau Phosphorylation at Threonine 231.

scientific article published on 9 July 2015

Structural characterization of beta-sheeted oligomers formed on the pathway of oxidative prion protein aggregation in vitro

scientific article published on 21 July 2006

Structural characterization of binding of Cu(II) to tau protein

scientific article published on 20 September 2008

Structural memory of natively unfolded tau protein detected by small-angle X-ray scattering

scientific article published on 10 May 2011

Structural polymorphism of 441-residue tau at single residue resolution

scientific article

Structural principles of tau and the paired helical filaments of Alzheimer's disease

scientific article published on January 2007

Structural variations in the catalytic and ubiquitin-associated domains of microtubule-associated protein/microtubule affinity regulating kinase (MARK) 1 and MARK2.

scientific article published on 27 June 2006

Structure and regulation of MARK, a kinase involved in abnormal phosphorylation of Tau protein

scientific article

Structure of the catalytic and ubiquitin-associated domains of the protein kinase MARK/Par-1.

scientific article published on February 2006

Structure, stability, and aggregation of paired helical filaments from tau protein and FTDP-17 mutants probed by tryptophan scanning mutagenesis

scientific article published on 26 August 2002

Structures of kinesin motor proteins

scientific article

Swimming against the tide: mobility of the microtubule-associated protein tau in neurons

article

Synergy and antagonism of macroautophagy and chaperone-mediated autophagy in a cell model of pathological tau aggregation

scientific article published on January 2010

Tau Protein Diffuses along the Microtubule Lattice ⬇️

scientific article published on September 27, 2012

Tau aggregation is driven by a transition from random coil to beta sheet structure

scientific article

Tau fragmentation, aggregation and clearance: the dual role of lysosomal processing

scientific article

Tau in physiology and pathology

scientific article

Tau mutant A152T, a risk factor for FTD/PSP, induces neuronal dysfunction and reduced lifespan independently of aggregation in a C. elegans Tauopathy model

scientific article

Tau paired helical filaments from Alzheimer's disease brain and assembled in vitro are based on beta-structure in the core domain

scientific journal article

Tau protein and tau aggregation inhibitors

scientific article published on 10 February 2010

Tau protein liquid-liquid phase separation can initiate tau aggregation

scientific article published on 22 February 2018

Tau stabilizes microtubules by binding at the interface between tubulin heterodimers

scientific article published on June 2015

Tau-based treatment strategies in neurodegenerative diseases

scientific article published on July 2008

Tau: From research to clinical development

scientific article published on 3 May 2016

The "jaws" of the tau-microtubule interaction

scientific article published on 15 February 2007

The Dynamic Structure of Filamentous Tau ⬇️

scientific article published on October 11, 2011

The Tau/A152T mutation, a risk factor for frontotemporal-spectrum disorders, leads to NR2B receptor-mediated excitotoxicity

scientific article published on March 2016

The beta-propensity of Tau determines aggregation and synaptic loss in inducible mouse models of tauopathy

scientific article published in Journal of Biological Chemistry

The binding mode of a repeat-like Tau sequence with tubulin

scientific article published on 3 January 2018

The core of tau-paired helical filaments studied by scanning transmission electron microscopy and limited proteolysis

scientific article published in May 2006

The fuzzy coat of pathological human Tau fibrils is a two-layered polyelectrolyte brush

scientific article published on 26 December 2012

The natively unfolded character of tau and its aggregation to Alzheimer-like paired helical filaments

scientific article published on 11 September 2008

The potential for beta-structure in the repeat domain of tau protein determines aggregation, synaptic decay, neuronal loss, and coassembly with endogenous Tau in inducible mouse models of tauopathy.

scientific article

The release and trans-synaptic transmission of Tau via exosomes

scientific article

Time course of Tau toxicity and pharmacologic prevention in a cell model of Tauopathy

scientific article published on 3 May 2017

Transport and diffusion of Tau protein in neurons

scientific article published on April 2014

What is the evidence that tau pathology spreads through prion-like propagation?

scientific article published on 19 December 2017

X-ray structure and microtubule interaction of the motor domain of Neurospora crassa NcKin3, a kinesin with unusual processivity

scientific article

β-Sheet core of tau paired helical filaments revealed by solid-state NMR.

scientific article published on 15 August 2012

List of works by Eckhard Mandelkow

"Lest we forget you--methylene blue...".

A combinatorial native MS and LC-MS/MS approach reveals high intrinsic phosphorylation of human tau but minimal levels of other key modifications

A mechanistic model of tau amyloid aggregation based on direct observation of oligomers

Acetylation mimic of lysine 280 exacerbates human Tau neurotoxicity in vivo

Adenosine A1 receptor antagonist rolofylline alleviates axonopathy caused by human Tau ΔK280

Alternative conformations of the Tau repeat domain in complex with an engineered binding protein

Alzheimer Disease in 2020 ⬇️

Amyloid-β oligomers induce synaptic damage via Tau-dependent microtubule severing by TTLL6 and spastin

Anthraquinones inhibit tau aggregation and dissolve Alzheimer's paired helical filaments in vitro and in cells

Anti-aggregant tau mutant promotes neurogenesis

Assessment of the In Vivo Relationship Between Cerebral Hypometabolism, Tau Deposition, TSPO Expression, and Synaptic Density in a Tauopathy Mouse Model: a Multi-tracer PET Study

Atypical, non-standard functions of the microtubule associated Tau protein

Automatic assignment of the intrinsically disordered protein Tau with 441-residues

Axodendritic sorting and pathological missorting of Tau are isoform-specific and determined by axon initial segment architecture

Aβ Oligomers Cause Localized Ca2+Elevation, Missorting of Endogenous Tau into Dendrites, Tau Phosphorylation, and Destruction of Microtubules and Spines ⬇️

Backbone assignment for minimal protein amounts of low structural homogeneity in the absence of deuteration

Biochemistry and Cell Biology of Tau Protein in Neurofibrillary Degeneration ⬇️

Caenorhabditis elegans models of tauopathy

Cascade of tau toxicity in inducible hippocampal brain slices and prevention by aggregation inhibitors ⬇️

Characterization of Alzheimer's-like paired helical filaments from the core domain of tau protein using solid-state NMR spectroscopy

Cleavage of Tau by calpain in Alzheimer's disease: the quest for the toxic 17 kD fragment ⬇️

Competing interactions stabilize pro- and anti-aggregant conformations of human Tau.

Conformational changes specific for pseudophosphorylation at serine 262 selectively impair binding of tau to microtubules

Curcumin-derived pyrazoles and isoxazoles: Swiss army knives or blunt tools for Alzheimer's disease?

Deciphering Alzheimer disease

Degradation of tau protein by autophagy and proteasomal pathways ⬇️

Development of tau aggregation inhibitors for Alzheimer's disease

Domain conformation of tau protein studied by solution small-angle X-ray scattering

Dynamics and cooperativity of microtubule decoration by the motor protein kinesin11Edited by W. Baumeister

Evidence for a role of the rare p.A152T variant in MAPT in increasing the risk for FTD-spectrum and Alzheimer's diseases

Extracellular low-n oligomers of tau cause selective synaptotoxicity without affecting cell viability

Extracellular monomeric tau protein is sufficient to initiate the spread of tau protein pathology

FLEXITau: Quantifying Post-translational Modifications of Tau Protein in Vitro and in Human Disease

Folding of the Tau Protein on Microtubules

Gaining Insights into Specific Drug Formulation Additives for Solubilizing a Potential Anti-Alzheimer Disease Drug B4A1.

Generalizing the Concept of Specific Compound Formulation Additives towards Non-Fluorescent Drugs: A Solubilization Study on Potential Anti-Alzheimer-Active Small-Molecule Compounds

Global hairpin folding of tau in solution

Glycogen synthase kinase (GSK) 3beta directly phosphorylates Serine 212 in the regulatory loop and inhibits microtubule affinity-regulating kinase (MARK) 2.

Highly populated turn conformations in natively unfolded tau protein identified from residual dipolar couplings and molecular simulation

Hsp90-Tau complex reveals molecular basis for specificity in chaperone action

Human Tau isoforms assemble into ribbon-like fibrils that display polymorphic structure and stability

Human cyclophilin 40 unravels neurotoxic amyloids

Identification of Small Molecule Inhibitors of Tau Aggregation by Targeting Monomeric Tau As a Potential Therapeutic Approach for Tauopathies

Imbalance of Hsp70 family variants fosters tau accumulation

Inducible expression of Tau repeat domain in cell models of tauopathy: aggregation is toxic to cells but can be reversed by inhibitor drugs

Inhibition of APP trafficking by tau protein does not increase the generation of amyloid-beta peptides

Inhibition of Tau Filament Formation by Conformational Modulation ⬇️

Inhibition of Tau Protein Aggregation by Rhodanine-based Compounds Solubilized Via Specific Formulation Additives to Improve Bioavailability and Cell Viability

Inhibition of tau aggregation in a novel Caenorhabditis elegans model of tauopathy mitigates proteotoxicity

Inhibition of tau aggregation in cell models of tauopathy

Interaction of Tau Protein with Model Lipid Membranes Induces Tau Structural Compaction and Membrane Disruption ⬇️

Interplay of pathogenic forms of human tau with different autophagic pathways

Intrinsic fluorescent detection of tau conformation and aggregation

Investigating Fibrillar Aggregates of Tau Protein by Atomic Force Microscopy

Kinesin motors and disease

Liquid-liquid phase separation of the microtubule-binding repeats of the Alzheimer-related protein Tau.

Lost after translation: missorting of Tau protein and consequences for Alzheimer disease

Low-power solid-state NMR experiments for resonance assignment under fast magic-angle spinning

MARKK, a Ste20-like kinase, activates the polarity-inducing kinase MARK/PAR-1 ⬇️

Mechanistic Basis of Phenothiazine‐Driven Inhibition of Tau Aggregation ⬇️

Microscopic evidence for a minus-end-directed power stroke in the kinesin motor ncd.

Microtubule affinity regulating kinase activity in living neurons was examined by a genetically encoded fluorescence resonance energy transfer/fluorescence lifetime imaging-based biosensor: inhibitors with therapeutic potential

Microtubule-associated protein/microtubule affinity-regulating kinase (p110mark). A novel protein kinase that regulates tau-microtubule interactions and dynamic instability by phosphorylation at the Alzheimer-specific site serine 262

Modulation of kinesin binding by the C-termini of tubulin

N'-benzylidene-benzohydrazides as novel and selective tau-PHF ligands

Novel diffusion barrier for axonal retention of Tau in neurons and its failure in neurodegeneration ⬇️

Nucleotide-induced conformations in the neck region of dimeric kinesin

Oligomer formation of tau protein hyperphosphorylated in cells

On the structure of microtubules, tau, and paired helical filaments

PAK5 kinase is an inhibitor of MARK/Par-1, which leads to stable microtubules and dynamic actin

Pathological missorting of endogenous MAPT/Tau in neurons caused by failure of protein degradation systems

Phenylthiazolyl-hydrazide and its derivatives are potent inhibitors of tau aggregation and toxicity in vitro and in cells

Phosphorylation of human Tau protein by microtubule affinity-regulating kinase 2.

Predictive atomic resolution descriptions of intrinsically disordered hTau40 and α-synuclein in solution from NMR and small angle scattering

Preventive methylene blue treatment preserves cognition in mice expressing full-length pro-aggregant human Tau.

Pro-aggregant Tau impairs mossy fiber plasticity due to structural changes and Ca(++) dysregulation

Progress and Developments in Tau Aggregation Inhibitors for Alzheimer Disease ⬇️

Proline-directed pseudo-phosphorylation at AT8 and PHF1 epitopes induces a compaction of the paperclip folding of Tau and generates a pathological (MC-1) conformation

Proteasomal degradation of the intrinsically disordered protein tau at single-residue resolution