List of works - Shareen Doak

A Crosstalk Between K ras (Kirsten Rat Sarcoma Viral Oncogene Homologue) and Adherence Molecular Complex Leads to Disassociation of Cells-A Possible Contribution Towards Metastasis in Colorectal Cancer

scientific article published on 4 March 2016

A comparison of the genotoxicity of benzo[a]pyrene in four cell lines with differing metabolic capacity

scientific article published on 26 July 2016

A role for STEAP2 in prostate cancer progression

scientific article

Acute dosing and p53-deficiency promote cellular sensitivity to DNA methylating agents.

scientific article

Adipose regeneration and implications for breast reconstruction: update and the future

scientific article

Aligning nanotoxicology with the 3Rs: What is needed to realise the short, medium and long-term opportunities?

scientific article published on 22 October 2017

An Alternative Perspective towards Reducing the Risk of Engineered Nanomaterials to Human Health

scientific article published on 05 August 2020

Analysis of the premalignant stages of Barrett's oesophagus through to adenocarcinoma by comparative genomic hybridization

scientific article

Aneuploidy in upper gastro-intestinal tract cancers--a potential prognostic marker?

scientific article

Aneuploidy involving chromosome 1 may be an early predictive marker of intestinal type gastric cancer.

scientific article published on 27 May 2009

Automation and validation of micronucleus detection in the 3D EpiDerm™ human reconstructed skin assay and correlation with 2D dose responses.

scientific article published on 27 March 2014

Bone morphogenic factor gene dosage abnormalities in prostatic intraepithelial neoplasia and prostate cancer

scientific article published on July 2007

Cell type-dependent changes in CdSe/ZnS quantum dot uptake and toxic endpoints ⬇️

scientific article

Characterisation of p53 status at the gene, chromosomal and protein levels in oesophageal adenocarcinoma.

scientific article published on November 2003

Chromosome 4 hyperploidy represents an early genetic aberration in premalignant Barrett's oesophagus.

scientific article published on May 2003

Chromosome breakage induced by the genotoxic agents mitomycin C and cytosine arabinoside is concentration and p53 dependent

scientific article published on 27 March 2014

Chromosome morphology after long-term storage investigated by scanning near-field optical microscopy

scientific article published on 01 March 2006

Coating of Quantum Dots strongly defines their effect on lysosomal health and autophagy

scientific article

Comparative genomic hybridization (CGH) of augmentation cystoplasties

scientific article published on June 2007

Confounding experimental considerations in nanogenotoxicology

scientific article published on 07 April 2009

Cytotoxic effects of gold nanoparticles: a multiparametric study

scientific article published on 8 June 2012

Dextran coated ultrafine superparamagnetic iron oxide nanoparticles: compatibility with common fluorometric and colorimetric dyes

scientific article

Dietary and lifestyle factors effect erythrocyte PIG-A mutant frequency in humans

scientific article published on 12 October 2020

Differential expression of the MAD2, BUB1 and HSP27 genes in Barrett's oesophagus-their association with aneuploidy and neoplastic progression

scientific article published in March 2004

Do dose response thresholds exist for genotoxic alkylating agents?

scientific article

Dynamic Fluid Flow Exacerbates the (Pro-)Inflammatory Effects of Aerosolised Engineered Nanomaterials In Vitro

scientific article published on 30 September 2022

Early p53 mutations in nondysplastic Barrett's tissue detected by the restriction site mutation (RSM) methodology.

scientific article published on April 2003

Emerging metrology for high-throughput nanomaterial genotoxicology

scientific article

Empirical analysis of BMD metrics in genetic toxicology part I: in vitro analyses to provide robust potency rankings and support MOA determinations

scientific article published on 19 December 2015

Factors affecting the in vitro micronucleus assay for evaluation of nanomaterials

scientific article

Fluorescence imaging and investigations of directly labelled chromosomes using scanning near-field optical microscopy

scientific article published on 18 September 2006

Fluorescence in situ hybridisation analysis of chromosomal aberrations in gastric tissue: the potential involvement of Helicobacter pylori

scientific article published on May 2005

Fluorescence in-situ hybridisation on biopsies from clam ileocystoplasties and on a clam cancer

scientific article published on March 2006

Fluorescent non-porous silica nanoparticles for long-term cell monitoring: cytotoxicity and particle functionality

scientific article published on 9 May 2013

Generation of locus-specific probes for interphase fluorescence in situ hybridisation--application in Barrett's esophagus.

scientific article

Genetic pathways involved in the progression of Barrett's metaplasia to adenocarcinoma

scientific article

Genetic toxicity assessment of engineered nanoparticles using a 3D in vitro skin model (EpiDerm™) ⬇️

scientific article

Genotoxic capacity of Cd/Se semiconductor quantum dots with differing surface chemistries ⬇️

scientific article published on 14 August 2015

Genotoxic thresholds, DNA repair, and susceptibility in human populations.

scientific article

Genotoxicity of nanomaterials: refining strategies and tests for hazard identification

scientific article

Genotoxins induce binucleation in L5178Y and TK6 cells

scientific article

High-resolution imaging using a novel atomic force microscope and confocal laser scanning microscope hybrid instrument: essential sample preparation aspects

scientific article

Highly sensitive covalently functionalised integrated silicon nanowire biosensor devices for detection of cancer risk biomarker

scientific article published on 3 September 2013

How do forensic scientists learn to become competent in casework reporting in practice: a theoretical and empirical approach

scientific article published in August 2006

Identification of Early p53 Mutations in Clam Ileocystoplasties Using Restriction Site Mutation Assay

scientific article published on 24 October 2007

In Vitro Primary-Indirect Genotoxicity in Bronchial Epithelial Cells Promoted by Industrially Relevant Few-Layer Graphene

scientific article published on 30 July 2020

In vitro genotoxicity testing strategy for nanomaterials and the adaptation of current OECD guidelines ⬇️

scientific article published on September 28, 2011

Increased expression of ARF GTPases in prostate cancer tissue

scientific article published on 12 July 2015

Influence of DNA repair on nonlinear dose-responses for mutation

scientific article

Mechanisms of cell-cell adhesion identified by immunofluorescent labelling with quantum dots: a scanning near-field optical microscopy approach.

scientific article

Mechanistic influences for mutation induction curves after exposure to DNA-reactive carcinogens

scientific article published on April 2007

Modification of Schottky interface by the inclusion of DNA interlayer to create metal / organic / inorganic structures

article published in 2012

N-methylpurine DNA glycosylase plays a pivotal role in the threshold response of ethyl methanesulfonate-induced chromosome damage

scientific article published on 11 November 2010

NanoGenotoxicology: the DNA damaging potential of engineered nanomaterials.

scientific article published on 08 May 2009

Nanotoxicology. Preface.

scientific article

No-observed effect levels are associated with up-regulation of MGMT following MMS exposure.

scientific article

Non-linear dose-response of DNA-reactive genotoxins: recommendations for data analysis

scientific article

Opinion of the Scientific Committee on consumer safety (SCCS) - Opinion on the use of 2,2′-methylene-bis-(6-(2H-benzotriazol-2-yl)-4-(1,1,3,3-tetramethylbutyl)phenol) (nano) – S79 – In cosmetic products

scientific article published on 09 January 2016

Potential toxicity of superparamagnetic iron oxide nanoparticles (SPION)

scientific article

Pro-oxidant induced DNA damage in human lymphoblastoid cells: homeostatic mechanisms of genotoxic tolerance

scientific article

Putative prognostic epithelial-to-mesenchymal transition biomarkers for aggressive prostate cancer

scientific article published on 06 August 2013

Quantum dots for multiplexed detection and characterisation of prostate cancer cells using a scanning near-field optical microscope

scientific article

Real-time reverse-transcription polymerase chain reaction: technical considerations for gene expression analysis

scientific article published in January 2012

Recommendations, evaluation and validation of a semi-automated, fluorescent-based scoring protocol for micronucleus testing in human cells

scientific article published on 4 April 2014

Risk Governance of Emerging Technologies Demonstrated in Terms of its Applicability to Nanomaterials

scientific article published on 23 July 2020

STEM mode in the SEM: a practical tool for nanotoxicology

scientific article

Single-walled carbon nanotubes: differential genotoxic potential associated with physico-chemical properties.

scientific article published on 20 January 2012

The bile acid deoxycholic acid (DCA) at neutral pH activates NF-kappaB and induces IL-8 expression in oesophageal cells in vitro

scientific article

The clastogenicity of 4NQO is cell-type dependent and linked to cytotoxicity, length of exposure and p53 proficiency.

scientific article

The effect of nanoparticle degradation on amphiphilic polymer-coated quantum dot toxicity: the importance of particle functionality assessment in toxicology [corrected].

scientific article published on 10 October 2013

The in vitro micronucleus assay and kinetochore staining: methodology and criteria for the accurate assessment of genotoxicity and cytotoxicity

scientific article published on January 2013

The influence of exposure approaches to in vitro lung epithelial barrier models to assess engineered nanomaterial hazard

scientific article published on 2 January 2022

The jury is still out on the safety of silver nanoparticles

scientific article

The role of adhesion molecules as biomarkers for the aggressive prostate cancer phenotype

scientific article

The role of iron redox state in the genotoxicity of ultrafine superparamagnetic iron oxide nanoparticles.

scientific article

Translating Scientific Advances in the AOP Framework to Decision Making for Nanomaterials

scientific article published on 24 June 2020

Unraveling the effects of siRNA carrier systems on cell physiology: a multiparametric approach demonstrated on dextran nanogels

scientific article published on 12 June 2013

Vinblastine and diethylstilboestrol tested in the in vitro mammalian cell micronucleus test (MNvit) at Swansea University UK in support of OECD draft Test Guideline 487.

scientific article published on 8 August 2009

List of works by Shareen Doak

A Crosstalk Between K ras (Kirsten Rat Sarcoma Viral Oncogene Homologue) and Adherence Molecular Complex Leads to Disassociation of Cells-A Possible Contribution Towards Metastasis in Colorectal Cancer

A comparison of the genotoxicity of benzo[a]pyrene in four cell lines with differing metabolic capacity

A role for STEAP2 in prostate cancer progression

Acute dosing and p53-deficiency promote cellular sensitivity to DNA methylating agents.

Adipose regeneration and implications for breast reconstruction: update and the future

Aligning nanotoxicology with the 3Rs: What is needed to realise the short, medium and long-term opportunities?

An Alternative Perspective towards Reducing the Risk of Engineered Nanomaterials to Human Health

Analysis of the premalignant stages of Barrett's oesophagus through to adenocarcinoma by comparative genomic hybridization

Aneuploidy in upper gastro-intestinal tract cancers--a potential prognostic marker?

Aneuploidy involving chromosome 1 may be an early predictive marker of intestinal type gastric cancer.

Automation and validation of micronucleus detection in the 3D EpiDerm™ human reconstructed skin assay and correlation with 2D dose responses.

Bone morphogenic factor gene dosage abnormalities in prostatic intraepithelial neoplasia and prostate cancer

Cell type-dependent changes in CdSe/ZnS quantum dot uptake and toxic endpoints ⬇️

Characterisation of p53 status at the gene, chromosomal and protein levels in oesophageal adenocarcinoma.

Chromosome 4 hyperploidy represents an early genetic aberration in premalignant Barrett's oesophagus.

Chromosome breakage induced by the genotoxic agents mitomycin C and cytosine arabinoside is concentration and p53 dependent

Chromosome morphology after long-term storage investigated by scanning near-field optical microscopy

Coating of Quantum Dots strongly defines their effect on lysosomal health and autophagy

Comparative genomic hybridization (CGH) of augmentation cystoplasties

Confounding experimental considerations in nanogenotoxicology

Cytotoxic effects of gold nanoparticles: a multiparametric study

Dextran coated ultrafine superparamagnetic iron oxide nanoparticles: compatibility with common fluorometric and colorimetric dyes

Dietary and lifestyle factors effect erythrocyte PIG-A mutant frequency in humans

Differential expression of the MAD2, BUB1 and HSP27 genes in Barrett's oesophagus-their association with aneuploidy and neoplastic progression

Do dose response thresholds exist for genotoxic alkylating agents?

Dynamic Fluid Flow Exacerbates the (Pro-)Inflammatory Effects of Aerosolised Engineered Nanomaterials In Vitro

Early p53 mutations in nondysplastic Barrett's tissue detected by the restriction site mutation (RSM) methodology.

Emerging metrology for high-throughput nanomaterial genotoxicology

Empirical analysis of BMD metrics in genetic toxicology part I: in vitro analyses to provide robust potency rankings and support MOA determinations

Factors affecting the in vitro micronucleus assay for evaluation of nanomaterials

Fluorescence imaging and investigations of directly labelled chromosomes using scanning near-field optical microscopy

Fluorescence in situ hybridisation analysis of chromosomal aberrations in gastric tissue: the potential involvement of Helicobacter pylori

Fluorescence in-situ hybridisation on biopsies from clam ileocystoplasties and on a clam cancer

Fluorescent non-porous silica nanoparticles for long-term cell monitoring: cytotoxicity and particle functionality

Generation of locus-specific probes for interphase fluorescence in situ hybridisation--application in Barrett's esophagus.

Genetic pathways involved in the progression of Barrett's metaplasia to adenocarcinoma

Genetic toxicity assessment of engineered nanoparticles using a 3D in vitro skin model (EpiDerm™) ⬇️

Genotoxic capacity of Cd/Se semiconductor quantum dots with differing surface chemistries ⬇️

Genotoxic thresholds, DNA repair, and susceptibility in human populations.

Genotoxicity of nanomaterials: refining strategies and tests for hazard identification

Genotoxins induce binucleation in L5178Y and TK6 cells

High-resolution imaging using a novel atomic force microscope and confocal laser scanning microscope hybrid instrument: essential sample preparation aspects

Highly sensitive covalently functionalised integrated silicon nanowire biosensor devices for detection of cancer risk biomarker

How do forensic scientists learn to become competent in casework reporting in practice: a theoretical and empirical approach

Identification of Early p53 Mutations in Clam Ileocystoplasties Using Restriction Site Mutation Assay

In Vitro Primary-Indirect Genotoxicity in Bronchial Epithelial Cells Promoted by Industrially Relevant Few-Layer Graphene

In vitro genotoxicity testing strategy for nanomaterials and the adaptation of current OECD guidelines ⬇️

Increased expression of ARF GTPases in prostate cancer tissue

Influence of DNA repair on nonlinear dose-responses for mutation

Mechanisms of cell-cell adhesion identified by immunofluorescent labelling with quantum dots: a scanning near-field optical microscopy approach.

Mechanistic influences for mutation induction curves after exposure to DNA-reactive carcinogens

Modification of Schottky interface by the inclusion of DNA interlayer to create metal / organic / inorganic structures

N-methylpurine DNA glycosylase plays a pivotal role in the threshold response of ethyl methanesulfonate-induced chromosome damage

NanoGenotoxicology: the DNA damaging potential of engineered nanomaterials.

Nanotoxicology. Preface.

No-observed effect levels are associated with up-regulation of MGMT following MMS exposure.

Non-linear dose-response of DNA-reactive genotoxins: recommendations for data analysis

Opinion of the Scientific Committee on consumer safety (SCCS) - Opinion on the use of 2,2′-methylene-bis-(6-(2H-benzotriazol-2-yl)-4-(1,1,3,3-tetramethylbutyl)phenol) (nano) – S79 – In cosmetic products

Potential toxicity of superparamagnetic iron oxide nanoparticles (SPION)

Pro-oxidant induced DNA damage in human lymphoblastoid cells: homeostatic mechanisms of genotoxic tolerance

Putative prognostic epithelial-to-mesenchymal transition biomarkers for aggressive prostate cancer

Quantum dots for multiplexed detection and characterisation of prostate cancer cells using a scanning near-field optical microscope

Real-time reverse-transcription polymerase chain reaction: technical considerations for gene expression analysis

Recommendations, evaluation and validation of a semi-automated, fluorescent-based scoring protocol for micronucleus testing in human cells

Risk Governance of Emerging Technologies Demonstrated in Terms of its Applicability to Nanomaterials

STEM mode in the SEM: a practical tool for nanotoxicology

Single-walled carbon nanotubes: differential genotoxic potential associated with physico-chemical properties.

The bile acid deoxycholic acid (DCA) at neutral pH activates NF-kappaB and induces IL-8 expression in oesophageal cells in vitro

The clastogenicity of 4NQO is cell-type dependent and linked to cytotoxicity, length of exposure and p53 proficiency.

The effect of nanoparticle degradation on amphiphilic polymer-coated quantum dot toxicity: the importance of particle functionality assessment in toxicology [corrected].

The in vitro micronucleus assay and kinetochore staining: methodology and criteria for the accurate assessment of genotoxicity and cytotoxicity

The influence of exposure approaches to in vitro lung epithelial barrier models to assess engineered nanomaterial hazard

The jury is still out on the safety of silver nanoparticles

The role of adhesion molecules as biomarkers for the aggressive prostate cancer phenotype

The role of iron redox state in the genotoxicity of ultrafine superparamagnetic iron oxide nanoparticles.

Translating Scientific Advances in the AOP Framework to Decision Making for Nanomaterials

Unraveling the effects of siRNA carrier systems on cell physiology: a multiparametric approach demonstrated on dextran nanogels

Vinblastine and diethylstilboestrol tested in the in vitro mammalian cell micronucleus test (MNvit) at Swansea University UK in support of OECD draft Test Guideline 487.