Search filters

List of works by Judith Campisi

A direct comparison of interphase FISH versus low-coverage single cell sequencing to detect aneuploidy reveals respective strengths and weaknesses

scientific article published on 19 July 2019

A human-like senescence-associated secretory phenotype is conserved in mouse cells dependent on physiological oxygen

scientific article

A novel form of the telomere-associated protein TIN2 localizes to the nuclear matrix

scientific article

A novel suicide gene therapy for the treatment of p16Ink4a-overexpressing tumors

scientific article published on 28 December 2017

A proteomic atlas of senescence-associated secretomes for aging biomarker development

scientific article published on 16 January 2020

A role for fibroblasts in mediating the effects of tobacco-induced epithelial cell growth and invasion

scientific article published on July 2008

A role for p53 in maintaining and establishing the quiescence growth arrest in human cells

scientific article

A versatile viral system for expression and depletion of proteins in mammalian cells

scientific article

ARDD 2020: from aging mechanisms to interventions

scientific article published on 30 December 2020

ATM suppresses SATB1-induced malignant progression in breast epithelial cells

scientific article

ATR and ATM-dependent movement of BLM helicase during replication stress ensures optimal ATM activation and 53BP1 focus formation

scientific article

Age-related telomere attrition causes aberrant gene expression in sub-telomeric regions

scientific article published on 21 May 2021

Aging and cancer cell biology, 2009.

scientific article published on 27 March 2009

Aging and drug discovery

scientific article published on 01 November 2018

Aging and genome maintenance: lessons from the mouse?

scientific article (publication date: 28 February 2003)

Aging: past, present and future

scientific article published on 7 January 2009

An essential role for senescent cells in optimal wound healing through secretion of PDGF-AA

scientific article

Analysis of individual cells identifies cell-to-cell variability following induction of cellular senescence

scientific article published on 11 July 2017

Apigenin suppresses the senescence-associated secretory phenotype and paracrine effects on breast cancer cells.

scientific article

Astrocyte senescence promotes glutamate toxicity in cortical neurons

scientific article published on 16 January 2020

Author Correction: Senescent cells promote tissue NAD<sup>+</sup> decline during ageing via the activation of CD38<sup>+</sup> macrophages

scientific article published on 10 December 2020

Bloom syndrome cells undergo p53-dependent apoptosis and delayed assembly of BRCA1 and NBS1 repair complexes at stalled replication forks ⬇️

scientific article published on September 29, 2003

Cancer and aging: more puzzles, more promises?

scientific article

Cancer and aging: the importance of telomeres in genome maintenance

scientific article

Caspase-independent cytochrome c release is a sensitive measure of low-level apoptosis in cell culture models

scientific article published on 01 August 2005

Cell Autonomous and Non-Autonomous Effects of Senescent Cells in the Skin.

scientific article published on 9 April 2015

Cell senescence abrogates the therapeutic potential of human mesenchymal stem cells in the lethal endotoxemia model.

scientific article

Cell surface-bound IL-1alpha is an upstream regulator of the senescence-associated IL-6/IL-8 cytokine network

scientific article published on 28 September 2009

Cellular Senescence Is Induced by the Environmental Neurotoxin Paraquat and Contributes to Neuropathology Linked to Parkinson's Disease.

scientific article published on 28 January 2018

Cellular Senescence Promotes Adverse Effects of Chemotherapy and Cancer Relapse.

scientific article

Cellular Senescence and the Senescence-Associated Secretory Phenotype as Drivers of Skin Photoaging

scientific article published on 18 December 2020

Cellular Senescence: Defining a Path Forward

scientific article published on 01 October 2019

Cellular senescence and the aging brain

scientific article

Cellular senescence and the senescent secretory phenotype: therapeutic opportunities

scientific article

Cellular senescence promotes skin carcinogenesis through p38MAPK and p44/p42MAPK signaling

scientific article published on 08 July 2020

Cellular senescence: A link between cancer and age-related degenerative disease? ⬇️

scientific article published on September 10, 2011

Chronic inflammation (inflammaging) and its potential contribution to age-associated diseases

scientific article

Chronic inflammation in the etiology of disease across the life span

scientific article published on 05 December 2019

Clearance of senescent cells by ABT263 rejuvenates aged hematopoietic stem cells in mice

scientific article

Collaboration of Werner syndrome protein and BRCA1 in cellular responses to DNA interstrand cross-links

scientific article

Comprehensive microRNA profiling in B-cells of human centenarians by massively parallel sequencing ⬇️

scientific article published on July 31, 2012

Context-dependent effects of cellular senescence in cancer development

scientific article published on 03 May 2016

Control of the replicative life span of human fibroblasts by p16 and the polycomb protein Bmi-1

scientific article

Controlled induction of DNA double-strand breaks in the mouse liver induces features of tissue ageing

scientific article

Correction of cellular phenotypes of Hutchinson-Gilford Progeria cells by RNA interference

scientific article

DNA-SCARS: distinct nuclear structures that sustain damage-induced senescence growth arrest and inflammatory cytokine secretion ⬇️

scientific article published on November 30, 2010

Deficiency in the DNA repair protein ERCC1 triggers a link between senescence and apoptosis in human fibroblasts and mouse skin

scientific article published on 18 November 2019

Depletion of senescent-like neuronal cells alleviates cisplatin-induced peripheral neuropathy in mice

scientific article published on 25 August 2020

Disease drivers of aging

scientific article published on December 2016

Do p53 stress responses impact organismal aging?

scientific article published in December 2016

Does damage to DNA and other macromolecules play a role in aging? If so, how?

scientific article published on 19 February 2009

Effect of Ku80 deficiency on mutation frequencies and spectra at a LacZ reporter locus in mouse tissues and cells

scientific article

Elimination of senescent osteoclast progenitors has no effect on the age-associated loss of bone mass in mice

scientific article published on 17 February 2019

Epithelial-Mesenchymal Transition Induced by Senescent Fibroblasts ⬇️

scientific article published on June 25, 2011

FOXO3 targets are reprogrammed as Huntington's disease neural cells and striatal neurons face senescence with p16INK4a increase

scientific article published on 06 November 2020

Four faces of cellular senescence ⬇️

scientific article published on February 14, 2011

From Ancient Pathways to Aging Cells-Connecting Metabolism and Cellular Senescence

scientific article published on June 2016

From discoveries in ageing research to therapeutics for healthy ageing

scientific article published on 10 July 2019

GROα regulates human embryonic stem cell self-renewal or adoption of a neuronal fate.

scientific article

Generation and characterization of telomere length maintenance in tankyrase 2-deficient mice

scientific article

Genomic instability, aging, and cellular senescence

scientific article published in June 2004

Geroscience: linking aging to chronic disease

scientific article

Glucocorticoids suppress selected components of the senescence‐associated secretory phenotype ⬇️

scientific article published on April 17, 2012

Higher-order nuclear organization in growth arrest of human mammary epithelial cells: a novel role for telomere-associated protein TIN2

scientific article

IL-17 and immunologically induced senescence regulate response to injury in osteoarthritis

scientific article published on 21 September 2020

Inflammatory networks during cellular senescence: causes and consequences

scientific article

Inhibition of USP7 activity selectively eliminates senescent cells in part via restoration of p53 activity

scientific article published on 16 February 2020

Ionizing radiation-induced long-term expression of senescence markers in mice is independent of p53 and immune status

scientific article

Ku80 deletion suppresses spontaneous tumors and induces a p53-mediated DNA damage response

scientific article

Lack of WRN results in extensive deletion at nonhomologous joining ends

scientific article published on 01 January 2002

Lamin B1 loss is a senescence-associated biomarker.

scientific article

Local clearance of senescent cells attenuates the development of post-traumatic osteoarthritis and creates a pro-regenerative environment

scientific article published on 24 April 2017

MTOR regulates the pro-tumorigenic senescence-associated secretory phenotype by promoting IL1A translation

scientific article

Matters of life and breath: A role for hypoxia in determining cell state.

scientific article

Measuring Aging and Identifying Aging Phenotypes in Cancer Survivors

scientific article published on 01 December 2019

Mechanisms of cellular senescence in human and mouse cells.

scientific article published on January 2004

Meeting report: Translational Research at the Aging and Cancer Interface

scientific article published in May 2007

Methods to detect biomarkers of cellular senescence: the senescence-associated beta-galactosidase assay

scientific article

MicroRNAs miR-146a/b negatively modulate the senescence-associated inflammatory mediators IL-6 and IL-8

scientific article

MicroRNAs: an important player in maintaining a balance between inflammation and tumor suppression.

scientific article

Mitochondrial Dysfunction Induces Senescence with a Distinct Secretory Phenotype

scientific article published on 9 December 2015

Mitochondrial oxidative stress caused by Sod2 deficiency promotes cellular senescence and aging phenotypes in the skin ⬇️

scientific article published on January 1, 2012

Mus musculus and Mus spretus homologues of the human telomere-associated protein TIN2

scientific journal article

Mutant frequencies and spectra depend on growth state and passage number in cells cultured from transgenic lacZ-plasmid reporter mice

scientific article published on 26 August 2005

No restriction points in life and science.

scientific article published in March 2002

Non-canonical ATM/MRN activities temporally define the senescence secretory program

scientific article published on 12 August 2020

Non-catalytic Roles for XPG with BRCA1 and BRCA2 in Homologous Recombination and Genome Stability

scientific article

Of flies, mice, and men: evolutionarily conserved tissue damage responses and aging

scientific article

Oncogene-induced senescence pathways weave an intricate tapestry

scientific article published on January 2007

Oncogenic senescence: a multi-functional perspective

scientific article

Oxidation resistance 1 is a novel senolytic target

scientific article published on 15 May 2018

Oxygen accelerates the accumulation of mutations during the senescence and immortalization of murine cells in culture

scientific article published on December 2003

Persistent DNA damage signalling triggers senescence-associated inflammatory cytokine secretion.

scientific article published on 13 July 2009

Pleiotropic age-dependent effects of mitochondrial dysfunction on epidermal stem cells

scientific article

Responses of human embryonic stem cells and their differentiated progeny to ionizing radiation

scientific article

Reversal of human cellular senescence: roles of the p53 and p16 pathways

scientific article published on August 2003

Reversible manipulation of telomerase expression and telomere length. Implications for the ionizing radiation response and replicative senescence of human cells

scientific article

SILAC Analysis Reveals Increased Secretion of Hemostasis-Related Factors by Senescent Cells

scientific article published on 01 September 2019

Secretion of leukotrienes by senescent lung fibroblasts promotes pulmonary fibrosis

scientific article published on 19 December 2019

Secretion of vascular endothelial growth factor by primary human fibroblasts at senescence

scientific article published on 31 July 2006

Senescence and apoptosis: dueling or complementary cell fates?

scientific article

Senescence cell-associated extracellular vesicles serve as osteoarthritis disease and therapeutic markers

scientific article published on 04 April 2019

Senescence-associated secretory phenotypes reveal cell-nonautonomous functions of oncogenic RAS and the p53 tumor suppressor

scientific article (publication date: 2 December 2008)

Senescent cells and osteoarthritis: a painful connection.

scientific article published on 2 April 2018

Senescent cells and their secretory phenotype as targets for cancer therapy.

scientific article

Senescent cells as a source of inflammatory factors for tumor progression

scientific article

Senescent cells evade immune clearance via HLA-E-mediated NK and CD8+ T cell inhibition.

scientific article

Senescent cells promote tissue NAD+ decline during ageing via the activation of CD38+ macrophages

scientific article published on 16 November 2020

Senescent intimal foam cells are deleterious at all stages of atherosclerosis

scientific article

Simvastatin suppresses breast cancer cell proliferation induced by senescent cells

scientific article

Single-cell profiling of skeletal muscle reveals a novel senolytic target: CRYAB

scholarly article

Small-molecule MDM2 antagonists attenuate the senescence-associated secretory phenotype

scientific article

Strategies to Prevent or Remediate Cancer and Treatment-Related Aging

scientific article published on 29 April 2020

Stromal-epithelial interactions in aging and cancer: senescent fibroblasts alter epithelial cell differentiation

scientific article published on 18 January 2005

Systemic clearance of p16INK4a -positive senescent cells mitigates age-associated intervertebral disc degeneration.

scientific article published on 21 March 2019

TIN2 mediates functions of TRF2 at human telomeres

scientific article

Targetable mechanisms driving immunoevasion of persistent senescent cells link chemotherapy-resistant cancer to aging

scientific article published on 11 June 2019

Targeted Apoptosis of Senescent Cells Restores Tissue Homeostasis in Response to Chemotoxicity and Aging

scientific article

Targeted quantitation of site-specific cysteine oxidation in endogenous proteins using a differential alkylation and multiple reaction monitoring mass spectrometry approach

scientific article

Targeting amphiregulin (AREG) derived from senescent stromal cells diminishes cancer resistance and averts programmed cell death 1 ligand (PD-L1)-mediated immunosuppression

scientific article published on 07 September 2019

Targeting senescent cells alleviates obesity-induced metabolic dysfunction

scientific article published on 25 March 2019

Telomere dysfunction and cell survival: roles for distinct TIN2-containing complexes

scientific article

Telomere length mediates the effects of telomerase on the cellular response to genotoxic stress

scientific article published on August 2004

Telomere-associated protein TIN2 is essential for early embryonic development through a telomerase-independent pathway

scientific article published on August 2004

The Bloom Syndrome Protein BLM Is Selectively Cleaved during Apoptotic Cell Death

scientific article published on 09 November 2001

The Bmi-1 oncogene induces telomerase activity and immortalizes human mammary epithelial cells

scientific article

The DNA damage response induces inflammation and senescence by inhibiting autophagy of GATA4.

scientific article

The DNA repair endonuclease XPG interacts directly and functionally with the WRN helicase defective in Werner syndrome

scientific article

The aging factor in health and disease: the promise of basic research on aging

scientific article published on April 2004

The demographic and biomedical case for late-life interventions in aging

scientific article published on July 2010

The human telomere-associated protein TIN2 stimulates interactions between telomeric DNA tracts in vitro

scientific article

The inherent challenges of classifying senescence-Response

scientific article

The power of proteomics to monitor senescence-associated secretory phenotypes and beyond: toward clinical applications

scientific article published on 19 May 2020

The role of inflammation in age-related disease

scientific article published on January 2013

The second international conference "genetics of aging and longevity".

scientific article published on May 2012

The thorny path linking cellular senescence to organismal aging

scientific article

Time to talk SENS: critiquing the immutability of human aging.

scientific article

To help aging populations, classify organismal senescence

scientific article

Treatment-induced damage to the tumor microenvironment promotes prostate cancer therapy resistance through WNT16B.

scientific article

Tumor suppressor and aging biomarker p16(INK4a) induces cellular senescence without the associated inflammatory secretory phenotype

scientific article

Two faces of p53: aging and tumor suppression

scientific article

Unmasking Transcriptional Heterogeneity in Senescent Cells

scientific article published on 21 August 2017

Using proteolysis-targeting chimera technology to reduce navitoclax platelet toxicity and improve its senolytic activity

scientific article published on 24 April 2020

WRN, the protein deficient in Werner syndrome, plays a critical structural role in optimizing DNA repair

scientific article

When DNA damage goes invisible

scientific article published on 01 November 2009

Whole Chromosome Instability induces senescence and promotes SASP.

scientific article published on 12 October 2016

Withdrawal: Selective cleavage of BLM, the Bloom syndrome protein, during apoptotic cell death

scientific article published on 01 December 2020

mTORC1 and p53: clash of the gods?

scientific article published on January 2013

miR-335 correlates with senescence/aging in human mesenchymal stem cells and inhibits their therapeutic actions through inhibition of AP-1 activity

scientific article published on August 2014

p16(INK4a) -mediated suppression of telomerase in normal and malignant human breast cells

scientific article

p38MAPK is a novel DNA damage response-independent regulator of the senescence-associated secretory phenotype

scientific article

p53 and rapamycin are additive.

scientific article

p53-dependent integration of telomere and growth factor deprivation signals

scholarly article

p53-dependent release of Alarmin HMGB1 is a central mediator of senescent phenotypes

scientific article published on 6 May 2013

p53: Pro-aging or pro-longevity?

scientific article published on July 2010

Paulina is supported by:

About Paulina

Help