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List of works by Stephen Anthony Cusack

A hybrid structural model of the complete Brugia malayi cytoplasmic asparaginyl-tRNA synthetase

scientific article

A methodology and an instrument for the temperature-controlled optimization of crystal growth

scientific article published on 21 February 2007

A quasi-atomic model of human adenovirus type 5 capsid

scientific article published on 21 April 2005

A second class of synthetase structure revealed by X-ray analysis of Escherichia coli seryl-tRNA synthetase at 2.5 A.

scientific article

A structure-based model of RIG-I activation

scientific article

A succession of substrate induced conformational changes ensures the amino acid specificity of Thermus thermophilus prolyl-tRNA synthetase: comparison with histidyl-tRNA synthetase

scientific article

A triple beta-spiral in the adenovirus fibre shaft reveals a new structural motif for a fibrous protein

scientific article

Adenovirus Type 40 Virions Contain Two Distinct Fibers

article by Alistair H. Kidd et al published January 1993 in Virology

Adenovirus complex structures

scientific article

Aminoacetylation Reaction Catalyzed by Leucyl-tRNA Synthetase Operates via a Self-Assisted Mechanism Using a Conserved Residue and the Aminoacyl Substrate

scientific article

An RNA Hybridization Assay for Screening Influenza A Virus Polymerase Inhibitors Using the Entire Ribonucleoprotein Complex

scientific article published on October 2015

An antifungal agent inhibits an aminoacyl-tRNA synthetase by trapping tRNA in the editing site

scientific article

An in vitro fluorescence based study of initiation of RNA synthesis by influenza B polymerase

scientific article published on 26 January 2017

An investigation of the structure of Alfalfa mosaic virus by small-angle neutron scattering ⬇️

scientific article published on January 25, 1981

Analysis of the Resistance Mechanism of a Benzoxaborole Inhibitor Reveals Insight into the Leucyl-tRNA Synthetase Editing Mechanism

scientific article

Antimalarial Benzoxaboroles Target Plasmodium falciparum Leucyl-tRNA Synthetase

scientific article published on 06 June 2016

Atomic Structure and Biochemical Characterization of an RNA Endonuclease in the N Terminus of Andes Virus L Protein

scientific article

Author Correction: Structural analysis of human ARS2 as a platform for co-transcriptional RNA sorting.

scientific article

Automation of sample mounting for macromolecular crystallography

scientific article published on 19 September 2006

Bunyaviridae RNA Polymerases (L-Protein) Have an N-Terminal, Influenza-Like Endonuclease Domain, Essential for Viral Cap-Dependent Transcription ⬇️

scientific article published on September 16, 2010

CBC-ARS2 stimulates 3'-end maturation of multiple RNA families and favors cap-proximal processing

scientific article published on 24 November 2013

Capped RNA primer binding to influenza polymerase and implications for the mechanism of cap-binding inhibitors.

scientific article

Characterization of PA-N terminal domain of Influenza A polymerase reveals sequence specific RNA cleavage

scientific article published on 11 July 2013

Characterization of influenza virus variants induced by treatment with the endonuclease inhibitor baloxavir marboxil.

scientific article

Class I tyrosyl-tRNA synthetase has a class II mode of cognate tRNA recognition

scientific article

Cloning, expression, crystallization and preliminary X-ray analysis of the first two Ig domains from human roundabout 1 (Robo1).

scientific article published on 21 July 2007

Co-crystallization of the human nuclear cap-binding complex with a m7GpppG cap analogue using protein engineering

scientific article

Cocrystallization of Lysyl-tRNA synthetase fromThermus thermophilus with its cognate tRNAlys and withEscherichia coli tRNAlys

scholarly article by A. D. Yaremchuk published in March 1995

Comparative Structural and Functional Analysis of Bunyavirus and Arenavirus Cap-Snatching Endonucleases

scientific article

Comparative structural and functional analysis of orthomyxovirus polymerase cap-snatching domains

scientific article

Comparison of Structure and Sequence of Influenza B/Yamagata and B/Beijing Neuraminidases Shows a Conserved "Head" but Much Greater Variability in the "Stalk" and NB Protein

scientific article published on 01 February 1993

Conformational changes in Lassa virus L protein associated with promoter binding and RNA synthesis activity

scientific article published on 02 December 2021

Conserved tertiary base pairing ensures proper RNA folding and efficient assembly of the signal recognition particle Alu domain

scientific article published on 21 September 2004

Cryptosporidium and Toxoplasma Parasites Are Inhibited by a Benzoxaborole Targeting Leucyl-tRNA Synthetase

scientific article published on 18 July 2016

Crystal Structure of Vaccinia Virus mRNA Capping Enzyme Provides Insights into the Mechanism and Evolution of the Capping Apparatus

scientific article published on 4 March 2014

Crystal structure analysis of the activation of histidine by Thermus thermophilus histidyl-tRNA synthetase

scientific article

Crystal structure of a eukaryote/archaeon-like protyl-tRNA synthetase and its complex with tRNAPro(CGG)

scientific article published on September 2000

Crystal structure of a signal recognition particle Alu domain in the elongation arrest conformation

scientific article

Crystal structure of an early protein-RNA assembly complex of the signal recognition particle

scientific article

Crystal structure of enteric adenovirus serotype 41 short fiber head

scientific article

Crystal structure of species D adenovirus fiber knobs and their sialic acid binding sites

scientific article published on July 2004

Crystal structure of the RNA-dependent RNA polymerase from influenza C virus

scientific article

Crystal structure of the UPF2-interacting domain of nonsense-mediated mRNA decay factor UPF1.

scientific article

Crystal structure of the human nuclear cap binding complex

scientific article

Crystal structures of the human and fungal cytosolic Leucyl-tRNA synthetase editing domains: A structural basis for the rational design of antifungal benzoxaboroles

scientific article

Crystallization and preliminary X-ray analysis of the Escherichia coli adaptor protein ClpS, free and in complex with the N-terminal domain of ClpA.

scientific article

Crystallization and preliminary X-ray diffraction analysis ofThermus thermophilusprolyl-tRNA synthetase

scientific article published on 01 February 2000

Crystallization and preliminary crystallographic analysis ofThermus thermophilusleucyl-tRNA synthetase and its complexes with leucine and a non-hydrolysable leucyl-adenylate analogue

scientific article published on 01 May 2000

Crystallization of Thermus thermophilus histidyl-tRNA synthetase and Its complex with tRNAHis

scientific article published on 01 August 1995

Crystallization, microPIXE and preliminary crystallographic analysis of the complex between the third KH domain of hnRNP K and single-stranded DNA.

scientific article published on 23 March 2004

Crystals of seryl-tRNA synthetase from Escherichia coli. Preliminary crystallographic data

scientific article

Design, synthesis, and evaluation of N-acyl modified sialic acids as inhibitors of adenoviruses causing epidemic keratoconjunctivitis

scientific article

Determination of the elastic constants of collagen by Brillouin light scattering

scientific article

Dimeric structure of the coxsackievirus and adenovirus receptor D1 domain at 1.7 A resolution

scientific article

Direct Measurement of Hydration-Related Dynamic Changes in Lysozyme using Inelastic Neutron Scattering Spectroscopy

article

Discovering New Classes of Brugia malayi Asparaginyl-tRNA Synthetase Inhibitors and Relating Specificity to Conformational Change

scientific article published on 01 March 2006

Discovery of Novel Oral Protein Synthesis Inhibitors of Mycobacterium tuberculosis That Target Leucyl-tRNA Synthetase

scientific article

Discovery of a Novel Class of Boron-Based Antibacterials with Activity against Gram-Negative Bacteria

scientific article

Diverse role of three tyrosines in binding of the RNA 5' cap to the human nuclear cap binding complex

scientific article published on 8 November 2008

Dynamic instability of liquidlike motions in a globular protein observed by inelastic neutron scattering

scientific article published in Physical Review Letters

Dynamical transition of myoglobin revealed by inelastic neutron scattering

scientific article

Electron density and pair correlation functions in metals

doctoral thesis

Electron microscopy of the low pH structure of influenza virus haemagglutinin

scientific article

Errors in the deposited SFTSV L protein structure

scientific article published in 2021

Escherichia coli SecA shape and dimensions

scientific article published on 01 October 1998

Evidence for the absence of swelling of alfalfa mosaic virions

scientific article published in February 1981

First steps towards effective methods in exploiting high-throughput technologies for the determination of human protein structures of high biomedical value.

scientific article published on 19 September 2006

Head-to-tail dimers and interdomain flexibility revealed by the crystal structure of HIV-1 capsid protein (p24) complexed with a monoclonal antibody Fab.

scientific article published on March 1999

Hierarchical assembly of the Alu domain of the mammalian signal recognition particle

scientific article

High-throughput sample handling and data collection at synchrotrons: embedding the ESRF into the high-throughput gene-to-structure pipeline.

scientific article

Host Determinant Residue Lysine 627 Lies on the Surface of a Discrete, Folded Domain of Influenza Virus Polymerase PB2 Subunit

scientific article

Identification of a minimal Alu RNA folding domain that specifically binds SRP9/14.

scientific article published on November 1997

Improved crystals ofThermus thermophilusprolyl-tRNA synthetase complexed with cognate tRNA obtained by crystallization from precipitate

scientific article published on 01 February 2000

Inducing phase changes in crystals of macromolecules: status and perspectives for controlled crystal dehydration.

scientific article

Inelastic neutron scattering analysis of hexokinase dynamics and its modification on binding of glucose

scientific article published in Nature

Inelastic neutron scattering analysis of picosecond internal protein dynamics

article

Inelastic neutron scattering studies of hexokinase in solution.

scientific article published in January 1984

Influence of adenoviral fiber mutations on viral encapsidation, infectivity and in vivo tropism

scientific article published in January 2001

Influenza A virus polymerase: structural insights into replication and host adaptation mechanisms

scientific article

Influenza A virus progeny vRNP trafficking in live infected cells studied with the virus-encoded fluorescently tagged PB2 protein

scientific article

Influenza Polymerase Can Adopt an Alternative Configuration Involving a Radical Repacking of PB2 Domains

scientific article published on 16 December 2015

Inhibition of mRNA deadenylation by the nuclear cap binding complex (CBC).

scientific article

Instrumental effects on the scattering curves

article by Stephen Anthony Cusack published 1 January 1981 in Journal of Molecular Biology

Investigating a macromolecular complex: the toolkit of methods

scientific article published on 18 May 2011

Kinetic Origin of Substrate Specificity in Post-Transfer Editing by Leucyl-tRNA Synthetase

scientific article published on 27 October 2017

Kinetic analysis of adenovirus fiber binding to its receptor reveals an avidity mechanism for trimeric receptor-ligand interactions

scientific article published on 20 December 2000

Kinetic discrimination of self/non-self RNA by the ATPase activity of RIG-I and MDA5

scientific article published on 28 July 2015

Large-scale induced fit recognition of an m(7)GpppG cap analogue by the human nuclear cap-binding complex

scientific article

Leucyl-tRNA synthetase editing domain functions as a molecular rheostat to control codon ambiguity in Mycoplasma pathogens

scientific article

Low resolution structure of the influenza C glycoprotein determined by electron microscopy

scientific article published on 01 May 1984

Molecular basis for the regulation of the H3K4 methyltransferase activity of PRDM9

scientific article

Molecular basis of host-adaptation interactions between influenza virus polymerase PB2 subunit and ANP32A

scientific article published on 21 July 2020

Molecular mechanism of influenza A NS1-mediated TRIM25 recognition and inhibition.

scientific article

Msl1-mediated dimerization of the dosage compensation complex is essential for male X-chromosome regulation in Drosophila

scientific article

Mutational and metal binding analysis of the endonuclease domain of the influenza virus polymerase PA subunit

scientific article published on 30 June 2010

Mutual conformational adaptations in antigen and antibody upon complex formation between an Fab and HIV-1 capsid protein p24

scientific article

NOVEL WAY OF CAPPING mRNA TRIMER AND STUDIES OF ITS INTERACTION WITH HUMAN NUCLEAR CAP-BINDING COMPLEX

scientific article published on 01 January 2005

Neutron scattering

scientific article published in Nature

Neutron scattering studies of virus structure

scientific article

New 7-methylguanine derivatives targeting the influenza polymerase PB2 cap-binding domain

scientific article

New strategy for targeting influenza virus replication

scientific article published in April 2009

Nuclear import and assembly of influenza A virus RNA polymerase studied in live cells by fluorescence cross-correlation spectroscopy.

scientific article

Piéger le produit pour inhiber spécifiquement l’enzyme

Plant tumour biocontrol agent employs a tRNA-dependent mechanism to inhibit leucyl-tRNA synthetase

scientific article

Pre-initiation and elongation structures of full-length La Crosse virus polymerase reveal functionally important conformational changes

scientific article published on 17 July 2020

Production of Slit2 LRR domains in mammalian cells for structural studies and the structure of human Slit2 domain 3

scientific article

Protein microcrystals and the design of a microdiffractometer: current experience and plans at EMBL and ESRF/ID13

scientific article published on 01 October 1999

RIG-I self-oligomerization is either dispensable or very transient for signal transduction

scientific article

RIP2 filament formation is required for NOD2 dependent NF-κB signalling

scientific article published in Nature Communications

RNA clamping by Vasa assembles a piRNA amplifier complex on transposon transcripts

scientific article

RNA-protein complexes

scientific article

Replication-competent influenza A virus that encodes a split-green fluorescent protein-tagged PB2 polymerase subunit allows live-cell imaging of the virus life cycle

scientific article

Segmented negative strand RNA virus nucleoprotein structure

scientific article published on 30 January 2014

Small is beautiful: protein micro-crystallography

scientific article published in August 1998

Solution scattering study on the structure of alfalfa mosaic virus strain VRU.

scientific article published in December 1983

Solution structure of NOD1 CARD and mutational analysis of its interaction with the CARD of downstream kinase RICK

scientific article

Specificity of recognition of mRNA 5' cap by human nuclear cap-binding complex

scientific article published on 25 July 2005

Structural Analysis of Specific Metal Chelating Inhibitor Binding to the Endonuclease Domain of Influenza pH1N1 (2009) Polymerase

scientific article

Structural Analysis of dsRNA Binding to Anti-viral Pattern Recognition Receptors LGP2 and MDA5

scientific article published on May 2016

Structural Insights into Bunyavirus Replication and Its Regulation by the vRNA Promoter.

scientific article published on 21 May 2015

Structural analysis of human ARS2 as a platform for co-transcriptional RNA sorting.

scientific article published on 27 April 2018

Structural analysis of the KANSL1/WDR5/KANSL2 complex reveals that WDR5 is required for efficient assembly and chromatin targeting of the NSL complex

scientific article

Structural analysis of the adaptor protein ClpS in complex with the N-terminal domain of ClpA

scientific article

Structural and biochemical characterization of a human adenovirus 2/12 penton base chimera

scientific article published on September 2006

Structural and functional analysis of the three MIF4G domains of nonsense-mediated decay factor UPF2

scientific article

Structural and mechanistic basis of pre- and posttransfer editing by leucyl-tRNA synthetase

scientific article (publication date: April 2003)

Structural and mutational analysis of human Ad37 and canine adenovirus 2 fiber heads in complex with the D1 domain of coxsackie and adenovirus receptor.

scientific article published on 21 August 2006

Structural basis for MOF and MSL3 recruitment into the dosage compensation complex by MSL1

scientific article

Structural basis for encapsidation of genomic RNA by La Crosse Orthobunyavirus nucleoprotein

scientific article

Structural basis for mutually exclusive co-transcriptional nuclear cap-binding complexes with either NELF-E or ARS2.

scientific article published on 3 November 2017

Structural basis for orthogonal tRNA specificities of tyrosyl-tRNA synthetases for genetic code expansion

scientific article (publication date: June 2003)

Structural basis for the activation of innate immune pattern-recognition receptor RIG-I by viral RNA

scientific article

Structural basis of an essential interaction between influenza polymerase and Pol II CTD.

scientific article published on 21 December 2016

Structural characterization of antibiotic self-immunity tRNA synthetase in plant tumour biocontrol agent

scientific article published on 07 October 2016

Structural characterization of recombinant IAV polymerase reveals a stable complex between viral PA-PB1 heterodimer and host RanBP5.

scientific article published on 20 April 2016

Structural dynamics of the aminoacylation and proofreading functional cycle of bacterial leucyl-tRNA synthetase

scientific article

Structural genomics of the Epstein-Barr virus

scientific article published on 19 September 2006

Structural insight into cap-snatching and RNA synthesis by influenza polymerase

scientific article

Structural insights into RNA synthesis by the influenza virus transcription-replication machine

scientific article published on 20 January 2017

Structural insights into reptarenavirus cap-snatching machinery.

scientific article

Structural insights into the Slit-Robo complex

scientific article

Structural insights into the mechanism and evolution of the vaccinia virus mRNA cap N7 methyl-transferase

scientific article

Structural insights into viral genome replication by the severe fever with thrombocytopenia syndrome virus L protein

scientific article published in 2023

Structural investigations of influenza B virus

scientific article published in September 1981

Structural snapshots of actively transcribing influenza polymerase

scientific article published on 03 June 2019

Structure and RNA recognition by the snRNA and snoRNA transport factor PHAX

scientific article

Structure and assembly of the Alu domain of the mammalian signal recognition particle

scientific article

Structure and composition of influenza virus. A small-angle neutron scattering study

scientific article published on December 1985

Structure and functional relevance of the Slit2 homodimerization domain

scientific article

Structure and nuclear import function of the C-terminal domain of influenza virus polymerase PB2 subunit

scientific article

Structure of SRP14 from the Schizosaccharomyces pombe signal recognition particle

scientific article

Structure of dimeric SecA, the Escherichia coli preprotein translocase motor

scientific article

Structure of influenza A polymerase bound to the viral RNA promoter

scientific article published on 19 November 2014

Structure of influenza virus RNP. I. Influenza virus nucleoprotein melts secondary structure in panhandle RNA and exposes the bases to the solvent

scientific article (publication date: July 1994)

Structure of the C-terminal head domain of the fowl adenovirus type 1 short fibre

scientific article

Structure of the Top a-t component of alfalfa mosaic virus. A non-icosahedral virion

scientific article published on December 1983

Structure of the fiber head of Ad3, a non-CAR-binding serotype of adenovirus

scientific article

Structure of the human adenovirus serotype 2 fiber head domain at 1.5 A resolution

scientific article

Structure of the influenza virus haemagglutinin complexed with its receptor, sialic acid

scientific article

Structure, Folding and Assembly of Adenovirus Fibers

Structures of Two Bacterial Prolyl-tRNA Synthetases with and without a cis-Editing Domain

scientific article published on 01 October 2006

Structures of the inactive and active states of RIP2 kinase inform on the mechanism of activation

scientific article

Systems to establish bunyavirus genome replication in the absence of transcription

scientific article

Targeting Toxoplasma gondii CPSF3 as a new approach to control toxoplasmosis

scientific article published on February 2017

The 2 A structure of helix 6 of the human signal recognition particle RNA

scientific article

The 2 Å crystal structure of leucyl-tRNA synthetase and its complex with a leucyl-adenylate analogue

scientific article

The 2.2 A resolution crystal structure of influenza B neuraminidase and its complex with sialic acid

scientific article

The 2.9 A crystal structure of T. thermophilus seryl-tRNA synthetase complexed with tRNA(Ser)

scientific article

The Cell Adhesion Molecule “CAR” and Sialic Acid on Human Erythrocytes Influence Adenovirus In Vivo Biodistribution

scientific article

The RBPome of influenza A virus NP-mRNA reveals a role for TDP-43 in viral replication

scientific article published in 2024

The Structural Basis for the Integrity of Adenovirus Ad3 Dodecahedron

scientific article

The cap-snatching endonuclease of influenza virus polymerase resides in the PA subunit

scientific article

The crystal structure of asparaginyl-tRNA synthetase from Thermus thermophilus and its complexes with ATP and asparaginyl-adenylate: the mechanism of discrimination between asparagine and aspartic acid

scientific article

The crystal structure of leucyl-tRNA synthetase complexed with tRNALeu in the post-transfer-editing conformation

scientific article

The crystal structure of the signal recognition particle Alu RNA binding heterodimer, SRP9/14.

scientific article

The crystal structure of the ternary complex of T.thermophilus seryl-tRNA synthetase with tRNA(Ser) and a seryl-adenylate analogue reveals a conformational switch in the active site

scientific article

The crystal structures of T. thermophilus lysyl-tRNA synthetase complexed with E. coli tRNA(Lys) and a T. thermophilus tRNA(Lys) transcript: anticodon recognition and conformational changes upon binding of a lysyl-adenylate analogue

scientific article

The monomeric dUTPase from Epstein-Barr virus mimics trimeric dUTPases

scientific article

The multiple Tudor domain-containing protein TDRD1 is a molecular scaffold for mouse Piwi proteins and piRNA biogenesis factors

scientific article

The physiological target for LeuRS translational quality control is norvaline

scientific article

The structural basis for cap binding by influenza virus polymerase subunit PB2

scientific article

The structural basis for seryl-adenylate and Ap4A synthesis by seryl-tRNA synthetase

scientific article published on 01 April 1995

The structural basis for the interaction between nonsense-mediated mRNA decay factors UPF2 and UPF3

scientific article (publication date: April 2004)

The structure of the Escherichia coli EF-Tu.EF-Ts complex at 2.5 A resolution

scientific article

The structure of the human adenovirus 2 penton

scientific article published on January 2005

Three-dimensional model for the isolated recombinant influenza virus polymerase heterotrimer

scientific article published on 21 May 2007

Three-dimensional molecular shape determination from a limited number of projections

scientific article published in January 1985

Time-Resolved Visualisation of Nearly-Native Influenza A Virus Progeny Ribonucleoproteins and Their Individual Components in Live Infected Cells

scientific article (publication date: 2016)

Towards a structural understanding of RNA synthesis by negative strand RNA viral polymerases

scientific article

Towards an atomic resolution understanding of the influenza virus replication machinery

scientific article published on 12 January 2010

Towards the structure of the mammalian signal recognition particle

scientific article (publication date: February 2002)

Unusual bipartite mode of interaction between the nonsense-mediated decay factors, UPF1 and UPF2

scientific article

Variation of longitudinal acoustic velocity at gigahertz frequencies with water content in rat-tail tendon fibers

scientific article published in 1984

X-ray crystallographic and NMR studies of the third KH domain of hnRNP K in complex with single-stranded nucleic acids

scientific article published in July 2005

[RIG-I: a viral RNA detector molecular switch].

scientific article

tRNA(Pro) anticodon recognition by Thermus thermophilus prolyl-tRNA synthetase

scientific article

tRNA-like recognition of group I introns by a tyrosyl-tRNA synthetase

scientific article

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