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List of works by Jan Topinka

Accumulation and persistence of DNA adducts of the synthetic steroid cyproterone acetate in rat liver

scientific article

Activation of the aryl hydrocarbon receptor is the major toxic mode of action of an organic extract of a reference urban dust particulate matter mixture: the role of polycyclic aromatic hydrocarbons.

scientific article

Adaptation of the human population to the environment: Current knowledge, clues from Czech cytogenetic and "omics" biomonitoring studies and possible mechanisms

scientific article published on 12 July 2017

Adaptive changes in global gene expression profile of lung carcinoma A549 cells acutely exposed to distinct types of AhR ligands

scientific article published on 25 April 2018

Adverse reproductive outcomes from exposure to environmental mutagens.

scientific article published on July 1999

Air pollutants, genes and early childhood acute bronchitis

scientific article

An acellular assay to assess the genotoxicity of complex mixtures of organic pollutants bound on size segregated aerosol. Part I: DNA adducts.

scientific article published on 30 June 2010

An acellular assay to assess the genotoxicity of complex mixtures of organic pollutants bound on size segregated aerosol. Part II: oxidative damage to DNA.

scientific article published on 23 July 2010

Analysis of biomarkers in a Czech population exposed to heavy air pollution. Part I: bulky DNA adducts

article

Analysis of biomarkers in a Czech population exposed to heavy air pollution. Part II: chromosomal aberrations and oxidative stress

scientific article published on 10 October 2012

Analysis of gene expression changes in A549 cells induced by organic compounds from respirable air particles.

scientific article published on 3 November 2014

Benzo[a]pyrene and tumor necrosis factor-α coordinately increase genotoxic damage and the production of proinflammatory mediators in alveolar epithelial type II cells.

scientific article published on 2 July 2011

Benzo[a]pyrene-enhanced mutagenesis by asbestos in the lung of lambda-lacI transgenic rats

scientific article

Benzo[a]pyrene-enhanced mutagenesis by man-made mineral fibres in the lung of lamda-lacI transgenic rats.

scientific article published in March 2006

Bioassay-directed chemical analysis and detection of mutagenicity in ambient air of the coke oven

scientific article published in September 1999

Biomarkers of air pollution exposure—A study of policemen in Prague

scientific article published on 19 April 2007

Biomarkers of exposure to tobacco smoke and environmental pollutants in mothers and their transplacental transfer to the foetus. Part I: bulky DNA adducts.

scientific article published on 9 May 2009

Biomarkers of exposure to tobacco smoke and environmental pollutants in mothers and their transplacental transfer to the foetus. Part II. Oxidative damage.

scientific article published on 9 May 2009

Biomarkers of genotoxicity of urban air pollution. Overview and descriptive data from a molecular epidemiology study on populations exposed to moderate-to-low levels of polycyclic aromatic hydrocarbons: the AULIS project.

scientific article

Butyrate alters expression of cytochrome P450 1A1 and metabolism of benzo[a]pyrene via its histone deacetylase activity in colon epithelial cell models.

scientific article published on 9 November 2016

Coke oven workers study: the effect of exposure and GSTM1 and NAT2 genotypes on DNA adduct levels in white blood cells and lymphocytes as determined by 32P-postlabelling

scientific article published in August 1998

Comparative Analysis of Toxic Responses of Organic Extracts from Diesel and Selected Alternative Fuels Engine Emissions in Human Lung BEAS-2B Cells

scientific article

Comparison of the health of Roma and non-Roma children living in the district of Teplice

article

Cyproterone acetate generates DNA adducts in rat liver and in primary rat hepatocyte cultures.

scientific article published on March 1993

Cyproterone acetate is an integral part of hepatic DNA adducts induced by this steroidal drug

scientific article

DNA Damage Potential of Engine Emissions Measured In Vitro by Micronucleus Test in Human Bronchial Epithelial Cells.

scientific article

DNA adduct formation in mammalian cell cultures by polycyclic aromatic hydrocarbons (PAH) and nitro-PAH in coke oven emission extract.

scientific article published on November 1998

DNA adducts formation and induction of apoptosis in rat liver epithelial 'stem-like' cells exposed to carcinogenic polycyclic aromatic hydrocarbons

scientific article published on 16 September 2007

DNA-damaging activity of the cyproterone acetate analogues chlormadinone acetate and megestrol acetate in rat liver

article

DNA-repair capacity and lipid peroxidation in chronic alcoholics.

scientific article published on July 1991

Day-to-day variability of toxic events induced by organic compounds bound to size segregated atmospheric aerosol

scientific article published on 26 March 2015

Deregulation of gene expression induced by environmental tobacco smoke exposure in pregnancy.

scientific article published on 21 February 2012

Dibenzanthracenes and benzochrysenes elicit both genotoxic and nongenotoxic events in rat liver 'stem-like' cells

scientific article published on 10 January 2007

Differences in DNA damage and repair produced by systemic, hepatocarcinogenic and sarcomagenic dibenzocarbazole derivatives in a model of rat liver progenitor cells.

scientific article

Differential gene expression in umbilical cord blood and maternal peripheral blood

scientific article published on 2 June 2009

Effect of maternal tobacco smoke exposure on the placental transcriptome

scientific article published on 25 January 2010

Effects of methylated chrysenes on AhR-dependent and -independent toxic events in rat liver epithelial cells

scientific article published on 26 February 2008

Environmental tobacco smoke exposure in children in two districts of the Czech Republic

scientific article published on 28 August 2007

Gene expression changes in human prostate carcinoma cells exposed to genotoxic and nongenotoxic aryl hydrocarbon receptor ligands

scientific article

Gene expression profiling in healthy newborns from diverse localities of the Czech Republic

scientific article published on 30 March 2018

Genetic variability of HVRII mtDNA in cord blood and respiratory morbidity in children

scientific article published on 18 March 2009

Genotoxic polycyclic aromatic hydrocarbons fail to induce the p53-dependent DNA damage response, apoptosis or cell-cycle arrest in human prostate carcinoma LNCaP cells

scientific article published on 11 June 2010

Genotoxic potential of organic extracts from particle emissions of diesel and rapeseed oil powered engines

article

Genotoxicity but not the AhR-mediated activity of PAHs is inhibited by other components of complex mixtures of ambient air pollutants

scientific article published on 26 January 2014

Genotoxicity of 7H-dibenzo[c,g]carbazole and its methyl derivatives in human keratinocytes

scientific article published on 28 January 2012

Genotoxicity of 7H-dibenzo[c,g]carbazole and its tissue-specific derivatives in human hepatoma HepG2 cells is related to CYP1A1/1A2 expression.

scientific article published in August 2011

Genotoxicity of urban air pollutants in the Czech Republic. Part I. Bacterial mutagenic potencies of organic compounds adsorbed on PM10 particulates.

scientific article published on August 2000

Genotoxicity of urban air pollutants in the Czech Republic. Part II. DNA adduct formation in mammalian cells by extractable organic matter.

scientific article published on August 2000

Global gene expression changes in human embryonic lung fibroblasts induced by organic extracts from respirable air particles.

scientific article published on 12 January 2012

HVRII of mtDNA in cord blood cells of newborn children and in their saliva 10 years later

scientific article published on January 1, 2011

Health impact of air pollution to children

article

High throughput toxicity screening and intracellular detection of nanomaterials

scientific article (publication date: 7 June 2016)

Impact of air pollution and genotype variability on DNA damage in Prague policemen

scientific article published on 25 May 2007

Impact of phase I or phase II enzyme polymorphisms on lymphocyte DNA adducts in subjects exposed to urban air pollution and environmental tobacco smoke.

scientific article published on April 2004

In Vitro Transformation of Human Bronchial Epithelial Cells by Diesel Exhaust Particles: Gene Expression Profiling and Early Toxic Responses

scientific article published on 01 November 2018

In vitro genotoxicity of PAH mixtures and organic extract from urban air particles part I: acellular assay.

scientific article published on 12 March 2007

In vitro genotoxicity of PAH mixtures and organic extract from urban air particles part II: human cell lines.

scientific article published on 12 March 2007

Influence of immunization with non-genotoxic PAH–KLH conjugates on the resistance of organisms exposed to benzo(a)pyrene

scientific article published on 25 November 2011

Inhibition of DNA repair synthesis in the rat by in vivo exposure to psychotropic drugs and reversal of the effect by co-administration with alpha-tocopherol

scientific article published in August 1990

Inhibition of β-catenin signalling promotes DNA damage elicited by benzo[a]pyrene in a model of human colon cancer cells via CYP1 deregulation

scientific article published on 24 March 2015

Interactions between CYP1A1 polymorphisms and exposure to environmental tobacco smoke in the modulation of lymphocyte bulky DNA adducts and chromosomal aberrations.

scientific article published on 30 September 2004

Kinetics of ROS generation induced by polycyclic aromatic hydrocarbons and organic extracts from ambient air particulate matter in model human lung cell lines

scientific article published on 31 January 2018

Monitoring genotoxic exposure in uranium miners.

scientific article published in March 1993

Mutagenesis by asbestos in the lung of lambda-lacI transgenic rats.

scientific article

Mutagenesis by man-made mineral fibres in the lung of rats.

scientific article published in March 2006

Mutagenicity studies on paracetamol in human volunteers II. Unscheduled DNA synthesis and micronucleus test

article

Nano-TiO stability in medium and size as important factors of toxicity in macrophage-like cells

article

No-effect level in the mutagenic activity of the drug cyproterone acetate in rat liver. Part I. Single dose treatment

scientific article

No-effect level in the mutagenic activity of the drug cyproterone acetate in rat liver. Part II. Multiple dose treatment

scientific article

Nonhomologous DNA end joining and chromosome aberrations in human embryonic lung fibroblasts treated with environmental pollutants.

scientific article published on 30 March 2014

Nucleotide excision repair is not induced in human embryonic lung fibroblasts treated with environmental pollutants.

scientific article published on 19 July 2013

Personal exposure to carcinogenic polycyclic aromatic hydrocarbons in the Czech Republic

scientific article published on 19 December 2012

Personal exposure to volatile organic compounds in the Czech Republic

scientific article published on 06 June 2012

Personal exposures to PM(2.5) and polycyclic aromatic hydrocarbons and their relationship to environmental tobacco smoke at two locations in Greece.

scientific article published on May 2001

Reduced gene expression levels after chronic exposure to high concentrations of air pollutants.

scientific article

Sensitivity of different endpoints for in vitro measurement of genotoxicity of extractable organic matter associated with ambient airborne particles (PM10).

scientific article published on 7 March 2007

Source apportionment of aerosol particles at a European air pollution hot spot using particle number size distributions and chemical composition

scientific article published on 22 November 2017

Temporal variation in the genotoxic potential of urban air particulate matter.

scientific article

The DNA repair gene XPD/ERCC2 polymorphisms Arg156Arg (exon 6) and Lys751Gln (exon 23) are closely associated

article

The aryl hydrocarbon receptor-mediated and genotoxic effects of fractionated extract of standard reference diesel exhaust particle material in pulmonary, liver and prostate cells.

scientific article published on 10 December 2014

The effect of paracetamol on oxidative damage in human peripheral lymphocytes

scientific article published on 01 July 1990

The influence of α-tocopherol and pyritinol on oxidative DNA damage and lipid peroxidation in human lymphocytes

scientific article published on 01 March 1989

The relevance of monitoring of antibodies against the polycyclic aromatic hydrocarbon (PAH) and PAH-DNA adducts in serum in relation to lung cancer and chronic obstructive pulmonary disease (COPD).

scientific article published in January 2013

The role of human cytochrome P4503A4 in biotransformation of tissue-specific derivatives of 7H-dibenzo[c,g]carbazole ⬇️

scientific article published on July 21, 2011

Toxic Effects of the Major Components of Diesel Exhaust in Human Alveolar Basal Epithelial Cells (A549)

scientific article

Toxic effects of methylated benz[a]anthracenes in liver cells.

scientific article published on 19 January 2008

Toxic effects of methylated benzo[a]pyrenes in rat liver stem-like cells.

scientific article published on 3 June 2011

Transcriptional response to organic compounds from diverse gasoline and biogasoline fuel emissions in human lung cells.

scientific article published on 9 February 2018

Transcriptome alterations in maternal and fetal cells induced by tobacco smoke.

scientific article

Tumor necrosis factor-alpha potentiates genotoxic effects of benzo[a]pyrene in rat liver epithelial cells through upregulation of cytochrome P450 1B1 expression

scientific journal article

Ultrafine particles are not major carriers of carcinogenic PAHs and their genotoxicity in size-segregated aerosols.

scientific article

Urinary 8-oxodeoxyguanosine levels in children exposed to air pollutants

scientific article

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