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List of works by Chris Dobson

13C-CP/MAS NMR studies of the cyclomalto-oligosaccharide (cyclodextrin) hydrates

scientific article published on September 2, 1992

1H nuclear magnetic resonance studies of hen lysozyme-N-acetylglucosamine oligosaccharide complexes in solution. Application of chemical shifts for the comparison of conformational changes in solution and in the crystal

scientific article published on January 1994

1H nuclear magnetic resonance studies of the interaction of urea with hen lysozyme. Origins of the conformational change induced in hen lysozyme by N-acetylglucosamine oligosaccharides

scientific article published on September 5, 1992

1H, 13C and 15N assignments of a camelid nanobody directed against human α-synuclein

article

1H, 15N and 13C assignments of domain 5 of Dictyostelium discoideum gelation factor (ABP-120) in its native and 8M urea-denatured states.

scientific article published on 18 December 2008

1H, 15N and 13C assignments of the dimeric ribosome binding domain of trigger factor from Escherichia coli.

scientific article

1H, 15N and 13C assignments of yellow fluorescent protein (YFP) Venus

scientific article published on 13 January 2009

9 Use of two-dimensional 1H nuclear magnetic resonance to study high-affinity antibody-peptide interactions

scientific article published on January 1, 1991

A Ca(2+)-binding chimera of human lysozyme and bovine alpha-lactalbumin that can form a molten globule

scientific article published on May 1995

A Coupled Equilibrium Shift Mechanism in Calmodulin-Mediated Signal Transduction

scientific article

A FRET sensor for non-invasive imaging of amyloid formation in vivo

scientific article

A Fragment-Based Method of Creating Small-Molecule Libraries to Target the Aggregation of Intrinsically Disordered Proteins

scientific article

A Nanobody Binding to Non-Amyloidogenic Regions of the Protein Human Lysozyme Enhances Partial Unfolding but Inhibits Amyloid Fibril Formation

scientific article

A Rationally Designed Six-Residue Swap Generates Comparability in the Aggregation Behavior of α-Synuclein and β-Synuclein

scientific article published in 2012

A camelid antibody fragment inhibits the formation of amyloid fibrils by human lysozyme

scientific article

A clear view of polymorphism, twist, and chirality in amyloid fibril formation

scientific article published on December 2013

A conformational isomer of bovine pancreatic trypsin inhibitor protein produced by refolding

scientific article

A generic mechanism of emergence of amyloid protofilaments from disordered oligomeric aggregates

scientific article

A glimpse at the organization of the protein universe

scientific article

A highly amyloidogenic region of hen lysozyme

scientific article

A kinetic study of beta-lactoglobulin amyloid fibril formation promoted by urea

scientific article

A label-free, quantitative assay of amyloid fibril growth based on intrinsic fluorescence

scientific article published on 16 April 2013

A microfluidic diffusion platform for characterizing the size of lipid vesicles and the thermodynamics of protein-lipid interactions.

scientific article published on 9 January 2018

A molecular chaperone breaks the catalytic cycle that generates toxic Aβ oligomers

scientific article

A natural product inhibits the initiation of α-synuclein aggregation and suppresses its toxicity

scientific article

A new two-disulphide intermediate in the refolding of reduced bovine pancreatic trypsin inhibitor ⬇️

scientific article published on April 5, 1984

A non-natural variant of human lysozyme (I59T) mimics the in vitro behaviour of the I56T variant that is responsible for a form of familial amyloidosis

scientific article published on 9 April 2010

A relationship between mRNA expression levels and protein solubility in E. coli

scientific article published on 10 March 2009

A relationship between the transient structure in the monomeric state and the aggregation propensities of α-synuclein and β-synuclein

scientific article

A simple lattice model that captures protein folding, aggregation and amyloid formation

scientific article published on 15 January 2014

A study of D52S hen lysozyme-GlcNAc oligosaccharide complexes by NMR spectroscopy and electrospray mass spectrometry

scientific article

A three-disulphide derivative of hen lysozyme. Structure, dynamics and stability

scientific article published on January 1991

A transcriptional signature of Alzheimer's disease is associated with a metastable subproteome at risk for aggregation

scientific article published on 11 April 2016

ANS binding reveals common features of cytotoxic amyloid species

scientific article published in August 2010

Absolute Quantification of Amyloid Propagons by Digital Microfluidics

scientific article published on 3 October 2017

Acceleration of the folding of hen lysozyme by trifluoroethanol

scientific article published in January 1997

Accurate determination of interstrand distances and alignment in amyloid fibrils by magic angle spinning NMR ⬇️

scientific article

Adult staphylococcal scalded skin syndrome: histological pitfalls and new diagnostic perspectives

scientific article

Alpha-2-Macroglobulin Is Acutely Sensitive to Freezing and Lyophilization: Implications for Structural and Functional Studies

scientific article published on 23 June 2015

Alpha-Synuclein Oligomers Interact with Metal Ions to Induce Oxidative Stress and Neuronal Death in Parkinson's Disease

scientific article published on 12 November 2015

Alpha-lactalbumin forms a compact molten globule in the absence of disulfide bonds.

scientific article

Altered aggregation properties of mutant gamma-crystallins cause inherited cataract

scientific journal article

Alzheimer’s disease: addressing a twenty-first century plague

scholarly article by Chris Dobson published 19 August 2015 in Accademia Nazionale dei Lincei. Atti. Scienze Fisiche e Naturali. Rendiconti

Amide hydrogen exchange in a highly denatured state. Hen egg-white lysozyme in urea

scientific article

Amyloid fibril formation by a helical cytochrome.

scientific article

Amyloid fibril formation by bovine milk kappa-casein and its inhibition by the molecular chaperones alphaS- and beta-casein

scientific article published in December 2005

Amyloid fibril formation by lens crystallin proteins and its implications for cataract formation

scientific article published on 13 November 2003

Amyloid fibril formation can proceed from different conformations of a partially unfolded protein

scientific article published on 16 September 2005

Amyloid fibrils from muscle myoglobin

scientific article

Amyloid formation by globular proteins under native conditions

scientific article

Amyloid formation by the pro-inflammatory S100A8/A9 proteins in the ageing prostate

scientific article published on 15 May 2009

Amyloid formation from HypF-N under conditions in which the protein is initially in its native state

scientific article published on 27 January 2005

Amyloid protofilaments from the calcium-binding protein equine lysozyme: formation of ring and linear structures depends on pH and metal ion concentration

scientific article

Amyloid-like Fibrils from an α-Helical Transmembrane Protein

scientific article published on 11 May 2017

Amyloid-β and α-Synuclein Decrease the Level of Metal-Catalyzed Reactive Oxygen Species by Radical Scavenging and Redox Silencing

scientific article published on 11 March 2016

Amyloid-β oligomers are sequestered by both intracellular and extracellular chaperones

scientific journal article

Amyloidogenicity and aggregate cytotoxicity of human glucagon-like peptide-1 (hGLP-1).

scientific article

An Environmentally Sensitive Fluorescent Dye as a Multidimensional Probe of Amyloid Formation

scientific article published on 11 February 2016

An NMR study of the dynamics of inhibitor‐induced conformational changes in lysozyme ⬇️

scientific article published on August 15, 1975

An analytical solution to the kinetics of breakable filament assembly

scientific article

An anticancer drug suppresses the primary nucleation reaction that initiates the production of the toxic Aβ42 aggregates linked with Alzheimer's disease

scientific article published on 12 February 2016

Analysis of main chain torsion angles in proteins: prediction of NMR coupling constants for native and random coil conformations

scientific article

Analysis of sub-tauc and supra-tauc motions in protein Gbeta1 using molecular dynamics simulations

scientific article

Analysis of the Native Structure, Stability and Aggregation of Biotinylated Human Lysozyme ⬇️

scientific article published on November 16, 2012

Antibodies and protein misfolding: From structural research tools to therapeutic strategies

scientific article

Antigen mobility in the combining site of an anti-peptide antibody.

scientific article

Assignment of aromatic amino acid PMR resonances of horse ferricytochrome c ⬇️

scientific article published on March 1, 1975

Atmospheric aerosols as prebiotic chemical reactors

scientific article

Atomic structure and hierarchical assembly of a cross-  amyloid fibril

scientific article

Author Correction: Dynamics of oligomer populations formed during the aggregation of Alzheimer's Aβ42 peptide

scientific article published on 17 April 2020

Automated Ex Situ Assays of Amyloid Formation on a Microfluidic Platform

scientific article published on February 2016

Bacterial production and direct functional screening of expanded molecular libraries for discovering inhibitors of protein aggregation

scientific article published on 16 October 2019

Bifunctional Anti-Non-Amyloid Component α-Synuclein Nanobodies Are Protective In Situ

scientific article

Binding of a substrate analogue can induce co-operative structure in the plasmin serine-proteinase domain

scientific article published on July 1993

Binding of the molecular chaperone αB-crystallin to Aβ amyloid fibrils inhibits fibril elongation

scientific article

Biophotonics of Native Silk Fibrils

scientific article published on 29 January 2018

Biophysical approaches for the study of interactions between molecular chaperones and protein aggregates

scientific article published on 02 September 2015

Biophysical studies of protein misfolding and aggregation in in vivo models of Alzheimer's and Parkinson's diseases

scientific article published on 04 June 2020

Biophysical studies of protein misfolding and aggregation in in vivo models of Alzheimer's and Parkinson's diseases - ERRATUM

scientific article published on 18 November 2020

Biosensor-based label-free assays of amyloid growth

scientific article published on 11 June 2009

Bridging the gap: from protein misfolding to protein misfolding diseases

scientific article published on 21 June 2009

C-terminal truncation of α-synuclein promotes amyloid fibril amplification at physiological pH

scientific article published on 24 May 2018

Ca2+ is a key factor in α-synuclein-induced neurotoxicity

scientific article published on 17 March 2016

Calculation of mutational free energy changes in transition states for protein folding

scientific article

Cavity hydration as a gateway to unfolding: An NMR study of hen lysozyme at high pressure and low temperature ⬇️

scientific article published on February 3, 2011

Chaperome screening leads to identification of Grp94/Gp96 and FKBP4/52 as modulators of the α-synuclein-elicited immune response.

scientific article published on 6 October 2015

Chaperone proteostasis in Parkinson's disease: stabilization of the Hsp70/alpha-synuclein complex by Hip

scientific article

Characterisation of amyloid fibril formation by small heat-shock chaperone proteins human alphaA-, alphaB- and R120G alphaB-crystallins

article

Characterisation of disulfide-bond dynamics in non-native states of lysozyme and its disulfide deletion mutants by NMR.

scientific article

Characterisation of protein unfolding by NMR diffusion measurements

Characterization of Collapsed States in the Early Stages of the Refolding of Hen Lysozyme ⬇️

scientific article published on June 9, 1998

Characterization of Single-Tryptophan Mutants of Histidine-Containing Phosphocarrier Protein: Evidence for Local Rearrangements during Folding from High Concentrations of Denaturant ⬇️

scientific article published on May 6, 2003

Characterization of a trifluoroethanol-induced partially folded state of alpha-lactalbumin

scientific article published in January 1994

Characterization of conformational preferences in a partly folded protein by heteronuclear NMR spectroscopy: assignment and secondary structure analysis of hen egg-white lysozyme in trifluoroethanol

scientific article published on October 1995

Characterization of folding the four-helix bundle protein Rop by real-time NMR.

scientific article

Characterization of oligomeric species on the aggregation pathway of human lysozyme

scientific article

Characterization of structural and folding properties of streptokinase by n.m.r. spectroscopy

scientific article

Characterization of the interdomain motions in hen lysozyme using residual dipolar couplings as replica-averaged structural restraints in molecular dynamics simulations

scientific article published on 9 September 2013

Characterization of the nanoscale properties of individual amyloid fibrils

scholarly article

Characterization of the nucleation barriers for protein aggregation and amyloid formation

scientific article published on 27 July 2007

Characterizing intermolecular interactions that initiate native-like protein aggregation ⬇️

scientific article published on 5 June 2012

Characterizing the first steps of amyloid formation for the ccbeta peptide

scientific article

Chemical biology: More charges against aggregation

scientific article published in October 2007

Chemical dissection and reassembly of amyloid fibrils formed by a peptide fragment of transthyretin

scientific article published in April 2000

Chemical kinetics for drug discovery to combat protein aggregation diseases

scientific article published on 20 February 2014

Chemical modification of insulin in amyloid fibrils ⬇️

scientific article published on November 1, 2003

Chemical properties of lipids strongly affect the kinetics of the membrane-induced aggregation of α-synuclein

scientific article

Cholesterol catalyses Aβ42 aggregation through a heterogeneous nucleation pathway in the presence of lipid membranes

scientific article published on 07 May 2018

Clusterin facilitates in vivo clearance of extracellular misfolded proteins

scientific article published on 20 April 2011

Clusterin protects neurons against intracellular proteotoxicity

scientific article published on 7 November 2017

Comments on the proposed rigidity of staphylococcal protease

scientific article published on November 1975

Comparison of MD Simulations and NMR Experiments for Hen Lysozyme. Analysis of Local Fluctuations, Cooperative Motions, and Global Changes ⬇️

scientific article published on August 29, 1995

Comparison of four independently determined structures of human recombinant interleukin–4 ⬇️

scientific article published on May 1, 1994

Comparison of the denaturant-induced unfolding of the bovine and human alpha-lactalbumin molten globules

scientific article

Comparison of the structural and dynamical properties of holo and apo bovine alpha-lactalbumin by NMR spectroscopy.

scientific article

Competition between folding, native-state dimerisation and amyloid aggregation in beta-lactoglobulin

scientific article published on 24 December 2008

Conformation of GroEL-bound alpha-lactalbumin probed by mass spectrometry.

scientific article

Conformational Effects of the A21G Flemish Mutation on the Aggregation of Amyloid β Peptide.

scientific article

Conformational Properties of Four Peptides Spanning the Sequence of Hen Lysozyme

scientific article published in September 1995

Conformational Stability of Muscle Acylphosphatase: The Role of Temperature, Denaturant Concentration, and pH ⬇️

scientific article published on February 3, 1998

Conformational mobility within the structure of muscular parvalbumins. An NMR study of the aromatic resonances of phenylalanine residues ⬇️

scientific article published on June 1, 1976

Conformational studies on muscular parvalbumins cooperative binding of calcium (II) to parvalbumins

scientific article published on January 1, 1979

Conformations and conformational dynamics of proteins in solution studied by nuclear magnetic double resonance.

scientific article

Conformations of intermediates in the folding of the pancreatic trypsin inhibitor

scientific article

Conservation of mechanism, variation of rate: folding kinetics of three homologous four-helix bundle proteins

scientific article

Conserved C-Terminal Charge Exerts a Profound Influence on the Aggregation Rate of α-Synuclein ⬇️

scientific article published on June 12, 2011

Conserved S/T Residues of the Human Chaperone DNAJB6 Are Required for Effective Inhibition of Aβ42 Amyloid Fibril Formation

scientific article published on 30 July 2018

Contribution of rotational diffusion to pulsed field gradient diffusion measurements

Correction to 'Bifunctional fluorescent probes for detection of amyloid aggregates and reactive oxygen species'.

scientific article

Crossing the boundary

scientific article published in Nature

Cytochrome display on amyloid fibrils

scientific article

De novo designed peptide-based amyloid fibrils

scientific article

Delivery of Native Proteins into C. elegans Using a Transduction Protocol Based on Lipid Vesicles

scientific article published on 8 November 2017

Demonstration by NMR of folding domains in lysozyme

scientific article

Dependence on solution conditions of aggregation and amyloid formation by an SH3 domain

scientific article

Detection of a Monomeric Intermediate Associated with Dimerization of Protein Hu by Mass Spectrometry

scientific article published in 1998

Detection of early locomotor abnormalities in a Drosophila model of Alzheimer's disease

scientific article published on 18 February 2011

Detection of transient protein folding populations by mass spectrometry

scientific article

Detergent-like interaction of Congo red with the amyloid beta peptide

scientific article published in February 2010

Determination of a transition state at atomic resolution from protein engineering data

scientific article published in November 2002

Determination of an ensemble of structures representing the denatured state of the bovine acyl-coenzyme a binding protein

scientific article published in March 2004

Determination of the folding transition states of barnase by using PhiI-value-restrained simulations validated by double mutant PhiIJ-values

scientific article

Determination of the free energy landscape of alpha-synuclein using spin label nuclear magnetic resonance measurements

scientific article

Determination of the transition state ensemble for the folding of ubiquitin from a combination of Phi and Psi analyses

scientific article published on 15 January 2008

Developing NMR methods for macromolecular machines: Measurement of residual dipolar couplings to probe dynamic regions of the ribosome

scholarly article published 10 May 2018

Differences in nucleation behavior underlie the contrasting aggregation kinetics of the Aβ40 and Aβ42 peptides

scientific article

Different soluble aggregates of Aβ42 can give rise to cellular toxicity through different mechanisms

article

Different subdomains are most protected from hydrogen exchange in the molten globule and native states of human alpha-lactalbumin

scientific article

Differential phospholipid binding of alpha-synuclein variants implicated in Parkinson's disease revealed by solution NMR spectroscopy

scientific article

Dipolar NMR relaxation of nonprotonated aromatic carbons in proteins. Structural and dynamical effects ⬇️

scientific article published on July 1, 1982

Direct characterization of amyloidogenic oligomers by single-molecule fluorescence

scholarly article

Direct measurement of lipid membrane disruption connects kinetics and toxicity of Aβ42 aggregation

scientific article published on 10 August 2020

Direct observation of heterogeneous amyloid fibril growth kinetics via two-color super-resolution microscopy

scientific article published on 11 December 2013

Direct observation of the interconversion of normal and toxic forms of α-synuclein

scientific article

Direct observation of the three regions in α-synuclein that determine its membrane-bound behaviour

scientific article

Disease‐related amyloidogenic variants of human lysozyme trigger the unfolded protein response and disturb eye development inDrosophila melanogaster ⬇️

scientific article published on September 29, 2011

Dissection of multi-protein complexes using mass spectrometry: Subunit interactions in transthyretin and retinol-binding protein complexes

Dissection of multi-protein complexes using mass spectrometry: subunit interactions in transthyretin and retinol-binding protein complexes

scientific article

Distinct thermodynamic signatures of oligomer generation in the aggregation of the amyloid-β peptide.

scientific article published on 26 March 2018

Disulfide bonds reduce the toxicity of the amyloid fibrils formed by an extracellular protein

scientific article published on 10 June 2011

Dynamics of oligomer populations formed during the aggregation of Alzheimer's Aβ42 peptide

scientific article published on 13 April 2020

Dynamics of the multidomain fibrinolytic protein urokinase from two-dimensional NMR

scientific article published in Nature

Effect of molecular chaperones on aberrant protein oligomers in vitro: super-versus sub-stoichiometric chaperone concentrations

scientific article published on 19 January 2016

Effects of the Known Pathogenic Mutations on the Aggregation Pathway of the Amyloidogenic Peptide of Apolipoprotein A-I

article

Electrostatic effects and hydrogen exchange behaviour in proteins. The pH dependence of exchange rates in lysozyme

scientific article published in September 1987

Electrostatic effects in filamentous protein aggregation

scientific article

Engineering a camelid antibody fragment that binds to the active site of human lysozyme and inhibits its conversion into amyloid fibrils

scientific article published on 25 September 2008

Enthalpic and entropic contributions mediate the role of disulfide bonds on the conformational stability of interleukin-4.

scientific article published in January 2006

Enzymatically Active Microgels from Self-Assembling Protein Nanofibrils for Microflow Chemistry

scientific article

Erratum: Prediction of variable translation rate effects on cotranslational protein folding

scientific article published in Nature Communications

Evidence for a mechanism of amyloid formation involving molecular reorganisation within native-like precursor aggregates

scientific article published in August 2005

Exacerbation of psoriasis by thalidomide in Behçet's syndrome

scientific article published in August 2003

Experimental characterization of disordered and ordered aggregates populated during the process of amyloid fibril formation

scientific article

Experimental free energy surfaces reveal the mechanisms of maintenance of protein solubility

scientific article

Experimental investigation of protein folding and misfolding

scientific article published in September 2004

Exploration of partially unfolded states of human alpha-lactalbumin by molecular dynamics simulation

scientific article

Exploring amyloid formation by a de novo design

scholarly article

Exploring the role of post-translational modifications in regulating α-synuclein interactions by studying the effects of phosphorylation on nanobody binding.

scientific article

Expression in drosophila of tandem amyloid β peptides provides insights into links between aggregation and neurotoxicity

scientific article

Expression, purification, and characterization of the recombinant calcium-binding equine lysozyme secreted by the filamentous fungus Aspergillus niger: comparisons with the production of hen and human lysozymes

scientific article published in June 1999

Fast and slow tracks in lysozyme folding: insight into the role of domains in the folding process

scientific article published on April 1997

Fast flow microfluidics and single-molecule fluorescence for the rapid characterization of α-synuclein oligomers

scientific article published on 10 August 2015

Folding kinetics of the SH3 domain of PI3 kinase by real-time NMR combined with optical spectroscopy ⬇️

scientific article published on February 27, 1998

Folding of small proteins by Monte Carlo simulations with chemical shift restraints without the use of molecular fragment replacement or structural homology

scientific article published in June 2009

Folding study of Venus reveals a strong ion dependence of its yellow fluorescence under mildly acidic conditions

scientific article

Formation of Mixed Fibrils Demonstrates the Generic Nature and Potential Utility of Amyloid Nanostructures

scientific article published in 2000

Formation of native and non-native interactions in ensembles of denatured ACBP molecules from paramagnetic relaxation enhancement studies

scientific article published on 27 January 2005

From macroscopic measurements to microscopic mechanisms of protein aggregation

scientific article published on 08 March 2012

Functionalised amyloid fibrils for roles in cell adhesion

scientific article published on 31 December 2007

Functionalised fibrils for bio-nanotechnology

scholarly article published 2006

Getting out of shape

scientific article

Glial innate immunity generated by non-aggregated alpha-synuclein in mouse: differences between wild-type and Parkinson's disease-linked mutants

scientific article

Glycine residues appear to be evolutionarily conserved for their ability to inhibit aggregation

scientific article

Heat shock protein 70 inhibits alpha-synuclein fibril formation via preferential binding to prefibrillar species

scientific journal article

Hen egg white lysozyme expressed in, and secreted from, Aspergillus niger is correctly processed and folded

scientific article

Heteronuclear NMR investigations of dynamic regions of intact Escherichia coli ribosomes

scholarly article

High Hydrostatic Pressure Dissociates Early Aggregates of TTR105–115, but not the Mature Amyloid Fibrils

High resolution 13C MAS NMR spectra of paramagnetic lanthanide complexes

article by Anthony N. Clayton et al published 1990 in Journal of the Chemical Society. Chemical communications

High-resolution MAS NMR analysis of PI3-SH3 amyloid fibrils: backbone conformation and implications for protofilament assembly and structure .

scientific article

High-resolution molecular structure of a peptide in an amyloid fibril determined by magic angle spinning NMR spectroscopy

scientific article

High-sensitivity fluorescence anisotropy detection of protein-folding events: application to alpha-lactalbumin

scientific article

Higher order amyloid fibril structure by MAS NMR and DNP spectroscopy

scientific article published on 13 December 2013

Hinge-bending and folding

scientific article published in Nature

Hsp70 inhibits the nucleation and elongation of tau and sequesters tau aggregates with high affinity

scientific article published on 4 January 2018

Hsp70 oligomerization is mediated by an interaction between the interdomain linker and the substrate-binding domain

scientific article

Human interleukin 4. The solution structure of a four-helix bundle protein

scientific article published on April 20, 1992

Hydrodynamic radii of native and denatured proteins measured by pulse field gradient NMR techniques

scientific article published in December 1999

Hydrogen exchange in native and denatured states of hen egg-white lysozyme

scientific article published in October 1992

Hydrogen exchange properties of proteins in native and denatured states monitored by mass spectrometry and NMR.

scientific article

Hydrophobic clustering in nonnative states of a protein: interpretation of chemical shifts in NMR spectra of denatured states of lysozyme

scientific article published in January 1991

Hydrophobicity and conformational change as mechanistic determinants for nonspecific modulators of amyloid β self-assembly

scientific article

Identification of Small Molecule Inhibitors of Tau Aggregation by Targeting Monomeric Tau As a Potential Therapeutic Approach for Tauopathies

scientific article (publication date: 19 October 2015)

Identification of small-molecule binding pockets in the soluble monomeric form of the Aβ42 peptide

scientific article published on July 2013

Identification of the epitopes of calcitonin gene‐related peptide (CGRP) for two anti‐CGRP monoclonal antibodies by 2D NMR ⬇️

scientific article published on September 1, 1997

Identifying A- and P-site locations on ribosome-protected mRNA fragments using Integer Programming

scientific article published on 18 April 2019

Imaging amyloid fibrils within cells using a Se-labelling strategy.

scientific article published on 25 July 2009

Immunization with α-synuclein/Grp94 reshapes peripheral immunity and suppresses microgliosis in a chronic Parkinsonism model

scientific article

Immunological features of alpha-synuclein in Parkinson's disease

scientific article published on 30 July 2008

Improved photo-CIDNP methods for studying protein structure and folding.

scientific article

In situ measurements of the formation and morphology of intracellular β-amyloid fibrils by super-resolution fluorescence imaging

scientific article

In vitro characterization of lactoferrin aggregation and amyloid formation

scientific article

In vivo translation rates can substantially delay the cotranslational folding of the Escherichia coli cytosolic proteome

scientific article

In-cell NMR characterization of the secondary structure populations of a disordered conformation of α-synuclein within E. coli cells

scientific article (publication date: 2013)

Increased Secondary Nucleation Underlies Accelerated Aggregation of the Four-Residue N-Terminally Truncated Aβ42 Species Aβ5-42

scientific article published on 08 March 2019

Independent Nucleation and Heterogeneous Assembly of Structure During Folding of Equine Lysozyme

Inhibiting the Ca2+ Influx Induced by Human CSF.

scientific article published in December 2017

Inhibition of α-Synuclein Fibril Elongation by Hsp70 Is Governed by a Kinetic Binding Competition between α-Synuclein Species

scientific article published on 23 February 2017

Initial denaturing conditions influence the slow folding phase of acylphosphatase associated with proline isomerization

scientific article published on August 2000

Insight into a random coil conformation and an isolated helix: structural and dynamical characterisation of the C-helix peptide from hen lysozyme

scientific article published on August 1996

Instability, unfolding and aggregation of human lysozyme variants underlying amyloid fibrillogenesis

scientific article

Interaction of the molecular chaperone DNAJB6 with growing amyloid-beta 42 (Aβ42) aggregates leads to sub-stoichiometric inhibition of amyloid formation

scientific article (publication date: 7 November 2014)

Interactions between amyloidophilic dyes and their relevance to studies of amyloid inhibitors

scientific article published on November 2010

Intermolecular structure determination of amyloid fibrils with magic-angle spinning and dynamic nuclear polarization NMR.

scientific article published on 12 August 2011

Intrinsic determinants of neurotoxic aggregate formation by the amyloid beta peptide

scientific article

Intrinsic disorder modulates protein self-assembly and aggregation

scientific article

Inversion of the balance between hydrophobic and hydrogen bonding interactions in protein folding and aggregation

scientific article published on 13 October 2011

Investigating the mechanisms of amylolysis of starch granules by solution-state NMR.

scientific article

Kinetic analysis reveals the diversity of microscopic mechanisms through which molecular chaperones suppress amyloid formation

scientific article published on 24 March 2016

Kinetic barriers to α-synuclein protofilament formation and conversion into mature fibrils

scientific article published on 01 July 2018

Kinetic fingerprints differentiate the mechanisms of action of anti-Aβ antibodies

scientific article published on 28 September 2020

Kinetic model of the aggregation of alpha-synuclein provides insights into prion-like spreading

scientific article published on 16 February 2016

Kinetic modelling indicates that fast-translating codons can coordinate cotranslational protein folding by avoiding misfolded intermediates

scientific article published in January 2014

Kinetic studies of protein folding using NMR spectroscopy

scientific article published on July 1, 1998

Kinetics and thermodynamics of amyloid formation from direct measurements of fluctuations in fibril mass

scholarly article

Label-free detection of amyloid growth with microcantilever sensors

article published in 2008

Latent analysis of unmodified biomolecules and their complexes in solution with attomole detection sensitivity

scientific article published on 14 September 2015

Life on the edge: a link between gene expression levels and aggregation rates of human proteins

article

Lithostathine quadruple-helical filaments form proteinase K-resistant deposits in Creutzfeldt-Jakob disease

scientific article published on 16 September 2003

Local and global cooperativity in the human alpha-lactalbumin molten globule

scientific article published in April 2004

Local cooperativity in an amyloidogenic state of human lysozyme observed at atomic resolution

scientific article

Local cooperativity in the unfolding of an amyloidogenic variant of human lysozyme

Long-range correlations between aliphatic 13C nuclei in protein MAS NMR spectroscopy

scientific article

Long-range interactions within a nonnative protein

scientific article published in March 2002

Low-populated folding intermediates of Fyn SH3 characterized by relaxation dispersion NMR.

scientific article

Lymph-Node Palpation--No Laughing Matter

scientific article published in March 2016

Main-chain dynamics of a partially folded protein: 15N NMR relaxation measurements of hen egg white lysozyme denatured in trifluoroethanol

scientific article published on April 1996

Mapping Long-Range Interactions in α-Synuclein using Spin-Label NMR and Ensemble Molecular Dynamics Simulations

article

Mapping Surface Hydrophobicity of α-Synuclein Oligomers at the Nanoscale

scientific article published on 07 November 2018

Mass spectrometry of ribosomes and ribosomal subunits ⬇️

scientific article published on June 23, 1998

Massively parallel C. elegans tracking provides multi-dimensional fingerprints for phenotypic discovery

scientific article published on 13 February 2018

Measurement of amyloid fibril length distributions by inclusion of rotational motion in solution NMR diffusion measurements.

scientific article

Measurement of the individual pKa values of acidic residues of hen and turkey lysozymes by two-dimensional 1H NMR.

scientific article

Mechanisms of hydrogen exchange in proteins from nuclear magnetic resonance studies of individual tryptophan indole NH hydrogens in lysozyme

scientific article

Mechanistic studies of the folding of human lysozyme and the origin of amyloidogenic behavior in its disease-related variants.

scientific article

Membrane lipid composition and its physicochemical properties define cell vulnerability to aberrant protein oligomers ⬇️

scientific article published on February 17, 2012

Methods and models in neurodegenerative and systemic protein aggregation diseases

scientific article published on January 2010

Microfluidic Diffusion Analysis of the Sizes and Interactions of Proteins under Native Solution Conditions

scientific article published on 17 December 2015

Microfluidic approaches for probing amyloid assembly and behaviour

scientific article published on 12 March 2018

Modulation of electrostatic interactions to reveal a reaction network unifying the aggregation behaviour of the Aβ42 peptide and its variants

scientific article published on 26 April 2017

Molecular conformation of a peptide fragment of transthyretin in an amyloid fibril

scientific article

Molecular determinants of the aggregation behavior of alpha- and beta-synuclein

scientific article published in May 2008

Molecular determinants of the interaction of EGCG with ordered and disordered proteins

scientific article published on 30 March 2018

Molecular dynamics simulations of human alpha-lactalbumin: changes to the structural and dynamical properties of the protein at low pH.

scientific article published in July 1999

Molecular dynamics simulations of peptide fragments from hen lysozyme: insight into non-native protein conformations ⬇️

scientific article published on July 24, 1998

Molecular mechanisms of protein aggregation from global fitting of kinetic models.

scientific article published on 7 January 2016

Molecular recycling within amyloid fibrils

scientific article

Monitoring Protein Folding Using Time-Resolved Biophysical Techniques

Monomeric and fibrillar α-synuclein exert opposite effects on the catalytic cycle that promotes the proliferation of Aβ42 aggregates

scientific article

Multiple tight phospholipid-binding modes of alpha-synuclein revealed by solution NMR spectroscopy

scientific article published on 27 May 2009

Multiple-frequency decoupling in magic-angle-spinning NMR of paramagnetic solids

article by Daniel P Raleigh et al published March 1992 in Journal of Magnetic Resonance

Multistep Inhibition of α-Synuclein Aggregation and Toxicity in Vitro and in Vivo by Trodusquemine

article

Mutational analysis of the aggregation-prone and disaggregation-prone regions of acylphosphatase

scientific article published on 12 September 2008

Mutations associated with familial Parkinson's disease alter the initiation and amplification steps of α-synuclein aggregation

scientific article

Myoglobin forms amyloid fibrils by association of unfolded polypeptide segments

scholarly article

NMR Spectroscopy and Protein Folding: Studies of Lysozyme and α-Lactalbumin ⬇️

scientific article published on January 1, 1991

NMR analysis of main-chain conformational preferences in an unfolded fibronectin-binding protein

article

Nanobodies Raised against Monomeric α-Synuclein Distinguish between Fibrils at Different Maturation Stages

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Nanobodies as Structural Probes of Protein Misfolding and Fibril Formation ⬇️

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Nanobodies raised against monomeric ɑ-synuclein inhibit fibril formation and destabilize toxic oligomeric species

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Optical Structural Analysis of Individual α-Synuclein Oligomers

Optical structural analysis of individual α-synuclein oligomers

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Phage display and kinetic selection of antibodies that specifically inhibit amyloid self-replication ⬇️

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Probing small molecule binding to amyloid fibrils

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Probing the exposure of tyrosine and tryptophan residues in partially folded proteins and folding intermediates by CIDNP pulse-labeling

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Probing the mechanism of amyloidogenesis through a tandem repeat of the PI3-SH3 domain suggests a generic model for protein aggregation and fibril formation

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Probing the origins, diagnosis and treatment of amyloid diseases using antibodies

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Probing the pressure-temperature stability of amyloid fibrils provides new insights into their molecular properties

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Proliferation of amyloid-β42 aggregates occurs through a secondary nucleation mechanism

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Protease-activated alpha-2-macroglobulin can inhibit amyloid formation via two distinct mechanisms

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Proteasome-targeted nanobodies alleviate pathology and functional decline in an α-synuclein-based Parkinson's disease model

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Protein aggregation and amyloid fibril formation by an SH3 domain probed by limited proteolysis

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Quantification of the Relative Contributions of Loss-of-function and Gain-of-function Mechanisms in TAR DNA-binding Protein 43 (TDP-43) Proteinopathies

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Rapid sample-mixing technique for transient NMR and photo-CIDNP spectroscopy: applications to real-time protein folding

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Rare fluctuations of native proteins sampled by equilibrium hydrogen exchange.

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Rare individual amyloid-β oligomers act on astrocytes to initiate neuronal damage

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Rational design of aggregation-resistant bioactive peptides: reengineering human calcitonin

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Recombinant amyloidogenic domain of ApoA-I: Analysis of its fibrillogenic potential

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Reduced global cooperativity is a common feature underlying the amyloidogenicity of pathogenic lysozyme mutations

Relationship between prion propensity and the rates of individual molecular steps of fibril assembly

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Relaxation data in NMR structure determination: model calculations for the lysozyme-Gd3+ complex

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Reversal of protein aggregation provides evidence for multiple aggregated States

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Rivaroxaban Versus Enoxaparin for Venous Thromboembolism Prophylaxis after Hip and Knee Arthroplasty

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SOD1 protein aggregates stimulate macropinocytosis in neurons to facilitate their propagation

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Secondary nucleation and elongation occur at different sites on Alzheimer's amyloid-β aggregates

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Secondary structure and topology of human interleukin 4 in solution

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Selective targeting of primary and secondary nucleation pathways in Aβ42 aggregation using a rational antibody scanning method

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Selenium-enhanced electron microscopic imaging of different aggregate forms of a segment of the amyloid β peptide in cells.

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Self-templated nucleation in peptide and protein aggregation

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Sequential Release of Proteins from Structured Multishell Microcapsules

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Sequestration of the Abeta peptide prevents toxicity and promotes degradation in vivo

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Short amino acid stretches can mediate amyloid formation in globular proteins: the Src homology 3 (SH3) case

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Similarities in the thermodynamics and kinetics of aggregation of disease-related Abeta(1-40) peptides

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Simultaneous determination of protein structure and dynamics.

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Single molecule characterization of the interactions between amyloid-β peptides and the membranes of hippocampal cells

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Single point mutations induce a switch in the molecular mechanism of the aggregation of the Alzheimer's disease associated Aβ42 peptide

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Single-Molecule Characterization of the Interactions between Extracellular Chaperones and Toxic α-Synuclein Oligomers.

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Single-Molecule Imaging of Individual Amyloid Protein Aggregates in Human Biofluids

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Single-molecule FRET studies on alpha-synuclein oligomerization of Parkinson's disease genetically related mutants

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Single-molecule imaging reveals that small amyloid-β1-42 oligomers interact with the cellular prion protein (PrP(C))

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Slow Cooperative Folding of a Small Globular Protein HPr ⬇️

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Small-molecule sequestration of amyloid-β as a drug discovery strategy for Alzheimer's disease

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Solution conditions determine the relative importance of nucleation and growth processes in α-synuclein aggregation

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Solution-State Nuclear Magnetic Resonance Spectroscopy and Protein Folding ⬇️

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Solvent effects on the conformation of the transmembrane peptide gramicidin A: insights from electrospray ionization mass spectrometry

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Solvent exposure of Tyr10 as a probe of structural differences between monomeric and aggregated forms of the amyloid-β peptide

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Spatial persistence of angular correlations in amyloid fibrils

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Spinal motor neuron protein supersaturation patterns are associated with inclusion body formation in ALS.

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Stimulation and inhibition of fibril formation by a peptide in the presence of different concentrations of SDS.

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Structural Effects of Two Camelid Nanobodies Directed to Distinct C-Terminal Epitopes on α-Synuclein

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Structural Ensembles of Membrane-bound α-Synuclein Reveal the Molecular Determinants of Synaptic Vesicle Affinity

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Structural and Dynamical Characterization of a Biologically Active Unfolded Fibronectin-Binding Protein fromStaphylococcusaureus†

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Structural and dynamical properties of a denatured protein. Heteronuclear 3D NMR experiments and theoretical simulations of lysozyme in 8 M urea

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Structural basis of membrane disruption and cellular toxicity by α-synuclein oligomers

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Structural basis of synaptic vesicle assembly promoted by α-synuclein

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Structural biology: Protein self-assembly intermediates

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Structural characterisation and comparison of the native and A-states of equine lysozyme

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Structural characterization of the interaction of α-synuclein nascent chains with the ribosomal surface and trigger factor

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Structural characterization of toxic oligomers that are kinetically trapped during α-synuclein fibril formation.

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Structural dissection of alkaline-denatured pepsin

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Structural information from NMR studies of paramagnetic solids; 23Na MAS spectra of sodium lanthanide salts of ethylenediaminetetraacetic acid

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Structural reorganisation and potential toxicity of oligomeric species formed during the assembly of amyloid fibrils

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Structure and binding properties of hen lysozyme modified at tryptophan 62 ⬇️

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Structure and dynamics of a partially folded protein are decoupled from its mechanism of aggregation

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Structure and dynamics of a ribosome-bound nascent chain by NMR spectroscopy

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Structure and intermolecular dynamics of aggregates populated during amyloid fibril formation studied by hydrogen/deuterium exchange.

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Structure and properties of a complex of α-synuclein and a single-domain camelid antibody

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Structure and stability of the molten globule state of guinea-pig alpha-lactalbumin: a hydrogen exchange study

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Structure of the regulatory apparatus of a calcium-dependent protein kinase (CDPK): a novel mode of calmodulin-target recognition

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Structure, dynamics and folding of an immunoglobulin domain of the gelation factor (ABP-120) from Dictyostelium discoideum

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Structures and relative free energies of partially folded states of proteins

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Supersaturation is a major driving force for protein aggregation in neurodegenerative diseases

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Surface attachment of protein fibrils via covalent modification strategies

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Systematic in vivo analysis of the intrinsic determinants of amyloid Beta pathogenicity

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Targeting the intrinsically disordered structural ensemble of α-synuclein by small molecules as a potential therapeutic strategy for Parkinson's disease

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Temperature dependent molecular motion of a tyrosine residue of ferrocytochromeC ⬇️

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The Aggregation and Neurotoxicity of TDP-43 and Its ALS-Associated 25 kDa Fragment Are Differentially Affected by Molecular Chaperones in Drosophila ⬇️

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The Amyloid Phenomenon and Its Links with Human Disease

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The Application of High Resolution Nuclear Magnetic Resonance to Biological Systems ⬇️

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The N-terminal Acetylation of α-Synuclein Changes the Affinity for Lipid Membranes but not the Structural Properties of the Bound State

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The S/T-Rich Motif in the DNAJB6 Chaperone Delays Polyglutamine Aggregation and the Onset of Disease in a Mouse Model.

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The Significance of the Location of Mutations for the Native-State Dynamics of Human Lysozyme

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The amyloid state and its association with protein misfolding diseases.

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The behaviour of polyamino acids reveals an inverse side chain effect in amyloid structure formation

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The circularization of amyloid fibrils formed by apolipoprotein C-II.

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The concept of a random coil. Residual structure in peptides and denatured proteins

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The contribution of biophysical and structural studies of protein self-assembly to the design of therapeutic strategies for amyloid diseases

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The cytochrome c fold can be attained from a compact apo state by occupancy of a nascent heme binding site

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The determination of the structure of proteins in solution: lysozyme ⬇️

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The domain organization of streptokinase: nuclear magnetic resonance, circular dichroism, and functional characterization of proteolytic fragments

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The extracellular chaperone clusterin influences amyloid formation and toxicity by interacting with prefibrillar structures

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The extracellular chaperone clusterin sequesters oligomeric forms of the amyloid-β(1-40) peptide

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The folding of hen lysozyme involves partially structured intermediates and multiple pathways

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The folding process of hen lysozyme: a perspective from the ‘new view’ ⬇️

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The formation of amyloid fibrils by relaxin

The formation of spherulites by amyloid fibrils of bovine insulin

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The fundamentals of protein folding: bringing together theory and experiment

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The iFly tracking system for an automated locomotor and behavioural analysis of Drosophila melanogaster

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The importance of loop length in the folding of an immunoglobulin domain

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The importance of sequence diversity in the aggregation and evolution of proteins

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The influence of novel gemini surfactants containing cycloalkyl side-chains on the structural phases of DNA in solution

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The interaction of alphaB-crystallin with mature alpha-synuclein amyloid fibrils inhibits their elongation

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The interaction of the molecular chaperone alpha-crystallin with unfolding alpha-lactalbumin: a structural and kinetic spectroscopic study

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The non-core regions of human lysozyme amyloid fibrils influence cytotoxicity

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The physical chemistry of the amyloid phenomenon: thermodynamics and kinetics of filamentous protein aggregation

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The protofilament structure of insulin amyloid fibrils

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The release of toxic oligomers from α-synuclein fibrils induces dysfunction in neuronal cells

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The small heat shock protein Hsp27 binds α-synuclein fibrils, preventing elongation and cytotoxicity

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The structural basis of protein folding and its links with human disease

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The study of conformational states of proteins by nuclear magnetic resonance

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Thermal unfolding of an intermediate is associated with non-arrhenius kinetics in the folding of hen lysozyme

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Thermodynamics of Polypeptide Supramolecular Assembly in the Short-Chain Limit

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Three key residues form a critical contact network in a protein folding transition state

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Three-dimensional structures of translating ribosomes by Cryo-EM.

scientific article published on April 2004

Time-resolved biophysical methods in the study of protein folding

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Toward a Description of the Conformations of Denatured States of Proteins. Comparison of a Random Coil Model with NMR Measurements

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Towards a structural biology of the hydrophobic effect in protein folding

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Towards complete descriptions of the free-energy landscapes of proteins

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Towards multiparametric fluorescent imaging of amyloid formation: studies of a YFP model of alpha-synuclein aggregation

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Transient tertiary structure formation within the ribosome exit port

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Transition state contact orders correlate with protein folding rates

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Transition states for protein folding have native topologies despite high structural variability

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Trapping folding intermediates

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Trigger factor slows co-translational folding through kinetic trapping while sterically protecting the nascent chain from aberrant cytosolic interactions.

scientific article published on 22 June 2012

Trodusquemine displaces protein misfolded oligomers from cell membranes and abrogates their cytotoxicity through a generic mechanism

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Twisting transition between crystalline and fibrillar phases of aggregated peptides

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Two-Dimensional15N−1H Photo-CIDNP as a Surface Probe of Native and Partially Structured Proteins

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Ultrasensitive Measurement of Ca2+ Influx into Lipid Vesicles Induced by Protein Aggregates

Ultrasensitive Measurement of Ca2+ Influx into Lipid Vesicles Induced by Protein Aggregates.

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Ultrastructural organization of amyloid fibrils by atomic force microscopy

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Understanding how proteins fold: the lysozyme story so far.

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Understanding the influence of codon translation rates on cotranslational protein folding

scientific article published on May 2014

Unfolding and aggregation during the thermal denaturation of streptokinase

scientific article published in August 2002

Unfolding studies of the protease domain of urokinase-type plasminogen activator: the existence of partly folded states and stable subdomains.

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Use of protonless NMR spectroscopy to alleviate the loss of information resulting from exchange-broadening.

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Widespread Proteome Remodeling and Aggregation in Aging C. elegans

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Widespread Proteome Remodeling and Aggregation in Aging C. elegans.

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Widespread aggregation and neurodegenerative diseases are associated with supersaturated proteins

scientific article published on 31 October 2013

Yttrium-89 magic angle spinning NMR study of rare-earth pyrochlores: paramagnetic shifts in the solid state

scholarly article by Clare Grey et al published June 1990 in Journal of the American Chemical Society

¹H, ¹³C and ¹⁵N resonance assignments of human muscle acylphosphatase

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α-Synuclein senses lipid packing defects and induces lateral expansion of lipids leading to membrane remodeling

scientific article published on 5 June 2013

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